J:Acta Endocrinol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT1310 Pomc Regulation of Localization of Prl 9 1 0.40 0.61 4.96
2 INT44716 Binding of ABL2 and PDYN 2 1 0.40 0.66 4.77
3 INT11248 Gh Positive_regulation of Ghrh 2 1 0.26 0.09 4.04
4 INT2169 Penk Regulation of Localization of Prl 6 4 0.48 0 4.03
5 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 2 0.46 0 2.23
6 INT34310 CRH Positive_regulation of POMC 3 2 0.42 0.62 2.21
7 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 2 0.41 0.63 1.66
8 INT32412 Penk Regulation of Pomc 3 2 0.21 0.36 1.62
9 INT28992 Tmpo Positive_regulation of Pomc 1 4 0.36 3.18 1.41
10 INT32182 PRL Regulation of GHRH 2 1 0.17 0 1.12
11 INT29874 OXTR Negative_regulation of POMC 1 3 0.22 0 1.1
12 INT35157 GH1 Regulation of GHRH 3 1 0.17 0.5 0.99
13 INT35160 GH1 Regulation of PRL 2 1 0.37 0 0.89
14 INT29875 OXTR Negative_regulation of Positive_regulation of POMC 1 2 0.31 0 0.7
15 INT25248 GNRH1 Regulation of CGA 4 1 0.30 1.22 0.62
16 INT42269 POMC Negative_regulation of Localization of AVP 1 1 0.09 0 0.61
17 INT34311 Regulation of CRH Positive_regulation of POMC 1 1 0.24 0 0.59
18 INT45736 Prl Positive_regulation of Gene_expression of Gnrhr 1 1 0.00 0.1 0.56
19 INT7849 Man2a2 Positive_regulation of Localization of Gcg 1 1 0.08 0 0.51
20 INT7851 Man2a2 Positive_regulation of Adra2a 1 1 0.13 0 0.49
21 INT34411 Ebf1 Regulation of LH 1 1 0.06 0 0.4
22 INT28991 Tmpo Positive_regulation of Gene_expression of Pomc 1 1 0.34 0.82 0.37
23 INT16896 GHSR Regulation of GH1 2 1 0.23 0.24 0.36
24 INT16893 GHSR Positive_regulation of GH1 2 1 0.26 0.24 0.35
25 INT31713 Adra2c Regulation of Localization of Ins1 1 1 0.22 0.31 0.35
26 INT7850 Adra2c Regulation of Localization of Gcg 1 1 0.08 0 0.27
27 INT29876 OXTR Regulation of Regulation of PRL 1 1 0.15 0 0.12
28 INT29877 OXTR Regulation of GGH 1 1 0.10 0 0.12
29 INT29872 OXTR Regulation of POMC 1 1 0.27 0 0.12
30 INT29873 OXTR Regulation of PRL 1 1 0.25 0 0.12
31 INT31714 Hrh1 Positive_regulation of Localization of Ins1 1 1 0.00 0.36 0.11
32 INT31224 POMC Regulation of PPY 2 1 0.03 0 0.1
33 INT31225 POMC Regulation of Gene_expression of PPY 2 1 0.04 0 0.1
34 INT42586 EPO Regulation of POMC 1 1 0.02 0.19 0.09
35 INT42587 EPO Regulation of GHRH 1 1 0.01 0.19 0.09
36 INT26912 SUPT7L Positive_regulation of Localization of Prl 1 1 0.44 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 26 2431 0.81 378.96 952.2
2 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
3 INT292 Localization of Penk 4 876 0.81 88.44 669.14
4 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
5 INT155 Positive_regulation of Prl 9 1233 0.70 317.93 457.82
6 INT1045 Localization of LH 11 1211 0.81 87.04 456.25
7 INT443 Localization of POMC 25 1020 0.81 284.52 443.17
8 INT467 Gene_expression of POMC 10 1048 0.78 332.8 394.16
9 INT157 Positive_regulation of Localization of Prl 8 790 0.70 104.54 374.78
10 INT439 Localization of Gnrh1 12 976 0.81 100.96 363.25
11 INT720 Positive_regulation of POMC 17 807 0.70 237.37 353.83
12 INT876 Localization of Gh1 5 843 0.80 67.75 340.82
13 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
14 INT162 Regulation of Prl 6 794 0.62 165.01 322.24
15 INT477 Localization of Avp 3 813 0.81 131.58 300.4
16 INT161 Regulation of Localization of Prl 3 615 0.62 65.37 298.66
17 INT886 Gene_expression of Pomc 6 676 0.78 129.87 295.98
18 INT1893 Localization of Gh 4 1041 0.79 340.23 256.58
19 INT3948 Regulation of Cck 2 291 0.62 58.07 255.88
20 INT738 Regulation of POMC 13 459 0.62 111.19 243.74
21 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
22 INT767 Localization of Gnrhr 4 565 0.80 106.68 214.57
23 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
24 INT156 Negative_regulation of Prl 5 542 0.59 131.97 192.24
25 INT528 Gene_expression of Prl 6 693 0.78 217.18 192.2
26 INT2085 Positive_regulation of LH 12 441 0.70 60.15 191.02
27 INT1652 Regulation of Pomc 2 387 0.62 61.01 186.51
28 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
29 INT739 Negative_regulation of POMC 8 358 0.59 102.28 166.77
30 INT1114 Localization of Ins1 12 748 0.80 192.95 165.48
31 INT4768 Positive_regulation of OPRM1 1 212 0.70 31.09 164.28
32 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
33 INT880 Positive_regulation of Localization of Gh1 2 304 0.70 14.79 150.23
34 INT2451 Positive_regulation of Avp 3 355 0.70 102.66 147.69
35 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
36 INT812 Localization of INS 2 1026 0.81 515.6 145.31
37 INT425 Localization of PRL 4 455 0.81 189.64 144.8
38 INT2379 Positive_regulation of Localization of LH 3 349 0.70 27.86 144.53
39 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
40 INT1047 Negative_regulation of LH 8 314 0.59 53.71 135.89
41 INT695 Binding of POMC 1 304 0.48 56.66 126.85
42 INT416 Regulation of LH 3 253 0.62 31.48 125.55
43 INT2106 Regulation of Localization of LH 2 279 0.62 22.37 122.77
44 INT252 Localization of GH1 5 529 0.80 227.4 122.05
45 INT6128 Positive_regulation of Localization of POMC 5 256 0.70 68.77 121.64
46 INT2555 Positive_regulation of Localization of Penk 1 116 0.70 24.35 119.73
47 INT7395 Localization of GNRH1 2 399 0.81 62.88 117.68
48 INT1438 Localization of Pomc 2 360 0.81 101.26 116.47
49 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
50 INT1793 Localization of CGA 4 379 0.81 67.38 114.69
51 INT1530 Regulation of Gh 4 382 0.61 115.96 112.47
52 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
53 INT915 Positive_regulation of PRL 5 342 0.70 141.96 104.31
54 INT5940 Negative_regulation of Avp 2 236 0.59 67.86 101.2
55 INT2159 Regulation of Localization of Gnrh1 5 200 0.62 13.28 99.07
56 INT874 Positive_regulation of Gh1 4 244 0.70 27.17 97.98
57 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
58 INT2122 Negative_regulation of Localization of Gnrh1 2 226 0.59 26.92 92.04
59 INT214 Localization of AVP 7 370 0.81 208.51 91.09
60 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
61 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
62 INT875 Regulation of Localization of Gh1 2 166 0.62 12.87 84.97
63 INT914 Positive_regulation of GH1 13 292 0.69 100.7 84.91
64 INT4289 Positive_regulation of Localization of Gnrh1 3 202 0.70 12.3 84.01
65 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
66 INT1309 Positive_regulation of Localization of Gnrhr 2 152 0.69 24.25 81.56
67 INT403 Localization of Trh 1 241 0.81 28.55 81.45
68 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
69 INT2289 Gene_expression of PENK 2 203 0.78 55.62 79.49
70 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
71 INT881 Negative_regulation of Localization of Gh1 1 164 0.58 15.1 75.28
72 INT7886 Regulation of Localization of Avp 2 146 0.62 14.53 72.99
73 INT442 Localization of PDYN 3 99 0.81 11.87 72.75
74 INT5128 Positive_regulation of Lhb 1 232 0.69 44.23 71.26
75 INT2055 Regulation of Gnrh1 2 185 0.62 23.65 71.26
76 INT5993 Positive_regulation of Nts 1 122 0.70 26.82 70.45
77 INT1377 Positive_regulation of Trh 2 172 0.70 40.55 69.83
78 INT2123 Positive_regulation of Gnrh1 2 209 0.70 24.2 68.97
79 INT1988 Positive_regulation of Localization of Ins1 12 254 0.69 59.25 68.37
80 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
81 INT253 Regulation of PRL 5 184 0.62 47.27 65.79
82 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
83 INT2056 Negative_regulation of Gnrh1 2 175 0.59 33.43 63.32
84 INT5095 Localization of Ghrh 2 185 0.81 28.09 62.08
85 INT17401 Gene_expression of IGF1 3 475 0.78 232.18 62.07
86 INT12175 Positive_regulation of PDYN 5 86 0.69 18.27 62.04
87 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
88 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
89 INT1794 Regulation of Localization of CGA 4 136 0.57 13.39 59.07
90 INT770 Regulation of Localization of Gnrhr 1 127 0.61 17.91 58.23
91 INT5819 Regulation of Localization of Penk 1 64 0.62 6.69 57.68
92 INT1510 Binding of PDYN 1 94 0.48 4.68 56.44
93 INT5453 Regulation of Localization of POMC 6 114 0.62 20.56 56.34
94 INT1463 Binding of Pomc 1 129 0.48 15.89 56.27
95 INT1782 Regulation of Gh1 3 125 0.62 22 55.74
96 INT1579 Gene_expression of PRL 3 279 0.78 119.2 55.41
97 INT251 Regulation of INS 5 398 0.62 232.47 55.04
98 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
99 INT249 Localization of GHRH 3 215 0.80 78.02 51.87
100 INT1781 Negative_regulation of Gh1 5 127 0.59 16.94 51.77
101 INT921 Regulation of GH1 6 172 0.60 52.88 51.04
102 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
103 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
104 INT1197 Negative_regulation of Localization of POMC 4 109 0.59 28.29 48.02
105 INT1977 Negative_regulation of Positive_regulation of Prl 1 98 0.59 17.06 47.88
106 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
107 INT873 Gene_expression of Gh1 1 130 0.76 26.15 46.75
108 INT847 Regulation of Lhb 1 131 0.61 22.08 46.54
109 INT683 Positive_regulation of AVP 1 173 0.70 74.55 46.41
110 INT531 Gene_expression of GH1 3 376 0.75 193.45 46.24
111 INT20492 Gene_expression of MMP12 1 89 0.76 81.36 46.12
112 INT619 Positive_regulation of Positive_regulation of Prl 1 116 0.70 22.69 45.06
113 INT2275 Negative_regulation of Localization of Ins1 4 183 0.59 51.02 44.94
114 INT2262 Negative_regulation of Lhb 1 142 0.59 25.47 44.81
115 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
116 INT1474 Regulation of Localization of Ins1 2 132 0.61 25.96 43.07
117 INT5130 Regulation of GNRH1 4 139 0.62 31.95 42.08
118 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
119 INT5454 Localization of CRH 3 124 0.79 79.18 41.53
120 INT957 Positive_regulation of GHRH 4 136 0.70 36.84 40.52
121 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
122 INT4862 Localization of PENK 1 62 0.81 11.57 40.28
123 INT685 Regulation of AVP 2 124 0.62 34.9 39.91
124 INT3252 Negative_regulation of INS 3 428 0.59 271.65 39.52
125 INT2782 Regulation of Gene_expression of Pomc 1 75 0.62 15.04 38.97
126 INT1931 Positive_regulation of Gene_expression of POMC 1 116 0.70 37.26 38.67
127 INT916 Regulation of Localization of PRL 2 92 0.62 22.98 38.13
128 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
129 INT1976 Regulation of Gene_expression of Prl 1 80 0.62 20.19 36
130 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
131 INT1361 Negative_regulation of Gnrhr 2 118 0.58 57.77 35.54
132 INT255 Regulation of Localization of GH1 1 89 0.62 18.71 35.3
133 INT326 Gene_expression of Gnrhr 2 105 0.76 35.87 34.93
134 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
135 INT248 Positive_regulation of Localization of GH1 2 137 0.69 49.25 32.92
136 INT5868 Positive_regulation of GNRH1 1 122 0.69 20.96 32.8
137 INT985 Negative_regulation of GH1 3 213 0.57 89.53 32.39
138 INT3117 Regulation of Oxt 2 103 0.61 17.93 32.28
139 INT22939 Gene_expression of Csf2 3 164 0.78 85.1 32.22
140 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
141 INT610 Regulation of PENK 2 47 0.62 14.17 31.55
142 INT7396 Regulation of Localization of GNRH1 1 81 0.62 6.57 31.31
143 INT15347 Positive_regulation of Localization of Pomc 1 81 0.70 28.1 31.01
144 INT7975 Regulation of PLOD1 5 97 0.62 20.9 30.51
145 INT1473 Localization of Gcg 7 95 0.80 17.35 30.31
146 INT5100 Positive_regulation of Ghrh 1 100 0.64 24.2 30.21
147 INT7397 Negative_regulation of Localization of GNRH1 1 86 0.59 15.45 29.78
148 INT7412 Positive_regulation of SST 2 71 0.70 24.44 29.48
149 INT1196 Positive_regulation of Positive_regulation of POMC 4 51 0.70 15.99 28.58
150 INT7035 Regulation of CGA 4 87 0.45 29.04 28.45
151 INT5135 Negative_regulation of GNRH1 1 106 0.58 36.63 27.71
152 INT6174 Regulation of Gene_expression of POMC 2 49 0.61 9.75 27.69
153 INT10799 Localization of ENG 1 63 0.78 18.67 27.28
154 INT1638 Negative_regulation of PLOD1 2 92 0.59 21.69 26.61
155 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
156 INT9682 Positive_regulation of IGF1 1 238 0.70 120.03 26.36
157 INT2261 Gene_expression of Lhb 1 121 0.77 42.78 26.04
158 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
159 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
160 INT3028 Negative_regulation of Oxt 2 76 0.58 18.52 24.4
161 INT6441 Positive_regulation of CRH 3 98 0.69 57.22 24.12
162 INT682 Negative_regulation of AVP 2 97 0.59 50.67 23.91
163 INT9526 Negative_regulation of Localization of Pomc 1 41 0.58 6.93 23.3
164 INT250 Regulation of GHRH 5 65 0.61 17.46 23.19
165 INT956 Negative_regulation of PRL 2 94 0.59 42.72 23.01
166 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
167 INT16303 Negative_regulation of Localization of GH1 1 89 0.59 37.31 22.15
168 INT1644 Regulation of FSHR 5 77 0.55 15.62 21.49
169 INT6127 Regulation of Localization of AVP 3 60 0.62 15.12 20.84
170 INT1792 Positive_regulation of CGA 2 123 0.70 64.73 20.79
171 INT955 Gene_expression of GHRH 5 126 0.78 59.91 20.74
172 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
173 INT7364 Regulation of Ghrh 1 49 0.58 8.05 19.05
174 INT13454 Positive_regulation of Positive_regulation of Gh 1 49 0.68 14.53 18.49
175 INT14724 Negative_regulation of CYP19A1 1 233 0.59 96.56 18.26
176 INT3118 Negative_regulation of Positive_regulation of POMC 1 33 0.59 9.42 18.07
177 INT213 Negative_regulation of Localization of AVP 2 46 0.59 19.78 16.79
178 INT984 Positive_regulation of Localization of GHRH 1 58 0.70 12.66 16.51
179 INT1000 Localization of Ggh 2 31 0.75 2.74 16.41
180 INT4242 Negative_regulation of Positive_regulation of Gh1 3 26 0.58 1.47 15.75
181 INT7970 Gene_expression of PLOD1 1 120 0.71 44.42 15.54
182 INT129 Localization of OXTR 3 51 0.80 11.08 15.36
183 INT26538 Positive_regulation of FSHR 1 103 0.69 30.95 15.33
184 INT2156 Positive_regulation of Positive_regulation of LH 2 33 0.69 3.18 14.33
185 INT6947 Negative_regulation of Gene_expression of POMC 1 37 0.59 10.32 14.14
186 INT18012 Gene_expression of EPO 1 169 0.78 108.36 13.75
187 INT2005 Positive_regulation of Gene_expression of PRL 1 55 0.70 21.4 13.44
188 INT4298 Positive_regulation of Positive_regulation of Gh1 1 30 0.50 1.79 13.32
189 INT6575 Positive_regulation of Localization of Gcg 4 33 0.69 3.48 13.31
190 INT4145 Gene_expression of FSHR 1 124 0.77 44.98 13.04
191 INT9678 Positive_regulation of Positive_regulation of GH1 6 32 0.68 8.14 12.97
192 INT44 Positive_regulation of Adra1a 1 30 0.68 7.09 12.73
193 INT3104 Negative_regulation of CGA 1 76 0.54 29.81 12.23
194 INT11121 Positive_regulation of NPPA 1 64 0.70 34.09 11.96
195 INT2160 Negative_regulation of Negative_regulation of LH 1 22 0.58 4.58 11.53
196 INT254 Regulation of Localization of GHRH 2 30 0.60 5.17 11.46
197 INT29964 Positive_regulation of Positive_regulation of PDYN 3 9 0.67 1.56 11.31
198 INT1436 Negative_regulation of Localization of Pomc 1 41 0.58 10.85 11.26
199 INT987 Localization of TRH 2 37 0.78 10.53 11.1
200 INT7132 Localization of NPPA 2 53 0.81 19.79 10.86
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