INT99898

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 28.54
Pain Relevance 16.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
fibroblasts 6
microglia 3
leukocyte 2
spinal cord 2
joint 1
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2890 100.00 Very High Very High Very High
rheumatoid arthritis 120 99.84 Very High Very High Very High
Spinal cord 207 99.68 Very High Very High Very High
Central nervous system 690 99.58 Very High Very High Very High
glial activation 23 99.16 Very High Very High Very High
cytokine 279 99.14 Very High Very High Very High
chemokine 151 94.64 High High
Osteoarthritis 21 94.24 High High
Inflammation 230 88.36 High High
Bioavailability 2 76.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 1260 99.86 Very High Very High Very High
Multiple Sclerosis 1173 99.84 Very High Very High Very High
Rheumatoid Arthritis 166 99.84 Very High Very High Very High
Disease 182 99.64 Very High Very High Very High
Targeted Disruption 395 99.42 Very High Very High Very High
Lung Cancer 138 97.64 Very High Very High Very High
Fibrosis 51 97.48 Very High Very High Very High
Sprains And Strains 55 97.12 Very High Very High Very High
Injury 278 96.96 Very High Very High Very High
Frailty 2 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functional consequence of this specific pattern of MT-MMP expression is unknown.
Gene_expression (expression) of MT-MMP
1) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.82 Pain Relevance 0.72
did not lead to different regulation of MT-MMP expression in EAE spinal cord.


Gene_expression (expression) of MT-MMP in spinal cord associated with multiple sclerosis and spinal cord
2) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.63 Pain Relevance 0.22
showed similar regulation in all three in vivo models used, they seemed unlikely candidates to account for the differences seen in MT-MMP expression.
Gene_expression (expression) of MT-MMP
3) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.64 Pain Relevance 0.26
We investigated microglial MT-MMP expression at peak disease (Fig. 2).
Spec (investigated) Gene_expression (expression) of MT-MMP associated with disease
4) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 1.03 Pain Relevance 0.21
Microglial expression of MMP-14 and 16 (Fig. 2A and 2C) were not significantly altered in EAE.
Gene_expression (expression) of MMP-14 associated with multiple sclerosis
5) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.87 Pain Relevance 0.22
does not regulate microglial MT-MMP expression in vitro
Gene_expression (expression) of MT-MMP
6) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.61 Pain Relevance 0.20
Microglial MT-MMP expression in EAE
Gene_expression (expression) of MT-MMP associated with multiple sclerosis
7) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.99 Pain Relevance 0.20
played a regulatory role with respect to MT-MMP expression.
Gene_expression (expression) of MT-MMP
8) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.65 Pain Relevance 0.28
We studied MT-MMP expression following a stab lesion to the entorhinal cortex.
Gene_expression (expression) of MT-MMP in cortex
9) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.64 Pain Relevance 0.56
as possible candidates for regulators of MT-MMP expression.
Gene_expression (expression) of MT-MMP
10) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.52 Pain Relevance 0.43
After PTx-induced parenchymal CNS infiltration in CCL2 Tg mice, we noted no change in MT-MMP expression.
Gene_expression (expression) of MT-MMP associated with targeted disruption and central nervous system
11) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.50 Pain Relevance 0.34
regulates MT-MMP expression by microglia, we isolated microglia from CNS of adult WT and IFN?
Gene_expression (expression) of MT-MMP in microglia associated with central nervous system
12) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.59 Pain Relevance 0.20
We investigated whether regulation of proinflammatory cytokines could account for the differences seen in MT-MMP expression.
Gene_expression (expression) of MT-MMP associated with cytokine
13) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.60 Pain Relevance 0.36
To investigate the relationship between the general process of leukocyte infiltration of the CNS, and the pattern of MT-MMP expression, we used a model of neuroinflammation that we have previously described [20].
Gene_expression (expression) of MT-MMP in leukocyte associated with central nervous system
14) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.84 Pain Relevance 0.34
-/- mice, and assessing MT-MMP expression in the spinal cord using real-time PCR.
Gene_expression (expression) of MT-MMP in spinal cord associated with spinal cord
15) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.66 Pain Relevance 0.28
The different regulation of MT-MMP expression in these three in vivo models of neuroinflammation could potentially be due to different involvement of glial responses and cytokine levels.
Gene_expression (expression) of MT-MMP associated with cytokine
16) Confidence 0.56 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.54 Pain Relevance 0.37
did not change MT-MMP expression by microglia in vitro.


Gene_expression (expression) of MT-MMP in microglia
17) Confidence 0.49 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.67 Pain Relevance 0.44
-/- mice with grade 4 EAE were compared to unmanipulated WT mice, we observed the same pattern of MT-MMP expression as in WT mice with grade 4 EAE (data not shown).
Gene_expression (expression) of MT-MMP associated with multiple sclerosis
18) Confidence 0.49 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.66 Pain Relevance 0.28
did not change the regulation of MT-MMP expression in EAE.
Gene_expression (expression) of MT-MMP associated with multiple sclerosis
19) Confidence 0.49 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.66 Pain Relevance 0.38
Expression of membrane-type matrix metalloproteinase -14 messenger RNA and gelatinase activity was elevated in accordance with the development of adenomyosis.
Gene_expression (Expression) of membrane-type matrix metalloproteinase -14 messenger RNA
20) Confidence 0.44 Published 2001 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 11744912 Disease Relevance 0.07 Pain Relevance 0

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