INT99896

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.52
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
macrophages 4
uterine 4
leucocytes 2
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 76 100.00 Very High Very High Very High
Inflammatory mediators 3 99.44 Very High Very High Very High
chemokine 8 97.72 Very High Very High Very High
cytokine 22 97.12 Very High Very High Very High
Dismenorea 4 97.04 Very High Very High Very High
Inflammatory response 9 91.08 High High
Inflammation 76 88.24 High High
Tendonitis 1 75.00 Quite High
Pain 1 74.52 Quite High
tolerance 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 30 100.00 Very High Very High Very High
INFLAMMATION 85 99.24 Very High Very High Very High
Obesity 252 98.00 Very High Very High Very High
Dysmenorrhea 4 97.04 Very High Very High Very High
Arthropathy 1 94.88 High High
Rotator Cuff Tears 3 93.08 High High
Synovitis 1 87.72 High High
Hyperinsulinism 8 85.44 High High
Thrombosis 1 82.84 Quite High
Necrosis 5 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased invasion activity of endometrial stromal cells and elevated expression of matrix metalloproteinase messenger RNA in the uterine tissues of mice with experimentally induced adenomyosis.
Positive_regulation (elevated) of Gene_expression (expression) of metalloproteinase in uterine associated with dismenorea and metalloproteinase
1) Confidence 0.38 Published 2001 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 11744912 Disease Relevance 0.10 Pain Relevance 0.28
Increased invasion activity of endometrial stromal cells and elevated expression of matrix metalloproteinase messenger RNA in the uterine tissues of mice with experimentally induced adenomyosis.
Positive_regulation (elevated) of Gene_expression (expression) of metalloproteinase in uterine associated with dismenorea and metalloproteinase
2) Confidence 0.28 Published 2001 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 11744912 Disease Relevance 0.10 Pain Relevance 0.28
These crystals stimulate metalloproteinase production in vitro and also suppress metalloproteinase inhibitor production.
Positive_regulation (stimulate) of Gene_expression (production) of metalloproteinase associated with metalloproteinase
3) Confidence 0.21 Published 2003 Journal Curr Rheumatol Rep Section Abstract Doc Link 12744818 Disease Relevance 0.98 Pain Relevance 0.26
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (induced) of Gene_expression (expression) of metalloproteinase in macrophages associated with metalloproteinase and apoptosis
4) Confidence 0.02 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.22 Pain Relevance 0.20
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Positive_regulation (increased) of Gene_expression (expression) of metalloproteinase in macrophages associated with metalloproteinase and apoptosis
5) Confidence 0.02 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.23 Pain Relevance 0.23
In this study, we analysed the movement of leucocytes after T. nattereri venom injection in the intraplantar region of Swiss mice, the production of pro-inflammatory mediators and the venom potential to elicit matrix metalloproteinase production and extracellular matrix degradation.
Positive_regulation (elicit) of Gene_expression (production) of metalloproteinase in leucocytes associated with inflammatory mediators and metalloproteinase
6) Confidence 0.01 Published 2009 Journal Int J Exp Pathol Section Abstract Doc Link 19200249 Disease Relevance 0.88 Pain Relevance 0.54

General Comments

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