INT99951

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.65
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
retina 1
Muscle 1
paw 1
neurons 1
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 7 100.00 Very High Very High Very High
Inflammation 11 97.62 Very High Very High Very High
IPN 4 96.00 Very High Very High Very High
nMDA receptor 2 95.12 Very High Very High Very High
ASIC 20 93.20 High High
cINOD 1 92.48 High High
Root ganglion neuron 1 91.76 High High
Analgesic 1 88.88 High High
Pain 7 84.68 Quite High
Hyperalgesia 12 80.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 99.28 Very High Very High Very High
INFLAMMATION 12 97.62 Very High Very High Very High
Inflammatory Pain 4 96.00 Very High Very High Very High
Nociception 1 93.80 High High
Sprains And Strains 1 93.20 High High
Ganglion Cysts 2 91.44 High High
Toxicity 1 90.96 High High
Acidosis 1 86.16 High High
Drug Induced Neurotoxicity 1 85.68 High High
Pain 4 84.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was achieved by (1) direct comparison of the sensitivity of ASIC1, ASIC2, ASIC3 and TRPV1 knockout mice versus wildtype littermates to acute thermal and mechanical noxious stimuli and (2) studying the behavioural responses of each transgenic strain to hind paw inflammation with either complete Freund's adjuvant (CFA) or formalin.
Regulation (sensitivity) of ASIC2 in paw associated with targeted disruption, inflammation and sprains and strains
1) Confidence 0.26 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18801682 Disease Relevance 0.90 Pain Relevance 0.59
Muscle inflammation causes bilateral increases of ASIC2 and ASIC3 but not ASIC1 (neither ASIC1a nor ASIC1b) mRNA, suggesting differential regulation of ASIC1 versus ASIC2 and ASIC3 mRNA.
Regulation (regulation) of ASIC2 in Muscle associated with inflammation
2) Confidence 0.25 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 1.34 Pain Relevance 0.71
Therefore ASIC2 and 3 are targets for benzamil to inhibit colonic afferent mechanosensitivity.
Regulation (targets) of ASIC2
3) Confidence 0.23 Published 2007 Journal Pain Section Abstract Doc Link 17467171 Disease Relevance 0.07 Pain Relevance 0.29
A recent finding has shown that ASIC2 in mice is expressed in retina where it acts as a negative modulator of rod phototransduction, and that functional ASIC2 channels are important for the maintenance of retinal integrity 40.
Regulation (important) of ASIC2 in retina
4) Confidence 0.05 Published 2006 Journal International Journal of Biological Sciences Section Body Doc Link PMC1458428 Disease Relevance 0 Pain Relevance 0.05
Here we have used cultured cerebellar neurons to test the hypothesis that nefopam may modulate voltage sensitive sodium channel (VSSC) activity.
Regulation (modulate) of voltage sensitive sodium channel in neurons associated with sodium channel
5) Confidence 0.01 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747898 Disease Relevance 0.34 Pain Relevance 0.45

General Comments

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