INT99941

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.24
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
lungs 2
T cell 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.24 Very High Very High Very High
Inflammation 39 98.48 Very High Very High Very High
Endogenous opioid 1 94.56 High High
mu opioid receptor 2 86.92 High High
opioid receptor 1 84.64 Quite High
Opioid 3 83.28 Quite High
Enkephalin 2 75.00 Quite High
cytokine 16 73.44 Quite High
agonist 14 59.24 Quite High
Inflammatory response 4 18.76 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 40 98.48 Very High Very High Very High
Death 37 97.40 Very High Very High Very High
Pleurisy 16 92.48 High High
Adult Respiratory Distress Syndrome 3 89.04 High High
Apoptosis 58 87.68 High High
Stress 2 75.56 Quite High
Lymphadenopathy 13 66.76 Quite High
Pheochromocytoma 1 62.64 Quite High
Lymphopenia 1 62.12 Quite High
Leukemia 1 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that FasL activation was significantly reduced in lungs from mice treated with T0901317.
Negative_regulation (reduced) of Positive_regulation (activation) of FasL in lungs
1) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.09 Pain Relevance 0.20
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Negative_regulation (inhibited) of Positive_regulation (inactivation) of FasL in T cell associated with death
2) Confidence 0.39 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.94 Pain Relevance 0.04
Cytotoxic concentrations of DADLE, on the other hand, caused an increase of Fas-ligand (FasL) in PC12 cells that was attenuated by a selective mu antagonist.
Negative_regulation (attenuated) of Positive_regulation (increase) of FasL associated with antagonist
3) Confidence 0.09 Published 2002 Journal Synapse Section Abstract Doc Link 11746737 Disease Relevance 0.20 Pain Relevance 0.69

General Comments

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