INT99823

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 21.52
Pain Relevance 5.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 10
neuronal 6
plaques 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 39 100.00 Very High Very High Very High
cytokine 49 99.98 Very High Very High Very High
isoflurane 19 98.66 Very High Very High Very High
cINOD 28 96.60 Very High Very High Very High
anesthesia 11 96.36 Very High Very High Very High
Inflammation 62 92.44 High High
nMDA receptor 5 91.68 High High
Hippocampus 38 89.32 High High
depression 19 85.40 High High
nMDA receptor antagonist 2 83.28 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 442 100.00 Very High Very High Very High
Targeted Disruption 86 100.00 Very High Very High Very High
Neurodegenerative Disease 114 99.92 Very High Very High Very High
Disease 784 99.64 Very High Very High Very High
Volume Depletion And Dehydration 2 98.12 Very High Very High Very High
Apoptosis 146 97.52 Very High Very High Very High
Stress 123 97.36 Very High Very High Very High
Adhesions 6 96.88 Very High Very High Very High
Delirium 9 95.82 Very High Very High Very High
Dementia 114 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: We found that isoflurane induces cellular apoptosis in a dose-dependent manner, and that Congo red inhibits isoflurane-induced apoptosis in H4 human neuroglioma cells overexpressing APP.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP
1) Confidence 0.70 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 17234824 Disease Relevance 0.08 Pain Relevance 0
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
2) Confidence 0.70 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.84 Pain Relevance 0.36
Overexpression of APP, overproduction of A?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of APP
3) Confidence 0.69 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.48 Pain Relevance 0
secretion in SWEAPP293 cells (derived from a HEK cell line which overexpressed APP carrying the Swedish mutation, SWEAPP293).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of APP
4) Confidence 0.58 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.86 Pain Relevance 0.07
We have also shown that in cultures of cells overexpressing APP and formalin fixed and dehydrated both antibodies, 6E10 and 4G8 do not detect APP but they detect A?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP
5) Confidence 0.50 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.24 Pain Relevance 0
In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 cleavage in the NOTCH receptor and release of the NOTCH intracellular domain, a finding with conceptual implications for the development of safer drugs targeting Abeta production through gamma-secretase modulation.
Positive_regulation (targeting) of Gene_expression (production) of Abeta in cleavage associated with cinod and abeta
6) Confidence 0.49 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12777371 Disease Relevance 0.32 Pain Relevance 0.54
CHO cells stably transfected with the APP751 cDNA bearing the Val 717 Phe familial AD mutation (referred to as 7PA2 cells) [28,29] were obtained from Dr.
Positive_regulation (transfected) of Gene_expression (transfected) of APP associated with disease
7) Confidence 0.49 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.10 Pain Relevance 0
BH2 and AAA mutants, whereas the expression of WT or the vBcl-2 ??
Positive_regulation (whereas) of Gene_expression (mutants) of AAA
8) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.83 Pain Relevance 0
It has been reported that H2O2 can induce APP expression and thereby enhance A?
Positive_regulation (induce) of Gene_expression (expression) of APP
9) Confidence 0.48 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.89 Pain Relevance 0.04
New lines of transgenic mice were developed for this study that express high levels of APPswe/ind under the control of a tetracycline-responsive promoter.
Positive_regulation (levels) of Gene_expression (express) of APP associated with targeted disruption
10) Confidence 0.45 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.83 Pain Relevance 0.03
Despite an equivalent overexpression of the human sAPP and human tau transgenes, the 3xTg-AD mice developed extracellular As deposits before tangle formation, consistent with the amyloid cascade hypothesis.
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP associated with alzheimer's dementia and disease
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.18 Pain Relevance 0.07
Previously, we demonstrated that the combination of the proinflammatory cytokines TNFalpha with IFNgamma induces the production of Abeta-42 and Abeta-40 in human neuronal cells.
Positive_regulation (induces) of Gene_expression (production) of Abeta in neuronal associated with abeta and cytokine
12) Confidence 0.45 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11741404 Disease Relevance 0.82 Pain Relevance 0.70
Recently it has also been reported that NMDA-receptor stimulation also upregulates APP synthesis with a concomitant increase in A?
Positive_regulation (upregulates) of Gene_expression (synthesis) of APP
13) Confidence 0.44 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.57 Pain Relevance 0.04
To address the molecular mechanisms of dementia and delirium associated with anesthesia and surgery, we assessed whether the Abeta fibrillar aggregation inhibitor Congo red can attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells overexpressing human beta-amyloid precursor protein (APP).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of beta-amyloid precursor protein associated with anesthesia, dementia, alzheimer's dementia, delirium, isoflurane and abeta
14) Confidence 0.44 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Abstract Doc Link 17234824 Disease Relevance 0.84 Pain Relevance 0.36
, by electrochemiluminescence-based multiplex assays indicated no significant difference for sAPP?
Neg (no) Positive_regulation (difference) of Neg (no) Gene_expression (difference) of sAPP
15) Confidence 0.44 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.83 Pain Relevance 0
Additionally, further APP fragments were discovered and TDP-43 as well as ?
Positive_regulation (discovered) of Gene_expression (discovered) of APP
16) Confidence 0.44 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.59 Pain Relevance 0
-secretase leads to the production of the insoluble beta-amyloid protein that deposits into plaques.
Positive_regulation (leads) of Gene_expression (production) of beta-amyloid protein in plaques associated with alzheimer's dementia
17) Confidence 0.43 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866463 Disease Relevance 1.46 Pain Relevance 0.06
-secretase substrate APP at Thr668, thereby facilitating APP processing and A?
Positive_regulation (facilitating) of Gene_expression (processing) of APP
18) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.13 Pain Relevance 0
-secretase substrate APP at Thr668, thereby facilitating APP processing and A?
Positive_regulation (facilitating) of Gene_expression (substrate) of APP
19) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.13 Pain Relevance 0
-secretase-mediated APP cleavage was not affected by a low concentration of H2O2 (from 1 to 100 ?
Positive_regulation (mediated) of Gene_expression (cleavage) of APP in cleavage
20) Confidence 0.42 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.31 Pain Relevance 0.03

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