J:Acta Histochemica et Cytochemica

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 2 0.05 1.65 1.42
2 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 2 0.08 1.64 1.42
3 INT202909 Binding of Tacr1 and Fig4 1 2 0.03 0.33 0.74
4 INT292814 Binding of VEGFA and Kdr 8 1 0.18 3.63 0.48
5 INT205567 Regulation of Binding of Fgf1 and Chat 1 4 0.29 0.28 0.41
6 INT205566 Binding of Fgf1 and Chat 1 4 0.24 0.28 0.41
7 INT245640 Nr3c2 Regulation of Positive_regulation of Hpse 1 1 0.08 0.66 0.26
8 INT202296 Binding of Slc18a3 and Gopc 1 1 0.02 0 0.23
9 INT202297 Pde5a Positive_regulation of Prkg1 1 1 0.00 0.13 0.18
10 INT245641 Nr3c2 Regulation of Gene_expression of Hpse 1 2 0.14 2.67 0.17
11 INT205555 Sst Negative_regulation of Ins1 1 1 0.05 0.77 0.14
12 INT208207 Binding of Cadm1 and Pvrl3 1 4 0.12 1.06 0.12
13 INT205204 LPA Positive_regulation of Positive_regulation of Pik3c3 1 1 0.02 0.22 0.09
14 INT245642 Nr3c1 Regulation of Gene_expression of Hpse 1 1 0.05 1.33 0.08
15 INT205244 Cldn3 Regulation of Gene_expression of Ocln 1 1 0.04 0.29 0.07
16 INT205237 Cldn2 Regulation of Gene_expression of Cldn5 1 1 0.03 0.29 0.07
17 INT205238 Cldn3 Regulation of Gene_expression of Cldn2 1 1 0.03 0.29 0.07
18 INT205228 Cldn5 Regulation of Gene_expression of Cldn1 1 1 0.03 0.29 0.07
19 INT205245 Cldn5 Regulation of Gene_expression of Cldn3 1 1 0.02 0.29 0.07
20 INT205229 Cldn2 Regulation of Gene_expression of Ocln 1 1 0.07 0.29 0.07
21 INT205236 Cldn5 Regulation of Tjp1 1 1 0.03 0.28 0.07
22 INT205239 Cldn3 Regulation of Gene_expression of Cldn5 1 1 0.02 0.29 0.07
23 INT205240 Cldn3 Regulation of Tjp1 1 1 0.04 0.29 0.07
24 INT205231 Cldn2 Regulation of Tjp1 1 1 0.07 0.29 0.07
25 INT205248 Cldn2 Regulation of Gene_expression of Tjp1 1 1 0.07 0.29 0.07
26 INT205232 Cldn5 Regulation of Gene_expression of Cldn2 1 1 0.03 0.29 0.07
27 INT205235 Cldn2 Regulation of Gene_expression of Cldn1 1 1 0.06 0.29 0.07
28 INT205233 Cldn5 Regulation of Gene_expression of Ocln 1 1 0.03 0.28 0.07
29 INT205227 Cldn3 Regulation of Gene_expression of Cldn1 1 1 0.03 0.29 0.07
30 INT205247 Cldn3 Regulation of Gene_expression of Tjp1 1 1 0.04 0.29 0.07
31 INT205246 Cldn5 Regulation of Gene_expression of Tjp1 1 1 0.03 0.28 0.07
32 INT205234 Cldn2 Regulation of Gene_expression of Cldn3 1 1 0.03 0.29 0.07
33 INT251373 Binding of Cdh2 and Cdh1 1 1 0.17 0 0.04
34 INT208211 Binding of Pira1 and Cadm2 1 1 0.00 0.15 0.04
35 INT208208 Binding of Pira1 and Cadm1 1 1 0.02 0.15 0.04
36 INT300448 Binding of VEGFA and Flt1 3 2 0.10 1.93 0
37 INT251370 Cdh2 Regulation of Gene_expression of Cdh1 1 1 0.21 0.35 0
38 INT312330 Binding of Kdr and Flt1 1 1 0.12 0.37 0
39 INT312318 Binding of Cdh1 and Regulation of Transcription of Prl 1 1 0.30 0.39 0
40 INT319042 Negative_regulation of Binding of Fgf7 and Fig4 1 1 0.07 0.2 0
41 INT208209 Binding of Gapdh and Cadm1 1 1 0.36 0.09 0
42 INT202901 Binding of Esr1 and Lman1 1 2 0.01 0 0
43 INT312316 Gene_expression of Cdh1 Negative_regulation of Prl 1 1 0.29 0 0
44 INT210873 Binding of Ntrk2 and Adarb1 1 1 0.00 0 0
45 INT312331 Binding of Flt1 and Pgf 1 1 0.08 0.31 0
46 INT319043 Binding of Fgf7 and Fig4 1 2 0.06 0.26 0
47 INT251372 Cdh1 Regulation of Gene_expression of Cdh2 1 1 0.21 0.35 0
48 INT312317 Cdh1 Regulation of Transcription of Prl 1 1 0.41 0.39 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 4 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
3 INT16260 Gene_expression of Bdnf 10 671 0.78 283.44 339.1
4 INT162 Regulation of Prl 5 794 0.62 165.01 322.24
5 INT5680 Gene_expression of Ngf 1 530 0.78 264.29 310.56
6 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
7 INT68684 Gene_expression of VEGFA 22 2371 0.78 1742.52 259.2
8 INT1005 Localization of Sst 2 385 0.81 26.31 244.56
9 INT4893 Gene_expression of Tacr1 9 366 0.78 129.67 213.92
10 INT16259 Positive_regulation of Bdnf 1 336 0.70 183.48 209.82
11 INT156 Negative_regulation of Prl 6 542 0.59 131.97 192.24
12 INT528 Gene_expression of Prl 11 693 0.78 217.18 192.2
13 INT159 Negative_regulation of Localization of Prl 2 416 0.59 55.34 171.8
14 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
15 INT120811 Gene_expression of Gopc 3 1174 0.59 428.49 150.55
16 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
17 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
18 INT170025 Gene_expression of Fig4 25 588 0.67 183.27 113.32
19 INT7362 Gene_expression of Sst 5 185 0.78 41.73 111.37
20 INT4936 Localization of Tacr1 1 125 0.80 35.7 107.7
21 INT4742 Gene_expression of Tac1 4 177 0.78 69.99 102.66
22 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
23 INT67682 Localization of Bdnf 4 204 0.81 72.36 88.92
24 INT4631 Positive_regulation of Sst 1 127 0.70 17.37 83.29
25 INT68682 Positive_regulation of VEGFA 4 640 0.70 454.14 81.65
26 INT403 Localization of Trh 5 241 0.81 28.55 81.45
27 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
28 INT2155 Negative_regulation of Sst 1 111 0.59 16.58 77.74
29 INT8346 Gene_expression of Qrfp 1 136 0.70 19.49 70.21
30 INT1376 Binding of Trh 1 121 0.48 20 69.86
31 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
32 INT79494 Positive_regulation of Gene_expression of VEGFA 7 577 0.70 442.94 69.73
33 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
34 INT47690 Regulation of Bdnf 1 118 0.62 53.02 64.5
35 INT822 Gene_expression of ESR1 10 529 0.78 302.16 63.64
36 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
37 INT18981 Gene_expression of ABAT 2 78 0.68 38.35 61.36
38 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
39 INT64159 Gene_expression of Prkca 1 90 0.78 34.65 55.97
40 INT4985 Positive_regulation of Tac1 1 81 0.69 35.79 50.67
41 INT2197 Gene_expression of Gnrh1 1 184 0.78 40.04 50.57
42 INT19488 Localization of ABAT 1 56 0.69 21.51 50.56
43 INT2323 Gene_expression of Trh 7 146 0.78 29.92 49.5
44 INT4345 Gene_expression of Gtf3a 2 157 0.67 80.75 48.47
45 INT170646 Negative_regulation of Fig4 3 213 0.37 81.29 46.92
46 INT80124 Negative_regulation of VEGFA 3 450 0.58 311.19 44.53
47 INT1474 Regulation of Localization of Ins1 1 132 0.61 25.96 43.07
48 INT27798 Gene_expression of Ntrk2 9 111 0.78 56.08 42.68
49 INT4850 Binding of Tac1 1 57 0.47 14.25 42.17
50 INT173693 Localization of Gopc 2 249 0.65 70.49 38.81
51 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
52 INT107576 Gene_expression of Atf3 2 114 0.78 72.42 38.64
53 INT65125 Gene_expression of Tacr1 1 81 0.77 23.9 38.35
54 INT12029 Gene_expression of Car1 2 143 0.67 29.69 36.39
55 INT14559 Gene_expression of Igf1 1 254 0.78 112 34.17
56 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
57 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
58 INT9650 Gene_expression of LPA 1 141 0.75 104.57 29
59 INT66200 Gene_expression of Gfap 10 215 0.78 88.04 28.25
60 INT177581 Regulation of Fig4 4 113 0.41 39.26 27.75
61 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
62 INT13415 Positive_regulation of Hpse 2 58 0.70 24.9 25.53
63 INT10240 Gene_expression of Gap43 4 58 0.78 22.11 24.45
64 INT129157 Positive_regulation of Atf3 2 48 0.69 35.42 22.87
65 INT91891 Gene_expression of Kit 6 268 0.78 158.89 22.67
66 INT823 Negative_regulation of ESR1 2 144 0.58 63.72 22.52
67 INT7573 Positive_regulation of Nr3c2 8 38 0.67 20 21.84
68 INT48692 Binding of VEGFA 6 345 0.48 210.3 21.31
69 INT117527 Binding of Prkca 1 25 0.48 6.43 21.05
70 INT171820 Localization of Fig4 2 144 0.65 27.38 20.88
71 INT170444 Binding of Gopc 1 172 0.39 45.05 20.71
72 INT47689 Positive_regulation of Ntrk2 1 44 0.68 16.84 19.59
73 INT12031 Negative_regulation of Car1 2 44 0.59 20.46 19.36
74 INT8392 Regulation of Gene_expression of Qrfp 1 37 0.54 6.9 19.02
75 INT56749 Gene_expression of PCNA 4 219 0.77 111.25 18.42
76 INT871 Negative_regulation of Gene_expression of Prl 2 53 0.58 18.89 17.79
77 INT68681 Transcription of VEGFA 1 132 0.71 80.47 17.03
78 INT10841 Positive_regulation of Gene_expression of Gh 1 101 0.59 45.39 16.96
79 INT170033 Positive_regulation of Gene_expression of Fig4 1 59 0.43 20.99 16.69
80 INT120966 Positive_regulation of Pik3cb 1 34 0.68 15.15 16.59
81 INT86790 Gene_expression of P2rx6 1 34 0.74 14.04 15.92
82 INT92354 Localization of ESR1 1 77 0.75 33.04 15.51
83 INT4851 Positive_regulation of Chat 1 53 0.70 9.21 15.11
84 INT11945 Regulation of Chat 1 38 0.62 7.75 14.97
85 INT105387 Gene_expression of HIF1A 2 116 0.77 98.62 14.66
86 INT65263 Positive_regulation of Gene_expression of Igf1 1 61 0.69 25.69 14.49
87 INT4736 Gene_expression of Chat 4 67 0.77 17.15 14.24
88 INT77619 Gene_expression of Prkaca 1 43 0.75 8.55 14.13
89 INT12321 Binding of Nr3c2 1 19 0.46 5.44 13.46
90 INT101147 Gene_expression of Uchl1 17 31 0.76 14.73 13.22
91 INT14098 Regulation of Gene_expression of Sst 1 13 0.44 4.01 12.92
92 INT174844 Binding of Fig4 1 81 0.41 18.03 12.87
93 INT12315 Gene_expression of Nr3c2 19 37 0.75 19.28 11.97
94 INT16659 Gene_expression of Eef1a1 1 34 0.64 6.1 11.85
95 INT121796 Gene_expression of NeuN 1 92 0.78 23.18 10.53
96 INT100379 Positive_regulation of HIF1A 2 69 0.69 57.31 10.4
97 INT7577 Regulation of Nr3c2 7 16 0.56 7.7 10.1
98 INT49474 Gene_expression of Hpse 1 24 0.55 20.11 10.03
99 INT1378 Negative_regulation of Regulation of Prl 1 27 0.43 9.16 9.9
100 INT40609 Binding of Prkaca 1 23 0.36 3.42 9.19
101 INT9899 Gene_expression of Vwf 4 91 0.74 45.06 9.13
102 INT49325 Gene_expression of Cd34 1 102 0.78 82.75 8.97
103 INT97649 Gene_expression of Dlat 6 48 0.66 13.77 8.94
104 INT1647 Negative_regulation of FSHR 2 54 0.45 13.44 8.87
105 INT6499 Localization of Ntrk2 2 44 0.79 11.78 8.75
106 INT15308 Localization of Chat 1 29 0.81 2.35 8.47
107 INT5194 Positive_regulation of Lpo 3 63 0.70 26.44 8.37
108 INT86672 Negative_regulation of Bcl2 1 50 0.53 34.16 8.37
109 INT205203 Gene_expression of Lpar1 6 6 0.39 11.83 8.08
110 INT12028 Regulation of Car1 2 28 0.43 9.01 7.84
111 INT73354 Gene_expression of Gap43 1 36 0.77 13.74 7.47
112 INT91445 Regulation of Bcl2 1 50 0.56 38.8 7.41
113 INT5195 Negative_regulation of Lpo 4 32 0.59 14.45 7.3
114 INT12314 Negative_regulation of Nr3c2 13 16 0.56 14.82 6.72
115 INT205198 Positive_regulation of Lpar1 1 2 0.35 7.35 6.37
116 INT7564 Positive_regulation of Nr3c1 1 16 0.68 4.98 6.25
117 INT4958 Gene_expression of Pcyt1b 1 18 0.65 3.4 5.66
118 INT77252 Gene_expression of Nr3c1 6 17 0.67 9.71 5.38
119 INT213741 Gene_expression of Kdr 12 60 0.75 44.24 5.35
120 INT21956 Negative_regulation of Mmp7 1 12 0.34 7.32 5.34
121 INT148402 Gene_expression of Chrm2 2 95 0.54 24.25 5.27
122 INT105284 Gene_expression of Ocln 13 39 0.78 14.98 5.08
123 INT130203 Gene_expression of P2ry4 1 14 0.50 8.79 4.82
124 INT124375 Gene_expression of Wnt2 1 67 0.56 38.03 4.67
125 INT105289 Gene_expression of Tjp1 18 28 0.76 11.72 4.67
126 INT133905 Gene_expression of Ncam1 3 24 0.78 10.2 4.62
127 INT55552 Regulation of Gene_expression of Nr3c2 7 5 0.59 5.93 4.53
128 INT75629 Gene_expression of Mtap2 11 41 0.66 8.19 4.51
129 INT97254 Positive_regulation of Gap43 1 22 0.46 7.36 4.48
130 INT106778 Regulation of Gene_expression of P2rx6 1 5 0.34 4.3 4.38
131 INT55044 Positive_regulation of Si 1 15 0.24 1.73 4.2
132 INT47686 Regulation of Gene_expression of Ntrk2 1 5 0.44 5.24 4.14
133 INT88278 Binding of Kit 2 33 0.37 24.45 4.13
134 INT100372 Gene_expression of Flt1 3 47 0.71 24.33 4.09
135 INT52980 Positive_regulation of Dlat 1 20 0.37 5.14 4.06
136 INT39945 Binding of Dlat 1 27 0.32 14.95 3.88
137 INT48143 Gene_expression of Fgf1 16 32 0.78 8.2 3.72
138 INT173751 Transcription of Fig4 1 31 0.46 8.28 3.7
139 INT192129 Gene_expression of P2rx2 1 24 0.67 7.62 3.68
140 INT124185 Negative_regulation of Kit 1 57 0.59 35.43 3.61
141 INT18920 Binding of Egf 1 24 0.48 9.43 3.57
142 INT67726 Gene_expression of Notch1 1 36 0.75 9.77 3.54
143 INT41541 Regulation of Gene_expression of Car1 1 9 0.41 3.82 3.52
144 INT93468 Gene_expression of Cldn1 12 15 0.27 10.12 3.51
145 INT205196 Gene_expression of Lpar2 3 18 0.74 12.19 3.49
146 INT13321 Negative_regulation of Hpse 1 11 0.56 4.64 3.39
147 INT73127 Gene_expression of Pde5a 1 18 0.76 5.25 3.31
148 INT107962 Gene_expression of Pttg1 4 34 0.53 34.05 3.11
149 INT125901 Gene_expression of Cldn3 3 10 0.41 7.27 3.06
150 INT7571 Transcription of Nr3c2 1 6 0.58 2.15 3.03
151 INT98686 Gene_expression of Calb2 1 28 0.51 12.07 2.84
152 INT82841 Localization of Car1 1 11 0.68 3.91 2.84
153 INT136964 Gene_expression of Dmp1 8 10 0.75 3.69 2.83
154 INT85078 Positive_regulation of PCNA 1 36 0.49 17.06 2.81
155 INT10516 Localization of Vwf 3 30 0.79 7.54 2.77
156 INT125905 Gene_expression of Cldn5 3 7 0.57 4.33 2.66
157 INT21721 Gene_expression of Lpo 7 25 0.60 16.33 2.57
158 INT153492 Gene_expression of Gmcl1 2 44 0.65 15.77 2.56
159 INT157399 Localization of Pcyt1b 2 9 0.69 2.3 2.54
160 INT70273 Gene_expression of CALB2 1 9 0.75 7.85 2.54
161 INT102856 Positive_regulation of Srgn 1 7 0.61 1.27 2.54
162 INT123016 Gene_expression of Sec22b 4 11 0.41 5.1 2.5
163 INT110284 Negative_regulation of Positive_regulation of Nr3c2 1 4 0.53 2.08 2.48
164 INT66544 Binding of Igf1 1 23 0.46 8.33 2.44
165 INT208898 Gene_expression of FDX1 1 8 0.10 5.58 2.39
166 INT65034 Regulation of Fgf1 1 7 0.61 2.42 2.34
167 INT8484 Localization of Nr3c1 4 8 0.53 3.12 2.32
168 INT205199 Gene_expression of Lpar3 5 5 0.26 3.29 2.29
169 INT20176 Transcription of Prl 7 15 0.72 7.32 2.25
170 INT125902 Positive_regulation of Gene_expression of Cldn5 1 5 0.51 3.13 2.16
171 INT205216 Gene_expression of Cldn4 43 47 0.53 9.47 2.08
172 INT33394 Negative_regulation of esterase 1 10 0.57 1.57 2.06
173 INT133906 Positive_regulation of Gene_expression of Ncam1 2 6 0.70 1.9 2
174 INT135692 Localization of Nr3c2 6 7 0.77 4.14 1.98
175 INT50539 Regulation of Pvalb 1 7 0.60 1.05 1.89
176 INT90315 Positive_regulation of Gene_expression of Nr3c2 2 4 0.55 2 1.83
177 INT162725 Binding of Kdr 2 13 0.42 8.86 1.79
178 INT101476 Binding of P2rx6 1 4 0.24 1.04 1.78
179 INT144581 Gene_expression of S1pr1 13 4 0.77 1.64 1.77
180 INT33591 Negative_regulation of Positive_regulation of Hpse 1 6 0.32 3.42 1.63
181 INT194073 Gene_expression of Gpx6 4 22 0.09 10.02 1.62
182 INT68889 Regulation of Lpo 1 4 0.53 2.6 1.55
183 INT73816 Positive_regulation of Fgf1 1 5 0.70 2.31 1.49
184 INT205190 Localization of Sec22b 6 8 0.09 2.36 1.48
185 INT7578 Transcription of Nr3c1 1 5 0.32 0.43 1.47
186 INT96324 Negative_regulation of Gene_expression of Nr3c2 2 3 0.56 1.01 1.43
187 INT63328 Binding of Fgf1 3 10 0.37 1.5 1.4
188 INT147540 Negative_regulation of Si 2 5 0.20 3.58 1.32
189 INT36549 Gene_expression of Ociad1 1 6 0.59 1.42 1.29
190 INT26081 Gene_expression of S1pr5 2 3 0.73 0.3 1.29
191 INT245636 Regulation of Positive_regulation of Nr3c2 1 2 0.59 1.55 1.25
192 INT116279 Binding of Dmp1 1 3 0.04 0 1.2
193 INT122103 Negative_regulation of Cdh1 1 5 0.49 2.05 1.18
194 INT202906 Negative_regulation of Atf3 1 2 0.43 5.65 1.17
195 INT76890 Gene_expression of FGFR2 23 42 0.65 13.91 1.08
196 INT105285 Regulation of Gene_expression of Tjp1 4 6 0.26 2.73 1.08
197 INT102249 Binding of HIF1A 1 39 0.36 30.47 1.04
198 INT202264 Positive_regulation of Pttg1 2 8 0.45 8.03 1.04
199 INT202907 Localization of Atf3 1 3 0.75 1.26 1.03
200 INT105283 Positive_regulation of Gene_expression of Tjp1 2 4 0.68 1.86 1.01
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