INT99909

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.88
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
skin 2
leg 2
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 99.20 Very High Very High Very High
cINOD 28 95.72 Very High Very High Very High
Analgesic 1 89.08 High High
cytokine 1 65.56 Quite High
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
withdrawal 1 21.00 Low Low
Pain 12 5.00 Very Low Very Low Very Low
visual analogue scale 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.20 Very High Very High Very High
Skin Ulcer 6 99.16 Very High Very High Very High
Phosphate Metabolism Disorders 55 98.28 Very High Very High Very High
Leg Ulcer 3 97.96 Very High Very High Very High
Hypoxia 1 97.64 Very High Very High Very High
Cv General 4 Under Development 1 97.16 Very High Very High Very High
Wound Healing 1 42.60 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
Fatigue 5 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, up-regulation of COX-2 is most likely responsible for the persistent inflammation in chronic venous leg ulcers.
Spec (likely) Regulation (responsible) of Positive_regulation (up-regulation) of COX in leg associated with leg ulcer and inflammation
1) Confidence 0.35 Published 2001 Journal J. Pathol. Section Abstract Doc Link 11745699 Disease Relevance 1.05 Pain Relevance 0.31
We show that the LPS-induced up-regulation of COX-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1).
Regulation (depends) of Positive_regulation (up-regulation) of COX
2) Confidence 0.16 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16950767 Disease Relevance 0.09 Pain Relevance 0.09
A significant increase of COX-2 gene expression and subsequent increase of PGE2 concentrations in the supernatant were noted in fibroblasts isolated from normal skin, HP skin and HP dura mater, after addition of calcium pyrophosphate but not pyridoxal phosphate.
Regulation (noted) of Positive_regulation (increase) of COX in skin associated with phosphate metabolism disorders
3) Confidence 0.12 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.74 Pain Relevance 0.13

General Comments

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