J:Acta Endocrinol.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT1310	Pomc Regulation of Localization of Prl	9	1	0.40	0.61	4.96
2	INT44716	Binding of ABL2 and PDYN	2	1	0.40	0.66	4.77
3	INT11248	Gh Positive_regulation of Ghrh	2	1	0.26	0.09	4.04
4	INT2169	Penk Regulation of Localization of Prl	6	4	0.48	0	4.03
5	INT18197	Ghrh Positive_regulation of Localization of Ggh	4	2	0.46	0	2.23
6	INT34310	CRH Positive_regulation of POMC	3	2	0.42	0.62	2.21
7	INT18520	Adra2c Positive_regulation of Localization of Ins1	3	2	0.41	0.63	1.66
8	INT32412	Penk Regulation of Pomc	3	2	0.21	0.36	1.62
9	INT28992	Tmpo Positive_regulation of Pomc	1	4	0.36	3.18	1.41
10	INT32182	PRL Regulation of GHRH	2	1	0.17	0	1.12
11	INT29874	OXTR Negative_regulation of POMC	1	3	0.22	0	1.1
12	INT35157	GH1 Regulation of GHRH	3	1	0.17	0.5	0.99
13	INT35160	GH1 Regulation of PRL	2	1	0.37	0	0.89
14	INT29875	OXTR Negative_regulation of Positive_regulation of POMC	1	2	0.31	0	0.7
15	INT25248	GNRH1 Regulation of CGA	4	1	0.30	1.22	0.62
16	INT42269	POMC Negative_regulation of Localization of AVP	1	1	0.09	0	0.61
17	INT34311	Regulation of CRH Positive_regulation of POMC	1	1	0.24	0	0.59
18	INT45736	Prl Positive_regulation of Gene_expression of Gnrhr	1	1	0.00	0.1	0.56
19	INT7849	Man2a2 Positive_regulation of Localization of Gcg	1	1	0.08	0	0.51
20	INT7851	Man2a2 Positive_regulation of Adra2a	1	1	0.13	0	0.49
21	INT34411	Ebf1 Regulation of LH	1	1	0.06	0	0.4
22	INT28991	Tmpo Positive_regulation of Gene_expression of Pomc	1	1	0.34	0.82	0.37
23	INT16896	GHSR Regulation of GH1	2	1	0.23	0.24	0.36
24	INT16893	GHSR Positive_regulation of GH1	2	1	0.26	0.24	0.35
25	INT31713	Adra2c Regulation of Localization of Ins1	1	1	0.22	0.31	0.35
26	INT7850	Adra2c Regulation of Localization of Gcg	1	1	0.08	0	0.27
27	INT29876	OXTR Regulation of Regulation of PRL	1	1	0.15	0	0.12
28	INT29877	OXTR Regulation of GGH	1	1	0.10	0	0.12
29	INT29872	OXTR Regulation of POMC	1	1	0.27	0	0.12
30	INT29873	OXTR Regulation of PRL	1	1	0.25	0	0.12
31	INT31714	Hrh1 Positive_regulation of Localization of Ins1	1	1	0.00	0.36	0.11
32	INT31224	POMC Regulation of PPY	2	1	0.03	0	0.1
33	INT31225	POMC Regulation of Gene_expression of PPY	2	1	0.04	0	0.1
34	INT42586	EPO Regulation of POMC	1	1	0.02	0.19	0.09
35	INT42587	EPO Regulation of GHRH	1	1	0.01	0.19	0.09
36	INT26912	SUPT7L Positive_regulation of Localization of Prl	1	1	0.44	0	0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT158	Localization of Prl	26	2431	0.81	378.96	952.2
2	INT1912	Gene_expression of Calca	1	1152	0.78	453.25	739.84
3	INT292	Localization of Penk	4	876	0.81	88.44	669.14
4	INT728	Positive_regulation of Penk	2	1068	0.70	186.9	636.87
5	INT155	Positive_regulation of Prl	9	1233	0.70	317.93	457.82
6	INT1045	Localization of LH	11	1211	0.81	87.04	456.25
7	INT443	Localization of POMC	25	1020	0.81	284.52	443.17
8	INT467	Gene_expression of POMC	10	1048	0.78	332.8	394.16
9	INT157	Positive_regulation of Localization of Prl	8	790	0.70	104.54	374.78
10	INT439	Localization of Gnrh1	12	976	0.81	100.96	363.25
11	INT720	Positive_regulation of POMC	17	807	0.70	237.37	353.83
12	INT876	Localization of Gh1	5	843	0.80	67.75	340.82
13	INT2649	Regulation of Calca	1	433	0.62	146.05	330.95
14	INT162	Regulation of Prl	6	794	0.62	165.01	322.24
15	INT477	Localization of Avp	3	813	0.81	131.58	300.4
16	INT161	Regulation of Localization of Prl	3	615	0.62	65.37	298.66
17	INT886	Gene_expression of Pomc	6	676	0.78	129.87	295.98
18	INT1893	Localization of Gh	4	1041	0.79	340.23	256.58
19	INT3948	Regulation of Cck	2	291	0.62	58.07	255.88
20	INT738	Regulation of POMC	13	459	0.62	111.19	243.74
21	INT1308	Localization of Pomc	1	457	0.81	66.83	217.5
22	INT767	Localization of Gnrhr	4	565	0.80	106.68	214.57
23	INT2651	Positive_regulation of Pomc	1	403	0.70	95.72	206.24
24	INT156	Negative_regulation of Prl	5	542	0.59	131.97	192.24
25	INT528	Gene_expression of Prl	6	693	0.78	217.18	192.2
26	INT2085	Positive_regulation of LH	12	441	0.70	60.15	191.02
27	INT1652	Regulation of Pomc	2	387	0.62	61.01	186.51
28	INT159	Negative_regulation of Localization of Prl	1	416	0.59	55.34	171.8
29	INT739	Negative_regulation of POMC	8	358	0.59	102.28	166.77
30	INT1114	Localization of Ins1	12	748	0.80	192.95	165.48
31	INT4768	Positive_regulation of OPRM1	1	212	0.70	31.09	164.28
32	INT3448	Positive_regulation of Gh	3	521	0.69	180.03	161.18
33	INT880	Positive_regulation of Localization of Gh1	2	304	0.70	14.79	150.23
34	INT2451	Positive_regulation of Avp	3	355	0.70	102.66	147.69
35	INT1033	Positive_regulation of Ca2	1	507	0.68	131.76	147.64
36	INT812	Localization of INS	2	1026	0.81	515.6	145.31
37	INT425	Localization of PRL	4	455	0.81	189.64	144.8
38	INT2379	Positive_regulation of Localization of LH	3	349	0.70	27.86	144.53
39	INT1273	Gene_expression of Avp	1	356	0.78	90.56	138.7
40	INT1047	Negative_regulation of LH	8	314	0.59	53.71	135.89
41	INT695	Binding of POMC	1	304	0.48	56.66	126.85
42	INT416	Regulation of LH	3	253	0.62	31.48	125.55
43	INT2106	Regulation of Localization of LH	2	279	0.62	22.37	122.77
44	INT252	Localization of GH1	5	529	0.80	227.4	122.05
45	INT6128	Positive_regulation of Localization of POMC	5	256	0.70	68.77	121.64
46	INT2555	Positive_regulation of Localization of Penk	1	116	0.70	24.35	119.73
47	INT7395	Localization of GNRH1	2	399	0.81	62.88	117.68
48	INT1438	Localization of Pomc	2	360	0.81	101.26	116.47
49	INT4207	Regulation of Avp	1	267	0.62	63.72	115.33
50	INT1793	Localization of CGA	4	379	0.81	67.38	114.69
51	INT1530	Regulation of Gh	4	382	0.61	115.96	112.47
52	INT3038	Gene_expression of INS	2	1583	0.78	1174.16	107.01
53	INT915	Positive_regulation of PRL	5	342	0.70	141.96	104.31
54	INT5940	Negative_regulation of Avp	2	236	0.59	67.86	101.2
55	INT2159	Regulation of Localization of Gnrh1	5	200	0.62	13.28	99.07
56	INT874	Positive_regulation of Gh1	4	244	0.70	27.17	97.98
57	INT203	Positive_regulation of Pomc	1	257	0.70	90.56	92.84
58	INT2122	Negative_regulation of Localization of Gnrh1	2	226	0.59	26.92	92.04
59	INT214	Localization of AVP	7	370	0.81	208.51	91.09
60	INT1639	Negative_regulation of OPRM1	1	107	0.59	13.86	90.37
61	INT4798	Gene_expression of Nts	1	169	0.77	29.56	86.04
62	INT875	Regulation of Localization of Gh1	2	166	0.62	12.87	84.97
63	INT914	Positive_regulation of GH1	13	292	0.69	100.7	84.91
64	INT4289	Positive_regulation of Localization of Gnrh1	3	202	0.70	12.3	84.01
65	INT339	Regulation of Trh	1	156	0.62	39.27	83.55
66	INT1309	Positive_regulation of Localization of Gnrhr	2	152	0.69	24.25	81.56
67	INT403	Localization of Trh	1	241	0.81	28.55	81.45
68	INT1498	Gene_expression of Gh	1	521	0.75	220.84	81.16
69	INT2289	Gene_expression of PENK	2	203	0.78	55.62	79.49
70	INT4358	Positive_regulation of Localization of Avp	1	195	0.70	30.79	77.58
71	INT881	Negative_regulation of Localization of Gh1	1	164	0.58	15.1	75.28
72	INT7886	Regulation of Localization of Avp	2	146	0.62	14.53	72.99
73	INT442	Localization of PDYN	3	99	0.81	11.87	72.75
74	INT5128	Positive_regulation of Lhb	1	232	0.69	44.23	71.26
75	INT2055	Regulation of Gnrh1	2	185	0.62	23.65	71.26
76	INT5993	Positive_regulation of Nts	1	122	0.70	26.82	70.45
77	INT1377	Positive_regulation of Trh	2	172	0.70	40.55	69.83
78	INT2123	Positive_regulation of Gnrh1	2	209	0.70	24.2	68.97
79	INT1988	Positive_regulation of Localization of Ins1	12	254	0.69	59.25	68.37
80	INT1046	Gene_expression of LH	1	180	0.77	29.75	66.87
81	INT253	Regulation of PRL	5	184	0.62	47.27	65.79
82	INT8347	Gene_expression of SST	1	181	0.78	104.59	65.45
83	INT2056	Negative_regulation of Gnrh1	2	175	0.59	33.43	63.32
84	INT5095	Localization of Ghrh	2	185	0.81	28.09	62.08
85	INT17401	Gene_expression of IGF1	3	475	0.78	232.18	62.07
86	INT12175	Positive_regulation of PDYN	5	86	0.69	18.27	62.04
87	INT1430	Regulation of PDYN	1	88	0.60	16.99	60.32
88	INT3161	Regulation of Localization of Gh	1	163	0.61	35.43	59.45
89	INT1794	Regulation of Localization of CGA	4	136	0.57	13.39	59.07
90	INT770	Regulation of Localization of Gnrhr	1	127	0.61	17.91	58.23
91	INT5819	Regulation of Localization of Penk	1	64	0.62	6.69	57.68
92	INT1510	Binding of PDYN	1	94	0.48	4.68	56.44
93	INT5453	Regulation of Localization of POMC	6	114	0.62	20.56	56.34
94	INT1463	Binding of Pomc	1	129	0.48	15.89	56.27
95	INT1782	Regulation of Gh1	3	125	0.62	22	55.74
96	INT1579	Gene_expression of PRL	3	279	0.78	119.2	55.41
97	INT251	Regulation of INS	5	398	0.62	232.47	55.04
98	INT1456	Regulation of Oprl1	1	61	0.62	19.5	52.87
99	INT249	Localization of GHRH	3	215	0.80	78.02	51.87
100	INT1781	Negative_regulation of Gh1	5	127	0.59	16.94	51.77
101	INT921	Regulation of GH1	6	172	0.60	52.88	51.04
102	INT1199	Positive_regulation of INS	1	579	0.70	399.64	50.43
103	INT937	Positive_regulation of Oxt	1	195	0.70	37.82	49.3
104	INT1197	Negative_regulation of Localization of POMC	4	109	0.59	28.29	48.02
105	INT1977	Negative_regulation of Positive_regulation of Prl	1	98	0.59	17.06	47.88
106	INT375	Positive_regulation of REN	1	293	0.70	152.46	47.55
107	INT873	Gene_expression of Gh1	1	130	0.76	26.15	46.75
108	INT847	Regulation of Lhb	1	131	0.61	22.08	46.54
109	INT683	Positive_regulation of AVP	1	173	0.70	74.55	46.41
110	INT531	Gene_expression of GH1	3	376	0.75	193.45	46.24
111	INT20492	Gene_expression of MMP12	1	89	0.76	81.36	46.12
112	INT619	Positive_regulation of Positive_regulation of Prl	1	116	0.70	22.69	45.06
113	INT2275	Negative_regulation of Localization of Ins1	4	183	0.59	51.02	44.94
114	INT2262	Negative_regulation of Lhb	1	142	0.59	25.47	44.81
115	INT935	Localization of Gtf3a	1	124	0.70	35.72	43.3
116	INT1474	Regulation of Localization of Ins1	2	132	0.61	25.96	43.07
117	INT5130	Regulation of GNRH1	4	139	0.62	31.95	42.08
118	INT3933	Positive_regulation of PLOD1	1	128	0.70	30.76	42.03
119	INT5454	Localization of CRH	3	124	0.79	79.18	41.53
120	INT957	Positive_regulation of GHRH	4	136	0.70	36.84	40.52
121	INT918	Positive_regulation of Localization of PRL	1	90	0.70	23.97	40.3
122	INT4862	Localization of PENK	1	62	0.81	11.57	40.28
123	INT685	Regulation of AVP	2	124	0.62	34.9	39.91
124	INT3252	Negative_regulation of INS	3	428	0.59	271.65	39.52
125	INT2782	Regulation of Gene_expression of Pomc	1	75	0.62	15.04	38.97
126	INT1931	Positive_regulation of Gene_expression of POMC	1	116	0.70	37.26	38.67
127	INT916	Regulation of Localization of PRL	2	92	0.62	22.98	38.13
128	INT3253	Negative_regulation of Localization of INS	1	205	0.59	130.39	36.61
129	INT1976	Regulation of Gene_expression of Prl	1	80	0.62	20.19	36
130	INT927	Gene_expression of Oxt	1	184	0.78	44.71	35.79
131	INT1361	Negative_regulation of Gnrhr	2	118	0.58	57.77	35.54
132	INT255	Regulation of Localization of GH1	1	89	0.62	18.71	35.3
133	INT326	Gene_expression of Gnrhr	2	105	0.76	35.87	34.93
134	INT692	Negative_regulation of SST	1	72	0.59	28.68	34.52
135	INT248	Positive_regulation of Localization of GH1	2	137	0.69	49.25	32.92
136	INT5868	Positive_regulation of GNRH1	1	122	0.69	20.96	32.8
137	INT985	Negative_regulation of GH1	3	213	0.57	89.53	32.39
138	INT3117	Regulation of Oxt	2	103	0.61	17.93	32.28
139	INT22939	Gene_expression of Csf2	3	164	0.78	85.1	32.22
140	INT7082	Gene_expression of CRH	1	180	0.78	64.66	31.74
141	INT610	Regulation of PENK	2	47	0.62	14.17	31.55
142	INT7396	Regulation of Localization of GNRH1	1	81	0.62	6.57	31.31
143	INT15347	Positive_regulation of Localization of Pomc	1	81	0.70	28.1	31.01
144	INT7975	Regulation of PLOD1	5	97	0.62	20.9	30.51
145	INT1473	Localization of Gcg	7	95	0.80	17.35	30.31
146	INT5100	Positive_regulation of Ghrh	1	100	0.64	24.2	30.21
147	INT7397	Negative_regulation of Localization of GNRH1	1	86	0.59	15.45	29.78
148	INT7412	Positive_regulation of SST	2	71	0.70	24.44	29.48
149	INT1196	Positive_regulation of Positive_regulation of POMC	4	51	0.70	15.99	28.58
150	INT7035	Regulation of CGA	4	87	0.45	29.04	28.45
151	INT5135	Negative_regulation of GNRH1	1	106	0.58	36.63	27.71
152	INT6174	Regulation of Gene_expression of POMC	2	49	0.61	9.75	27.69
153	INT10799	Localization of ENG	1	63	0.78	18.67	27.28
154	INT1638	Negative_regulation of PLOD1	2	92	0.59	21.69	26.61
155	INT3559	Negative_regulation of Localization of Gnrhr	1	73	0.58	18.89	26.41
156	INT9682	Positive_regulation of IGF1	1	238	0.70	120.03	26.36
157	INT2261	Gene_expression of Lhb	1	121	0.77	42.78	26.04
158	INT17625	Localization of GCG	1	210	0.80	55.69	24.97
159	INT2140	Regulation of REN	1	104	0.62	28.24	24.49
160	INT3028	Negative_regulation of Oxt	2	76	0.58	18.52	24.4
161	INT6441	Positive_regulation of CRH	3	98	0.69	57.22	24.12
162	INT682	Negative_regulation of AVP	2	97	0.59	50.67	23.91
163	INT9526	Negative_regulation of Localization of Pomc	1	41	0.58	6.93	23.3
164	INT250	Regulation of GHRH	5	65	0.61	17.46	23.19
165	INT956	Negative_regulation of PRL	2	94	0.59	42.72	23.01
166	INT3330	Gene_expression of AGT	1	149	0.76	98.65	22.73
167	INT16303	Negative_regulation of Localization of GH1	1	89	0.59	37.31	22.15
168	INT1644	Regulation of FSHR	5	77	0.55	15.62	21.49
169	INT6127	Regulation of Localization of AVP	3	60	0.62	15.12	20.84
170	INT1792	Positive_regulation of CGA	2	123	0.70	64.73	20.79
171	INT955	Gene_expression of GHRH	5	126	0.78	59.91	20.74
172	INT5096	Positive_regulation of Gtf3a	1	79	0.60	42.26	20.62
173	INT7364	Regulation of Ghrh	1	49	0.58	8.05	19.05
174	INT13454	Positive_regulation of Positive_regulation of Gh	1	49	0.68	14.53	18.49
175	INT14724	Negative_regulation of CYP19A1	1	233	0.59	96.56	18.26
176	INT3118	Negative_regulation of Positive_regulation of POMC	1	33	0.59	9.42	18.07
177	INT213	Negative_regulation of Localization of AVP	2	46	0.59	19.78	16.79
178	INT984	Positive_regulation of Localization of GHRH	1	58	0.70	12.66	16.51
179	INT1000	Localization of Ggh	2	31	0.75	2.74	16.41
180	INT4242	Negative_regulation of Positive_regulation of Gh1	3	26	0.58	1.47	15.75
181	INT7970	Gene_expression of PLOD1	1	120	0.71	44.42	15.54
182	INT129	Localization of OXTR	3	51	0.80	11.08	15.36
183	INT26538	Positive_regulation of FSHR	1	103	0.69	30.95	15.33
184	INT2156	Positive_regulation of Positive_regulation of LH	2	33	0.69	3.18	14.33
185	INT6947	Negative_regulation of Gene_expression of POMC	1	37	0.59	10.32	14.14
186	INT18012	Gene_expression of EPO	1	169	0.78	108.36	13.75
187	INT2005	Positive_regulation of Gene_expression of PRL	1	55	0.70	21.4	13.44
188	INT4298	Positive_regulation of Positive_regulation of Gh1	1	30	0.50	1.79	13.32
189	INT6575	Positive_regulation of Localization of Gcg	4	33	0.69	3.48	13.31
190	INT4145	Gene_expression of FSHR	1	124	0.77	44.98	13.04
191	INT9678	Positive_regulation of Positive_regulation of GH1	6	32	0.68	8.14	12.97
192	INT44	Positive_regulation of Adra1a	1	30	0.68	7.09	12.73
193	INT3104	Negative_regulation of CGA	1	76	0.54	29.81	12.23
194	INT11121	Positive_regulation of NPPA	1	64	0.70	34.09	11.96
195	INT2160	Negative_regulation of Negative_regulation of LH	1	22	0.58	4.58	11.53
196	INT254	Regulation of Localization of GHRH	2	30	0.60	5.17	11.46
197	INT29964	Positive_regulation of Positive_regulation of PDYN	3	9	0.67	1.56	11.31
198	INT1436	Negative_regulation of Localization of Pomc	1	41	0.58	10.85	11.26
199	INT987	Localization of TRH	2	37	0.78	10.53	11.1
200	INT7132	Localization of NPPA	2	53	0.81	19.79	10.86