INT9993

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 131
Total Number 131
Disease Relevance 46.27
Pain Relevance 30.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cells 57
PBMC 16
lymphocytes 13
NK cell 11
blood 10
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1007 100.00 Very High Very High Very High
Inflammation 633 100.00 Very High Very High Very High
chemokine 68 100.00 Very High Very High Very High
aspirin 123 99.98 Very High Very High Very High
fluoxetine 6 99.98 Very High Very High Very High
anesthesia 10 99.96 Very High Very High Very High
spinal inflammation 149 99.84 Very High Very High Very High
Morphine 21 99.76 Very High Very High Very High
Spinal cord 8 99.76 Very High Very High Very High
Opioid 44 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 671 100.00 Very High Very High Very High
Cancer 303 100.00 Very High Very High Very High
Necrosis 57 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Low Back Pain 185 99.84 Very High Very High Very High
Adhesions 31 99.84 Very High Very High Very High
Coronary Artery Disease 7 99.82 Very High Very High Very High
Syndrome 123 99.64 Very High Very High Very High
Aging 414 99.48 Very High Very High Very High
Disease 374 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in interleukin-2 receptor expression were seen on lymphocytes collected on one occasion from each of two patients 30 min postinfusion.
Positive_regulation (Increases) of Gene_expression (expression) of interleukin-2 in lymphocytes
1) Confidence 0.69 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.86 Pain Relevance 0.30
Studies done 24 hr after infusions revealed increases in interleukin-2 production in one patient, but when pre- and posttreatment values were compared there were no significant changes in numbers of circulating T cells of any phenotype or in T-cell responses to mitogens or antigens.
Positive_regulation (increases) of Gene_expression (production) of interleukin-2 in T-cell
2) Confidence 0.69 Published 1988 Journal J. Clin. Immunol. Section Abstract Doc Link 2967309 Disease Relevance 0.90 Pain Relevance 0.34
Human IL-2 mRNA was detected by in situ hybridization in the spinal pia mater and parenchyma of the lumbar, sacral, thoracic and cervical regions, and gray matter had higher level of IL-2 expression than white matter.
Positive_regulation (level) of Gene_expression (expression) of IL-2 in parenchyma
3) Confidence 0.69 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.66 Pain Relevance 0.73
Induction of IL-2 production
Positive_regulation (Induction) of Gene_expression (production) of IL-2
4) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
This could improve DC interaction with T lymphocytes and increase IL-2 production.
Positive_regulation (increase) of Gene_expression (production) of IL-2 in T lymphocytes
5) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.23 Pain Relevance 0
An increase in IL-2 production was also apparent in cultures from both SMT-C and SMT-NC subjects relative to baseline and venipuncture controls.
Positive_regulation (increase) of Gene_expression (production) of IL-2
6) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
It is therefore unlikely that the observed increments in SPA-induced production of IL-2 ensued from in vivo (systemic) pre-activation of circulating peripheral blood T lymphocytes.
Positive_regulation (-) of Gene_expression (production) of IL-2 in T lymphocytes
7) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03
Such improved interaction has been shown to be mediated by another cytokine, interleukin 15 (IL-15) resulting in increased IL-2 production by T lymphocytes, such as observed in our study.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in T lymphocytes associated with cytokine
8) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.08 Pain Relevance 0.05
The increased IL-2 synthesis by PBMCs was not accompanied by a systemic (in vivo) release of IL-2 in response to any of the interventions.
Positive_regulation (increased) of Gene_expression (synthesis) of IL-2
9) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
The production of IL-2 increased in cultures from SMT-C as well as SMT-NC subjects relative to baseline and venipuncture controls 20 minutes following the manipulative interventions.
Positive_regulation (increased) of Gene_expression (production) of IL-2
10) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
IL-2 synthesis in PBMC cultures was induced by two different methods.
Positive_regulation (induced) of Gene_expression (synthesis) of IL-2 in PBMC
11) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Thus, an increase in the number of IL-2 secreting DCs in the PBMC preparations examined after the intervention, might explain the observed increase in IL-2 production in cultures derived from SMT-C and SMT-NC – treated subjects.
Positive_regulation (increase) of Gene_expression (production) of IL-2
12) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.15 Pain Relevance 0
Furthermore, the in vitro induction of IL-2 synthesis may be achieved either via mitogen-related transmembrane signaling or by a chemical stimulation which bypasses such requirements.
Positive_regulation (induction) of Gene_expression (synthesis) of IL-2
13) Confidence 0.69 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.15
Immunological variables of the cellular and humoral immune axis showed that 1) total lymphocyte counts and the distribution of lymphocyte subpopulations, including helper T-cell/suppressor cytotoxic T-cell ratios (CD4/CD8 ratios), did not change compared with baseline or healthy control subjects; 2) proliferation of peripheral mononuclear cells (PMC) was not impaired by morphine treatment; 3) interleukin 2 production increased after 4 wk of treatment with morphine; and 4) immunoglobulin (Ig) production was reduced before initiation of therapy in pain patients and decreased further during morphine treatment, whereas Ig concentrations in the circulation remained at normal levels.
Positive_regulation (increased) of Gene_expression (production) of interleukin 2 in cytotoxic T-cell associated with pain and morphine
14) Confidence 0.67 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9428873 Disease Relevance 0.53 Pain Relevance 1.25
The effect of thymopentin is assumed to be due to T-helper cell activation resulting in enhanced interleukin-2 production with subsequent proliferation of cytotoxic T lymphocytes and natural killer cells which are capable of producing immune interferon.
Positive_regulation (enhanced) of in T-helper cell Gene_expression (production) of interleukin-2 in cytotoxic T lymphocytes
15) Confidence 0.67 Published 1984 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6085327 Disease Relevance 0.84 Pain Relevance 0.08
In addition, naloxone had an apparent additive effect on the morphine-associated enhancement of IFN gamma and IL-2 expression in the dual-infection model.
Positive_regulation (enhancement) of Gene_expression (expression) of IL-2 associated with narcan, infection and morphine
16) Confidence 0.65 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.25 Pain Relevance 1.22
Effects of aspirin and thymosin on enhancement of IL-2 production.
Positive_regulation (enhancement) of Gene_expression (production) of IL-2 associated with aspirin
17) Confidence 0.64 Published 1985 Journal Immunopharmacology Section Title Doc Link 3926716 Disease Relevance 0 Pain Relevance 0.19
Our studies demonstrate that aspirin, an inhibitor of the cyclooxygenase pathway, given in vivo, or added to cultures in vitro, results in two-fold increased IL-2 production by PHA-stimulated PBL.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in PBL associated with aspirin
18) Confidence 0.64 Published 1985 Journal Immunopharmacology Section Abstract Doc Link 3926716 Disease Relevance 0 Pain Relevance 0.19
Activation of the T lymphocytes, especially the TH, with increased production of IL-2, might be a critical step in the whole process of immunoenhancement.
Positive_regulation (increased) of Gene_expression (production) of IL-2 in T lymphocytes
19) Confidence 0.58 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517054 Disease Relevance 0.09 Pain Relevance 0.03
These data demonstrated that the IL-2 gene was transfected into spinal cord regions relevant to pain modulation.
Positive_regulation (transfected) of Gene_expression (transfected) of IL-2 gene in spinal cord associated with pain and spinal cord
20) Confidence 0.50 Published 2003 Journal Gene Ther. Section Abstract Doc Link 12883536 Disease Relevance 0.65 Pain Relevance 0.74

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