INT99942

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 37
Total Number 37
Disease Relevance 32.61
Pain Relevance 6.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
T cell 5
synovium 3
hippocampus 2
lungs 2
cortex 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 357 99.52 Very High Very High Very High
Inflammation 343 99.16 Very High Very High Very High
Chronic pancreatitis 6 99.14 Very High Very High Very High
Hippocampus 4 98.88 Very High Very High Very High
opioid receptor 2 98.78 Very High Very High Very High
mu opioid receptor 4 98.12 Very High Very High Very High
antagonist 7 97.84 Very High Very High Very High
Infliximab 36 97.76 Very High Very High Very High
Etanercept 31 97.48 Very High Very High Very High
cytokine 276 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 884 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 175 99.88 Very High Very High Very High
Infection 395 99.84 Very High Very High Very High
Rheumatoid Arthritis 357 99.52 Very High Very High Very High
Pleurisy 32 99.50 Very High Very High Very High
Arthritis 20 99.36 Very High Very High Very High
Colitis 36 99.32 Very High Very High Very High
INFLAMMATION 363 99.16 Very High Very High Very High
Death 315 99.14 Very High Very High Very High
Pancreatitis 8 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FasL was only moderately increased at 24 hours and showed maximum expression at 7 days.
Positive_regulation (increased) of FasL
1) Confidence 0.68 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 1.29 Pain Relevance 0.25
Furthermore, Fas and FasL upregulation seems to be independent of neuroinflammation since no differences were found between cytokine-/- and wild-type mice.
Positive_regulation (upregulation) of FasL associated with cytokine
2) Confidence 0.68 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 0.83 Pain Relevance 0.18
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (up-regulation) of FasL in hippocampus associated with hippocampus, apoptosis and death
3) Confidence 0.64 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.80 Pain Relevance 0.12
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Positive_regulation (upregulation) of FasL in T cell associated with death
4) Confidence 0.64 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.84 Pain Relevance 0.04
We confirm here that the inflammatory process (carrageenan-induced pleurisy) leads to a substantial activation of FasL in the lung tissues which likely contribute in different capacities to the evolution of acute inflammation.
Positive_regulation (activation) of FasL in lung associated with inflammation and pleurisy
5) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.99 Pain Relevance 0.22
In the present study, we found that FasL activation was significantly reduced in lungs from mice treated with T0901317.
Positive_regulation (activation) of FasL in lungs
6) Confidence 0.53 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 1.08 Pain Relevance 0.20
We herein present a mouse model for chronic pancreatitis, which was induced by TLR3 signaling that generated the Fas/Fas ligand (FasL)-mediated cytotoxicity.
Positive_regulation (generated) of FasL associated with chronic pancreatitis
7) Confidence 0.50 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.43 Pain Relevance 0.17
FasL and IL-2R were upregulated in the beginning of infection and deceased further.
Positive_regulation (upregulated) of FasL associated with infection
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.99 Pain Relevance 0.11
Both the chronic methadone and repeated withdrawal groups showed up-regulation of several pro-apoptotic proteins (FasL, the active fragment of caspase-8, and Bad) in the cortex and hippocampus, indicating activation of both the death-receptor and mitochondrial apoptotic pathways.
Positive_regulation (up-regulation) of FasL in hippocampus
9) Confidence 0.49 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.08 Pain Relevance 0
This combination of RA synovium and SCID mice allows for repeated FasL gene transfer mediated by adenovirus vector into RA synovium in vivo because the C.B-17 SCID mice lack an immune response to the adenovirus vector.
Positive_regulation (allows) of FasL gene in synovium associated with severe combined immunodeficiency and rheumatoid arthritis
10) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.74 Pain Relevance 0.42
The transducibility of Ad-LacZ and Ad-FasL was evaluated by detection of ?
Positive_regulation (transducibility) of FasL
11) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.46 Pain Relevance 0.04
Time dependent FasL transgene expression in engrafted human synovium in vivo in SCID mice
Positive_regulation (dependent) of FasL in synovium associated with severe combined immunodeficiency
12) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.55 Pain Relevance 0.03
It was demonstrated later that an increase in the level of Fas-FasL regulates the extent of cardiac inflammation, cardiomyocytes destruction and heart failure in Chagas disease patients [19,20].
Positive_regulation (increase) of FasL in heart associated with inflammation, american trypanosomiasis and myocardial infarction
13) Confidence 0.47 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.94 Pain Relevance 0.13
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (upregulate) of FasL in T cells associated with death
14) Confidence 0.46 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.37 Pain Relevance 0
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Positive_regulation (inactivation) of FasL in T cell associated with death
15) Confidence 0.46 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.89 Pain Relevance 0.04
Here the effect of continuous activation of Fas/FasL interaction through a repeated FasL gene transfer was explored to determine if this treatment could result in the death of inflammatory synoviocytes in RA synovium and elimination of RA tissue in vivo.
Positive_regulation (activation) of FasL in synovium associated with inflammation, rheumatoid arthritis and death
16) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.83 Pain Relevance 0.55
Upregulation of Fas/FasL interaction in arthritic joints by virus vector mediated FasL gene transfer or anti-Fas antibody treatment intra-articularly can induce apoptosis in inflammatory synoviocytes, as has been identified by many groups [5,12-18].
Positive_regulation (Upregulation) of FasL in joints associated with inflammation, apoptosis and arthritis
17) Confidence 0.44 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.83 Pain Relevance 0.53
It appears likely that repeated TCR stimulation causes activation of the FasL-Fas signaling pathway in T cells during chronic infection (Brunner et al., 1995; Dhein et al., 1995), but how Bim is induced in this setting is less clear.
Positive_regulation (activation) of FasL in T cells associated with infection
18) Confidence 0.43 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.58 Pain Relevance 0.04
Results obtained through in vitro and in vivo experiments suggest that the Fas–FasL system also mediates the intrinsic apoptotic pathways.
Positive_regulation (mediates) of FasL associated with apoptosis
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 2.00 Pain Relevance 0.12
The serum FasL levels are reported to be increased in patients with various clinical conditions, namely sepsis,[29] viral infections,[3031] and disseminated intravascular coagulation.[32] Also concentrations of FasL and other soluble molecules in the supernatant of blood units have been found to be increased in stored blood units.
Positive_regulation (increased) of FasL in blood associated with viral infection, thrombosis and sepsis
20) Confidence 0.39 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.48 Pain Relevance 0.13

General Comments

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