INT9996

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.95
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cells 4
nasal 2
skin 2
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 1 99.96 Very High Very High Very High
aspirin 13 99.84 Very High Very High Very High
Antihistamine 24 98.96 Very High Very High Very High
Inflammation 19 97.76 Very High Very High Very High
cytokine 6 97.56 Very High Very High Very High
antagonist 2 97.12 Very High Very High Very High
Inflammatory response 1 97.12 Very High Very High Very High
spastic colon 2 96.44 Very High Very High Very High
Pain 3 94.88 High High
nud 1 94.52 High High
Disease Link Frequency Relevance Heat
Nasal Polyps 1 98.44 Very High Very High Very High
INFLAMMATION 26 97.76 Very High Very High Very High
Functional Bowel Disorder 2 96.44 Very High Very High Very High
Pain 2 94.88 High High
Dyspepsia 1 94.52 High High
Cancer 2 94.36 High High
Necrosis 1 94.12 High High
Wheal 4 86.00 High High
Hypersensitivity 36 81.92 Quite High
Eosinophilia 1 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel drugs with an increased potential in the control of MC function (e.g., anti-IgE antibodies, the intracellular protein tyrosine kinase inhibitor Syk) and mediator release (e.g., second generation antihistamines, proteinase-activated receptor antagonists) may be useful pharmacological tools for these common disorders.
Positive_regulation (increased) of Localization (release) of IgE associated with antagonist and antihistamine
1) Confidence 0.49 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 16371078 Disease Relevance 0.56 Pain Relevance 0.54
None of the skin test-negative patients had specific IgE or positive histamine release to chlorhexidine.
Positive_regulation (had) of Localization (release) of IgE in skin
2) Confidence 0.45 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0.07 Pain Relevance 0
From these data it is reasonable to assume that a major decrease in free IgE induces, through FC?
Positive_regulation (induces) of Localization (decrease) of IgE
3) Confidence 0.37 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727776 Disease Relevance 0.16 Pain Relevance 0.12
A concentration dependent inhibition of anti-IgE and CI induced release of histamine from lung mast cells was also observed with TLCK, TPCK and protamine.
Positive_regulation (induced) of Localization (release) of IgE in mast cells
4) Confidence 0.33 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0
IgE dependent tryptase release from dispersed lung mast cells was inhibited to a maximum of approximately 53.8% and 44.5% by N-a-tosyl-L-lysine chloromethyl ketone (TLCK) and N-p-Tosyl-L-phenylalanine chloromethyl ketone (TPCK), respectively.
Positive_regulation (dependent) of Localization (release) of IgE in mast cells
5) Confidence 0.30 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0
Therapeutic levels of aspirin and salicylates (<or=0.3 mM, i.e., the concentrations observed in vivo in the use of antipyretic analgesic) increased IgE-mediated LTC(4) secretion.
Positive_regulation (increased) of Localization (secretion) of IgE associated with aspirin and analgesic
6) Confidence 0.17 Published 2009 Journal Clin. Immunol. Section Abstract Doc Link 19144570 Disease Relevance 0.16 Pain Relevance 0.79
Results from the in vitro study demonstrated an increased mitogen-induced blastogenesis and interleukin 2 (IL-2) production together with a reduced polyclonal immunoglobulin (Ig) secretion in the presence of the drug.
Positive_regulation (increased) of Localization (secretion) of Ig
7) Confidence 0.15 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1452412 Disease Relevance 0.09 Pain Relevance 0.14
In vitro ebastine inhibits anti-IgE-induced release of prostaglandins and leukotrienes by nasal polyp cells and cytokines, including granulocyte–macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor, and IL-8.
Positive_regulation (induced) of Localization (release) of IgE in nasal associated with necrosis, cancer, nasal polyps and cytokine
8) Confidence 0.03 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC3003605 Disease Relevance 0.90 Pain Relevance 0.22

General Comments

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