J:Am. J. Chin. Med.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT154114 PENK Positive_regulation of YY1 1 1 0.50 0.06 1.41
2 INT154111 POMC Positive_regulation of Localization of PENK 1 1 0.34 0.05 1.41
3 INT154110 PENK Positive_regulation of Localization of POMC 1 1 0.34 0.05 1.41
4 INT154113 POMC Positive_regulation of YY1 1 1 0.70 0.06 1.41
5 INT161655 Gsr Regulation of Gene_expression of Il1b 1 2 0.20 1.84 0.9
6 INT161662 Gsr Regulation of Gene_expression of TNF 1 1 0.01 0.93 0.46
7 INT161653 Gsr Regulation of Gene_expression of Ifih1 1 1 0.04 1.05 0.46
8 INT161652 Gsr Regulation of Gene_expression of Tnf 1 1 0.17 0.98 0.46
9 INT161654 Gsr Regulation of Gpx1 1 1 0.14 0.85 0.42
10 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 1 0.05 0.91 0.42
11 INT168434 Binding of GLRX and Gpx1 1 1 0.04 0.9 0.42
12 INT156438 Cpox Positive_regulation of Nos2 3 1 0.14 1.24 0.4
13 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 1 0.14 0.52 0.28
14 INT156440 Cpox Positive_regulation of NOS1 1 1 0.01 0.52 0.28
15 INT65663 Tns1 Regulation of Vip 1 2 0.11 0.2 0.25

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 9 3083 0.78 894.43 1639.02
2 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
3 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
4 INT5228 Positive_regulation of Fos 1 934 0.70 209.8 503.87
5 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
6 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
7 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
8 INT6056 Negative_regulation of Gene_expression of Fos 4 601 0.59 193.05 386.84
9 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
10 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
11 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
12 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
13 INT5591 Regulation of Gene_expression of Fos 1 425 0.62 129.06 265.78
14 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
15 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
16 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
17 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
18 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
19 INT22548 Positive_regulation of Casp3 1 483 0.70 258.78 213.07
20 INT48955 Gene_expression of Nos2 3 753 0.78 403.87 208.08
21 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
22 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
23 INT6488 Gene_expression of Tnf 8 484 0.78 339.61 191.58
24 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
25 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
26 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
27 INT51921 Gene_expression of Cpox 6 501 0.73 229.81 157.81
28 INT66280 Gene_expression of Nos2 5 534 0.78 330.78 157.07
29 INT2910 Regulation of Abat 2 169 0.62 36.95 153.53
30 INT49134 Gene_expression of Grin1 3 270 0.78 84.78 148.61
31 INT9852 Positive_regulation of Gpt 4 563 0.70 364.64 146.82
32 INT90910 Phosphorylation of Grin1 11 150 0.82 68.23 139.24
33 INT48953 Positive_regulation of Nos2 5 486 0.70 239.85 131.87
34 INT6128 Positive_regulation of Localization of POMC 1 256 0.70 68.77 121.64
35 INT14151 Gene_expression of Casp3 1 311 0.78 140.26 120.68
36 INT7341 Positive_regulation of Grin1 3 169 0.70 65.86 118.38
37 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
38 INT8413 Gene_expression of Ptgs1 2 248 0.78 110.17 108.58
39 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
40 INT5587 Regulation of Fos 1 191 0.62 40.81 99.7
41 INT7944 Positive_regulation of Fos 1 193 0.70 60.69 98.31
42 INT74058 Gene_expression of Nos1 2 260 0.78 80.04 95.71
43 INT203 Positive_regulation of Pomc 4 257 0.70 90.56 92.84
44 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
45 INT5590 Negative_regulation of Fos 1 144 0.59 40.94 81.98
46 INT55944 Positive_regulation of Cpox 2 214 0.57 105.14 81.4
47 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
48 INT15769 Gene_expression of Il1b 7 146 0.78 114.51 75.35
49 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
50 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
51 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
52 INT6486 Positive_regulation of Tnf 3 168 0.70 123.47 66.05
53 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
54 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
55 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
56 INT5016 Negative_regulation of Crh 1 129 0.59 36.74 59.28
57 INT90911 Positive_regulation of Phosphorylation of Grin1 6 62 0.70 27.45 59.26
58 INT12717 Binding of Pck1 1 85 0.47 12.49 54.81
59 INT49993 Positive_regulation of Gene_expression of Il6 1 149 0.70 88.07 53.78
60 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
61 INT49017 Negative_regulation of Gene_expression of Nos2 2 169 0.59 80.64 52.67
62 INT5957 Positive_regulation of Cpe 1 65 0.69 21.07 51.22
63 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
64 INT2604 Positive_regulation of Got1 3 223 0.70 154.78 49.51
65 INT66029 Negative_regulation of Tnf 1 100 0.59 84.28 48.16
66 INT55670 Negative_regulation of Gene_expression of Tnf 2 83 0.59 57.16 46.33
67 INT29105 Positive_regulation of OPRK1 1 68 0.70 7.06 44.69
68 INT27493 Negative_regulation of Casp3 2 114 0.56 56.89 44.63
69 INT8824 Regulation of Vip 1 95 0.62 15.7 43.63
70 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
71 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
72 INT5502 Positive_regulation of Gene_expression of Crh 1 69 0.70 43.06 42.23
73 INT48075 Positive_regulation of Il1b 2 71 0.67 48.63 40.48
74 INT4862 Localization of PENK 1 62 0.81 11.57 40.28
75 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
76 INT102611 Negative_regulation of Positive_regulation of Mapk1 1 74 0.58 35.57 39.37
77 INT2531 Positive_regulation of Cebpz 2 166 0.00 43.08 38.86
78 INT11246 Binding of Grin1 1 65 0.48 14.53 36.93
79 INT316 Regulation of Cebpz 2 105 0.00 27.21 35.41
80 INT60710 Gene_expression of Col7a1 1 217 0.78 113.2 35.2
81 INT79060 Gene_expression of NOS2 4 116 0.78 69.25 34.84
82 INT67039 Positive_regulation of Cpox 1 144 0.65 98.4 33.77
83 INT2330 Regulation of CB 1 78 0.10 20.46 32.6
84 INT92837 Negative_regulation of Gene_expression of Nos2 1 116 0.59 59.67 31.82
85 INT56290 Negative_regulation of Gene_expression of Il6 1 79 0.59 47.98 31.07
86 INT11650 Negative_regulation of Gpt 3 122 0.59 69.15 30.36
87 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
88 INT106540 Negative_regulation of Phosphorylation of Grin1 3 15 0.58 9.32 29.13
89 INT57692 Positive_regulation of Gene_expression of Il1b 2 50 0.67 43.54 28.29
90 INT5966 Localization of Il1a 1 50 0.78 22.91 26.54
91 INT53949 Positive_regulation of Gene_expression of Cpox 2 82 0.65 38.12 25.93
92 INT95788 Positive_regulation of Positive_regulation of Mapk1 1 83 0.69 24.75 25.84
93 INT79061 Positive_regulation of NOS2 2 92 0.65 58.89 23.96
94 INT51029 Negative_regulation of Il1b 1 34 0.57 29.34 23.62
95 INT74059 Positive_regulation of Gene_expression of Nos1 1 55 0.70 11.5 21.39
96 INT5328 Positive_regulation of CD4 1 191 0.69 133.43 21.31
97 INT28216 Gene_expression of HRAS 4 173 0.75 93.97 20.78
98 INT53575 Regulation of Gene_expression of Tnf 3 46 0.62 34.35 20.63
99 INT7561 Positive_regulation of gr 1 70 0.57 31.92 20.22
100 INT53574 Regulation of Tnf 3 45 0.62 40.68 19.71
101 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
102 INT56301 Positive_regulation of IL4 1 68 0.56 54.51 18.65
103 INT5533 Binding of Oxt 1 43 0.48 8.69 18.35
104 INT73599 Negative_regulation of Gene_expression of Cpox 2 47 0.55 19.89 17.26
105 INT61513 Positive_regulation of Gpx1 4 71 0.64 37.91 17.07
106 INT88356 Negative_regulation of Positive_regulation of Grin1 1 16 0.58 4.72 16.58
107 INT1214 Gene_expression of PGE 1 70 0.72 29.07 16.22
108 INT2480 Negative_regulation of Got1 3 43 0.51 14.47 16.09
109 INT3362 Negative_regulation of Emg1 2 21 0.57 10.03 15.93
110 INT74098 Negative_regulation of Gene_expression of Nos1 2 36 0.59 16.25 14.82
111 INT49606 Gene_expression of Il1rn 1 30 0.66 15.78 14.82
112 INT53080 Positive_regulation of Ptgs1 1 42 0.42 23.58 14.37
113 INT53948 Regulation of Gene_expression of Cpox 1 40 0.51 20.97 13.87
114 INT111529 Phosphorylation of Mapk3 1 41 0.80 21.14 13.72
115 INT18539 Gene_expression of Pnmt 1 33 0.78 3.08 12.47
116 INT51028 Regulation of Il1b 2 28 0.60 21.15 12.47
117 INT41313 Gene_expression of Gpx1 1 68 0.78 34.24 11.77
118 INT12992 Negative_regulation of Gene_expression of Ptgs1 1 33 0.42 20.47 11.77
119 INT30008 Binding of Hrh1 1 17 0.45 6.8 11.41
120 INT95369 Positive_regulation of Gene_expression of NOS2 5 36 0.55 25.09 11.37
121 INT48956 Negative_regulation of Positive_regulation of Nos2 2 34 0.46 13.15 11.15
122 INT11649 Negative_regulation of Positive_regulation of Gpt 2 25 0.59 13.94 10.87
123 INT85017 Positive_regulation of Mc4r 2 13 0.67 7.56 10.86
124 INT60434 Negative_regulation of Positive_regulation of Tnf 1 20 0.46 10.01 10.64
125 INT16404 Regulation of CD4 1 54 0.61 33.05 10.29
126 INT64054 Positive_regulation of Tmprss11d 2 19 0.67 9.33 9.99
127 INT48078 Regulation of Gene_expression of Il1b 1 15 0.62 14.78 9.53
128 INT11047 Positive_regulation of Positive_regulation of IL6 1 45 0.66 28.7 9.37
129 INT37896 Positive_regulation of Gene_expression of PTGS1 2 37 0.67 17.28 9.27
130 INT4651 Gene_expression of Cebpz 1 39 0.00 20.19 8.5
131 INT72337 Positive_regulation of Positive_regulation of Nos2 1 37 0.65 17.02 8.11
132 INT4190 Localization of PGE 1 19 0.60 4.97 7.9
133 INT20234 Regulation of Gene_expression of Ptgs1 1 11 0.44 6.55 7.72
134 INT22919 Negative_regulation of Gpt 2 18 0.55 6.84 7.4
135 INT111377 Positive_regulation of Ifih1 1 16 0.60 11.22 6.99
136 INT154115 Positive_regulation of Localization of PENK 1 5 0.49 3.15 6.93
137 INT69980 Negative_regulation of Il1rn 1 11 0.33 7.75 6.7
138 INT29845 Positive_regulation of Sds 2 11 0.62 3.69 6.63
139 INT27591 Negative_regulation of Gene_expression of Alb 1 30 0.58 17.03 5.99
140 INT107441 Positive_regulation of Gene_expression of Il1rn 1 7 0.46 3.24 5.95
141 INT75501 Gene_expression of CCND1 1 90 0.76 60.86 5.93
142 INT94428 Negative_regulation of Gene_expression of NOS2 1 20 0.47 11.61 5.62
143 INT46152 Positive_regulation of CYP4F22 1 7 0.46 4.05 5.56
144 INT22943 Positive_regulation of Positive_regulation of Gpt 1 23 0.47 16.09 5.55
145 INT124605 Gene_expression of Ifih1 3 16 0.57 7.36 5.33
146 INT16405 Regulation of CD8A 1 38 0.45 19.04 5.31
147 INT12854 Negative_regulation of Gusb 1 11 0.42 3.25 5.28
148 INT27415 Negative_regulation of Positive_regulation of Got1 2 15 0.51 10.99 5.14
149 INT9863 Negative_regulation of Ifih1 5 17 0.20 10.58 5.07
150 INT35990 Negative_regulation of Sds 2 8 0.49 4.47 4.96
151 INT26459 Regulation of Prl 2 14 0.62 7.27 4.92
152 INT35895 Positive_regulation of Sord 1 8 0.69 3.25 4.45
153 INT52133 Regulation of Localization of Il6 1 7 0.61 5.35 4.37
154 INT111535 Negative_regulation of Phosphorylation of Mapk3 1 9 0.57 6.39 4.31
155 INT63113 Positive_regulation of HRAS 1 30 0.67 22.85 4.28
156 INT80175 Positive_regulation of Gene_expression of HRAS 3 24 0.67 14.69 3.97
157 INT123827 Positive_regulation of Phosphorylation of Mapk3 1 10 0.67 5.22 3.82
158 INT34085 Negative_regulation of Gene_expression of PGE 1 16 0.35 4.9 3.76
159 INT35683 Gene_expression of Gsr 1 24 0.46 16.94 3.6
160 INT53584 Regulation of Gpx1 1 19 0.62 14.38 3.48
161 INT38303 Binding of Gpt 1 21 0.47 15.84 3.43
162 INT1970 Localization of Gusb 1 11 0.75 3.46 3.42
163 INT1972 Negative_regulation of Localization of Gusb 1 8 0.55 3.24 3.27
164 INT75500 Negative_regulation of Gene_expression of CCND1 1 21 0.57 11.59 3.24
165 INT45050 Gene_expression of Tns1 1 5 0.66 1.09 3.02
166 INT1213 Positive_regulation of Gene_expression of PGE 1 12 0.46 4.85 2.83
167 INT88852 Protein_catabolism of Casp3 1 28 0.65 23.57 2.74
168 INT61645 Negative_regulation of Gc 1 15 0.51 10.44 2.71
169 INT145126 Positive_regulation of GLRX 3 5 0.12 4.55 2.53
170 INT64053 Negative_regulation of Positive_regulation of Tmprss11d 1 3 0.57 1.34 2.38
171 INT29393 Positive_regulation of APRT 1 18 0.67 5.28 2.13
172 INT61644 Gene_expression of Gc 1 16 0.70 11.35 1.95
173 INT127649 Regulation of Ifih1 1 6 0.23 4.21 1.92
174 INT30153 Regulation of PTHLH 1 13 0.58 7.72 1.87
175 INT46605 Positive_regulation of NAA50 2 17 0.49 6.33 1.76
176 INT2620 Regulation of TGM1 2 1 0.01 3.27 1.5
177 INT45952 Gene_expression of NAA50 1 2 0.65 2.11 1.46
178 INT2619 Positive_regulation of TGM1 1 7 0.49 5.97 1.41
179 INT87985 Positive_regulation of Dpagt1 1 3 0.67 1.52 1.37
180 INT63223 Transcription of Gpt 2 4 0.65 3.38 1.27
181 INT166171 Negative_regulation of Gene_expression of HRAS 1 5 0.07 3.98 1.11
182 INT3414 Positive_regulation of Negative_regulation of Alb 1 4 0.44 1.91 1.09
183 INT135027 Regulation of Positive_regulation of Tnf 1 3 0.38 2.84 1.05
184 INT21109 Phosphorylation of Gtpbp4 1 2 0.22 0.28 0.97
185 INT132617 Regulation of Gsr 1 3 0.42 1.55 0.96
186 INT87978 Positive_regulation of Sp6 1 2 0.37 0.81 0.95
187 INT87979 Positive_regulation of Lipi 1 1 0.08 0.81 0.92
188 INT139631 Gene_expression of Col4a3 1 1 0.03 1.37 0.91
189 INT141798 Negative_regulation of Transcription of Gpt 2 1 0.40 0.87 0.88
190 INT168432 Negative_regulation of Positive_regulation of Gpx1 1 4 0.40 2.89 0.75
191 INT166166 Gene_expression of GNB5 1 2 0.33 1.31 0.68
192 INT144953 Localization of LITAF 1 2 0.02 1.75 0.68
193 INT40698 Positive_regulation of Aes 1 3 0.32 3.84 0.65
194 INT46606 Positive_regulation of SP6 1 3 0.49 0.71 0.61
195 INT83618 Regulation of Positive_regulation of Il1b 1 2 0.44 1.04 0.58
196 INT46604 Regulation of Positive_regulation of NAA50 1 1 0.44 0.46 0.51
197 INT135768 Positive_regulation of Fbrs 1 2 0.40 3.17 0.5
198 INT158097 Regulation of Localization of PGE 1 1 0.33 0.44 0.47
199 INT77893 Negative_regulation of Regulation of Cebpz 1 3 0.43 0.77 0.44
200 INT141800 Negative_regulation of Transcription of Got2 1 1 0.03 0.43 0.44
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