J:Am. J. Med.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.


Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 5 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
3 INT443 Localization of POMC 3 1020 0.81 284.52 443.17
4 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
5 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
6 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
7 INT34869 Negative_regulation of PTGS2 4 778 0.59 366.76 319.85
8 INT49750 Negative_regulation of CPOX 6 735 0.58 360.06 274.19
9 INT767 Localization of Gnrhr 3 565 0.80 106.68 214.57
10 INT2391 Negative_regulation of PTGS1 4 501 0.59 207.62 205.6
11 INT50670 Gene_expression of CPOX 5 763 0.76 442.13 195.02
12 INT528 Gene_expression of Prl 2 693 0.78 217.18 192.2
13 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
14 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
15 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
16 INT50674 Gene_expression of PTGS2 6 459 0.78 253.33 118.51
17 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
18 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
19 INT4860 Positive_regulation of CALCA 1 148 0.00 73.35 97.61
20 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
21 INT214 Localization of AVP 1 370 0.81 208.51 91.09
22 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
23 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
24 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
25 INT749 Gene_expression of HLA-B 4 341 0.75 224.12 77.37
26 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
27 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
28 INT8357 Gene_expression of KNG1 3 153 0.75 77.26 68.66
29 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
30 INT3375 Gene_expression of IGHE 2 535 0.77 387.47 65.46
31 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
32 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
33 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
34 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
35 INT546 Binding of ALB 1 311 0.48 85.98 60.14
36 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
37 INT9408 Positive_regulation of Crp 4 296 0.69 242.27 57.35
38 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
39 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
40 INT52611 Negative_regulation of Ptgs2 4 142 0.59 66.31 52.71
41 INT53083 Gene_expression of Ptgs2 3 153 0.78 90.04 50.39
42 INT2604 Positive_regulation of Got1 2 223 0.70 154.78 49.51
43 INT7093 Negative_regulation of CYP2B6 2 146 0.58 37.3 48.39
44 INT654 Localization of REN 4 250 0.81 75.12 47.86
45 INT375 Positive_regulation of REN 6 293 0.70 152.46 47.55
46 INT4776 Localization of TAC1 1 82 0.78 16.89 45.21
47 INT69992 Negative_regulation of Hmox2 1 93 0.50 49.01 44.07
48 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
49 INT55135 Positive_regulation of Gene_expression of PTGS2 1 137 0.70 80.32 38.46
50 INT8837 Positive_regulation of TAC1 1 59 0.67 21.94 35.97
51 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
52 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
53 INT5069 Negative_regulation of Mthfs 1 69 0.57 22.54 31.36
54 INT608 Negative_regulation of KNG1 2 98 0.43 72.36 31.23
55 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
56 INT5117 Negative_regulation of Gene_expression of IL2 4 118 0.59 52.33 29.96
57 INT9650 Gene_expression of LPA 1 141 0.75 104.57 29
58 INT16814 Negative_regulation of COX5A 1 74 0.57 33.72 28.63
59 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
60 INT3286 Positive_regulation of Gpt 1 90 0.69 45.08 28.34
61 INT5298 Negative_regulation of MTHFS 10 70 0.57 27.07 28.11
62 INT5135 Negative_regulation of GNRH1 1 106 0.58 36.63 27.71
63 INT6624 Gene_expression of Pth 1 135 0.76 110.27 27.54
64 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
65 INT3559 Negative_regulation of Localization of Gnrhr 2 73 0.58 18.89 26.41
66 INT50490 Regulation of PTGS2 2 80 0.48 39.51 25.85
67 INT9886 Gene_expression of Ptgs1 2 92 0.77 40.66 25.31
68 INT4465 Gene_expression of CEL 1 116 0.77 98.35 23.58
69 INT19330 Binding of HLA-A 3 99 0.48 76.26 22.85
70 INT8640 Positive_regulation of HSD11B1 5 332 0.67 377.84 22.36
71 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
72 INT5328 Positive_regulation of CD4 1 191 0.69 133.43 21.31
73 INT1876 Positive_regulation of HLA-B 2 82 0.69 52.16 21.08
74 INT15796 Regulation of IL2 2 66 0.61 25.43 20.62
75 INT76336 Negative_regulation of PDE5A 2 192 0.59 112.02 20.09
76 INT12265 Positive_regulation of IgG 1 168 0.63 104.89 19.76
77 INT5398 Positive_regulation of ALPP 1 178 0.70 110.52 19.18
78 INT9230 Gene_expression of Htr3a 1 43 0.78 10.54 18.81
79 INT636 Binding of MRAP 2 54 0.48 40.36 18.77
80 INT4420 Positive_regulation of GOT1 10 103 0.64 88.4 18.38
81 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
82 INT6129 Positive_regulation of Localization of AVP 1 63 0.70 30.44 16.64
83 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
84 INT7475 Positive_regulation of Hdl1 1 138 0.67 175.81 15.05
85 INT1888 Protein_catabolism of F13A1 2 97 0.99 63.48 14.82
86 INT663 Negative_regulation of Adrb3 1 55 0.59 15.95 14.68
87 INT9649 Positive_regulation of LPA 1 105 0.69 74.75 13.89
88 INT655 Positive_regulation of Localization of REN 2 86 0.70 32.41 13.56
89 INT15921 Positive_regulation of Serpine1 2 85 0.68 81.24 13.4
90 INT3962 Regulation of AGT 2 50 0.62 20.96 13.01
91 INT89404 Regulation of Negative_regulation of TNF 2 30 0.45 24.47 12.71
92 INT12369 Negative_regulation of Htr3a 1 28 0.59 8.78 12.62
93 INT12992 Negative_regulation of Gene_expression of Ptgs1 1 33 0.42 20.47 11.77
94 INT744 Positive_regulation of PTH 1 130 0.70 95.02 11.7
95 INT1735 Gene_expression of HSD11B1 4 199 0.75 257.87 11.5
96 INT37390 Regulation of Crp 2 39 0.46 28.74 11.45
97 INT23402 Binding of HLA-DOA 1 74 0.48 52.01 10.89
98 INT8065 Binding of AGT 1 54 0.48 20.54 10.85
99 INT6515 Gene_expression of BGLAP 1 110 0.75 45.13 10.81
100 INT1734 Negative_regulation of HSD11B1 2 116 0.57 125.13 10.52
101 INT53081 Negative_regulation of Gene_expression of Ptgs2 1 29 0.59 15.83 10.39
102 INT637 Positive_regulation of MRAP 1 23 0.67 21.13 9.97
103 INT39188 Gene_expression of IGKV5-2 1 22 0.38 10.95 9.91
104 INT6516 Positive_regulation of BGLAP 1 45 0.67 26.61 9.9
105 INT57424 Positive_regulation of TNNT1 1 42 0.67 31.84 9.7
106 INT10139 Positive_regulation of F13A1 1 64 0.56 44.75 9.69
107 INT11679 Negative_regulation of F13A1 1 55 0.54 33.69 9.43
108 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
109 INT9899 Gene_expression of Vwf 1 91 0.74 45.06 9.13
110 INT3755 Positive_regulation of GBE1 2 29 0.40 8.99 8.91
111 INT2921 Positive_regulation of F8 1 53 0.59 41.56 8.56
112 INT19107 Positive_regulation of Tbxa2r 1 23 0.62 12.54 8.44
113 INT725 Negative_regulation of IgG 1 62 0.41 37.21 8.16
114 INT764 Gene_expression of OLAH 2 25 0.67 25.58 8.07
115 INT846 Positive_regulation of B2M 1 42 0.70 29.78 8.06
116 INT1925 Gene_expression of PLAT 1 47 0.75 34.76 7.88
117 INT17996 Binding of Crp 1 40 0.37 31.4 7.8
118 INT573 Negative_regulation of C3 1 60 0.59 41.37 7.78
119 INT10145 Gene_expression of Plg 2 28 0.62 12.68 7.46
120 INT1973 Positive_regulation of NAGLU 1 36 0.65 14.78 7
121 INT717 Regulation of F2 1 29 0.61 17.46 6.99
122 INT11957 Negative_regulation of LPA 1 52 0.59 39.09 6.84
123 INT4208 Regulation of Got1 1 23 0.44 6.72 6.62
124 INT23174 Gene_expression of NLRP3 1 51 0.72 35.49 6.47
125 INT10094 Negative_regulation of ALPP 1 36 0.37 20.45 6.45
126 INT10131 Gene_expression of Serpinf1 1 53 0.76 35.57 6.42
127 INT6512 Gene_expression of PTH 1 103 0.77 76.29 6.33
128 INT11826 Positive_regulation of LDLR 1 62 0.62 45.09 6.21
129 INT48270 Negative_regulation of RNF130 1 44 0.57 21.31 6.14
130 INT1126 Negative_regulation of CD79A 1 46 0.59 31.07 6
131 INT10147 Gene_expression of Serpinc1 1 28 0.76 17.73 5.77
132 INT52695 Regulation of Ptgs2 2 20 0.42 8.72 5.71
133 INT6577 Regulation of Alox5 1 18 0.47 9.19 5.06
134 INT44608 Gene_expression of C2 1 45 0.75 15.84 5.05
135 INT30738 Negative_regulation of Gene_expression of ALB 1 32 0.59 19.01 5.04
136 INT3647 Positive_regulation of Gene_expression of F13A1 1 20 0.41 15.71 5.02
137 INT10138 Negative_regulation of Gene_expression of KNG1 1 13 0.57 9.57 4.9
138 INT2725 Positive_regulation of FCER2 1 23 0.69 23.08 4.7
139 INT55758 Positive_regulation of Apoe 1 15 0.70 11.71 4.69
140 INT19967 Gene_expression of C9orf3 3 18 0.75 26.51 4.6
141 INT18995 Binding of CEL 1 23 0.47 14.46 4.5
142 INT19966 Positive_regulation of C9orf3 2 19 0.67 21.88 4.38
143 INT4097 Localization of Pth 1 66 0.81 47.17 4.36
144 INT35744 Binding of MAOB 2 13 0.46 7.52 4.26
145 INT69967 Negative_regulation of Positive_regulation of CPOX 1 11 0.35 7.73 4.07
146 INT6513 Positive_regulation of Gene_expression of BGLAP 1 24 0.67 11.69 3.96
147 INT17548 Negative_regulation of Serpine1 1 30 0.57 24.69 3.93
148 INT4464 Localization of CEL 1 21 0.80 8.09 3.88
149 INT17217 Regulation of Negative_regulation of Gnrh1 1 5 0.31 2.56 3.78
150 INT15033 Gene_expression of Apoe 2 18 0.78 14.97 3.75
151 INT10146 Negative_regulation of Vwf 1 27 0.40 17.11 3.69
152 INT13451 Positive_regulation of DPP4 1 23 0.68 9.33 3.62
153 INT31580 Negative_regulation of Cyp11a1 2 14 0.57 3.48 3.61
154 INT15982 Positive_regulation of NLRP3 1 25 0.65 23.19 3.57
155 INT3824 Negative_regulation of PTH 1 40 0.59 28.58 3.39
156 INT3881 Positive_regulation of Protein_catabolism of F13A1 3 21 0.41 20 3.28
157 INT10132 Negative_regulation of Serpinf1 1 14 0.58 11.72 3.14
158 INT9229 Negative_regulation of Gene_expression of Htr3a 1 5 0.41 0.83 3.13
159 INT12410 Negative_regulation of Ahsp 2 10 0.29 3.49 3.07
160 INT550 Negative_regulation of LDLR 1 66 0.43 44.71 3.04
161 INT43907 Binding of CD79A 1 28 0.48 28.11 3.04
162 INT10136 Negative_regulation of PLAT 1 23 0.42 11.18 3.02
163 INT45971 Negative_regulation of GOT1 1 9 0.51 6.2 2.84
164 INT10141 Gene_expression of A2M 1 11 0.35 9.37 2.75
165 INT92877 Gene_expression of PDE5A 1 35 0.76 17.1 2.7
166 INT32421 Gene_expression of FCER2 1 19 0.73 17.23 2.53
167 INT699 Positive_regulation of A2M 1 16 0.66 10.49 2.5
168 INT3735 Localization of Neu1 1 9 0.73 3.83 2.46
169 INT10044 Positive_regulation of Serpina1 1 5 0.69 0.99 2.45
170 INT20550 Gene_expression of Vwa2 1 8 0.04 4.29 2.14
171 INT7745 Regulation of Ptafr 1 7 0.40 1.99 2.12
172 INT14360 Positive_regulation of DDC 1 7 0.70 2.97 2.02
173 INT45176 Negative_regulation of LPL 3 34 0.59 22.22 2.01
174 INT24453 Binding of NLRP3 1 18 0.48 13.7 1.93
175 INT112612 Gene_expression of Fabp3 1 14 0.59 6.35 1.47
176 INT6514 Positive_regulation of Gene_expression of PTH 1 28 0.67 30.28 1.37
177 INT10829 Regulation of Ldlr 1 12 0.34 8.12 1.35
178 INT10133 Negative_regulation of F12 3 16 0.49 5.21 1.26
179 INT36330 Positive_regulation of Positive_regulation of GOT1 1 4 0.32 4.42 1.26
180 INT37530 Regulation of Salpa1 1 8 0.59 4.79 1.19
181 INT11109 Positive_regulation of Serpina1a 1 5 0.68 4.97 1.12
182 INT15773 Negative_regulation of C9orf3 1 8 0.57 6.26 1.06
183 INT17627 Binding of Ahsp 1 3 0.25 1.83 1.04
184 INT74977 Binding of FGFR1 1 6 0.41 4.66 1.02
185 INT24494 Binding of CD97 1 2 0.42 1.15 0.99
186 INT4096 Regulation of Localization of Pth 1 7 0.58 3.97 0.95
187 INT34863 Positive_regulation of Negative_regulation of MTHFS 2 1 0.49 1.02 0.86
188 INT19279 Negative_regulation of Negative_regulation of IL2 1 3 0.43 1.62 0.79
189 INT3732 Negative_regulation of Localization of Neu1 1 3 0.01 1 0.75
190 INT27593 Positive_regulation of FHL1 1 3 0.37 2.29 0.75
191 INT10710 Positive_regulation of Positive_regulation of HLA-B 1 2 0.38 0.83 0.73
192 INT44612 Positive_regulation of APOE 1 16 0.67 5.73 0.72
193 INT12099 Localization of GOT1 1 2 0.35 2.54 0.72
194 INT10130 Positive_regulation of Serpinf1 1 10 0.53 5.62 0.7
195 INT44614 Gene_expression of FCGR2C 1 7 0.29 5.6 0.68
196 INT19964 Negative_regulation of Positive_regulation of C9orf3 1 3 0.42 4.06 0.67
197 INT4238 Negative_regulation of ALPI 1 7 0.58 3.31 0.62
198 INT10140 Negative_regulation of ANXA3 1 4 0.07 6.07 0.62
199 INT3201 Positive_regulation of F9 2 11 0.49 5.12 0.56
200 INT10142 Gene_expression of ANXA3 1 4 0.35 3.1 0.54
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