INT99899

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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.31
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp23) endoplasmic reticulum (Mmp23)
Anatomy Link Frequency
uterine 1
Mmp23 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 51 100.00 Very High Very High Very High
cytokine 3 98.76 Very High Very High Very High
Dismenorea 2 97.60 Very High Very High Very High
Paracetamol 1 90.68 High High
Inflammation 10 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 8 99.22 Very High Very High Very High
Dysmenorrhea 2 97.60 Very High Very High Very High
Stress 13 97.08 Very High Very High Very High
Hepatitis 4 94.28 High High
Alzheimer's Dementia 41 92.72 High High
Liver Failure 2 91.56 High High
Amyloid Plaque 15 88.96 High High
Apoptosis 7 88.12 High High
Toxicity 3 78.80 Quite High
Targeted Disruption 25 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: This study was undertaken to determine whether changes in stromal cell invasiveness and matrix metalloproteinase activity in mouse uterine tissues were involved in the development of adenomyosis that was induced by ectopic pituitary grafting.
Spec (whether) Regulation (changes) of metalloproteinase in uterine associated with dismenorea and metalloproteinase
1) Confidence 0.17 Published 2001 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 11744912 Disease Relevance 0.17 Pain Relevance 0.26
These findings demonstrate that TIMP3 and ADAM17 cooperatively dictate cytokine signaling during death receptor activation and indicate that regulated metalloproteinase activity integrates survival and death signals during acute hepatotoxic stress.
Regulation (regulated) of metalloproteinase associated with stress, metalloproteinase, death and cytokine
2) Confidence 0.04 Published 2010 Journal J. Clin. Invest. Section Abstract Doc Link 20628198 Disease Relevance 1.12 Pain Relevance 0.29
TUDCA treatment did not alter the levels of this metalloproteinase which was equivalent to control non-treated animals.
Neg (not) Regulation (alter) of metalloproteinase associated with metalloproteinase
3) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.96 Pain Relevance 0.05
A range of studies demonstrated that the zinc metalloproteinase activity responsible for generating sAPP?
Regulation (responsible) of metalloproteinase associated with metalloproteinase
4) Confidence 0.01 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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