J:Allergy Asthma Clin Immunol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT312813 Binding of F2rl1 and Tpsab1 1 1 0.01 0.26 0.46
2 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 1 0.00 0.51 0.45
3 INT312814 TNF Positive_regulation of Spg21 1 1 0.00 0.6 0.45
4 INT310934 Positive_regulation of Tgm2 Positive_regulation of Binding of IGHE 1 2 0.14 1.33 0.34
5 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 2 0.01 1.35 0.22
6 INT312815 IL1B Positive_regulation of Localization of Il6 1 1 0.00 0.33 0.2
7 INT310939 Binding of ELANE and COPD 1 1 0.08 1.51 0.2
8 INT310938 Binding of ELANE and HRCT1 1 1 0.02 1.5 0.2
9 INT312708 DPP8 Positive_regulation of DPP4 1 1 0.24 0.54 0.19
10 INT312706 DPP9 Positive_regulation of DPP4 1 1 0.26 0.54 0.19
11 INT326464 KNG1 Positive_regulation of SERPING1 1 1 0.19 1.53 0.18
12 INT312819 IL5 Regulation of Il13 1 1 0.00 1.55 0.18
13 INT310932 Binding of Tgm2 and Serpinb1a 1 2 0.04 0.87 0.17
14 INT310937 Binding of CD8A and COPD 1 1 0.16 1.21 0.16
15 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 1 0.20 0.45 0.13
16 INT232015 SERPING1 Negative_regulation of F12 2 1 0.24 1.19 0.12
17 INT311871 Cav1 Regulation of Mch 1 1 0.01 0.24 0.11
18 INT284552 Binding of Cd8a and Mthfd1 2 1 0.03 1.32 0.1
19 INT309941 Edn1 Positive_regulation of Tlr2 1 1 0.02 1.31 0.07
20 INT310933 Il6 Positive_regulation of Tgm2 1 1 0.00 0.55 0.07
21 INT327162 Binding of SERPING1 and F12 1 1 0.05 0.29 0.04
22 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 1 0.00 0.32 0.03
23 INT342556 CCL11 Positive_regulation of Positive_regulation of EOE2 1 1 0.02 0.68 0
24 INT342553 NUDT6 Positive_regulation of Positive_regulation of EOE2 1 1 0.02 0.67 0
25 INT342552 Binding of MAPK1 and CCL11 1 1 0.05 1.07 0
26 INT342554 Positive_regulation of Binding of MAPK1 and CCL11 1 1 0.06 1.07 0
27 INT342559 FGF2 Positive_regulation of MAPK1 1 1 0.08 1.22 0
28 INT342558 FGF9 Positive_regulation of MAPK3 1 1 0.03 1.21 0
29 INT311816 CD79A Positive_regulation of RAB27A 1 1 0.01 0.47 0
30 INT342555 FGF9 Positive_regulation of MAPK1 1 1 0.07 1.22 0
31 INT342551 Binding of IL13 and EOE2 1 1 0.02 1.43 0
32 INT342557 FGF2 Positive_regulation of MAPK3 1 1 0.03 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT6483 Gene_expression of TNF 7 3152 0.78 2515.62 929.82
3 INT7114 Positive_regulation of Ltp 1 1192 0.62 290.76 755.77
4 INT50058 Negative_regulation of Cpox 9 907 0.58 426.28 428.29
5 INT9238 Gene_expression of IL6 4 1575 0.78 1135.66 424.22
6 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
8 INT6852 Localization of TNF 7 883 0.81 705.95 270.84
9 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
10 INT1562 Localization of Crh 4 499 0.81 126.74 236.68
11 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
12 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
13 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
14 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
15 INT24326 Gene_expression of Ngf 7 346 0.78 218.67 184.71
16 INT5116 Gene_expression of IL2 4 670 0.78 291.13 146.69
17 INT812 Localization of INS 2 1026 0.81 515.6 145.31
18 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
19 INT12339 Localization of IL8 3 437 0.81 251.87 117.39
20 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
21 INT60526 Gene_expression of IL10 4 449 0.78 292.71 107.84
22 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
23 INT4742 Gene_expression of Tac1 9 177 0.78 69.99 102.66
24 INT10838 Positive_regulation of IL8 5 381 0.70 295.51 101.62
25 INT71789 Positive_regulation of MAPK1 6 396 0.70 234.44 89.27
26 INT1724 Negative_regulation of ACE 5 437 0.59 315.64 74.48
27 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
28 INT56298 Gene_expression of IL4 2 306 0.78 182.18 72.92
29 INT8357 Gene_expression of KNG1 8 153 0.75 77.26 68.66
30 INT7344 Gene_expression of TAC1 2 132 0.75 35.48 68.26
31 INT7134 Localization of KNG1 5 127 0.79 65.73 67.97
32 INT19511 Localization of Il6 4 212 0.81 118.17 67.67
33 INT3375 Gene_expression of IGHE 24 535 0.77 387.47 65.46
34 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
35 INT39153 Positive_regulation of PTGS2 2 182 0.70 96.16 60.6
36 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
37 INT11491 Positive_regulation of KNG1 5 128 0.67 60.41 58.74
38 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
39 INT4509 Gene_expression of IGG 2 426 0.76 293.69 56.64
40 INT33567 Gene_expression of CALM1 2 139 0.67 48.85 56.14
41 INT78899 Gene_expression of CCL5 3 155 0.77 84.02 55.09
42 INT22112 Positive_regulation of Localization of TNF 3 164 0.70 115.66 52.18
43 INT27954 Positive_regulation of Gene_expression of Ngf 4 87 0.70 57.91 51.96
44 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
45 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
46 INT35975 Regulation of Cpox 2 109 0.39 57.88 49.69
47 INT654 Localization of REN 1 250 0.81 75.12 47.86
48 INT1322 Positive_regulation of Localization of INS 2 293 0.70 120.86 45.98
49 INT14853 Negative_regulation of Tac1 1 80 0.59 30.87 45.06
50 INT73502 Positive_regulation of IL10 2 154 0.69 124.87 43.5
51 INT100939 Gene_expression of Il13 3 176 0.73 125.1 43.38
52 INT115384 Positive_regulation of Mmp9 2 121 0.68 94.74 43.02
53 INT61619 Gene_expression of IL12A 4 194 0.77 146.07 41.97
54 INT3987 Positive_regulation of IGHE 10 316 0.70 283.2 40.16
55 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
56 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
57 INT20210 Localization of Ngf 2 69 0.79 46.22 38.57
58 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
59 INT133028 Gene_expression of TLR2 1 209 0.73 131.92 36.17
60 INT8837 Positive_regulation of TAC1 2 59 0.67 21.94 35.97
61 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
62 INT20380 Gene_expression of Il5 6 172 0.78 104.75 34.78
63 INT52350 Gene_expression of CD14 1 184 0.75 71.37 33.13
64 INT73498 Gene_expression of IL13 2 117 0.44 83.85 32.26
65 INT7538 Negative_regulation of IL2 3 95 0.57 47.31 31.7
66 INT608 Negative_regulation of KNG1 5 98 0.43 72.36 31.23
67 INT65960 Gene_expression of BCL2 2 352 0.78 312.03 30.73
68 INT5507 Regulation of Localization of Crh 1 57 0.61 8.43 30.26
69 INT77652 Negative_regulation of Gene_expression of IL8 1 99 0.59 67.57 30.21
70 INT5117 Negative_regulation of Gene_expression of IL2 2 118 0.59 52.33 29.96
71 INT9053 Negative_regulation of ALOX5 1 97 0.58 40.34 29.94
72 INT10915 Gene_expression of ITGAM 1 164 0.78 92.42 29.78
73 INT32165 Binding of CALM1 1 92 0.48 24.19 29.57
74 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
75 INT5653 Positive_regulation of ELANE 2 136 0.70 72.78 27.94
76 INT5206 Gene_expression of AR 1 316 0.78 113.83 27.29
77 INT21900 Gene_expression of Mthfd1 1 150 0.75 69.47 27.03
78 INT69157 Gene_expression of IL5 11 127 0.77 102.58 26.81
79 INT3167 Binding of KNG1 3 48 0.48 23.26 26.77
80 INT49850 Negative_regulation of PDE4A 1 105 0.58 76.91 26.59
81 INT70048 Positive_regulation of Gene_expression of IL10 2 90 0.55 71.34 25.66
82 INT12124 Gene_expression of MAPK1 4 141 0.75 82.4 25.58
83 INT8779 Binding of TAC1 1 50 0.47 11.19 25.57
84 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
85 INT10836 Negative_regulation of IL8 1 95 0.59 52.59 24.71
86 INT4809 Gene_expression of PTGDS 1 103 0.76 52.94 24.01
87 INT8775 Binding of IGHE 8 167 0.48 102.61 23.54
88 INT50039 Positive_regulation of Il4 1 48 0.55 34.8 23.34
89 INT100026 Gene_expression of Tnfrsf1b 1 73 0.72 43.26 23.23
90 INT93738 Gene_expression of Tnfrsf1a 2 63 0.74 57.66 23.09
91 INT15458 Gene_expression of NPY 1 50 0.76 22.67 23.03
92 INT74423 Localization of IL10 5 91 0.80 61.6 22.95
93 INT45437 Localization of Acot1 3 84 0.79 17.37 22.18
94 INT90849 Gene_expression of F2rl1 1 55 0.78 31.31 20.65
95 INT17848 Binding of PTGS2 2 70 0.46 32.1 20.6
96 INT78901 Localization of CCL5 2 67 0.78 40.79 20.59
97 INT20379 Localization of Il4 1 85 0.73 51.22 20.55
98 INT51474 Binding of Il6 1 55 0.48 44.99 20.52
99 INT125312 Positive_regulation of COPD 1 134 0.59 162.55 20.27
100 INT12265 Positive_regulation of IgG 6 168 0.63 104.89 19.76
101 INT11243 Localization of NPY 3 33 0.78 11.18 19.24
102 INT70614 Gene_expression of FAS 2 118 0.75 112.33 19.01
103 INT56301 Positive_regulation of IL4 1 68 0.56 54.51 18.65
104 INT73252 Positive_regulation of Mthfd1 4 124 0.59 59.48 18.35
105 INT17442 Gene_expression of ALOX5 3 110 0.75 51.55 18.29
106 INT70145 Gene_expression of Trav6-3 1 136 0.76 69.6 18.05
107 INT132997 Localization of Mmp9 4 59 0.80 45.9 17.61
108 INT84464 Gene_expression of DPP4 7 101 0.78 56.15 17.53
109 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
110 INT110767 Localization of Mcpt1 1 43 0.68 24.3 16.74
111 INT48238 Regulation of Gene_expression of Ngf 1 25 0.62 11.48 16.42
112 INT170308 Gene_expression of Ido1 2 159 0.75 69.51 15.98
113 INT9220 Gene_expression of Ighg1 1 125 0.77 85.74 15.92
114 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
115 INT24670 Gene_expression of FGF2 10 121 0.78 85.64 15.12
116 INT69303 Positive_regulation of Gene_expression of Il4 1 27 0.68 20.01 14.8
117 INT100938 Positive_regulation of Il13 3 47 0.69 42.11 14.36
118 INT20665 Gene_expression of ACE 1 87 0.78 51.71 14.19
119 INT104674 Positive_regulation of F2rl1 3 35 0.65 27.76 14.16
120 INT80688 Positive_regulation of Positive_regulation of MAPK1 1 72 0.69 39.35 14.11
121 INT7997 Gene_expression of Ltc4s 9 51 0.76 34.28 13.8
122 INT173505 Localization of Hand2 8 63 0.57 45.32 13.66
123 INT142593 Positive_regulation of Tlr2 1 85 0.70 75.9 13.62
124 INT80685 Gene_expression of MAPK8 1 90 0.72 51.91 13.36
125 INT33358 Gene_expression of Cysltr1 1 46 0.62 24.18 13.36
126 INT55255 Positive_regulation of Localization of Il6 1 48 0.69 24.88 12.76
127 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
128 INT22030 Negative_regulation of Cysltr1 1 31 0.39 21.83 12.49
129 INT70050 Negative_regulation of IL10 2 56 0.58 37.45 12.39
130 INT9832 Gene_expression of Shbg 1 96 0.75 56.71 12.19
131 INT148207 Gene_expression of CTLA4 1 53 0.77 29.13 12.07
132 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
133 INT16772 Gene_expression of MPO 1 81 0.78 90.98 11.9
134 INT102272 Regulation of TH1L 1 41 0.44 30.89 11.63
135 INT14204 Protein_catabolism of KNG1 1 41 0.96 20.94 11.47
136 INT80756 Gene_expression of CD86 2 77 0.77 46.68 11.36
137 INT12240 Negative_regulation of PRSS1 1 46 0.57 29.5 10.77
138 INT133030 Positive_regulation of Gene_expression of TLR2 1 53 0.65 38.15 10.65
139 INT701 Localization of IGHE 5 87 0.80 40.5 10.62
140 INT4806 Localization of TPSAB1 1 29 0.80 5.05 10.52
141 INT78895 Regulation of CCL5 2 30 0.46 20.45 10.18
142 INT181488 Positive_regulation of Spg21 6 13 0.12 15.52 10.03
143 INT102525 Gene_expression of CCR3 2 24 0.71 16.19 10
144 INT35164 Negative_regulation of IGHE 3 96 0.58 76.3 9.74
145 INT69306 Negative_regulation of TH1L 1 28 0.57 24.81 9.74
146 INT6361 Localization of Edn1 2 30 0.81 19.09 9.7
147 INT3988 Positive_regulation of Gene_expression of IGHE 6 98 0.68 91.46 9.61
148 INT81264 Positive_regulation of Localization of Ngf 2 13 0.58 9.82 9.53
149 INT132036 Negative_regulation of DPP4 10 126 0.59 63.24 9.51
150 INT97439 Positive_regulation of Il5 3 46 0.60 25.6 9.47
151 INT6510 Gene_expression of AFP 3 130 0.78 119.2 9.19
152 INT20664 Binding of ACE 4 60 0.48 35.27 9.16
153 INT1118 Gene_expression of C6orf25 1 73 0.77 47.24 9.1
154 INT23178 Gene_expression of H1 2 38 0.68 13.37 9.09
155 INT60436 Negative_regulation of COPD 2 76 0.37 84.22 9.08
156 INT76860 Gene_expression of HSPG2 1 32 0.65 37.14 9.06
157 INT35366 Binding of AR 1 87 0.47 30.52 8.9
158 INT150867 Regulation of COPD 1 54 0.48 71.38 8.8
159 INT70017 Positive_regulation of BCL2 1 87 0.67 66.62 8.68
160 INT20205 Binding of IgG 1 108 0.46 66.68 8.57
161 INT15529 Gene_expression of GCG 1 51 0.75 18.55 8.35
162 INT13085 Positive_regulation of ACE 2 50 0.70 44.2 8.31
163 INT65959 Positive_regulation of Gene_expression of BCL2 1 75 0.70 77.3 8.27
164 INT63401 Gene_expression of Il5 1 33 0.72 18.66 8.2
165 INT22700 Positive_regulation of Gene_expression of Tac1 2 13 0.69 6.89 8.2
166 INT61628 Negative_regulation of Gene_expression of IL4 2 31 0.55 20.96 8.18
167 INT26551 Positive_regulation of Gene_expression of KNG1 1 19 0.67 11.05 7.98
168 INT2971 Regulation of IGHE 3 42 0.61 28.81 7.87
169 INT71308 Gene_expression of CCL11 4 33 0.76 25.66 7.83
170 INT69160 Positive_regulation of IL5 5 41 0.65 36.04 7.75
171 INT93914 Gene_expression of CD80 1 70 0.75 36.35 7.74
172 INT51206 Regulation of Gene_expression of Tac1 1 13 0.45 5.92 7.74
173 INT90603 Positive_regulation of Ahr 1 103 0.69 58.65 7.73
174 INT14600 Positive_regulation of Tpsab1 1 51 0.68 22.1 7.7
175 INT224648 Gene_expression of Il21 3 15 0.39 18.71 7.47
176 INT63365 Gene_expression of Spg21 2 21 0.65 12.9 7.37
177 INT14599 Localization of Tpsab1 1 36 0.79 14.58 7.18
178 INT14637 Negative_regulation of MBP 1 19 0.43 7.06 7.18
179 INT16618 Negative_regulation of SERPING1 32 81 0.59 86.28 7.17
180 INT75382 Negative_regulation of HSPG2 1 20 0.57 15.18 7.03
181 INT181489 Localization of Spg21 8 16 0.12 10.89 6.84
182 INT213769 Binding of Spg21 16 18 0.03 7.96 6.77
183 INT10610 Negative_regulation of Plg 1 22 0.40 11.81 6.74
184 INT10917 Positive_regulation of ITGAM 1 31 0.67 16.39 6.69
185 INT50387 Negative_regulation of AR 1 67 0.45 26.31 6.61
186 INT62509 Gene_expression of MCS 2 58 0.67 21.46 6.57
187 INT181525 Localization of Il13 1 24 0.66 21.51 6.55
188 INT73499 Positive_regulation of IL13 2 23 0.39 20.03 6.53
189 INT60527 Transcription of IL10 1 16 0.56 13.57 6.42
190 INT59388 Gene_expression of Il9 3 16 0.66 21.79 6.42
191 INT64052 Positive_regulation of FGFR1 3 26 0.52 28.47 6.36
192 INT46383 Negative_regulation of TRGC1 10 42 0.55 44.03 6.2
193 INT75832 Positive_regulation of Positive_regulation of IL8 1 30 0.70 20.77 6.05
194 INT8803 Gene_expression of IL3 1 32 0.78 21.06 6.01
195 INT4587 Negative_regulation of Serping1 7 32 0.47 19.11 5.92
196 INT132573 Negative_regulation of Gene_expression of TH1L 1 16 0.42 11.52 5.76
197 INT21647 Negative_regulation of Positive_regulation of KNG1 2 11 0.43 5.54 5.73
198 INT69153 Positive_regulation of Gene_expression of IL5 3 22 0.32 23.59 5.7
199 INT83119 Negative_regulation of Gene_expression of IL12A 1 24 0.42 17.52 5.69
200 INT53684 Negative_regulation of Gene_expression of ITGAM 1 23 0.59 14.36 5.66
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