J:Am. J. Physiol. Endocrinol. Metab.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 1 0.50 4.37 1.69
2 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 5 0.07 0 1.3
3 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 3 0.05 0 0.77
4 INT142210 Adcyap1 Positive_regulation of Gh 1 3 0.05 0 0.77
5 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 2 0.05 0 0.63
6 INT139901 Ins1 Positive_regulation of Akt1 9 6 0.31 4.58 0.6
7 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 2 0.04 0 0.54
8 INT139900 Kcne2 Positive_regulation of Akt1 1 6 0.06 2.95 0.44
9 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 2 0.43 1.48 0.36
10 INT89381 INS Positive_regulation of AKT1 6 1 0.43 3.06 0.33
11 INT139902 Kcne2 Positive_regulation of Gpr83 1 3 0.03 1.43 0.22
12 INT135070 Preb Regulation of Gene_expression of PDYN 1 1 0.00 0 0.22
13 INT139903 Ins1 Positive_regulation of Gpr83 1 3 0.13 1.43 0.22
14 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 1 0.36 0 0.14
15 INT150532 LEP Negative_regulation of Adipoq 1 1 0.00 1.34 0.12
16 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 1 0.00 1.34 0.12
17 INT126922 Ins1 Positive_regulation of Localization of Slc2a4 1 1 0.23 0.75 0.11
18 INT115204 Ednra Regulation of Localization of Avp 1 1 0.55 0 0.08
19 INT142745 Atp6v1e1 Regulation of Gene_expression of Trpv6 1 1 0.07 0 0.07
20 INT142746 Atp6v1e1 Regulation of Trpv6 1 1 0.17 0 0.06
21 INT142744 Esr1 Regulation of Transcription of Trpv6 1 1 0.42 0 0.06
22 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 1 0.36 1.37 0.04
23 INT89380 IL6 Positive_regulation of Gene_expression of TNF 1 1 0.20 0.55 0.04
24 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 1 0.15 0.59 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
2 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
3 INT728 Positive_regulation of Penk 3 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
5 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
6 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
7 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
8 INT477 Localization of Avp 8 813 0.81 131.58 300.4
9 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
10 INT1893 Localization of Gh 6 1041 0.79 340.23 256.58
11 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
12 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
13 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
14 INT1114 Localization of Ins1 7 748 0.80 192.95 165.48
15 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
16 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
17 INT2451 Positive_regulation of Avp 1 355 0.70 102.66 147.69
18 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
19 INT6822 Gene_expression of Pdyn 2 215 0.78 35.99 125.76
20 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
21 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
22 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
23 INT3038 Gene_expression of INS 3 1583 0.78 1174.16 107.01
24 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
25 INT104000 Phosphorylation of Grin2b 1 73 0.82 48.34 93.48
26 INT1472 Positive_regulation of Ins1 6 349 0.69 146.2 86.36
27 INT2149 Positive_regulation of Oxt 1 181 0.70 24.8 85.43
28 INT1498 Gene_expression of Gh 4 521 0.75 220.84 81.16
29 INT3214 Localization of Ins1 2 527 0.80 196.9 79.26
30 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
31 INT3657 Gene_expression of Ins1 3 514 0.78 321.69 75.76
32 INT1497 Negative_regulation of Gh 4 415 0.59 192.95 74.71
33 INT79506 Gene_expression of Grin2b 1 122 0.78 43.71 73.42
34 INT1988 Positive_regulation of Localization of Ins1 7 254 0.69 59.25 68.37
35 INT5941 Gene_expression of Oxt 1 164 0.76 22.63 65.47
36 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
37 INT480 Negative_regulation of Localization of Avp 2 151 0.59 27.64 63.72
38 INT12175 Positive_regulation of PDYN 1 86 0.69 18.27 62.04
39 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
40 INT7032 Positive_regulation of Pdyn 2 94 0.66 26.51 58.83
41 INT1200 Negative_regulation of Ins1 4 274 0.58 155.17 56.14
42 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
43 INT117713 Phosphorylation of Akt1 10 275 0.82 95.82 54.34
44 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
45 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
46 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
47 INT1199 Positive_regulation of INS 4 579 0.70 399.64 50.43
48 INT40777 Positive_regulation of Akt1 2 163 0.69 59.41 49.43
49 INT17915 Gene_expression of Insr 1 141 0.75 47.45 48.59
50 INT51627 Gene_expression of Grin2a 1 82 0.76 25.09 47.6
51 INT2275 Negative_regulation of Localization of Ins1 3 183 0.59 51.02 44.94
52 INT1894 Negative_regulation of Localization of Gh 5 168 0.58 64.12 43.56
53 INT1474 Regulation of Localization of Ins1 1 132 0.61 25.96 43.07
54 INT7029 Regulation of Pdyn 1 51 0.61 12.89 40.34
55 INT3252 Negative_regulation of INS 3 428 0.59 271.65 39.52
56 INT48933 Gene_expression of Mapk3 1 93 0.75 44.39 37.92
57 INT82054 Positive_regulation of Grin2b 1 56 0.70 17.45 37.14
58 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
59 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
60 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
61 INT1473 Localization of Gcg 1 95 0.80 17.35 30.31
62 INT52690 Positive_regulation of Ptgs2 1 65 0.68 39.51 30.02
63 INT4868 Gene_expression of GAL 2 75 0.78 22.23 29.02
64 INT93033 Negative_regulation of Grin2b 1 48 0.58 20.94 28.54
65 INT2393 Positive_regulation of Mb 1 174 0.69 93.59 26.79
66 INT17625 Localization of GCG 2 210 0.80 55.69 24.97
67 INT18400 Localization of Glp1r 1 97 0.80 11.96 24.32
68 INT14556 Positive_regulation of Igf1 1 105 0.69 52.21 24.04
69 INT18323 Negative_regulation of Localization of Ins1 2 122 0.58 45.74 23.04
70 INT102281 Positive_regulation of Gene_expression of Grin2b 1 27 0.70 10.38 20.84
71 INT82434 Positive_regulation of LEP 1 117 0.70 95.45 20.22
72 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
73 INT86187 Positive_regulation of AKT1 2 199 0.69 122.13 19.44
74 INT90612 Positive_regulation of Grin2a 1 33 0.65 15.11 18.84
75 INT58896 Localization of Adcyap1 3 35 0.81 4.57 14.77
76 INT60197 Gene_expression of JUN 1 90 0.78 42.32 14.61
77 INT48259 Positive_regulation of Adcyap1 1 33 0.67 10.94 14.39
78 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
79 INT8210 Positive_regulation of Gene_expression of INS 1 188 0.68 146.57 12.83
80 INT89404 Regulation of Negative_regulation of TNF 1 30 0.45 24.47 12.71
81 INT89395 Negative_regulation of AKT1 1 127 0.58 70.27 12.54
82 INT90225 Gene_expression of Mapk10 1 2 0.78 3.89 12.28
83 INT12232 Regulation of Gene_expression of PDYN 1 21 0.60 9.91 12.18
84 INT117502 Positive_regulation of Adipoq 1 70 0.63 40.43 12.03
85 INT11794 Gene_expression of Cd2 1 27 0.76 17.31 10.99
86 INT4494 Regulation of GCG 2 41 0.45 18.38 9.68
87 INT15307 Regulation of Mtor 1 27 0.48 4.7 9.34
88 INT52924 Negative_regulation of GSR 1 49 0.58 28.08 9.28
89 INT5939 Regulation of Gene_expression of Oxt 1 27 0.51 2.84 9.1
90 INT6727 Positive_regulation of Ednra 7 27 0.64 18.75 8.71
91 INT3658 Regulation of Gcg 1 28 0.53 12.89 8.58
92 INT15308 Localization of Chat 1 29 0.81 2.35 8.47
93 INT15529 Gene_expression of GCG 4 51 0.75 18.55 8.35
94 INT81153 Gene_expression of Hcrt 2 31 0.77 6.04 8.16
95 INT1499 Negative_regulation of Gene_expression of Gh 3 58 0.42 25.17 7.86
96 INT3659 Negative_regulation of Gcg 2 26 0.51 10.08 7.39
97 INT75497 Regulation of JUN 1 28 0.61 11.04 7.09
98 INT74865 Gene_expression of Igh-Dex 1 16 0.22 8.95 6.59
99 INT3041 Positive_regulation of MIA3 1 34 0.56 21.11 6.49
100 INT28861 Binding of Gh 1 61 0.46 25.61 6.38
101 INT12054 Negative_regulation of MIA3 1 32 0.45 23.2 6.18
102 INT151032 Localization of Igf1 1 49 0.76 26.32 5.71
103 INT904 Positive_regulation of Ptgfr 1 23 0.49 7.98 5.55
104 INT117499 Negative_regulation of Adipoq 2 28 0.56 24.15 5.07
105 INT14681 Negative_regulation of GCG 1 31 0.57 13.55 4.98
106 INT87780 Gene_expression of Gja1 2 22 0.77 5.84 4.24
107 INT10842 Transcription of Gh 5 18 0.64 2.94 4.13
108 INT139898 Negative_regulation of Positive_regulation of Akt1 1 15 0.42 4.66 4.06
109 INT89394 Phosphorylation of INS 2 37 0.82 35.84 3.9
110 INT19104 Regulation of Gene_expression of Gh 1 24 0.40 8.42 3.88
111 INT4464 Localization of CEL 1 21 0.80 8.09 3.88
112 INT94291 Regulation of Gene_expression of Mapk3 1 4 0.40 3.05 3.8
113 INT113634 Gene_expression of Hcrtr1 1 5 0.77 34.43 3.76
114 INT2936 Gene_expression of AGL 2 36 0.49 9.55 3.63
115 INT142753 Gene_expression of Lcn2 5 28 0.76 10.03 3.62
116 INT92681 Positive_regulation of Ctgf 1 13 0.69 9.78 3.47
117 INT91070 Regulation of GSR 1 27 0.59 16.64 3.42
118 INT115203 Negative_regulation of Positive_regulation of Ednra 1 5 0.33 1.27 3.32
119 INT70958 Binding of NOS3 1 19 0.37 11.84 3.29
120 INT89392 Negative_regulation of Positive_regulation of AKT1 2 23 0.50 15.69 3.02
121 INT18399 Regulation of Glp1r 3 11 0.53 3.78 2.97
122 INT83190 Gene_expression of Olr1 1 26 0.59 12.47 2.91
123 INT2256 Regulation of Gip 1 14 0.47 4.69 2.91
124 INT89401 Negative_regulation of Phosphorylation of AKT1 2 68 0.58 35.61 2.8
125 INT89397 Positive_regulation of PIK3CA 2 33 0.67 16.98 2.78
126 INT151029 Positive_regulation of Gene_expression of Lcn2 5 8 0.68 4.04 2.65
127 INT151037 Gene_expression of Col10a1 2 13 0.68 4.47 2.64
128 INT100544 Positive_regulation of Fabp1 1 16 0.38 6.81 2.63
129 INT126581 Positive_regulation of Gli3 4 6 0.35 1.59 2.48
130 INT139896 Phosphorylation of Ins1 3 29 0.77 24.03 2.35
131 INT142741 Gene_expression of Atp6v1e1 1 28 0.31 9.41 2.34
132 INT3315 Negative_regulation of Positive_regulation of INS 2 31 0.57 14.73 2.27
133 INT142740 Gene_expression of Trpv6 5 15 0.78 6.1 2.06
134 INT126374 Gene_expression of Gli3 1 6 0.77 3.67 2.02
135 INT151036 Positive_regulation of Lcn2 2 13 0.49 8.57 2
136 INT87779 Positive_regulation of Gja1 1 4 0.53 0.9 1.95
137 INT151942 Regulation of Negative_regulation of Grin2b 1 2 0.41 0.41 1.92
138 INT77300 Negative_regulation of Positive_regulation of Adcyap1 1 3 0.35 0 1.88
139 INT3866 Positive_regulation of Positive_regulation of INS 1 30 0.59 21.58 1.86
140 INT94163 Negative_regulation of UCN2 1 11 0.57 6.86 1.75
141 INT115256 Localization of Slc2a4 1 13 0.77 8.06 1.72
142 INT72021 Localization of Ednra 3 7 0.58 3.13 1.53
143 INT65452 Negative_regulation of Cacna1c 1 8 0.09 0.8 1.44
144 INT98020 Gene_expression of PCK1 1 4 0.53 1.21 1.37
145 INT112645 Negative_regulation of OVGP1 3 7 0.33 3.17 1.34
146 INT90226 Gene_expression of Mapk9 1 3 0.65 1.94 1.34
147 INT151038 Localization of Lcn2 1 4 0.79 1.87 1.32
148 INT97474 Positive_regulation of UCN2 1 6 0.67 1.85 1.23
149 INT142205 Negative_regulation of Transcription of Gh 4 1 0.16 0 1.08
150 INT65589 Protein_catabolism of MBTPS1 1 5 0.58 1.22 0.99
151 INT23030 Positive_regulation of Pth 1 13 0.61 9.24 0.97
152 INT151035 Negative_regulation of Lcn2 1 5 0.42 1.99 0.96
153 INT68265 Positive_regulation of Negative_regulation of Ptgs2 1 3 0.46 0.08 0.92
154 INT92337 Localization of Ass1 1 3 0.41 1.42 0.86
155 INT151033 Positive_regulation of Gene_expression of Col10a1 1 2 0.26 1.06 0.86
156 INT98017 Protein_catabolism of Gtf3a 1 10 0.11 6.16 0.83
157 INT151943 Negative_regulation of Positive_regulation of UCN2 1 2 0.42 0.55 0.82
158 INT89407 Positive_regulation of IRS1 2 10 0.51 9.67 0.81
159 INT132127 Positive_regulation of Rps6 2 1 0.49 0.32 0.79
160 INT12057 Regulation of Negative_regulation of INS 1 7 0.40 3.92 0.76
161 INT141789 Gene_expression of Ucp3 3 19 0.78 4.12 0.75
162 INT134818 Regulation of Oxtr 1 4 0.45 1.11 0.67
163 INT69283 Gene_expression of PHEX 1 25 0.75 7.81 0.64
164 INT135064 Gene_expression of Preb 1 2 0.38 0.18 0.54
165 INT135062 Transcription of Gli3 2 1 0.05 0 0.52
166 INT141794 Negative_regulation of HSPB3 1 2 0.00 0 0.5
167 INT115202 Positive_regulation of Positive_regulation of Ednra 1 2 0.39 2.88 0.49
168 INT142742 Positive_regulation of Trpv6 2 5 0.70 0.85 0.47
169 INT151034 Regulation of Gene_expression of Col10a1 1 1 0.17 0 0.43
170 INT151030 Regulation of Gene_expression of Lcn2 1 1 0.41 0 0.42
171 INT151028 Positive_regulation of Frzb 1 1 0.19 0.08 0.41
172 INT151031 Localization of Frzb 1 1 0.29 0.08 0.4
173 INT132128 Positive_regulation of Phosphorylation of Rps6 1 1 0.49 0.16 0.4
174 INT132126 Phosphorylation of Rps6 1 1 0.80 0.16 0.39
175 INT126919 Regulation of Localization of Slc2a4 1 3 0.40 2.24 0.37
176 INT89403 Negative_regulation of PIK3CA 1 19 0.57 11.74 0.35
177 INT138356 Positive_regulation of Regulation of Glp1r 1 1 0.12 0.45 0.35
178 INT135069 Regulation of Localization of CEL 1 1 0.44 0 0.34
179 INT142743 Transcription of Trpv6 1 5 0.72 0.91 0.32
180 INT126920 Phosphorylation of Slc2a4 2 3 0.73 1.98 0.31
181 INT72022 Positive_regulation of Localization of Ednra 1 2 0.32 0.07 0.3
182 INT121349 Transcription of Oxtr 2 7 0.69 0.87 0.29
183 INT141793 Positive_regulation of Gene_expression of Ucp3 1 7 0.70 1.32 0.28
184 INT141791 Regulation of Ucp3 1 3 0.53 1.27 0.28
185 INT114417 Localization of Abcc8 1 1 0.63 0.07 0.26
186 INT114416 Negative_regulation of Localization of Abcc8 1 1 0.36 0.07 0.26
187 INT135061 Protein_catabolism of Gli3 1 1 0.04 0 0.25
188 INT89399 Negative_regulation of Positive_regulation of PIK3CA 2 3 0.57 1 0.22
189 INT89406 Negative_regulation of Positive_regulation of IRS1 2 1 0.22 0.93 0.22
190 INT126761 Negative_regulation of Gja1 1 1 0.33 0.08 0.22
191 INT126921 Positive_regulation of Phosphorylation of Slc2a4 1 2 0.41 1.26 0.21
192 INT89400 Phosphorylation of PTK2B 1 4 0.38 1.16 0.19
193 INT135060 Negative_regulation of Transcription of Gli3 1 1 0.03 0 0.19
194 INT150529 Positive_regulation of Negative_regulation of Adipoq 1 2 0.37 1.76 0.18
195 INT98016 Protein_catabolism of Pth 1 2 0.18 2.07 0.18
196 INT98018 Protein_catabolism of FGF23 1 2 0.65 1.58 0.17
197 INT126762 Gene_expression of Mat2a 1 1 0.08 0.08 0.17
198 INT98021 Regulation of PCK1 1 2 0.31 0.07 0.16
199 INT142739 Regulation of Gene_expression of Trpv6 1 2 0.45 0.25 0.16
200 INT89409 Negative_regulation of Phosphorylation of PTK2B 1 2 0.13 0.89 0.12
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