INT9999

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 15.75
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eosinophils 10
nasal 4
plasma cells 2
B cells 2
lymphocyte 2
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 369 100.00 Very High Very High Very High
Inflammation 312 100.00 Very High Very High Very High
chemokine 46 100.00 Very High Very High Very High
headache 9 100.00 Very High Very High Very High
Morphine 3 95.60 Very High Very High Very High
spinal inflammation 2 85.96 High High
qutenza 35 85.52 High High
Arthritis 4 84.36 Quite High
cINOD 1 81.64 Quite High
dexamethasone 2 73.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 323 100.00 Very High Very High Very High
Hypersensitivity 274 100.00 Very High Very High Very High
Spondylarthropathies 1 100.00 Very High Very High Very High
Schistosomiasis 27 99.92 Very High Very High Very High
Disease 320 99.76 Very High Very High Very High
Asthma 525 99.54 Very High Very High Very High
Heart Rate Under Development 39 99.50 Very High Very High Very High
Conjunctivitis 62 99.34 Very High Very High Very High
Malaria 433 99.20 Very High Very High Very High
Cerebral Malaria 413 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4 is the main cytokine responsible for IgE production, inducing antibody isotype switching from IgG and IgM to IgE [10].
Regulation (responsible) of Gene_expression (production) of IgE associated with cytokine
1) Confidence 0.60 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.52 Pain Relevance 0.12
OBJECTIVE: To determine whether omalizumab therapy affects nasal reactivity to allergen and local IgE production.
Spec (whether) Regulation (affects) of Gene_expression (production) of IgE in nasal
2) Confidence 0.58 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 15478383 Disease Relevance 0.19 Pain Relevance 0
However, its effect on IgE synthesis is unknown.
Regulation (effect) of Gene_expression (synthesis) of IgE
3) Confidence 0.58 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Abstract Doc Link 15478383 Disease Relevance 0 Pain Relevance 0
The production of IgE is regulated by genes, cytokines and the environment (Figure 2).
Regulation (regulated) of Gene_expression (production) of IgE associated with cytokine
4) Confidence 0.55 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0.33 Pain Relevance 0.05
Effect on IgE levels
Regulation (Effect) of Gene_expression (levels) of IgE
5) Confidence 0.45 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.64 Pain Relevance 0.12
However, the level of IgE production was correlated to IL-10 levels in UM and AI patients (Figure 4).
Regulation (correlated) of Gene_expression (production) of IgE associated with malaria
6) Confidence 0.44 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.83 Pain Relevance 0.12
A range of values of IgE levels was defined enabling the analysis of the frequency of normal, moderate and high IgE levels in each clinical group of patients.
Regulation (values) of Gene_expression (levels) of IgE
7) Confidence 0.44 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.66 Pain Relevance 0
Even in Gabonese patients, for whom the increase of IgE in the disease groups was not significant, a higher percentage of patients with clinical disease had higher IgE levels than controls and asymptomatic patients.
Regulation (controls) of Gene_expression (levels) of IgE associated with disease
8) Confidence 0.44 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 1.02 Pain Relevance 0
Functional parasite specific IgE response in P. falciparum infected patients
Regulation (specific) of Gene_expression (response) of IgE
9) Confidence 0.44 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.70 Pain Relevance 0
However, the absence of an effect on IgE-secreting B cells and epsilon mRNA in nasal lavage fluid suggests that omalizumab treatment for 6 months does not significantly modulate synthesis of nasal IgE.


Neg (not) Regulation (modulate) of Gene_expression (synthesis) of IgE in B cells
10) Confidence 0.42 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 15478383 Disease Relevance 0 Pain Relevance 0
Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis.
Regulation (Effects) of Gene_expression (synthesis) of IgE in nasal associated with headache
11) Confidence 0.42 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Title Doc Link 15478383 Disease Relevance 0 Pain Relevance 0.10
Factors regulating IgE levels include age, gene-by-environment interactions, genetic factors (such as certain polymorphisms), racial factors (higher levels are seen in African Americans and persons of Filipino descent), sex (males tending to have higher levels) and season (IgE levels may increase during pollen season in allergic individuals).


Regulation (regulating) of Gene_expression (levels) of IgE in pollen associated with hypersensitivity
12) Confidence 0.40 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0.25 Pain Relevance 0.12
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Regulation (critical) of Gene_expression (production) of IgE associated with cytokine
13) Confidence 0.29 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.69 Pain Relevance 0.29
The mechanism is a combination of altered regulation of IgE syntheses and induction of IgE-blocking antibodies, with the capacity to competitively inhibit the interaction between allergen and IgE.
Regulation (regulation) of Gene_expression (syntheses) of IgE
14) Confidence 0.27 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643106 Disease Relevance 0 Pain Relevance 0
Serum IgE levels were measured by the Siemens Immulite 2000® (Flanders NJ), using the Total IgE method.
Regulation (measured) of Gene_expression (levels) of IgE
15) Confidence 0.27 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2944146 Disease Relevance 0.28 Pain Relevance 0.07
This suggests that exposure to the parasite strongly influences the production of IgE, although this difference may also be due to other endemic factors [7].
Regulation (influences) of Gene_expression (production) of IgE
16) Confidence 0.26 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.65 Pain Relevance 0.03
IgE production is influenced by cytokines produced by activated T cells.
Regulation (influenced) of Gene_expression (production) of IgE in T cells associated with cytokine
17) Confidence 0.26 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.66 Pain Relevance 0.22
Treatment with beraprost did not affect the IgE production or peripheral blood eosinophil count.


Neg (not) Regulation (affect) of Gene_expression (production) of IgE in eosinophil
18) Confidence 0.26 Published 2007 Journal Cough Section Body Doc Link PMC1781075 Disease Relevance 0.65 Pain Relevance 0.16
T regulatory (Treg) cells have important influences on the regulation of IgE synthesis.
Regulation (regulation) of Gene_expression (synthesis) of IgE
19) Confidence 0.24 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.33
The object of this review is to summarize the historical and molecular aspects of IgE synthesis and the disorders associated with dysregulation of IgE production.


Regulation (dysregulation) of Gene_expression (production) of IgE
20) Confidence 0.24 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2837605 Disease Relevance 0.34 Pain Relevance 0

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