INT99961

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 15.13
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (SYP)
Anatomy Link Frequency
neuron 2
thyroid 1
smooth muscle 1
anterior 1
boutons 1
SYP (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 23 99.92 Very High Very High Very High
substantia gelatinosa 5 99.68 Very High Very High Very High
Inflammation 5 94.08 High High
allodynia 1 94.04 High High
Sciatic nerve 2 92.52 High High
cva 9 91.24 High High
anesthesia 1 91.04 High High
vincristine 1 90.00 High High
Pain 6 88.40 High High
cytokine 1 88.00 High High
Disease Link Frequency Relevance Heat
Neuroendocrine Cancer 63 100.00 Very High Very High Very High
Cancer 243 99.90 Very High Very High Very High
Ganglion Cysts 21 98.12 Very High Very High Very High
Nervous System Injury 5 98.04 Very High Very High Very High
Metastasis 105 97.88 Very High Very High Very High
Small Cell Lung Cancer 10 96.20 Very High Very High Very High
Injury 2 95.64 Very High Very High Very High
Carcinoid 67 95.32 Very High Very High Very High
Transitional Cell Carcinoma 1 94.80 High High
Necrosis 13 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies demonstrated positive immunoreactivity for neuron-specific enolase, synaptophysin, chromogranin, vimentin, S-100 protein and p30-32 MIC-2 gene product.
Positive_regulation (immunoreactivity) of synaptophysin in neuron
1) Confidence 0.67 Published 2005 Journal Acta Otolaryngol. Section Abstract Doc Link 15823816 Disease Relevance 0.74 Pain Relevance 0.13
Immunohistochemically, the tumor cells were positive for glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, and negative for cytokeratin, synaptophysin.
Positive_regulation (negative) of synaptophysin associated with cancer
2) Confidence 0.49 Published 2003 Journal Neurol. Res. Section Abstract Doc Link 12870256 Disease Relevance 0.55 Pain Relevance 0.17
Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.
Positive_regulation (positive) of synaptophysin associated with cancer
3) Confidence 0.49 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.35 Pain Relevance 0.26
Immunostains showed positive staining of tumor cells for HMB45, neuron-specific enolase, and calponin but were negative for S100 protein, melaninA, chromogranin, smooth muscle actin, desmin, caldesmon, epithelial membrane antigen, AE1/3, and synaptophysin.
Positive_regulation (negative) of synaptophysin in smooth muscle associated with cancer
4) Confidence 0.49 Published 2007 Journal J. Pediatr. Surg. Section Abstract Doc Link 17336201 Disease Relevance 0.77 Pain Relevance 0.09
The tumor was immunoreactive for synaptophysin and negative for p53 (Figure 7).
Positive_regulation (immunoreactive) of synaptophysin associated with cancer
5) Confidence 0.49 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2481265 Disease Relevance 1.47 Pain Relevance 0
The small cell carcinomatous component was positive for chromogranin, neuron specific enolase, synaptophysin, and pancytokeratin but negative for high molecular-weight cytokeratin (K-903) by immunohistochemistry.
Positive_regulation (positive) of synaptophysin in neuron
6) Confidence 0.45 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11748366 Disease Relevance 0.59 Pain Relevance 0.07
The tumor cells showed positive reactivity for synaptophysin, somatostatin, and CD56.
Positive_regulation (reactivity) of synaptophysin associated with cancer and somatostatin
7) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.23 Pain Relevance 0.12
Epithelioid cells showed positive reactivity for synaptophysin, somatostatin, and CD56.
Positive_regulation (reactivity) of synaptophysin associated with somatostatin
8) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2874790 Disease Relevance 0.99 Pain Relevance 0.18
Immunohistochemistry revealed that this lesion was positive for synaptophysin and CD56, but negative for chromogranin as well as CD10, CD7, and CD20, consistent with a well-differentiated neuroendocrine tumor.
Positive_regulation (positive) of synaptophysin associated with neuroendocrine cancer
9) Confidence 0.45 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2386474 Disease Relevance 1.16 Pain Relevance 0.07
Immunohistochemistry revealed that this lesion was positive for synaptophysin and CD56, but negative for chromogranin as well as CD10, CD7, and CD20.
Positive_regulation (positive) of synaptophysin
10) Confidence 0.45 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2386474 Disease Relevance 0.96 Pain Relevance 0
Fig. 11A 17-year-old female with an incidentally detected anterior mediastinal mass. a, b Axial contrast-enhanced CT images after biopsy demonstrate an infiltrating soft-tissue mass in the anterior mediastinum with enlarged pretracheal, subcarinal and hilar lymph nodes, and pleural studding (arrow). c Bone window image demonstrates multiple sclerotic lesions in the vertebral body, sacrum, and iliac wings consistent with metastatic disease. d Photomicrograph of H&E-stained section shows round cells with regular nuclei and salt-and-pepper chromatin. e, f Immunostaining is positive for the neuroendocrine tumor markers chromogranin (e) and synaptophysin (f)

Middle ear NETs

Positive_regulation (positive) of synaptophysin in anterior associated with neuroendocrine cancer and metastasis
11) Confidence 0.45 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.28 Pain Relevance 0.08
The numbers of larger sized synaptophysin-immunoreactive presynaptic boutons were found to be increased in the substantia gelatinosa ipsilateral to the nerve injury.
Positive_regulation (increased) of synaptophysin in boutons associated with substantia gelatinosa and nervous system injury
12) Confidence 0.45 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 19925847 Disease Relevance 1.21 Pain Relevance 1.29
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (positive) of synaptophysin in thyroid
13) Confidence 0.45 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
The tumor cells were weakly positive for synaptophysin, chromogranin A, CD56, and NSE.
Positive_regulation (positive) of synaptophysin associated with cancer
14) Confidence 0.45 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16673117 Disease Relevance 1.15 Pain Relevance 0.08
In contrast, spindle-shaped cells showed positive reactivity for S-100 protein, but not for synaptophysin, somatostatin or CD56.
Positive_regulation (reactivity) of synaptophysin associated with somatostatin
15) Confidence 0.45 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2874790 Disease Relevance 1.00 Pain Relevance 0.18

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