INT99965

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.50
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
outflow 4
NARFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 16 79.76 Quite High
metalloproteinase 16 37.28 Quite Low
headache 2 19.80 Low Low
Angina 3 18.76 Low Low
anesthesia 7 10.00 Low Low
lidocaine 10 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 374 100.00 Very High Very High Very High
Glaucoma 133 99.40 Very High Very High Very High
Hypotension 18 99.40 Very High Very High Very High
Macular Edema 24 80.68 Quite High
Ocular & Orbital Inflammation 2 79.76 Quite High
Ocular Toxicity (including Many Sub-types) 15 76.96 Quite High
Postoperative Complications 9 75.00 Quite High
Increased Venous Pressure Under Development 17 71.28 Quite High
Cataract 48 59.36 Quite High
Scotoma 2 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Supine 2 IOP (31 +/- 2 mmHg) decreased in comparison with prone 2 IOP (P < 0.05) but was relatively elevated in comparison with supine 1 and baseline (P < 0.05).
Positive_regulation (elevated) of Negative_regulation (decreased) of IOP
1) Confidence 0.40 Published 2001 Journal Anesthesiology Section Body Doc Link 11748391 Disease Relevance 0.05 Pain Relevance 0
Therefore, careful monitoring of IOP and IOP-lowering therapy may be necessary, especially in patients with glaucoma who have a compromised outflow facility.
Positive_regulation (necessary) of Negative_regulation (monitoring) of IOP in outflow associated with glaucoma and ocular hypertension
2) Confidence 0.17 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698691 Disease Relevance 1.09 Pain Relevance 0
Therefore, careful monitoring of IOP and IOP-lowering therapy may be necessary, especially in patients with glaucoma who have a compromised outflow facility.
Positive_regulation (necessary) of Negative_regulation (monitoring) of IOP-lowering in outflow associated with glaucoma and ocular hypertension
3) Confidence 0.17 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698691 Disease Relevance 1.09 Pain Relevance 0
Rates of non-compliance with glaucoma treatment instructions are as high as 50%.285 Persistency or maintenance of therapy, involves patient satisfaction with medication tolerability, physician satisfaction with IOP control, medication costs, ease of administration and patient understanding of long term medication use especially where an immediate effect is not noticed.212,286 The need for multiple medications with increasingly complex dosing regimens are real obstacles to good IOP control,285,287 and clearly once daily dosing of PGA is preferred.190
Positive_regulation (obstacles) of Negative_regulation (dosing) of IOP associated with glaucoma and ocular hypertension
4) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2915861 Disease Relevance 0.87 Pain Relevance 0.04
Moreover, the described method was found to result in a satisfactory IOP reduction in refractory glaucoma at 1 year postoperatively with a qualified success rate of 84.2%, comparable to those reported previously.



Positive_regulation (result) of Negative_regulation (reduction) of IOP associated with glaucoma and ocular hypertension
5) Confidence 0.03 Published 2009 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2694298 Disease Relevance 0.31 Pain Relevance 0
In 24-hour IOP measurements, latanoprost administered once a day in the
               evening induces a constant IOP reduction, although the hypotensive effect seems to
               be greatest during the day (Quaranta et al
                   2006).
Positive_regulation (induces) of Negative_regulation (reduction) of IOP associated with hypotension and ocular hypertension
6) Confidence 0.02 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699817 Disease Relevance 1.08 Pain Relevance 0

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