J:Adv. Exp. Med. Biol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT13969 Binding of Calca and Sst 3 1 0.32 0.6 4.02
2 INT50993 Il1b Positive_regulation of Fos 2 1 0.40 0.43 1.84
3 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 4 0.12 2.55 1.26
4 INT88193 Binding of IL2 and IL4 1 4 0.13 1.7 1.2
5 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 3 0.11 1.59 1.02
6 INT63103 AVP Regulation of OXT 1 4 0.28 0.68 1.02
7 INT77142 Binding of IFNG and IL4 2 2 0.03 1.16 0.95
8 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 2 0.07 0.94 0.66
9 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 2 0.05 0.81 0.58
10 INT162742 Binding of HLA-A and KIR3DL1 1 3 0.40 0.68 0.58
11 INT88696 Tac1 Regulation of Regulation of Mme 1 1 0.00 0.39 0.48
12 INT88192 IFNG Regulation of Gene_expression of ZAK 1 1 0.01 0.75 0.36
13 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 1 0.03 0.62 0.36
14 INT63102 OXT Regulation of CALCRL 1 1 0.01 0.25 0.27
15 INT162743 Binding of HLA-A and TNFRSF10B 1 2 0.40 0.4 0.25
16 INT88191 Binding of NCOR2 and ZAK 1 1 0.00 0.17 0.21
17 INT88698 Binding of Max and Cpm 1 1 0.00 0.27 0.18
18 INT88702 Binding of CPM and Max 1 1 0.01 0.27 0.18
19 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 1 0.06 1.07 0.1
20 INT102245 TNF Positive_regulation of Binding of HIF1A 1 1 0.18 1.09 0.1
21 INT102248 INS Positive_regulation of Binding of HIF1A 1 1 0.13 0.96 0.1
22 INT102246 Binding of HIF1A and INS 1 1 0.07 0.96 0.1
23 INT102247 Binding of EPO and HIF1A 1 1 0.41 0.65 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 4 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 6 2008 0.81 518.3 1408.65
3 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
4 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
5 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
6 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
7 INT5228 Positive_regulation of Fos 4 934 0.70 209.8 503.87
8 INT50058 Negative_regulation of Cpox 2 907 0.58 426.28 428.29
9 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
10 INT4758 Positive_regulation of Localization of Calca 2 557 0.70 138.55 411.04
11 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
12 INT2540 Negative_regulation of Calca 3 538 0.59 172.11 384.38
13 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
14 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
15 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
16 INT5979 Gene_expression of Oprd1 3 428 0.78 75.64 320.32
17 INT2365 Positive_regulation of Cck 3 354 0.70 87.8 277.41
18 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
19 INT5972 Gene_expression of IL1B 2 948 0.78 510.91 263.97
20 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
21 INT16259 Positive_regulation of Bdnf 1 336 0.70 183.48 209.82
22 INT4803 Transcription of Penk 3 435 0.72 59.09 182.4
23 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
24 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
25 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
26 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
27 INT1878 Binding of HLA-B 4 440 0.48 321.16 127.36
28 INT9235 Negative_regulation of Gene_expression of TNF 2 346 0.59 252.98 118.61
29 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
30 INT7327 Regulation of Th 1 164 0.62 29.67 110.14
31 INT69440 Gene_expression of ROS1 2 752 0.78 477.64 103.83
32 INT10272 Gene_expression of Il1b 1 194 0.78 121.02 103.03
33 INT11381 Positive_regulation of IL1B 2 330 0.70 209.31 100.9
34 INT5587 Regulation of Fos 2 191 0.62 40.81 99.7
35 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
36 INT29971 Gene_expression of Oprk1 3 126 0.78 35.32 93.97
37 INT18032 Positive_regulation of Oprk1 2 108 0.70 30.78 89.7
38 INT4798 Gene_expression of Nts 1 169 0.77 29.56 86.04
39 INT5590 Negative_regulation of Fos 1 144 0.59 40.94 81.98
40 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
41 INT403 Localization of Trh 1 241 0.81 28.55 81.45
42 INT2893 Localization of Oxt 5 219 0.80 28.96 79.43
43 INT749 Gene_expression of HLA-B 3 341 0.75 224.12 77.37
44 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
45 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
46 INT10274 Positive_regulation of Il1b 3 123 0.70 79.76 73.56
47 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
48 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
49 INT8388 Positive_regulation of Vip 1 142 0.70 39.72 67.61
50 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
51 INT20964 Gene_expression of OPRK1 1 96 0.78 23.54 58.18
52 INT10668 Positive_regulation of Gene_expression of Oprd1 1 61 0.69 15.21 52.12
53 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
54 INT35975 Regulation of Cpox 3 109 0.39 57.88 49.69
55 INT10304 Binding of OPRK1 1 89 0.48 9.28 49.42
56 INT937 Positive_regulation of Oxt 2 195 0.70 37.82 49.3
57 INT683 Positive_regulation of AVP 1 173 0.70 74.55 46.41
58 INT61619 Gene_expression of IL12A 4 194 0.77 146.07 41.97
59 INT2531 Positive_regulation of Cebpz 1 166 0.00 43.08 38.86
60 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
61 INT11292 Gene_expression of Mme 1 77 0.78 20.98 35.85
62 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
63 INT53577 Negative_regulation of Localization of TNF 2 110 0.59 59.28 35.23
64 INT6484 Binding of IL1B 1 122 0.47 75.84 35.07
65 INT1705 Gene_expression of pCA 1 126 0.65 88.65 34.81
66 INT6105 Positive_regulation of IL2 2 133 0.69 82.76 34.67
67 INT5489 Localization of CA2 1 172 0.80 39.46 33.56
68 INT7286 Regulation of Transcription of Penk 1 81 0.62 9.25 33.45
69 INT10763 Localization of IL2 4 157 0.80 81.11 33.21
70 INT7133 Negative_regulation of MME 6 85 0.59 29.22 33.1
71 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
72 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
73 INT11554 Negative_regulation of CSF2 3 129 0.59 108.55 29.44
74 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
75 INT67 Negative_regulation of Ddc 1 66 0.59 15.34 28.96
76 INT8698 Localization of Nka1 2 50 0.78 5.8 27.67
77 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
78 INT5650 Gene_expression of Mpo 1 117 0.77 80.27 26.42
79 INT10273 Positive_regulation of Gene_expression of Il1b 1 47 0.68 31.15 26.21
80 INT5948 Regulation of Il1b 1 44 0.60 22.8 25.4
81 INT17625 Localization of GCG 2 210 0.80 55.69 24.97
82 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
83 INT3028 Negative_regulation of Oxt 2 76 0.58 18.52 24.4
84 INT27933 Gene_expression of NCOR2 2 65 0.72 31.35 24.23
85 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
86 INT35716 Positive_regulation of NCOR2 2 45 0.60 18 23.54
87 INT8699 Gene_expression of Nka1 2 45 0.67 6.41 22.56
88 INT2911 Positive_regulation of Glul 1 36 0.70 11.09 22.07
89 INT1876 Positive_regulation of HLA-B 3 82 0.69 52.16 21.08
90 INT15796 Regulation of IL2 1 66 0.61 25.43 20.62
91 INT62042 Positive_regulation of Gene_expression of IL4 1 67 0.56 42.05 20.39
92 INT52457 Gene_expression of ABCB1 1 129 0.78 38.68 19.88
93 INT12243 Positive_regulation of PRSS1 1 91 0.70 52.87 19.48
94 INT9490 Regulation of Mme 1 44 0.56 6.69 19.21
95 INT12360 Regulation of Tac1 2 31 0.61 5.9 18
96 INT25517 Regulation of NFKB1 1 41 0.61 22.28 16.09
97 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
98 INT81088 Gene_expression of ASIC1 2 26 0.77 17.8 15.07
99 INT25266 Positive_regulation of Localization of IL1B 1 38 0.69 15.89 14.35
100 INT16919 Gene_expression of IL36RN 1 48 0.48 32.78 13.83
101 INT7997 Gene_expression of Ltc4s 4 51 0.76 34.28 13.8
102 INT17565 Regulation of Gpt 1 85 0.60 43.64 13.68
103 INT4931 Localization of IFNG 2 53 0.78 33.25 13.65
104 INT16635 Gene_expression of Ltb4r 2 27 0.64 17.05 13.21
105 INT99586 Binding of IRF6 1 60 0.36 27.87 13.2
106 INT62441 Gene_expression of ABCC1 1 56 0.78 21.01 12.93
107 INT4199 Binding of Agt 1 76 0.48 21.06 12.66
108 INT63104 Negative_regulation of CALCRL 1 29 0.37 13.62 12.42
109 INT99587 Positive_regulation of Gene_expression of Oprk1 1 15 0.57 5.26 12.39
110 INT520 Binding of Comt 1 24 0.48 8.98 12.21
111 INT4460 Regulation of Mpo 2 44 0.62 31.16 12.11
112 INT16772 Gene_expression of MPO 1 81 0.78 90.98 11.9
113 INT99336 Negative_regulation of FOLH1 8 30 0.57 8.83 11.53
114 INT152 Negative_regulation of MBD2 1 31 0.38 3.95 11.31
115 INT76138 Transcription of Oprk1 1 21 0.72 5.79 11.25
116 INT5464 Regulation of CALCRL 1 24 0.16 4.2 11.19
117 INT10019 Binding of CD8A 1 57 0.36 31.49 10.08
118 INT5465 Positive_regulation of CALCRL 1 25 0.49 7.24 9.8
119 INT2339 Positive_regulation of CB 1 30 0.29 10.68 9.12
120 INT80420 Gene_expression of IFI27 2 145 0.78 63.61 8.83
121 INT13085 Positive_regulation of ACE 1 50 0.70 44.2 8.31
122 INT31761 Positive_regulation of Itpr3 1 32 0.58 5.95 8.22
123 INT4021 Positive_regulation of PLA2G1B 1 35 0.70 23.27 8.2
124 INT6957 Positive_regulation of OXTR 2 38 0.70 6.55 7.81
125 INT24978 Binding of SFTPA1 1 22 0.47 15.09 7.76
126 INT50040 Localization of Il4 1 15 0.67 8.26 7.69
127 INT78199 Gene_expression of Neu1 2 65 0.75 62.88 7.16
128 INT115213 Regulation of SFTPA1 1 13 0.32 6.91 7.11
129 INT50990 Regulation of Cpb2 1 12 0.37 2.71 7.07
130 INT32709 Negative_regulation of Hbb 1 30 0.54 18.27 6.97
131 INT69439 Regulation of ROS1 1 46 0.45 31.22 6.94
132 INT12359 Negative_regulation of Tac1 2 26 0.58 8.16 6.89
133 INT6933 Gene_expression of ANTXRL 3 15 0.10 4.77 6.84
134 INT69441 Regulation of Gene_expression of ROS1 1 38 0.50 26.78 6.78
135 INT24800 Negative_regulation of AMPD1 4 44 0.59 21.19 6.76
136 INT11975 Transcription of Tac1 3 24 0.71 4.06 6.72
137 INT15872 Positive_regulation of EPO 2 74 0.70 45.35 6.67
138 INT38644 Positive_regulation of DST 1 30 0.53 12.48 6.59
139 INT24946 Binding of PRSS1 1 23 0.47 16.75 6.41
140 INT15528 Positive_regulation of GCG 1 38 0.63 20.47 6.14
141 INT15803 Regulation of IFNG 1 21 0.44 12.57 5.98
142 INT13418 Positive_regulation of Lpp 1 8 0.54 0.55 5.84
143 INT15143 Protein_catabolism of MME 1 16 1.00 4.56 5.54
144 INT77146 Binding of IL4 1 23 0.36 13.69 5.39
145 INT11062 Positive_regulation of MME 1 24 0.63 14.37 5.26
146 INT58060 Negative_regulation of HMI 3 30 0.44 11.9 5.06
147 INT21747 Localization of crf 2 8 0.47 5.32 5.06
148 INT29354 Regulation of Binding of OPRK1 1 7 0.60 1.72 5.04
149 INT11493 Positive_regulation of KLK1 2 21 0.67 9.22 5
150 INT14681 Negative_regulation of GCG 1 31 0.57 13.55 4.98
151 INT21650 Regulation of OXTR 3 29 0.61 5.99 4.91
152 INT63074 Gene_expression of FOSB 1 19 0.53 13.58 4.91
153 INT50991 Regulation of Nacc1 1 3 0.05 7.25 4.7
154 INT2144 Localization of COL7A1 1 36 0.74 20.92 4.67
155 INT16047 Negative_regulation of Positive_regulation of Il1b 1 11 0.57 5.27 4.66
156 INT23045 Positive_regulation of Hbb 1 31 0.64 19.35 4.54
157 INT26477 Regulation of ACE 1 26 0.45 16.31 4.33
158 INT10849 Negative_regulation of OXT 1 14 0.48 2.51 4.19
159 INT88390 Gene_expression of LGALS4 1 27 0.69 12.28 4.15
160 INT30014 Positive_regulation of HPSE 2 22 0.70 20.91 4.09
161 INT19300 Positive_regulation of OXT 1 34 0.43 4.43 4.07
162 INT17626 Positive_regulation of Localization of GCG 3 36 0.69 13.94 4.06
163 INT80421 Positive_regulation of IFI27 1 26 0.65 15.32 3.93
164 INT29138 Positive_regulation of Localization of IL2 4 25 0.50 10.06 3.89
165 INT52080 Gene_expression of Commd7 3 2 0.65 0.54 3.85
166 INT81231 Gene_expression of LGALS3 1 26 0.74 9.38 3.66
167 INT27466 Negative_regulation of Kng1 1 7 0.10 7.79 3.56
168 INT88197 Binding of ZAK 1 9 0.46 6.23 3.54
169 INT50380 Gene_expression of Cpm 2 7 0.73 4.43 3.38
170 INT87027 Positive_regulation of Localization of IFNG 2 12 0.67 5.78 3.35
171 INT95971 Negative_regulation of Gene_expression of ABCB1 1 7 0.58 5.61 3.34
172 INT19393 Gene_expression of Gfm1 1 31 0.51 18.9 3.2
173 INT41340 Binding of Htr1a 1 5 0.47 0.76 3.16
174 INT58527 Gene_expression of Prtn3 4 20 0.71 15.99 2.9
175 INT25601 Binding of IL36RN 1 5 0.35 1.93 2.9
176 INT597 Positive_regulation of PON1 1 26 0.62 19.14 2.87
177 INT10345 Positive_regulation of LOC682560 1 5 0.38 0.22 2.85
178 INT27918 Positive_regulation of Klk1c7 1 6 0.36 2.89 2.84
179 INT21775 Gene_expression of crf 1 8 0.54 4.96 2.7
180 INT4879 Positive_regulation of Gene_expression of MME 1 17 0.69 12.48 2.46
181 INT134811 Gene_expression of ICA1 1 22 0.44 6.47 2.42
182 INT24129 Positive_regulation of ZAK 2 13 0.70 2.29 2.39
183 INT57970 Positive_regulation of Rb1 1 17 0.67 7.03 2.36
184 INT139008 Positive_regulation of Gfm1 1 21 0.35 7.79 2.34
185 INT26434 Localization of MME 2 17 0.81 8.67 2.3
186 INT94002 Regulation of Lox 4 13 0.38 8.41 2.29
187 INT905 Regulation of Ptgfr 1 8 0.35 2.87 2.28
188 INT36927 Regulation of Transcription of Tac1 2 3 0.26 0.33 2.27
189 INT32312 Gene_expression of UGP2 6 1 0.60 1.35 2.24
190 INT19286 Negative_regulation of Cacna1c 1 11 0.46 5.12 2.22
191 INT50992 Regulation of Negative_regulation of Fos 1 2 0.26 0.73 2.22
192 INT105378 Regulation of IL12A 1 6 0.26 8.82 2.15
193 INT50994 Binding of Il27ra 1 5 0.11 1.77 2.15
194 INT63081 Localization of Itpr3 1 13 0.67 1.08 2.12
195 INT87028 Positive_regulation of Positive_regulation of NCOR2 2 4 0.01 0.92 2.09
196 INT88701 Gene_expression of MMD 1 15 0.44 6.04 1.94
197 INT27616 Protein_catabolism of Mbis1 1 2 0.01 0 1.85
198 INT16782 Binding of ERLEC1 1 15 0.10 8.23 1.7
199 INT17452 Regulation of Dlst 1 14 0.46 1.5 1.68
200 INT26451 Gene_expression of KLK1 1 14 0.75 5.79 1.66
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