J:Allergy, Asthma & Immunology Research

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT101942 Binding of CD40 and CD40LG 16 2 0.23 15.24 4.01
2 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 4 0.19 7.58 2
3 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 2 0.08 3.76 1
4 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 1 0.03 0.31 0.91
5 INT166983 Binding of HLA-B and HSPG2 4 1 0.08 4.66 0.88
6 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 1 0.31 0.92 0.55
7 INT334500 Binding of IGHE and SPARCL1 1 2 0.01 1.47 0.55
8 INT304098 Binding of Il13 and Aia1 1 5 0.01 5.78 0.41
9 INT304102 Il13 Positive_regulation of Gene_expression of IGHE 1 2 0.25 2.65 0.4
10 INT299181 Cysltr1 Regulation of Musk 1 1 0.08 1.21 0.4
11 INT334533 Binding of Foxq1 and Ngf 1 1 0.05 0.8 0.38
12 INT304099 Binding of IGHE and Il13 1 3 0.17 4.13 0.38
13 INT334499 Binding of AMELX and IL4 1 1 0.12 0.47 0.29
14 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 1 0.23 0.69 0.25
15 INT317775 GATA3 Positive_regulation of HDAC1 1 1 0.23 0.69 0.25
16 INT317771 GSR Positive_regulation of HDAC1 1 1 0.10 0.69 0.25
17 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 1 0.10 0.69 0.25
18 INT334522 Ngf Positive_regulation of Nrp1 1 1 0.19 0.93 0.22
19 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 1 0.19 0.93 0.22
20 INT304104 Il13 Positive_regulation of Positive_regulation of AHR 1 2 0.14 2.6 0.19
21 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 1 0.02 1.18 0.15
22 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 1 0.08 0.48 0.14
23 INT304094 Binding of AHR and SNRNP70 1 2 0.00 2.64 0.14
24 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 1 0.15 0.48 0.14
25 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 1 0.17 0.48 0.14
26 INT334530 Sema3a Regulation of Il18 1 1 0.18 1.61 0.13
27 INT334528 Nrp1 Negative_regulation of Sema3a 1 1 0.17 0.47 0.13
28 INT334524 Sema3a Regulation of Foxq1 1 1 0.04 1.61 0.13
29 INT317774 CRHR1 Positive_regulation of Localization of POMC 1 1 0.05 0.55 0.11
30 INT304100 Binding of CCL11 and Il13 1 1 0.05 0.86 0.08
31 INT304172 Il5 Positive_regulation of Bcl2l1 1 1 0.02 0.91 0.05
32 INT304103 Il13 Positive_regulation of Gene_expression of CCL11 1 1 0.64 0.69 0.04
33 INT304101 Il13 Positive_regulation of CCL11 1 1 0.43 0.69 0.04
34 INT334497 Positive_regulation of IGHG3 Positive_regulation of IGHE 1 1 0.01 0.81 0.04
35 INT334496 IGHG3 Positive_regulation of IGHE 1 1 0.01 0.75 0.04
36 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 1 0.10 3.1 0
37 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 1 0.01 0.51 0
38 INT334498 Binding of IL13 and KLF1 1 1 0.00 0.63 0
39 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 1 0.02 0.96 0
40 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 1 0.34 0.65 0
41 INT304135 Binding of CEL and Positive_regulation of CASP8 1 1 0.00 0.52 0
42 INT304176 Binding of IL1B and Il13 1 1 0.00 0.96 0
43 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 1 0.04 0.94 0
44 INT304168 Binding of Gata1 and Sfpi1 1 1 0.08 0.07 0
45 INT304171 Il13 Positive_regulation of Gene_expression of Vcam1 1 1 0.04 0.89 0
46 INT304174 Binding of IL1B and Il4 1 1 0.00 0.96 0
47 INT304093 Binding of IL10 and TGFB1 1 1 0.02 1.21 0
48 INT317778 Binding of ADRB2 and GOPC 1 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
3 INT76660 Gene_expression of Trpv1 1 691 0.78 329.46 386.42
4 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
5 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
6 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
7 INT6481 Binding of TNF 2 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
9 INT24326 Gene_expression of Ngf 9 346 0.78 218.67 184.71
10 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
11 INT65600 Positive_regulation of Casp3 2 376 0.70 198.44 128.03
12 INT20374 Gene_expression of Il4 6 515 0.76 306.15 114.12
13 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
14 INT21793 Positive_regulation of Ngf 2 154 0.70 94.78 85.27
15 INT56298 Gene_expression of IL4 5 306 0.78 182.18 72.92
16 INT14624 Gene_expression of Pax3 1 100 0.38 33.22 69.47
17 INT3375 Gene_expression of IGHE 36 535 0.77 387.47 65.46
18 INT1599 Positive_regulation of ADCY1 2 146 0.67 30.05 64.9
19 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
20 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
21 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
22 INT52264 Gene_expression of IK 1 180 0.77 90.87 51.87
23 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
24 INT110023 Negative_regulation of Mapk14 2 127 0.59 84.27 45.42
25 INT100939 Gene_expression of Il13 10 176 0.73 125.1 43.38
26 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
27 INT3987 Positive_regulation of IGHE 4 316 0.70 283.2 40.16
28 INT20210 Localization of Ngf 2 69 0.79 46.22 38.57
29 INT77307 Gene_expression of Bcl2 2 399 0.77 319.77 38
30 INT104551 Gene_expression of Il18 8 156 0.76 115.51 36.95
31 INT20380 Gene_expression of Il5 14 172 0.78 104.75 34.78
32 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
33 INT62830 Gene_expression of VCAM1 1 149 0.78 125.23 32.4
34 INT73498 Gene_expression of IL13 1 117 0.44 83.85 32.26
35 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
36 INT54302 Positive_regulation of Gene_expression of Il4 1 126 0.68 86.18 30.75
37 INT34729 Positive_regulation of IFN1@ 1 233 0.67 128.04 30.38
38 INT65597 Negative_regulation of Casp3 1 69 0.59 39.19 29.32
39 INT15174 Gene_expression of Itgam 1 238 0.73 104.92 29.26
40 INT3076 Regulation of KNG1 1 52 0.60 20.39 27.89
41 INT69157 Gene_expression of IL5 3 127 0.77 102.58 26.81
42 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
43 INT63769 Regulation of Ngf 1 44 0.62 21.82 25.84
44 INT130186 Gene_expression of Ccl5 1 101 0.74 79.96 25.01
45 INT73670 Gene_expression of Vcam1 2 128 0.78 123.79 24.96
46 INT4465 Gene_expression of CEL 6 116 0.77 98.35 23.58
47 INT8775 Binding of IGHE 10 167 0.48 102.61 23.54
48 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
49 INT96156 Gene_expression of Cd40 1 144 0.77 56.95 21.7
50 INT112017 Regulation of Hand2 2 77 0.36 62.23 18.04
51 INT133647 Negative_regulation of HDAC9 1 149 0.57 106.84 17.9
52 INT117220 Positive_regulation of TLR4 1 64 0.69 53.61 17.33
53 INT17313 Positive_regulation of HSPG2 3 57 0.67 55.78 16.65
54 INT22900 Positive_regulation of Cd4 3 126 0.67 82.77 16.43
55 INT10918 Gene_expression of ITGB2 1 93 0.76 71.8 16.34
56 INT9220 Gene_expression of Ighg1 4 125 0.77 85.74 15.92
57 INT11685 Regulation of CSF2 1 99 0.59 58.82 15.9
58 INT170754 Localization of IFN1@ 1 121 0.78 66.78 15.6
59 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
60 INT81627 Gene_expression of Fas 1 120 0.78 115.51 15.36
61 INT109511 Gene_expression of Bax 2 133 0.78 113.22 14.36
62 INT100938 Positive_regulation of Il13 5 47 0.69 42.11 14.36
63 INT120901 Positive_regulation of Gene_expression of Il13 4 36 0.57 31.63 13.36
64 INT141014 Positive_regulation of Gene_expression of Il18 3 46 0.68 47.63 13.3
65 INT132178 Binding of CD80 1 41 0.47 15.55 12.98
66 INT36263 Positive_regulation of CEL 1 53 0.69 34.88 12.87
67 INT22030 Negative_regulation of Cysltr1 2 31 0.39 21.83 12.49
68 INT69158 Localization of IL4 2 48 0.71 31.3 11.98
69 INT73829 Positive_regulation of Gene_expression of VCAM1 1 41 0.61 35.96 11.92
70 INT55886 Negative_regulation of Gene_expression of Il4 3 47 0.57 26.04 11.42
71 INT168409 Positive_regulation of Ccl5 1 47 0.64 45.84 10.83
72 INT701 Localization of IGHE 1 87 0.80 40.5 10.62
73 INT60198 Binding of JUN 1 54 0.48 11.56 10.27
74 INT27955 Negative_regulation of Gene_expression of Ngf 2 16 0.59 10.43 10.17
75 INT98130 Positive_regulation of CASP8 1 79 0.67 65.29 10.08
76 INT10019 Binding of CD8A 1 57 0.36 31.49 10.08
77 INT73504 Binding of CD28 1 35 0.45 15.99 10.04
78 INT102525 Gene_expression of CCR3 1 24 0.71 16.19 10
79 INT5788 Gene_expression of IL2RA 2 60 0.75 40.67 9.98
80 INT35164 Negative_regulation of IGHE 12 96 0.58 76.3 9.74
81 INT3988 Positive_regulation of Gene_expression of IGHE 1 98 0.68 91.46 9.61
82 INT70134 Negative_regulation of TXK 1 124 0.23 81.96 9.59
83 INT97439 Positive_regulation of Il5 1 46 0.60 25.6 9.47
84 INT76860 Gene_expression of HSPG2 4 32 0.65 37.14 9.06
85 INT2241 Negative_regulation of CEL 1 56 0.58 29.32 8.83
86 INT81444 Positive_regulation of Gene_expression of Vcam1 2 40 0.70 46.38 8.58
87 INT22481 Gene_expression of CADM1 1 28 0.65 30.26 8.5
88 INT61628 Negative_regulation of Gene_expression of IL4 1 31 0.55 20.96 8.18
89 INT2971 Regulation of IGHE 1 42 0.61 28.81 7.87
90 INT71308 Gene_expression of CCL11 3 33 0.76 25.66 7.83
91 INT78226 Gene_expression of Mbp 1 43 0.75 22.14 7.79
92 INT177759 Negative_regulation of IFN1@ 2 51 0.57 31.81 7.76
93 INT39417 Gene_expression of Fcer2a 3 65 0.76 32.1 7.37
94 INT75382 Negative_regulation of HSPG2 3 20 0.57 15.18 7.03
95 INT160562 Localization of Cd4 1 49 0.71 27.58 6.78
96 INT126984 Positive_regulation of Gene_expression of Il5 1 29 0.69 20.61 6.72
97 INT132822 Localization of IL13 2 26 0.67 22.85 6.66
98 INT181525 Localization of Il13 3 24 0.66 21.51 6.55
99 INT16359 Positive_regulation of Gene_expression of AGT 1 30 0.49 28.27 6.14
100 INT304151 Gene_expression of Siglec5 1 2 0.74 17.33 6.03
101 INT96234 Localization of Il13 1 11 0.62 10.94 5.48
102 INT113101 Gene_expression of Ccl11 3 41 0.76 22.36 5.47
103 INT10919 Positive_regulation of ITGB2 1 25 0.67 13.75 5.45
104 INT171562 Regulation of IL4 2 19 0.36 12.12 5.33
105 INT177526 Negative_regulation of Il5 1 17 0.36 11.13 5.31
106 INT117004 Gene_expression of Sfpi1 1 21 0.75 15.95 5.29
107 INT62041 Negative_regulation of Gene_expression of IGHE 13 37 0.58 37.86 5.27
108 INT89104 Binding of TGFB1 1 29 0.44 13.67 5.12
109 INT17312 Binding of HSPG2 2 30 0.41 33.01 4.88
110 INT142162 Binding of IL10 1 30 0.37 21.9 4.84
111 INT104549 Localization of Il18 2 16 0.78 13.01 4.64
112 INT18995 Binding of CEL 1 23 0.47 14.46 4.5
113 INT108342 Negative_regulation of EPHB2 1 18 0.57 9.48 4.46
114 INT153189 Gene_expression of Sema3a 7 19 0.75 14.37 4.21
115 INT194380 Negative_regulation of Gene_expression of IL5 1 22 0.42 15.78 4.1
116 INT72385 Phosphorylation of Shc1 1 11 0.52 1.62 4.1
117 INT123752 Regulation of Bax 1 19 0.60 16.45 4
118 INT204529 Positive_regulation of TLR9 1 18 0.62 15.62 3.99
119 INT112692 Localization of Bax 2 31 0.80 20.97 3.98
120 INT4464 Localization of CEL 1 21 0.80 8.09 3.88
121 INT146946 Gene_expression of Lyn 1 16 0.76 8.9 3.75
122 INT70919 Binding of Il4 1 19 0.36 6.58 3.59
123 INT85130 Regulation of IL5 2 14 0.27 8.37 3.55
124 INT9999 Regulation of Gene_expression of IGHE 1 32 0.60 15.75 3.53
125 INT115921 Positive_regulation of AHR 3 22 0.49 12.03 3.53
126 INT73500 Regulation of IL13 2 12 0.36 10.37 3.53
127 INT89966 Negative_regulation of Fas 1 26 0.58 24.83 3.5
128 INT118615 Negative_regulation of IL4 2 20 0.41 13.79 3.49
129 INT170438 Negative_regulation of Gene_expression of Pax3 1 4 0.04 1.03 3.42
130 INT10188 Positive_regulation of Il2ra 3 19 0.45 11.6 3.37
131 INT64234 Regulation of Bcl2 1 41 0.54 31.88 3.16
132 INT114276 Gene_expression of Nr4a1 1 20 0.77 7.71 3.14
133 INT24873 Binding of KLF1 1 12 0.07 6.73 3.1
134 INT41474 Gene_expression of ADRB2 1 10 0.75 1.56 2.94
135 INT50765 Positive_regulation of Fcer2a 1 23 0.68 10.22 2.92
136 INT164272 Gene_expression of Cysltr1 2 5 0.59 4.34 2.9
137 INT13634 Gene_expression of CYSLTR1 1 19 0.75 11.24 2.88
138 INT78702 Positive_regulation of CCL11 2 13 0.68 12.94 2.74
139 INT193251 Binding of CYSLTR1 1 13 0.32 8.32 2.57
140 INT11686 Regulation of IL3 1 15 0.45 8.69 2.54
141 INT32421 Gene_expression of FCER2 1 19 0.73 17.23 2.53
142 INT96876 Gene_expression of AHR 2 20 0.77 10.43 2.39
143 INT240113 Gene_expression of Nrp1 6 11 0.30 10.88 2.24
144 INT35866 Transcription of IGHE 4 9 0.60 12.83 2.19
145 INT118871 Negative_regulation of JAK2 1 15 0.57 11.4 2.16
146 INT140650 Positive_regulation of Gene_expression of CCL11 2 10 0.68 5.43 2.08
147 INT98225 Regulation of Il5 1 8 0.45 5.07 2.06
148 INT226492 Negative_regulation of IL13 3 11 0.28 7.17 2.04
149 INT94084 Regulation of Gene_expression of IL13 1 6 0.22 3.55 1.9
150 INT141002 Negative_regulation of Fcer2a 1 15 0.12 7.17 1.88
151 INT95650 Negative_regulation of Positive_regulation of Ngf 1 6 0.43 4.41 1.84
152 INT20377 Gene_expression of Il3 1 8 0.65 0.82 1.77
153 INT153190 Negative_regulation of Sema3a 3 7 0.56 7.94 1.76
154 INT20992 Regulation of ITGB2 1 11 0.37 9.04 1.73
155 INT25163 Positive_regulation of Gene_expression of IL2RA 1 8 0.45 5.37 1.71
156 INT85411 Regulation of IL9 1 4 0.10 0.85 1.65
157 INT248253 Positive_regulation of Gene_expression of HSPG2 1 3 0.44 4.61 1.65
158 INT186269 Binding of Il13 3 9 0.39 7.7 1.64
159 INT113340 Phosphorylation of JAK2 1 17 0.78 5.69 1.6
160 INT114279 Positive_regulation of Nr4a1 1 9 0.59 3.37 1.59
161 INT68250 Regulation of Gene_expression of Ighg1 1 7 0.40 2.99 1.56
162 INT234761 Binding of IL13 1 6 0.35 4.18 1.55
163 INT107641 Negative_regulation of Ighg1 2 19 0.39 11.44 1.54
164 INT304095 Binding of Aia1 1 2 0.03 3.93 1.5
165 INT114270 Gene_expression of Plscr1 1 6 0.47 1.33 1.49
166 INT36389 Binding of AHR 2 18 0.45 7.22 1.46
167 INT78704 Binding of CCL11 1 10 0.37 11.38 1.44
168 INT15800 Positive_regulation of CD69 1 14 0.43 9.28 1.43
169 INT112013 Negative_regulation of Gene_expression of Ighg1 1 7 0.38 3.57 1.42
170 INT179169 Transcription of IL13 2 11 0.15 4.22 1.37
171 INT56365 Regulation of Gene_expression of ITGB2 1 5 0.60 3.87 1.36
172 INT254666 Positive_regulation of Map2k2 1 37 0.56 23.85 1.35
173 INT221531 Gene_expression of Plxna1 2 7 0.75 4.51 1.31
174 INT112695 Negative_regulation of Protein_catabolism of Bax 1 3 0.36 1.72 1.3
175 INT190335 Negative_regulation of Positive_regulation of IFN1@ 1 16 0.42 4.6 1.29
176 INT102200 Gene_expression of Nr4a2 1 9 0.72 3.69 1.28
177 INT120764 Negative_regulation of Binding of JUN 1 7 0.25 2.65 1.23
178 INT112693 Protein_catabolism of Bax 1 5 0.74 3.17 1.2
179 INT38788 Negative_regulation of CYSLTR1 2 8 0.42 4.5 1.16
180 INT114272 Regulation of Gene_expression of Nr4a1 1 5 0.45 1.82 1.14
181 INT163794 Localization of CYSLTR1 1 4 0.45 2.4 1.08
182 INT226434 Positive_regulation of CCR3 1 8 0.35 4.87 1.07
183 INT120395 Regulation of HSPG2 4 4 0.26 5.96 1.03
184 INT164278 Localization of Cysltr1 1 2 0.57 2.3 1.01
185 INT117002 Negative_regulation of Sfpi1 1 16 0.58 9.72 1
186 INT317791 Localization of HDAC2 1 2 0.50 2.31 0.99
187 INT73450 Gene_expression of Pilra 1 7 0.05 2.87 0.97
188 INT192564 Binding of HAT1 1 5 0.15 2.77 0.96
189 INT19084 Negative_regulation of NRG1 1 5 0.42 4.9 0.96
190 INT138683 Regulation of Ighg1 2 15 0.30 7.95 0.94
191 INT123948 Positive_regulation of Plscr1 1 4 0.42 1.02 0.93
192 INT228727 Transcription of Il5 2 4 0.27 5.13 0.9
193 INT160830 Gene_expression of Siglece 1 6 0.39 2.37 0.85
194 INT126572 Positive_regulation of SYK 1 3 0.67 2.98 0.83
195 INT32418 Binding of NCS1 1 10 0.40 8.93 0.81
196 INT317792 Negative_regulation of Binding of HAT1 1 2 0.07 1.82 0.81
197 INT299178 Binding of Cysltr1 2 1 0.14 1.8 0.77
198 INT150165 Gene_expression of MTTP 1 21 0.75 10.1 0.73
199 INT94300 Negative_regulation of Gene_expression of Mbp 1 6 0.44 1.79 0.7
200 INT3536 Positive_regulation of Nrp1 1 2 0.19 0.93 0.7
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