J:Acta Pharmacol. Sin.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT70757 Binding of Oprl1 and Pnoc 5 3 0.03 0.23 2.55
2 INT95363 IFNG Positive_regulation of Gene_expression of NOS2 1 1 0.43 0 0.19
3 INT97562 Sftpd Regulation of Gene_expression of Fos 1 1 0.13 0 0
4 INT99983 Binding of Oprm1 and Gm9204 1 1 0.00 0 0
5 INT99985 Binding of Oprm1 and Gm9202 1 1 0.00 0 0
6 INT95364 IFNG Positive_regulation of IRF6 1 1 0.24 0 0
7 INT97555 Penk Regulation of Pdyn 1 1 0.02 0 0
8 INT97563 Sftpd Positive_regulation of Gene_expression of Fos 1 1 0.22 0 0
9 INT99984 Regulation of Binding of Oprm1 and Gm9202 1 1 0.00 0 0
10 INT130900 Jag2 Regulation of Localization of Ifng 1 1 0.01 0.05 0
11 INT130901 Jag2 Negative_regulation of Positive_regulation of Kitl 1 1 0.00 0.05 0
12 INT97561 Sftpd Regulation of Fos 1 1 0.13 0 0
13 INT95366 IFNG Negative_regulation of Gene_expression of NOS2 1 1 0.40 0 0
14 INT95365 Positive_regulation of IFNG Positive_regulation of IRF6 1 1 0.24 0 0
15 INT95362 IFNG Positive_regulation of NOS2 1 1 0.43 0 0
16 INT130903 Jag2 Negative_regulation of Positive_regulation of Il6 1 1 0.01 0.06 0
17 INT99986 Regulation of Binding of Oprm1 and Gm9204 1 1 0.00 0 0
18 INT130899 Jag2 Negative_regulation of Ifng 1 1 0.03 0.05 0
19 INT130902 Jag2 Regulation of Localization of Il2 1 1 0.01 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 18 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 4 1902 0.78 275.47 1057.59
4 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
5 INT5202 Positive_regulation of Gene_expression of Fos 8 1163 0.70 319.28 684
6 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
7 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
8 INT5228 Positive_regulation of Fos 3 934 0.70 209.8 503.87
9 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
10 INT5895 Gene_expression of Oprm1 3 525 0.78 120.67 407.29
11 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
12 INT6056 Negative_regulation of Gene_expression of Fos 2 601 0.59 193.05 386.84
13 INT16260 Gene_expression of Bdnf 2 671 0.78 283.44 339.1
14 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
15 INT9131 Positive_regulation of Prkcg 3 431 0.70 130.8 302.41
16 INT63932 Positive_regulation of Ephb1 7 537 0.70 259.67 296.14
17 INT5379 Gene_expression of Fos 2 656 0.78 255.5 292.54
18 INT5591 Regulation of Gene_expression of Fos 1 425 0.62 129.06 265.78
19 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
20 INT5597 Gene_expression of Pdyn 1 433 0.78 62.97 235.47
21 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
22 INT11009 Phosphorylation of Creb1 12 458 0.82 111.34 221.97
23 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
24 INT16259 Positive_regulation of Bdnf 2 336 0.70 183.48 209.82
25 INT9132 Negative_regulation of Prkcg 2 279 0.59 88.05 203.47
26 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
27 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
28 INT49134 Gene_expression of Grin1 2 270 0.78 84.78 148.61
29 INT1033 Positive_regulation of Ca2 4 507 0.68 131.76 147.64
30 INT11012 Positive_regulation of Creb1 3 258 0.70 84.4 132
31 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
32 INT5595 Positive_regulation of Pdyn 1 223 0.70 48.37 130.14
33 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
34 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
35 INT64201 Negative_regulation of Trpv1 2 203 0.59 79.18 119.75
36 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
37 INT62124 Gene_expression of NOS1 2 444 0.78 218.08 114.85
38 INT11011 Positive_regulation of Phosphorylation of Creb1 5 190 0.70 49.25 112.01
39 INT49651 Gene_expression of Creb1 5 276 0.78 114.77 111.96
40 INT48923 Gene_expression of Ephb1 7 211 0.77 106.23 109.9
41 INT114 Binding of Oprl1 1 139 0.48 23 103.35
42 INT10272 Gene_expression of Il1b 4 194 0.78 121.02 103.03
43 INT1898 Regulation of Crh 3 220 0.62 61.33 102.64
44 INT74058 Gene_expression of Nos1 5 260 0.78 80.04 95.71
45 INT1281 Negative_regulation of Maoa 9 203 0.59 22.47 91.66
46 INT1639 Negative_regulation of OPRM1 1 107 0.59 13.86 90.37
47 INT48767 Negative_regulation of NOS1 4 312 0.59 154.25 90.32
48 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
49 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
50 INT31774 Positive_regulation of Vta1 1 67 0.44 14.52 71.79
51 INT5843 Positive_regulation of Gfap 1 184 0.70 108.2 70.21
52 INT6824 Regulation of Gene_expression of Pdyn 1 114 0.62 9.48 66.73
53 INT5573 Negative_regulation of Gene_expression of Penk 1 113 0.59 21.83 64.66
54 INT47690 Regulation of Bdnf 3 118 0.62 53.02 64.5
55 INT66779 Binding of Pnoc 5 79 0.48 6.43 60.46
56 INT5016 Negative_regulation of Crh 1 129 0.59 36.74 59.28
57 INT6436 Positive_regulation of Positive_regulation of Fos 2 101 0.70 18.71 57.96
58 INT6669 Negative_regulation of Positive_regulation of Fos 1 98 0.59 23.5 56.82
59 INT8528 Negative_regulation of Gene_expression of Fos 1 100 0.59 41.15 55.6
60 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
61 INT6826 Transcription of Pdyn 2 130 0.71 22.19 54.88
62 INT15091 Gene_expression of SLC6A4 4 101 0.78 29.91 53.64
63 INT47680 Regulation of Gene_expression of Bdnf 1 92 0.62 41.61 53.24
64 INT50405 Negative_regulation of CYP3A4 1 238 0.59 53.65 51.51
65 INT1232 Positive_regulation of Pdpk1 2 78 0.42 24.33 50.17
66 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
67 INT1715 Positive_regulation of Nrm 1 51 0.70 24 47.53
68 INT57021 Positive_regulation of Gene_expression of Grin1 3 62 0.70 24.77 47.31
69 INT20345 Gene_expression of Dbi 1 136 0.78 56.41 46.2
70 INT1726 Positive_regulation of Kitl 2 65 0.70 38.81 44.85
71 INT49552 Negative_regulation of Positive_regulation of Casp3 1 76 0.55 36.04 44.78
72 INT88617 Positive_regulation of Gene_expression of Creb1 3 90 0.69 51.69 44.29
73 INT47683 Negative_regulation of Bdnf 2 92 0.59 47.53 43.55
74 INT1319 Gene_expression of Oprl1 1 65 0.78 9.34 42.41
75 INT18992 Negative_regulation of Pdpk1 1 53 0.42 19.02 40.95
76 INT16261 Transcription of Bdnf 1 101 0.72 49.41 40.64
77 INT48959 Positive_regulation of Positive_regulation of Prkcg 1 52 0.70 16.47 36.49
78 INT49 Negative_regulation of Ren 1 129 0.59 37.48 35.62
79 INT79060 Gene_expression of NOS2 2 116 0.78 69.25 34.84
80 INT11013 Negative_regulation of Phosphorylation of Creb1 1 55 0.59 18.74 34.66
81 INT7286 Regulation of Transcription of Penk 2 81 0.62 9.25 33.45
82 INT63933 Negative_regulation of Positive_regulation of Ephb1 1 53 0.58 22.83 33.43
83 INT63935 Positive_regulation of Gene_expression of Ephb1 4 52 0.61 24.3 33.05
84 INT9658 Negative_regulation of Gene_expression of Il6 1 110 0.59 66.29 32.58
85 INT6053 Transcription of Fos 1 107 0.72 20.97 31.88
86 INT64113 Positive_regulation of Gene_expression of NOS1 1 110 0.60 71.03 29.72
87 INT11010 Regulation of Phosphorylation of Creb1 3 52 0.62 7.26 29.04
88 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
89 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
90 INT15089 Regulation of SLC6A4 1 48 0.62 17.87 25.6
91 INT74688 Regulation of Nos1 1 55 0.62 22.16 25.3
92 INT66417 Localization of Pnoc 1 34 0.80 1.61 24.48
93 INT10349 Negative_regulation of Il1b 1 48 0.58 25.53 24.24
94 INT6726 Positive_regulation of Edn1 1 118 0.70 65.96 24.07
95 INT79061 Positive_regulation of NOS2 4 92 0.65 58.89 23.96
96 INT6866 Regulation of Gfap 2 51 0.61 19.6 23.56
97 INT74059 Positive_regulation of Gene_expression of Nos1 5 55 0.70 11.5 21.39
98 INT19580 Binding of Pag1 1 24 0.30 15.13 20.88
99 INT440 Regulation of Gene_expression of Crh 1 44 0.62 17.71 20.73
100 INT19509 Localization of Ifng 1 55 0.78 28.25 18.67
101 INT97984 Negative_regulation of SLC6A4 1 45 0.59 15.43 18.09
102 INT5198 Negative_regulation of Vta1 1 21 0.59 4.78 18.07
103 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
104 INT32515 Negative_regulation of B4GALNT1 1 82 0.43 28.1 17.46
105 INT62861 Regulation of Gria2 1 45 0.60 13.35 16.07
106 INT4616 Regulation of Maoa 5 40 0.62 6.09 15.94
107 INT57734 Binding of SLC6A4 1 36 0.48 11.94 15.42
108 INT59929 Negative_regulation of CYP2C9 1 60 0.59 16.33 15.39
109 INT25872 Positive_regulation of Adora1 1 19 0.69 4.9 15.01
110 INT32802 Negative_regulation of Ada 1 21 0.57 4.03 14.87
111 INT92513 Regulation of Grin1 1 26 0.59 9.12 13.94
112 INT79703 Gene_expression of Agtr1a 1 46 0.76 14.18 13.77
113 INT76863 Negative_regulation of Gene_expression of OPRM1 2 21 0.57 6.56 13.69
114 INT20381 Localization of Il2 1 71 0.77 34.23 13.03
115 INT109223 Negative_regulation of Cdk5 1 14 0.59 3.27 12.73
116 INT90909 Negative_regulation of Gene_expression of NOS1 2 44 0.55 23.83 12.47
117 INT95369 Positive_regulation of Gene_expression of NOS2 1 36 0.55 25.09 11.37
118 INT90114 Regulation of Gene_expression of Nos1 1 18 0.62 6.38 10.52
119 INT115614 Binding of Gria2 1 25 0.43 8.97 9.91
120 INT68372 Regulation of CYP2C9 1 28 0.62 5.64 9.53
121 INT46054 Gene_expression of Decr1 4 39 0.65 12.82 9.48
122 INT8524 Regulation of Transcription of Pdyn 2 20 0.60 5.47 9.03
123 INT7572 Regulation of Crhr1 2 8 0.45 5.6 8.93
124 INT6727 Positive_regulation of Ednra 1 27 0.64 18.75 8.71
125 INT5194 Positive_regulation of Lpo 1 63 0.70 26.44 8.37
126 INT6557 Gene_expression of Eno2 3 65 0.77 54.42 8.17
127 INT127853 Localization of Ephb1 2 20 0.74 5.47 7.96
128 INT4663 Positive_regulation of Ada 1 17 0.69 9.48 7.93
129 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
130 INT5195 Negative_regulation of Lpo 1 32 0.59 14.45 7.3
131 INT114642 Negative_regulation of Positive_regulation of Creb1 1 12 0.57 2.32 6.75
132 INT15092 Positive_regulation of SLC6A4 5 17 0.67 7.32 6.7
133 INT147366 Gene_expression of Hist1h1t 1 15 0.44 9.84 6.67
134 INT89131 Negative_regulation of NOS2 1 20 0.58 9.68 6.56
135 INT47681 Regulation of Ntrk2 1 17 0.62 3.61 6.31
136 INT23465 Gene_expression of S100b 4 31 0.76 15.09 6.2
137 INT55077 Positive_regulation of Positive_regulation of Pdpk1 1 6 0.26 1.77 5.78
138 INT29674 Gene_expression of Ada 2 16 0.78 4.59 5.69
139 INT94428 Negative_regulation of Gene_expression of NOS2 1 20 0.47 11.61 5.62
140 INT55578 Regulation of Gene_expression of Il1b 1 7 0.62 4.74 5.55
141 INT101604 Regulation of Cdk5 2 10 0.61 2.2 5.53
142 INT22707 Positive_regulation of Eno2 2 36 0.69 27.31 5.07
143 INT117204 Gene_expression of Tcm 1 39 0.58 10.58 4.88
144 INT16621 Negative_regulation of Esr1 1 20 0.54 8.2 4.84
145 INT5838 Negative_regulation of Positive_regulation of Gfap 1 10 0.58 6.52 4.39
146 INT102515 Binding of Nos3 1 19 0.45 9.41 4.01
147 INT16787 Negative_regulation of ZC3H12D 1 8 0.42 2.22 3.82
148 INT53217 Positive_regulation of Gene_expression of Decr1 2 5 0.06 1.85 3.51
149 INT46055 Regulation of Gene_expression of Decr1 1 5 0.06 1.91 3.4
150 INT115203 Negative_regulation of Positive_regulation of Ednra 1 5 0.33 1.27 3.32
151 INT9126 Negative_regulation of Xdh 1 20 0.58 8.58 3.28
152 INT82168 Positive_regulation of S100b 1 20 0.68 9.72 3.08
153 INT5510 Negative_regulation of Negative_regulation of Crh 1 8 0.43 1.05 2.61
154 INT63418 Regulation of Agtr1a 1 8 0.44 3.67 2.43
155 INT1219 Regulation of Maob 1 5 0.47 0.78 2.16
156 INT97558 Gene_expression of Sftpd 1 6 0.47 3.35 2.07
157 INT56817 Regulation of Eno2 2 16 0.61 10.64 1.99
158 INT124559 Gene_expression of Il1r1 1 4 0.54 2.14 1.89
159 INT10932 Binding of Cnnm1 4 7 0.09 0.4 1.86
160 INT124556 Negative_regulation of Positive_regulation of Adora1 1 3 0.51 1.2 1.81
161 INT65524 Regulation of Spn 1 8 0.21 3.82 1.7
162 INT125767 Positive_regulation of Gene_expression of S100b 1 6 0.49 4.08 1.52
163 INT97560 Regulation of Transcription of Fos 1 6 0.44 2.71 1.46
164 INT95367 Negative_regulation of Positive_regulation of IRF6 1 7 0.21 3.5 1.34
165 INT125766 Regulation of S100b 1 7 0.38 4.31 1.33
166 INT46632 Regulation of Negative_regulation of Maoa 1 4 0.62 0.05 1.18
167 INT72558 Regulation of CYP2C19 1 6 0.54 1.97 1.14
168 INT124560 Negative_regulation of Il1r1 1 2 0.07 0.77 1.14
169 INT56771 Regulation of Cor 1 7 0.23 1.33 0.93
170 INT51744 Regulation of Uts2 3 8 0.56 0.23 0.86
171 INT19824 Negative_regulation of Abr 2 3 0.59 0.88 0.84
172 INT31046 Negative_regulation of Uts2 1 6 0.42 0.44 0.76
173 INT23420 Positive_regulation of Spn 2 8 0.49 4.81 0.69
174 INT127854 Regulation of Localization of Ephb1 2 1 0.25 0.69 0.62
175 INT95368 Negative_regulation of Positive_regulation of NOS2 2 4 0.37 0.89 0.52
176 INT125765 Negative_regulation of Positive_regulation of S100b 1 2 0.42 0.06 0.4
177 INT53854 Regulation of Negative_regulation of Uts2 1 3 0.44 0 0.29
178 INT124558 Regulation of Gene_expression of Il1r1 1 1 0.07 0.29 0.28
179 INT104287 Binding of Abr 1 1 0.32 0.33 0.08
180 INT99950 Gene_expression of Hua 1 2 0.39 0.05 0.03
181 INT141562 Negative_regulation of ERCC6 1 11 0.50 3.04 0
182 INT141563 Regulation of ERCC6 2 6 0.59 2.54 0
183 INT99948 Positive_regulation of Hua 1 2 0.03 0 0
184 INT99981 Binding of Gm9204 1 1 0.01 0 0
185 INT125763 Protein_catabolism of Gfap 1 1 0.99 0.08 0
186 INT99991 Negative_regulation of Regulation of Maoa 1 1 0.43 0 0
187 INT125764 Positive_regulation of Protein_catabolism of Gfap 1 1 0.69 0.08 0
188 INT97559 Negative_regulation of Gene_expression of Sftpd 1 1 0.28 0 0
189 INT99980 Binding of Gm9202 1 1 0.00 0 0
190 INT99947 Positive_regulation of Gene_expression of Hua 1 1 0.01 0 0
191 INT115017 Positive_regulation of Camk4 1 1 0.49 0 0
192 INT141560 Positive_regulation of Uts2 1 1 0.50 0 0
193 INT99982 Regulation of Gm9204 1 1 0.00 0 0
194 INT99949 Negative_regulation of Positive_regulation of Hua 1 1 0.01 0 0
195 INT99979 Regulation of Binding of Gm9204 1 1 0.00 0 0
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