INT99865

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.13
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
sensory neurons 1
TMJ 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 9 100.00 Very High Very High Very High
qutenza 8 99.96 Very High Very High Very High
vanilloid receptor subtype 1 6 98.82 Very High Very High Very High
trigeminal ganglion 1 94.92 High High
Calcitonin gene-related peptide 1 90.64 High High
nociceptor 2 82.96 Quite High
dorsal root ganglion 5 78.44 Quite High
Spinal cord 4 75.00 Quite High
cerebral cortex 2 75.00 Quite High
Adelta 1 30.64 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 9 100.00 Very High Very High Very High
Ganglion Cysts 6 94.92 High High
Nociception 3 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although VRL-1 does not bind capsaicin, like VR1 it is activated by noxious heat (>52 degrees C).
VRL-1 Neg (not) Binding (bind) of associated with qutenza
1) Confidence 0.48 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.08 Pain Relevance 0.34
We present evidence that TRPV1 and TRPV2 can heteromultimerize efficiently in vitro.
TRPV2 Binding (heteromultimerize) of
2) Confidence 0.37 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16115206 Disease Relevance 0.08 Pain Relevance 0.31
The present findings may suggest that VRL-1 is associated with chemosensory functions in visceral sensory neurons.
VRL-1 Binding (associated) of in sensory neurons
3) Confidence 0.36 Published 2002 Journal Brain Res. Section Abstract Doc Link 11744001 Disease Relevance 0.08 Pain Relevance 0.11
VR1-ir TMJ neurons were mostly small to medium-sized, whereas VRL-1- and P2X3 receptor-ir TMJ neurons were predominantly medium-sized to large.
VRL-1 Binding (medium-sized) of in TMJ associated with vanilloid receptor subtype 1 and snapping jaw
4) Confidence 0.32 Published 2004 Journal Brain Res. Section Abstract Doc Link 15081392 Disease Relevance 0.89 Pain Relevance 1.49

General Comments

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