INT99889

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Context Info
Confidence 0.71
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 11
Disease Relevance 1.45
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRD5A1) small molecule metabolic process (SRD5A1) endoplasmic reticulum (SRD5A1)
cytoplasm (SRD5A1)
Anatomy Link Frequency
myometrium 4
testes 1
brain 1
gonads 1
SRD5A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 265 99.22 Very High Very High Very High
fluoxetine 3 97.40 Very High Very High Very High
gABA 4 92.64 High High
Lasting pain 5 87.76 High High
Analgesic 10 86.80 High High
Dismenorea 4 82.96 Quite High
Opioid 30 80.48 Quite High
Pain 96 76.56 Quite High
Eae 1 76.20 Quite High
opioid receptor 10 71.36 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 99.24 Very High Very High Very High
Aggression 2 90.24 High High
Anxiety Disorder 1 89.28 High High
Pain 101 87.76 High High
Apoptosis 1 86.48 High High
Dysmenorrhea 4 82.96 Quite High
Cognitive Disorder 15 79.12 Quite High
Depression 1 59.60 Quite High
Drug Dependence 1 42.04 Quite Low
Leukemia 1 37.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sought to determine relative mRNA expression of AKR1C1 and SRD5A1, which respectively encode for the key progesterone metabolizing enzymes, 20alpha-hydroxysteroid dehydrogenase and 5alpha-reductase type 1, in the myometrium and chorioamniotic membranes during human spontaneous or induced labor and nonlabor.
Spec (determine) Transcription (expression) of SRD5A1 in myometrium
1) Confidence 0.71 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.05 Pain Relevance 0.05
Quantitative real-time reverse-transcriptase polymerase chain reaction was used to compare relative mRNA expression of AKR1C1 and SRD5A1 in the myometrium and chorioamniotic membranes from 20 subjects during three different states of labor: not in labor ( N = 10), spontaneous labor ( N = 5), or induced labor ( N = 5).
Transcription (expression) of SRD5A1 in myometrium
2) Confidence 0.71 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.08 Pain Relevance 0.08
mRNA levels for 5-alpha reductase and P450-aromatase (Ct) were normalized to cyclophilin by subtracting the Ct value of the reference gene (cyclophilin) from the Ct value of the samples (?
Transcription (levels) of 5-alpha reductase
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0 Pain Relevance 0
5-alpha reductase (5aR-1) and aromatase (AROM) mRNA expression
Transcription (expression) of 5-alpha reductase
4) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.08 Pain Relevance 0.47
AKR1C1 and SRD5A1 messenger RNA expression at term in the human myometrium and chorioamniotic membranes.
Transcription (expression) of SRD5A1 in myometrium
5) Confidence 0.53 Published 2008 Journal Am J Perinatol Section Title Doc Link 18770491 Disease Relevance 0.07 Pain Relevance 0.07
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Transcription (expression) of 5-alpha reductase in brain associated with morphine
6) Confidence 0.52 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.02
In this experiment we study the mRNA expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM).
Transcription (expression) of 5-alpha reductase
7) Confidence 0.52 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.21 Pain Relevance 0.44
In addition, the expression of 5alpha-reductase Type I mRNA and protein was lower in socially-isolated mice than that in group-housed mice whereas 3alpha-HSD mRNA expression remained unchanged.
Transcription (expression) of 5alpha-reductase
8) Confidence 0.52 Published 2001 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 11744079 Disease Relevance 0.34 Pain Relevance 0.42
Based on these observations, we can assume that HLDF-6 peptide displays at least two effects on androgen hormones metabolism in males: it stimulates testosterone biosynthesis by both testes and adrenals and simultaneously inhibits its conversion to dihydrotestosterone (DHT), most probably by diminution of 5alpha-reductase isoform 1 mRNA expression.
Transcription (expression) of 5alpha-reductase in testes
9) Confidence 0.52 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15680477 Disease Relevance 0.23 Pain Relevance 0.10
We sought to determine relative mRNA expression of AKR1C1 and SRD5A1, which respectively encode for the key progesterone metabolizing enzymes, 20alpha-hydroxysteroid dehydrogenase and 5alpha-reductase type 1, in the myometrium and chorioamniotic membranes during human spontaneous or induced labor and nonlabor.
Spec (determine) Transcription (expression) of 5alpha-reductase in myometrium
10) Confidence 0.23 Published 2008 Journal Am J Perinatol Section Abstract Doc Link 18770491 Disease Relevance 0.06 Pain Relevance 0.06
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Transcription (expression) of 5-alpha reductase in gonads associated with morphine
11) Confidence 0.18 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.02

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