INT99895

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.64
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
spinal cord 3
blood 1
extracellular matrix 1
lungs 1
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 355 100.00 Very High Very High Very High
Spinal cord 45 99.06 Very High Very High Very High
Central nervous system 150 92.44 High High
Inflammation 119 92.44 High High
Inflammatory mediators 5 85.80 High High
Bioavailability 1 76.16 Quite High
cytokine 69 71.00 Quite High
chemokine 41 68.96 Quite High
fibrosis 40 50.00 Quite Low
Dismenorea 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Infection 110 99.84 Very High Very High Very High
Disease 38 99.74 Very High Very High Very High
Diabetes Mellitus 45 99.56 Very High Very High Very High
Colon Cancer 4 99.48 Very High Very High Very High
Multiple Sclerosis 255 99.40 Very High Very High Very High
Injury 212 99.32 Very High Very High Very High
Fibrosis 53 98.84 Very High Very High Very High
Sprains And Strains 14 98.72 Very High Very High Very High
Cancer 101 96.80 Very High Very High Very High
Mycobacterial Infection 155 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed that MT-MMPs are downregulated in spinal cord of mice with adoptively transferred EAE (AT-EAE) at peak disease, except for MMP-14 and MMP-25 which are upregulated [17].
Neg (except) Positive_regulation (upregulated) of MMP-14 in spinal cord associated with multiple sclerosis, metalloproteinase, disease and spinal cord
1) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.67 Pain Relevance 0.78
induce matrix metalloproteinase 2 (MMP2) and membrane type 1-MMP (MT1-MMP)
Positive_regulation (induce) of MT1-MMP associated with metalloproteinase
2) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.59 Pain Relevance 0.05
In particular we demonstrated that transient gene transfer of HOXA3 to skin wounds of diabetic mice resulted in the upregulation of target genes, such as Plaur, Mmp14, and Cdc42, that are involved in extracellular matrix remodeling and cell migration.
Positive_regulation (upregulation) of Mmp14 in extracellular matrix associated with diabetes mellitus and injury
3) Confidence 0.43 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.79 Pain Relevance 0.03
The functional consequence of upregulation of MMP-14, MMP-25 or secreted MMPs in neuroinflammation can be interpreted simply to reflect expression of proteinases by infiltrating cells, enabling them to cross the blood-brain barrier into the CNS by cleaving extracellular matrix proteins.
Positive_regulation (upregulation) of MMP-14 in blood associated with metalloproteinase and central nervous system
4) Confidence 0.39 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.26 Pain Relevance 0.51
Expression of membrane-type matrix metalloproteinase -14 messenger RNA and gelatinase activity was elevated in accordance with the development of adenomyosis.
Positive_regulation (elevated) of membrane-type matrix metalloproteinase -14 messenger RNA
5) Confidence 0.37 Published 2001 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 11744912 Disease Relevance 0.07 Pain Relevance 0
We confirmed that the previously established pattern of MT-MMP regulation in EAE spinal cord: downregulation of MMP-15, 16, 17 and 24, and upregulation of MMP-14 and 25 is independent of mouse strain, myelin antigen, and use of adjuvant.
Positive_regulation (upregulation) of MMP-14 in spinal cord associated with multiple sclerosis, sprains and strains and spinal cord
6) Confidence 0.34 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.44 Pain Relevance 0.55
We previously found that MMP-15, 16, 17 and 24 are downregulated in spinal cord of SJL mice with MBP-induced AT-EAE, whereas the remaining two MT-MMPs (MMP-14 and 25) are upregulated [17].
Positive_regulation (upregulated) of MMP-14 in spinal cord associated with multiple sclerosis, metalloproteinase and spinal cord
7) Confidence 0.34 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.62 Pain Relevance 0.15
Some differences in fold regulation were observed compared to AT-EAE in SJL mice, but statistically significant downregulation of MMP-15, 16, 17 and 24 was observed in both models, as well as upregulation of MMP-14 and 25.
Positive_regulation (upregulation) of MMP-14 associated with multiple sclerosis
8) Confidence 0.34 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.86 Pain Relevance 0.19
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Positive_regulation (activation) of MMP-14 associated with fibrosis
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.88 Pain Relevance 0.31
We also found that mRNAs encoding the matrix metalloprotease, MMP13, was induced in D21-infected lungs (Table 2).
Positive_regulation (induced) of matrix metalloprotease in lungs associated with infection
10) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.44 Pain Relevance 0.16

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