J:Agents Actions

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT13193 FPR1 Positive_regulation of ELANE 3 1 0.44 1.22 0.92
2 INT58633 Negative_regulation of Il1f5 Negative_regulation of Mpo 1 1 0.15 0.98 0.48
3 INT58634 Negative_regulation of Il1 Negative_regulation of Mpo 1 1 0.20 0.98 0.47
4 INT56631 Negative_regulation of FPR1 Positive_regulation of ELANE 1 1 0.38 0.54 0.44
5 INT20467 Lmo7 Positive_regulation of Localization of Prl 1 1 0.05 0 0.34
6 INT20468 Ran Negative_regulation of Localization of Prl 1 1 0.30 0 0.33
7 INT58305 AQP1 Regulation of Localization of TNF 1 1 0.10 0.16 0.22
8 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 1 0.10 0.16 0.22
9 INT58306 C4A Regulation of Gene_expression of IL1B 1 1 0.00 0.15 0.21
10 INT58304 C4A Regulation of Localization of TNF 1 1 0.00 0.15 0.21
11 INT46285 SCT Positive_regulation of PRSS1 1 1 0.16 0.1 0.19
12 INT46284 CCK Positive_regulation of CTRC 1 1 0.09 0.1 0.19
13 INT46286 SCT Positive_regulation of CTRC 1 1 0.24 0.1 0.19
14 INT46283 CCK Positive_regulation of PRSS1 1 1 0.06 0.1 0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
2 INT158 Localization of Prl 14 2431 0.81 378.96 952.2
3 INT6483 Gene_expression of TNF 6 3152 0.78 2515.62 929.82
4 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
5 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
6 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
7 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
8 INT6580 Negative_regulation of Ptgs1 8 929 0.59 381.53 376.26
9 INT157 Positive_regulation of Localization of Prl 8 790 0.70 104.54 374.78
10 INT876 Localization of Gh1 5 843 0.80 67.75 340.82
11 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
12 INT2649 Regulation of Calca 10 433 0.62 146.05 330.95
13 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
14 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
15 INT161 Regulation of Localization of Prl 8 615 0.62 65.37 298.66
16 INT1352 Localization of Acot1 1 728 0.80 73.01 296.01
17 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
18 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
19 INT6852 Localization of TNF 5 883 0.81 705.95 270.84
20 INT5972 Gene_expression of IL1B 6 948 0.78 510.91 263.97
21 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
22 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
23 INT767 Localization of Gnrhr 2 565 0.80 106.68 214.57
24 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
25 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
26 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
27 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
28 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
29 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
30 INT19472 Gene_expression of Il1 3 554 0.76 419.75 175.35
31 INT159 Negative_regulation of Localization of Prl 1 416 0.59 55.34 171.8
32 INT880 Positive_regulation of Localization of Gh1 2 304 0.70 14.79 150.23
33 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
34 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
35 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
36 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
37 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
38 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
39 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
40 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
41 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
42 INT10272 Gene_expression of Il1b 3 194 0.78 121.02 103.03
43 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
44 INT10166 Localization of Tnf 1 237 0.81 153.95 88.64
45 INT875 Regulation of Localization of Gh1 1 166 0.62 12.87 84.97
46 INT4857 Regulation of Tacr1 2 115 0.62 39.01 84.52
47 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
48 INT56291 Gene_expression of Ros1 1 503 0.63 274.12 81.5
49 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
50 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
51 INT2431 Positive_regulation of Mpo 2 275 0.70 211.99 78.47
52 INT15769 Gene_expression of Il1b 3 146 0.78 114.51 75.35
53 INT881 Negative_regulation of Localization of Gh1 2 164 0.58 15.1 75.28
54 INT10274 Positive_regulation of Il1b 1 123 0.70 79.76 73.56
55 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
56 INT39565 Gene_expression of Ptger2 1 424 0.75 229.28 72.68
57 INT11380 Negative_regulation of IL1B 2 215 0.59 125.62 72.35
58 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
59 INT5969 Gene_expression of Il1a 1 221 0.75 96.31 71.38
60 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
61 INT6849 Localization of IL1B 5 229 0.81 112.56 69.63
62 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
63 INT3375 Gene_expression of IGHE 1 535 0.77 387.47 65.46
64 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
65 INT9196 Gene_expression of PTGS1 2 215 0.77 96.99 60.5
66 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
67 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
68 INT4241 Regulation of CALCA 2 87 0.62 28.19 55.29
69 INT5759 Positive_regulation of Ptgs1 2 127 0.69 53.45 53.04
70 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
71 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
72 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
73 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
74 INT11406 Positive_regulation of Localization of CALCA 1 49 0.70 20.64 42.8
75 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
76 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
77 INT48075 Positive_regulation of Il1b 1 71 0.67 48.63 40.48
78 INT3987 Positive_regulation of IGHE 1 316 0.70 283.2 40.16
79 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
80 INT2782 Regulation of Gene_expression of Pomc 1 75 0.62 15.04 38.97
81 INT9094 Gene_expression of COL7A1 3 277 0.77 143.42 38.73
82 INT385 Gene_expression of Agt 1 182 0.78 63.62 37.91
83 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
84 INT53577 Negative_regulation of Localization of TNF 2 110 0.59 59.28 35.23
85 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
86 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
87 INT234 Binding of Alb 1 151 0.48 52.34 32.97
88 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
89 INT9347 Localization of Il1b 1 58 0.81 26.13 31.53
90 INT17886 Negative_regulation of Il1 2 95 0.57 70.91 31.25
91 INT5418 Negative_regulation of Alox5 3 108 0.57 42.09 31.17
92 INT2884 Positive_regulation of CCK 1 66 0.69 25.25 30.6
93 INT9053 Negative_regulation of ALOX5 1 97 0.58 40.34 29.94
94 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
95 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
96 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
97 INT10506 Gene_expression of PTAFR 1 86 0.76 37.57 28.58
98 INT57692 Positive_regulation of Gene_expression of Il1b 1 50 0.67 43.54 28.29
99 INT5298 Negative_regulation of MTHFS 2 70 0.57 27.07 28.11
100 INT3076 Regulation of KNG1 2 52 0.60 20.39 27.89
101 INT28834 Positive_regulation of Bdkrb1 2 38 0.69 30.48 26.89
102 INT22764 Localization of Ptger2 1 81 0.64 24.38 26.77
103 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
104 INT2609 Localization of ELANE 6 111 0.81 50.22 26.63
105 INT49850 Negative_regulation of PDE4A 1 105 0.58 76.91 26.59
106 INT5966 Localization of Il1a 2 50 0.78 22.91 26.54
107 INT5650 Gene_expression of Mpo 3 117 0.77 80.27 26.42
108 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
109 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
110 INT10349 Negative_regulation of Il1b 3 48 0.58 25.53 24.24
111 INT58301 Positive_regulation of Mpo 2 87 0.70 80.19 23.99
112 INT51029 Negative_regulation of Il1b 2 34 0.57 29.34 23.62
113 INT11746 Positive_regulation of Il1a 1 65 0.63 42.94 23.54
114 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
115 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
116 INT11893 Positive_regulation of Ptger2 1 96 0.69 31.49 21.92
117 INT614 Gene_expression of Cxcl2 1 29 0.76 25.53 20.8
118 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
119 INT7994 Gene_expression of Lta 1 113 0.67 69.81 19.59
120 INT4260 Negative_regulation of Positive_regulation of Npr1 1 29 0.43 4.39 19.57
121 INT6993 Negative_regulation of Mpo 3 72 0.59 61.83 19.51
122 INT18672 Gene_expression of Ncam1 1 54 0.78 36.64 18.79
123 INT667 Negative_regulation of Hrh2 2 38 0.58 18.11 18.01
124 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
125 INT15237 Protein_catabolism of Mme 1 31 0.96 10.26 16.69
126 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
127 INT43906 Regulation of Tlr4 1 71 0.53 35.18 15.49
128 INT615 Regulation of Alb 2 66 0.62 33.43 15.33
129 INT12087 Regulation of Localization of TNF 2 44 0.62 28.71 15.17
130 INT49532 Regulation of Gene_expression of Il6 1 43 0.61 25.8 14.99
131 INT1284 Negative_regulation of Mmp13 1 20 0.57 36.21 14.91
132 INT22276 Gene_expression of TBXA2R 1 65 0.77 23.22 14.21
133 INT29170 Negative_regulation of Gene_expression of Il1b 1 25 0.59 16.36 13.68
134 INT19191 Negative_regulation of Localization of IL1B 1 35 0.58 15.19 13.63
135 INT18191 Negative_regulation of Cyp3a23/3a1 1 48 0.57 10.21 13.38
136 INT22030 Negative_regulation of Cysltr1 1 31 0.39 21.83 12.49
137 INT51028 Regulation of Il1b 1 28 0.60 21.15 12.47
138 INT11244 Transcription of CALCA 2 21 0.69 3.61 12.27
139 INT4460 Regulation of Mpo 2 44 0.62 31.16 12.11
140 INT1139 Gene_expression of IgG-2a 2 35 0.65 19.19 12
141 INT12992 Negative_regulation of Gene_expression of Ptgs1 1 33 0.42 20.47 11.77
142 INT3057 Gene_expression of Ptgfr 1 60 0.58 14.54 11.73
143 INT20457 Regulation of Ptgs1 1 23 0.48 11.63 11.56
144 INT3597 Positive_regulation of Pla2g1b 2 37 0.63 17.94 11.41
145 INT23122 Gene_expression of Ptger3 1 31 0.72 11.94 11.37
146 INT17826 Positive_regulation of Pla2g1b 1 39 0.70 11.35 10.97
147 INT701 Localization of IGHE 3 87 0.80 40.5 10.62
148 INT20131 Negative_regulation of Mthfs 1 18 0.57 7.93 10.54
149 INT6574 Negative_regulation of Pla2g1b 3 35 0.59 11.4 10.44
150 INT25613 Gene_expression of Il1f5 1 32 0.77 13.29 10.44
151 INT17421 Negative_regulation of Alox5 1 41 0.57 15.23 10.05
152 INT17283 Positive_regulation of CSF1 1 37 0.59 24.16 10.01
153 INT6651 Localization of FPR1 1 18 0.73 3.27 9.9
154 INT7995 Positive_regulation of Lta 1 28 0.66 14.98 9.8
155 INT48078 Regulation of Gene_expression of Il1b 2 15 0.62 14.78 9.53
156 INT54834 Gene_expression of Col2a1 4 48 0.72 13.5 9.41
157 INT56292 Negative_regulation of Gene_expression of Ros1 1 70 0.38 36.14 9.17
158 INT12991 Negative_regulation of Gene_expression of PTGS1 1 28 0.41 13.39 8.9
159 INT9889 Gene_expression of Alox5 1 34 0.63 20.83 8.85
160 INT386 Positive_regulation of Gene_expression of Agt 1 37 0.70 15.92 8.73
161 INT13432 Positive_regulation of Klkb1 1 23 0.57 5.36 8.65
162 INT44003 Gene_expression of F3 1 40 0.75 27.92 8.29
163 INT4021 Positive_regulation of PLA2G1B 1 35 0.70 23.27 8.2
164 INT1138 Positive_regulation of IgG-2a 1 16 0.68 5.59 8.11
165 INT42707 Gene_expression of Tbce 1 24 0.65 12.92 7.93
166 INT14600 Positive_regulation of Tpsab1 2 51 0.68 22.1 7.7
167 INT4022 Negative_regulation of PLA2G1B 2 30 0.59 10.41 7.58
168 INT165 Regulation of HRH1 2 12 0.45 1.76 7.57
169 INT2802 Negative_regulation of Asrgl1 1 14 0.59 2.69 7.37
170 INT14599 Localization of Tpsab1 1 36 0.79 14.58 7.18
171 INT49506 Regulation of Ptger2 1 29 0.44 17.38 6.75
172 INT612 Positive_regulation of Orm1 1 15 0.68 5.24 6.73
173 INT25609 Localization of Il1f5 1 17 0.80 10.66 6.71
174 INT53572 Negative_regulation of Localization of Il1 1 18 0.40 12.78 6.7
175 INT43721 Gene_expression of Vegfa 1 49 0.77 36.18 6.63
176 INT38807 Negative_regulation of PLA2G6 5 29 0.59 10.1 6.42
177 INT21613 Gene_expression of Pla2g1b 1 25 0.68 9.05 6.39
178 INT5249 Gene_expression of Hrasls 1 8 0.58 10.39 6.27
179 INT27408 Phosphorylation of POMC 1 9 0.80 2.18 5.88
180 INT22765 Negative_regulation of Localization of Ptger2 1 14 0.34 3 5.75
181 INT28164 Regulation of ALOX5 1 25 0.60 12.76 5.47
182 INT13706 Localization of Npr1 1 10 0.59 0.83 5.42
183 INT14598 Gene_expression of Tpsab1 1 40 0.73 14.55 5.4
184 INT19541 Gene_expression of Ptgir 1 22 0.65 15.42 5.39
185 INT12039 Localization of TFPI 1 22 0.68 9.88 5.35
186 INT27415 Negative_regulation of Positive_regulation of Got1 1 15 0.51 10.99 5.14
187 INT10474 Regulation of Tbce 1 6 0.22 4.18 5.11
188 INT1285 Localization of Mmp13 1 12 0.78 8.98 4.93
189 INT17582 Negative_regulation of Localization of ELANE 2 17 0.53 6.11 4.89
190 INT9095 Regulation of Gene_expression of COL7A1 1 24 0.57 10.55 4.88
191 INT49405 Gene_expression of Itgal 1 40 0.75 27.3 4.8
192 INT57691 Regulation of Gene_expression of Ptger2 1 23 0.40 17.08 4.61
193 INT25263 Negative_regulation of Hrh1 1 11 0.58 3.35 4.61
194 INT1841 Negative_regulation of Hrasls 1 15 0.48 6.85 4.56
195 INT25634 Binding of Mpo 2 21 0.48 14.78 4.39
196 INT205 Negative_regulation of Cbr1 1 10 0.58 4.23 4.29
197 INT25334 Negative_regulation of Pla2g2a 1 16 0.56 9.01 4.23
198 INT4148 Gene_expression of HRH1 1 11 0.77 2.71 4.22
199 INT1701 Localization of Neu1 2 11 0.69 6.36 4.18
200 INT13190 Gene_expression of Pbk 1 10 0.31 1.97 4.14
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