INT9995

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 6.48
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) plasma membrane (C6orf25)
Anatomy Link Frequency
B cells 3
plasma cells 2
lymphocytes 2
fibroblasts 1
monocytes 1
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 22 98.00 Very High Very High Very High
cINOD 14 95.68 Very High Very High Very High
Inflammation 34 95.24 Very High Very High Very High
Angina 3 92.44 High High
corticosteroid 27 91.00 High High
Inflammatory response 1 89.36 High High
vincristine 1 88.48 High High
tolerance 5 61.28 Quite High
Enkephalin 2 55.36 Quite High
rheumatoid arthritis 262 50.00 Quite Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 41 99.96 Very High Very High Very High
Disease 157 99.88 Very High Very High Very High
Disease Susceptibility 1 98.36 Very High Very High Very High
Hyperammonemia 3 98.00 Very High Very High Very High
Parasitic Infection 1 97.96 Very High Very High Very High
Asthma 20 96.16 Very High Very High Very High
INFLAMMATION 47 95.24 Very High Very High Very High
Cancer 11 94.60 High High
Infection 82 93.52 High High
Shock 3 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the plaque-forming cells assay of bone marrow cells revealed secretion of monoclonal immunoglobulin from the myeloma cells.
Localization (secretion) of immunoglobulin in plaque
1) Confidence 0.69 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 2067085 Disease Relevance 0.75 Pain Relevance 0.14
Safety of subcutaneous immunoglobulin
Localization (Safety) of immunoglobulin
2) Confidence 0.52 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 1.01 Pain Relevance 0
Efficacy of subcutaneous immunoglobulin
Localization (Efficacy) of immunoglobulin
3) Confidence 0.52 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.06 Pain Relevance 0
The sequence analysis has revealed the localization of seven genes, whose precise position and order is cen-G7-G6-G6A-G6B-G6C-G6D-G6E-tel, five of which are fully encoded in the sequence, allowing their genomic structures to be defined.
Localization (localization) of G6B
4) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384126 Disease Relevance 0.28 Pain Relevance 0.04
TCDD inhibits immunoglobulin secretion and decreases resistance to bacterial, viral, and parasitic infections in exposed animals.
Localization (secretion) of immunoglobulin associated with parasitic infection
5) Confidence 0.17 Published 2002 Journal Environ Health Perspect Section Abstract Doc Link PMC1241102 Disease Relevance 0.10 Pain Relevance 0
Thus, plasma cells do not develop and immunoglobulin secretion is impaired.
Localization (secretion) of immunoglobulin in plasma cells
6) Confidence 0.11 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2365966 Disease Relevance 1.35 Pain Relevance 0
This study investigated effects of indomethacin and a new NSAID (d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid, termed as M-5011 in this study) on cytokine production, lymphocyte proliferation, activities of natural killer (NK) and lymphokine activated killer (LAK) cells and secretion of immunoglobulin (Ig).
Localization (secretion) of immunoglobulin in lymphocyte associated with cinod and cytokine
7) Confidence 0.10 Published 1998 Journal Immunopharmacology Section Abstract Doc Link 9858064 Disease Relevance 0.24 Pain Relevance 0.66
Results from the in vitro study demonstrated an increased mitogen-induced blastogenesis and interleukin 2 (IL-2) production together with a reduced polyclonal immunoglobulin (Ig) secretion in the presence of the drug.
Localization (secretion) of immunoglobulin
8) Confidence 0.09 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1452412 Disease Relevance 0.09 Pain Relevance 0.13
T helper-2 (TH-2) lymphocytes release cytokines, including IL-4, IL-5 and IL-13, that have a range of actions, including eosinophil activation and immunoglobulin secretion from B cells.
Localization (secretion) of immunoglobulin in B cells associated with cytokine
9) Confidence 0.04 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.05 Pain Relevance 0.47
The effects of beta-endorphin (beta-E) and contained peptides were investigated for their ability to regulate Staphylococcus aureus (SAC)-induced immunoglobulin secretion by human B lymphocytes.
Localization (secretion) of immunoglobulin in B lymphocytes
10) Confidence 0.03 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2142691 Disease Relevance 0 Pain Relevance 0
Co-culture of beta-E with SAC-stimulated peripheral blood-derived mononuclear cells, under serum-containing or serum-free conditions, resulted in a dose-dependent inhibition of immunoglobulin-secreting cell (ISC) formation.
Localization (secreting) of immunoglobulin in mononuclear cells
11) Confidence 0.03 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2142691 Disease Relevance 0 Pain Relevance 0.06
Prozone effect of serum IgE levels in a case of plasma cell leukemia

We describe a case of multiple myeloma (MM) and secondary plasma cell leukemia (PCL) secreting IgE-kappa immunoglobulin.

Localization (secreting) of immunoglobulin in plasma cell associated with multiple myeloma
12) Confidence 0.02 Published 2010 Journal J Hematol Oncol Section Title Doc Link PMC2944146 Disease Relevance 0.77 Pain Relevance 0
It is produced by T cells, B cells, lymphocytes, monocytes, and fibroblasts, and has a role in T cell activation and immunoglobulin secretion.
Localization (secretion) of immunoglobulin in T cells
13) Confidence 0.02 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.16 Pain Relevance 0.16
It is produced by T cells, B cells, lymphocytes, monocytes, and fibroblasts, and has a role in T cell activation and immunoglobulin secretion.
Localization (secretion) of immunoglobulin in B cells
14) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.16 Pain Relevance 0.16
It is produced by T cells, B cells, lymphocytes, monocytes, and fibroblasts, and has a role in T cell activation and immunoglobulin secretion.
Localization (secretion) of immunoglobulin in fibroblasts
15) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.16 Pain Relevance 0.16
It is produced by T cells, B cells, lymphocytes, monocytes, and fibroblasts, and has a role in T cell activation and immunoglobulin secretion.
Localization (secretion) of immunoglobulin in lymphocytes
16) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.16 Pain Relevance 0.16
It is produced by T cells, B cells, lymphocytes, monocytes, and fibroblasts, and has a role in T cell activation and immunoglobulin secretion.
Localization (secretion) of immunoglobulin in monocytes
17) Confidence 0.01 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.16 Pain Relevance 0.16

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