INT99844

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.05
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry1) mitochondrion (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
forebrain 2
pancreas 1
plaques 1
neuropil 1
P2ry1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 96 100.00 Very High Very High Very High
Glutamate 68 100.00 Very High Very High Very High
agonist 45 100.00 Very High Very High Very High
Spinal cord 16 99.82 Very High Very High Very High
Hippocampus 52 94.96 High High
antagonist 82 91.96 High High
cytokine 12 85.20 High High
Potency 1 78.20 Quite High
Central nervous system 52 71.04 Quite High
tolerance 16 70.80 Quite High
Disease Link Frequency Relevance Heat
Disease 44 98.98 Very High Very High Very High
Targeted Disruption 32 98.74 Very High Very High Very High
Amyloid Plaque 8 98.30 Very High Very High Very High
Neurodegenerative Disease 52 97.96 Very High Very High Very High
Pressure And Volume Under Development 26 92.48 High High
Death 20 85.24 High High
Alzheimer's Dementia 12 84.20 Quite High
Impaired Glucose Tolerance 20 69.32 Quite High
Apoptosis 16 66.32 Quite High
Nervous System Injury 4 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-cell function is improved in P2Y1-deficient mice, particularly in the presence of high glucose concentrations, pointing to a putative inhibitory effect of the P2Y1 receptor on insulin secretion.
Localization (secretion) of P2Y1
1) Confidence 0.74 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.13 Pain Relevance 0.07
These data suggest that ATP and UTP cause a decrease in systemic arterial pressure in the mouse via a cAMP-dependent pathway via a novel P2 receptor linked to adenylate cyclase and that nitric oxide release, prostaglandin synthesis, cGMP, and P2X1, P2Y1, and P2Y4 receptors play little or no role in the vascular effects of these purinergic agonists in the mouse.
Localization (release) of P2Y1 associated with agonist
2) Confidence 0.66 Published 2002 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11743236 Disease Relevance 0 Pain Relevance 0.39
-cell P2 receptors have not yet been unequivocally established, potent P2Y1 agonists have been shown to be strong insulin secretagogues in rat pancreas [16].
Localization (secretagogues) of P2Y1 in pancreas associated with agonist
3) Confidence 0.65 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0 Pain Relevance 0.09
Apparently, glutamate evokes a consecutive release (or formation) of ATP and adenosine, which successively activates P2Y1 and A1 receptors in Müller cells.
Localization (release) of P2Y1 associated with adenocard and glutamate
4) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072913 Disease Relevance 0.42 Pain Relevance 0.73
A stimulation applied to a single astrocyte in cocultures of rat forebrain astrocytes and associated neurons caused an elevation of [Ca2+]i and induced Ca2+ wave propagation in dorsal spinal cord through P2Y1 receptor activation [116] and glutamate release [117].
Localization (release) of P2Y1 receptor in forebrain associated with glutamate and spinal cord
5) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0 Pain Relevance 0.24
-amyloid plaques in a transgenic mouse model of AD [154].In contrast to the control human brain, the P2Y1 receptor was colocalized with a number of characteristic AD structures such as neurofibrillary tangles, neuritic plaques, and neuropil threads in the hippocampus and cortex [155].
Localization (colocalized) of P2Y1 receptor in plaques associated with targeted disruption, hippocampus, disease and amyloid plaque
6) Confidence 0.30 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.58 Pain Relevance 0.31
Weissman et al. [25] showed that [Ca2+]i waves and subsequent ATP release, with consequent P2Y1 receptor activation, accompanied radial glial cell-derived neurogenesis in cultured slices of the developing rat forebrain, as mentioned above.
Localization (release) of P2Y1 receptor in forebrain associated with neurodegenerative disease
7) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.33 Pain Relevance 0.06
-amyloid plaques in a transgenic mouse model of AD [154].In contrast to the control human brain, the P2Y1 receptor was colocalized with a number of characteristic AD structures such as neurofibrillary tangles, neuritic plaques, and neuropil threads in the hippocampus and cortex [155].
Localization (colocalized) of P2Y1 receptor in neuropil associated with targeted disruption, hippocampus, disease and amyloid plaque
8) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.58 Pain Relevance 0.31

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