INT99905

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.01
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
endothelial cells 2
peripheral nerve 2
dopaminergic neurons 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 13 100.00 Very High Very High Very High
Peripheral nerve injury 1 99.88 Very High Very High Very High
Neuropathic pain 7 99.28 Very High Very High Very High
allodynia 5 99.20 Very High Very High Very High
diclofenac 85 99.14 Very High Very High Very High
Hyperalgesia 1 98.64 Very High Very High Very High
Abeta 2 97.84 Very High Very High Very High
Inflammation 61 95.84 Very High Very High Very High
cINOD 99 91.04 High High
Potency 9 89.44 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 1 99.88 Very High Very High Very High
Neuropathic Pain 12 99.28 Very High Very High Very High
Cancer 83 98.80 Very High Very High Very High
Hyperalgesia 1 98.64 Very High Very High Very High
Alzheimer's Dementia 1 98.40 Very High Very High Very High
Parkinson's Disease 108 97.92 Very High Very High Very High
Convulsion 30 97.68 Very High Very High Very High
Drug Induced Neurotoxicity 9 97.40 Very High Very High Very High
Intestinal Cancer 4 97.36 Very High Very High Very High
INFLAMMATION 98 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia and hyperalgesia in neuropathic pain patients and animal models.
Negative_regulation (ineffective) of Negative_regulation (inhibitors) of COX in peripheral nerve associated with hyperalgesia, nervous system injury, allodynia, neuropathic pain and peripheral nerve injury
1) Confidence 0.35 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19346674 Disease Relevance 0.73 Pain Relevance 0.83
The antipyretic action of aspirin may be mediated by inhibition of COX-3 in hypothalamic endothelial cells or by inhibition of COX-1 localised close to sensory receptors of peripheral vagal afferents.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of COX in endothelial cells associated with aspirin
2) Confidence 0.28 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.52 Pain Relevance 0.94
In vitro, it has been demonstrated that non-selective inhibitors of COX can preferentially decrease the levels of the highly amyloidogenic amyloid-beta (Abeta)(1-42)peptide.
Negative_regulation (decrease) of Negative_regulation (inhibitors) of COX associated with alzheimer's dementia and abeta
3) Confidence 0.23 Published 2002 Journal J. Alzheimers Dis. Section Abstract Doc Link 12446975 Disease Relevance 1.55 Pain Relevance 0.76
In contrast only inhibition of COX-1 led to a decrease in BAL fluid levels of KC and only inhibition of COX-2 led to a decrease in levels of IL-6.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of COX
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 0.86 Pain Relevance 0.25
Both inhibition of COX-2 and genetic deficiency of COX-2 reduced SNpc microglial activation and mitigated MPTP-induced neurotoxicity on dopaminergic neurons in the SNpc.


Negative_regulation (inhibition) of Negative_regulation (deficiency) of COX in dopaminergic neurons associated with parkinson's disease and drug induced neurotoxicity
5) Confidence 0.14 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 1.55 Pain Relevance 0.23
This functional switch is clearly observed with the amide derivatives of the diclofenac series, compounds 1, 2, 4, 6 and 7, which lack substantial COX enzyme inhibition but are all M-channel openers, provided that a terminal hydroxyl function is maintained (Figure 2, see below).
Negative_regulation (lack) of Negative_regulation (inhibition) of COX enzyme associated with diclofenac
6) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0.20 Pain Relevance 0.46
Conversion of the carboxylate function into amide abolished COX inhibition but preserved M-channel modulation.
Negative_regulation (abolished) of Negative_regulation (inhibition) of COX
7) Confidence 0.07 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2131780 Disease Relevance 0.18 Pain Relevance 0.35
Hence, the combination of the amide function and the preservation of a terminal hydroxyl group are probably responsible for the profound loss of COX inhibition displayed by the amide derivatives, designed in this study.
Negative_regulation (loss) of Negative_regulation (inhibition) of COX
8) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0 Pain Relevance 0.34
If uniformly diminished PG synthesis by IDO was responsible for growth of RAW cell macroscopic foci, inhibiting PG synthesis with a pharmacological inhibitor of COX-1 and -2 ought to reproduce the effect of IDO expression.
Negative_regulation (inhibiting) of Negative_regulation (inhibitor) of COX
9) Confidence 0.07 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0 Pain Relevance 0
The epidemiologic evidence and rodent studies suggest strongly that nonselective inhibitors of cyclooxygenase (COX) enzymes such as aspirin, inhibiting both COX-1 and COX-2 isoforms, reduce the incidence of and mortality from intestinal tumors.
Negative_regulation (inhibitors) of Negative_regulation (inhibiting) of COX associated with aspirin and intestinal cancer
10) Confidence 0.07 Published 2001 Journal Int. J. Cancer Section Abstract Doc Link 11745453 Disease Relevance 0.45 Pain Relevance 0.05
COX inhibitors also reduce the growth rate of implanted tumors, suggesting potential therapeutic utility.
Negative_regulation (reduce) of Negative_regulation (inhibitors) of COX associated with cancer
11) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.95 Pain Relevance 0.14

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