J:Am. J. Physiol. Renal Physiol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT111221 MMEL1 Negative_regulation of HMOX1 1 1 0.01 1 1.16
2 INT124904 Binding of Tacr1 and Adarb1 2 1 0.01 0.5 0.63
3 INT153330 Binding of PTGER3 and Cm9 1 1 0.36 0.15 0.48
4 INT154756 Tnf Positive_regulation of Nfkb1 1 2 0.31 0.78 0.4
5 INT123398 TPSAB1 Positive_regulation of Gene_expression of PTAFR 1 1 0.14 0.51 0.32
6 INT123397 F2 Positive_regulation of Gene_expression of PTAFR 1 1 0.05 0.51 0.32
7 INT154755 Tnf Positive_regulation of Gene_expression of Ccl2 2 1 0.23 1.7 0.27
8 INT154757 Negative_regulation of Tnf Positive_regulation of Nfkb1 1 1 0.19 0.45 0.22
9 INT154754 Positive_regulation of Tnf Positive_regulation of Nfkb1 1 1 0.21 0.34 0.18
10 INT88137 Ren Regulation of Gene_expression of Spp1 1 1 0.04 0.24 0.09
11 INT129331 Binding of Trpv1 and Gipc1 1 1 0.01 0 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 3 3083 0.78 894.43 1639.02
2 INT5202 Positive_regulation of Gene_expression of Fos 2 1163 0.70 319.28 684
3 INT58061 Gene_expression of Trpv1 7 1117 0.78 451.54 637.59
4 INT50058 Negative_regulation of Cpox 1 907 0.58 426.28 428.29
5 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
6 INT6056 Negative_regulation of Gene_expression of Fos 2 601 0.59 193.05 386.84
7 INT18357 Gene_expression of TRPV1 2 825 0.78 307.11 382.81
8 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
9 INT9158 Gene_expression of Tnf 3 722 0.78 522.01 277.68
10 INT9381 Positive_regulation of TRPV1 4 523 0.70 187.4 276.05
11 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
12 INT4893 Gene_expression of Tacr1 4 366 0.78 129.67 213.92
13 INT51921 Gene_expression of Cpox 1 501 0.73 229.81 157.81
14 INT13353 Positive_regulation of Tnf 2 332 0.70 248.75 148.1
15 INT60126 Regulation of Trpv1 1 186 0.62 85.53 133.4
16 INT27096 Positive_regulation of Nfkb1 2 325 0.70 195.11 109.06
17 INT89054 Positive_regulation of Gene_expression of Trpv1 2 156 0.70 90.78 102.03
18 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
19 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
20 INT38731 Localization of Trpv1 3 138 0.81 52.73 90.49
21 INT10166 Localization of Tnf 2 237 0.81 153.95 88.64
22 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
23 INT4830 Binding of Trpv1 2 158 0.48 45.11 84.2
24 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
25 INT15769 Gene_expression of Il1b 2 146 0.78 114.51 75.35
26 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
27 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
28 INT102546 Gene_expression of Ccl2 2 197 0.78 192.8 67.41
29 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
30 INT64159 Gene_expression of Prkca 2 90 0.78 34.65 55.97
31 INT314 Positive_regulation of Ren 5 212 0.70 66.68 55.56
32 INT62543 Gene_expression of Icam1 4 231 0.78 187.58 52.71
33 INT83199 Gene_expression of Nos3 7 193 0.78 100.72 51.57
34 INT6165 Gene_expression of Adarb1 1 85 0.58 18.39 51.03
35 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
36 INT8465 Regulation of Ptgs1 1 100 0.57 36.03 44.41
37 INT48075 Positive_regulation of Il1b 2 71 0.67 48.63 40.48
38 INT4925 Binding of Tacr1 2 57 0.48 17.39 38.38
39 INT385 Gene_expression of Agt 2 182 0.78 63.62 37.91
40 INT390 Positive_regulation of Agt 2 170 0.70 61.47 36.08
41 INT1116 Regulation of Ren 3 103 0.62 27.66 33.26
42 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
43 INT1159 Negative_regulation of Agt 2 133 0.59 40.14 31.67
44 INT64164 Regulation of Prkca 1 34 0.62 10.44 30.99
45 INT1179 Negative_regulation of Ace 3 157 0.59 67.03 30.46
46 INT10506 Gene_expression of PTAFR 1 86 0.76 37.57 28.58
47 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
48 INT53949 Positive_regulation of Gene_expression of Cpox 1 82 0.65 38.12 25.93
49 INT141612 Gene_expression of Ccr1 1 92 0.77 72.09 24.14
50 INT51029 Negative_regulation of Il1b 2 34 0.57 29.34 23.62
51 INT71875 Localization of Nfkb1 2 92 0.78 48.13 22.94
52 INT101592 Gene_expression of TRPM8 1 82 0.78 70.61 22.89
53 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
54 INT48081 Localization of Il1b 2 46 0.80 21.59 22.4
55 INT10536 Gene_expression of Trib3 1 67 0.66 27.08 21.58
56 INT69877 Positive_regulation of Positive_regulation of Nfkb1 1 53 0.68 31.44 20.7
57 INT41494 Negative_regulation of Gene_expression of Tacr1 1 25 0.58 11.73 19.91
58 INT138696 Positive_regulation of Ccl2 1 57 0.67 59.57 19.58
59 INT66751 Negative_regulation of Localization of Tnf 4 48 0.59 26 19.36
60 INT56749 Gene_expression of PCNA 1 219 0.77 111.25 18.42
61 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
62 INT111416 Positive_regulation of Trpm8 2 65 0.70 14.62 17.13
63 INT62546 Positive_regulation of Gene_expression of Icam1 2 60 0.70 59.52 16.9
64 INT2066 Localization of Agt 1 56 0.80 9.95 16.25
65 INT56447 Positive_regulation of Icam1 2 64 0.64 64.14 16.16
66 INT79227 Negative_regulation of Gene_expression of Icam1 4 45 0.59 41.65 14.97
67 INT71879 Negative_regulation of Localization of Nfkb1 4 30 0.57 21.8 13.48
68 INT83200 Positive_regulation of Gene_expression of Nos3 4 48 0.70 24.75 12.99
69 INT13303 Positive_regulation of PTAFR 1 40 0.69 16.27 11.56
70 INT20457 Regulation of Ptgs1 1 23 0.48 11.63 11.56
71 INT111223 Positive_regulation of HMOX1 3 47 0.70 39.14 10.92
72 INT1180 Gene_expression of Ren 1 63 0.77 27.33 10.51
73 INT10982 Negative_regulation of Agtr1a 1 42 0.58 22.42 10.29
74 INT72759 Transcription of Cpox 1 40 0.39 17.26 10
75 INT105816 Gene_expression of P2RY2 5 53 0.78 16.47 9.67
76 INT135407 Negative_regulation of Ccl2 1 33 0.57 32.74 9.45
77 INT138700 Negative_regulation of Gene_expression of Ccl2 2 27 0.57 24.1 9.08
78 INT386 Positive_regulation of Gene_expression of Agt 2 37 0.70 15.92 8.73
79 INT108202 Positive_regulation of PIK3CG 1 47 0.67 25.83 8.25
80 INT134381 Regulation of Trpm8 1 25 0.54 8.31 8.25
81 INT114873 Phosphorylation of Stat3 2 63 0.82 30.19 8.23
82 INT4021 Positive_regulation of PLA2G1B 2 35 0.70 23.27 8.2
83 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
84 INT116163 Gene_expression of S1pr1 3 29 0.78 14.11 7.27
85 INT144945 Negative_regulation of Icam1 2 27 0.50 26.23 7.08
86 INT34767 Gene_expression of PTGIR 1 36 0.42 14.79 6.69
87 INT10507 Positive_regulation of Gene_expression of PTAFR 3 15 0.61 10.24 6.61
88 INT141611 Positive_regulation of Gene_expression of Ccr1 1 25 0.69 20.32 6.42
89 INT139580 Negative_regulation of Trpm8 1 19 0.58 3.8 6.26
90 INT93359 Positive_regulation of Trp53 1 90 0.70 69.77 6.24
91 INT82451 Negative_regulation of HMOX1 2 18 0.51 13.29 5.74
92 INT31829 Positive_regulation of Efs 1 13 0.42 2.83 5.6
93 INT144946 Localization of Icam1 2 21 0.75 21.84 5.33
94 INT76313 Gene_expression of CD38 1 30 0.64 20.74 5.27
95 INT18681 Gene_expression of Thy1 1 80 0.71 38.8 5.23
96 INT102547 Gene_expression of Cd68 1 25 0.75 14.47 5.22
97 INT72758 Positive_regulation of Transcription of Cpox 1 15 0.34 5.46 4.75
98 INT32324 Gene_expression of Eda 1 20 0.75 6.43 4.66
99 INT118274 Positive_regulation of Positive_regulation of PIK3CG 1 8 0.64 4.81 4.62
100 INT114871 Positive_regulation of Phosphorylation of Stat3 1 20 0.69 12.34 4.6
101 INT78995 Negative_regulation of Agtr2 1 26 0.42 13.05 4.56
102 INT118565 Gene_expression of Ddit3 1 35 0.75 23.62 4.32
103 INT27158 Negative_regulation of Positive_regulation of Rtcd1 1 7 0.13 1.84 4.25
104 INT387 Regulation of Ace 1 18 0.45 5.24 4.24
105 INT48544 Negative_regulation of Olr1469 1 3 0.31 0.98 4.2
106 INT19847 Positive_regulation of Localization of Alb 1 21 0.70 13.89 4.16
107 INT132700 Positive_regulation of Trpc1 1 6 0.39 4.33 3.89
108 INT5408 Localization of Alb 1 30 0.73 12.1 3.84
109 INT142984 Positive_regulation of S1pr1 1 13 0.70 7.9 3.84
110 INT36365 Positive_regulation of SK 2 15 0.41 4.13 3.56
111 INT14281 Gene_expression of Hspa5 1 44 0.63 34.19 3.31
112 INT136651 Binding of Calm2 2 30 0.42 1.09 3.11
113 INT88130 Gene_expression of Spp1 4 13 0.74 12.96 3.07
114 INT95778 Gene_expression of Prkcb 1 5 0.75 2.3 2.97
115 INT41721 Negative_regulation of MTOR 1 40 0.58 32.49 2.83
116 INT138437 Gene_expression of Sphk1 2 23 0.65 10.01 2.61
117 INT84599 Gene_expression of Aqp2 2 31 0.77 22.58 2.54
118 INT116164 Positive_regulation of Gene_expression of S1pr1 3 5 0.66 4.72 2.42
119 INT1178 Positive_regulation of Gene_expression of Ren 1 16 0.60 7.71 2.41
120 INT91046 Negative_regulation of Regulation of Tacr1 1 3 0.40 1.33 2.31
121 INT54061 Regulation of Casp14 1 4 0.26 0.96 2.25
122 INT111038 Gene_expression of Cdkn1b 2 23 0.75 25.35 2.22
123 INT10201 Positive_regulation of Localization of Agt 1 8 0.50 0.97 2.21
124 INT154751 Positive_regulation of Positive_regulation of Ccl2 1 2 0.48 2.43 2.06
125 INT141166 Positive_regulation of Gene_expression of Ddit3 1 15 0.56 10.32 1.92
126 INT138439 Positive_regulation of Gene_expression of Sphk1 2 14 0.48 5.93 1.86
127 INT15980 Positive_regulation of Positive_regulation of Agt 1 6 0.50 2.99 1.76
128 INT94163 Negative_regulation of UCN2 2 11 0.57 6.86 1.75
129 INT3152 Transcription of Agt 2 7 0.72 5.09 1.68
130 INT119346 Positive_regulation of PTGIR 1 9 0.58 6.2 1.61
131 INT1580 Negative_regulation of Pde2a 1 7 0.52 3.26 1.59
132 INT94614 Binding of PTGER3 1 7 0.35 2.54 1.58
133 INT107897 Protein_catabolism of Nfkbib 1 5 0.96 2.52 1.58
134 INT88136 Positive_regulation of Gene_expression of Spp1 5 8 0.66 4.5 1.57
135 INT128051 Gene_expression of FGF10 5 9 0.78 2.31 1.56
136 INT100420 Regulation of HMOX1 1 10 0.35 6.68 1.48
137 INT14477 Positive_regulation of TPSAB1 1 10 0.69 5.88 1.46
138 INT118559 Positive_regulation of Hspa5 3 20 0.61 15.66 1.45
139 INT41719 Gene_expression of MTOR 1 27 0.77 19.43 1.44
140 INT111222 Negative_regulation of MMEL1 1 2 0.37 2.5 1.36
141 INT88133 Positive_regulation of Spp1 1 8 0.66 10.07 1.33
142 INT78658 Localization of PTGIR 1 6 0.18 2.46 1.33
143 INT97474 Positive_regulation of UCN2 2 6 0.67 1.85 1.23
144 INT114220 Negative_regulation of Gene_expression of Cdkn1b 1 4 0.33 4.11 1.23
145 INT138434 Positive_regulation of Sphk1 1 10 0.48 2.18 1.18
146 INT54830 Regulation of Ptger3 1 4 0.39 1.31 1.16
147 INT130246 Negative_regulation of Gene_expression of TRPM8 1 4 0.59 3.35 1.14
148 INT79557 Localization of Aqp2 1 5 0.73 2 1.13
149 INT152808 Positive_regulation of Rcn1 2 1 0.52 1.19 1.08
150 INT40249 Regulation of Regulation of Ren 2 4 0.36 0.83 1.05
151 INT144767 Gene_expression of UCN2 1 5 0.65 1.78 1.04
152 INT119974 Negative_regulation of P2RY2 1 3 0.43 1.6 1.04
153 INT97052 Transcription of Trp53 2 12 0.64 6.52 1.01
154 INT84597 Transcription of Aqp2 1 3 0.55 2.11 0.98
155 INT152809 Negative_regulation of Hk2 1 2 0.57 1.95 0.98
156 INT153329 Gene_expression of Cm9 1 6 0.67 4.35 0.95
157 INT73742 Negative_regulation of TECR 1 3 0.51 0.63 0.94
158 INT43642 Positive_regulation of Slc12a3 1 3 0.41 0.7 0.83
159 INT108348 Positive_regulation of Aqp2 2 10 0.68 4.94 0.82
160 INT149243 Positive_regulation of Slc12a1 2 3 0.59 1.57 0.82
161 INT151943 Negative_regulation of Positive_regulation of UCN2 1 2 0.42 0.55 0.82
162 INT89776 Positive_regulation of Pde2a 1 2 0.47 2.84 0.81
163 INT27204 Gene_expression of Atrn 1 5 0.51 1.24 0.77
164 INT149238 Positive_regulation of Gene_expression of Aqp2 2 5 0.66 3.07 0.73
165 INT87445 Localization of TJP1 1 2 0.45 0.55 0.68
166 INT146711 Positive_regulation of Hk2 1 2 0.18 1.27 0.68
167 INT23612 Regulation of Negative_regulation of Ptgs1 1 3 0.19 0.69 0.64
168 INT146710 Negative_regulation of Mepce 1 1 0.01 0.68 0.63
169 INT70760 Positive_regulation of Actg2 2 8 0.48 6.23 0.61
170 INT149239 Gene_expression of Slc12a1 1 4 0.66 3.08 0.6
171 INT123401 Positive_regulation of Localization of PTGIR 2 1 0.06 0.98 0.6
172 INT154745 Protein_catabolism of Traf2 3 1 0.86 1.04 0.59
173 INT153328 Negative_regulation of Gene_expression of Cm9 1 1 0.37 0.28 0.59
174 INT154750 Positive_regulation of Protein_catabolism of Traf2 3 1 0.60 1.05 0.59
175 INT137968 Negative_regulation of Positive_regulation of Trpm8 1 5 0.43 0.9 0.49
176 INT154747 Positive_regulation of Protein_catabolism of Nfkbib 1 3 0.31 1.25 0.46
177 INT154748 Positive_regulation of Gene_expression of Hspa5 1 11 0.44 7.66 0.44
178 INT134856 Binding of FGF10 1 2 0.48 0.3 0.43
179 INT24663 Positive_regulation of F2RL3 1 3 0.21 1.8 0.4
180 INT149235 Positive_regulation of Transcription of Aqp2 1 1 0.45 0.72 0.4
181 INT149244 Positive_regulation of Localization of Aqp2 1 1 0.49 0.72 0.4
182 INT149234 Positive_regulation of Localization of Slc12a1 1 1 0.42 0.72 0.4
183 INT149241 Transcription of Slc12a1 1 2 0.45 1.05 0.39
184 INT149237 Gene_expression of Slc34a3 1 2 0.42 2.22 0.39
185 INT149242 Localization of Slc12a1 1 2 0.63 1.11 0.39
186 INT46545 Binding of Gipc1 1 2 0.02 0 0.38
187 INT156201 Negative_regulation of Gene_expression of MTOR 1 6 0.58 7.7 0.36
188 INT130453 Gene_expression of ELAVL2 1 6 0.36 2.28 0.34
189 INT117505 Gene_expression of Taf9 1 1 0.07 0.09 0.34
190 INT25424 Transcription of Ren 1 2 0.57 1.21 0.33
191 INT130452 Positive_regulation of Localization of HSD11B2 1 1 0.18 0.23 0.33
192 INT88134 Negative_regulation of Gene_expression of Spp1 1 2 0.41 1.94 0.32
193 INT149236 Positive_regulation of Gene_expression of Slc12a1 1 1 0.42 0.76 0.32
194 INT149240 Positive_regulation of Gene_expression of Slc34a3 1 1 0.07 0.75 0.32
195 INT130456 Negative_regulation of Localization of HSD11B2 1 1 0.17 0.23 0.31
196 INT130458 Negative_regulation of HSD11B2 1 1 0.16 0.23 0.31
197 INT130455 Localization of HSD11B2 1 1 0.27 0.23 0.3
198 INT154749 Negative_regulation of Gene_expression of Ddit3 1 2 0.41 1.15 0.27
199 INT123399 Positive_regulation of Positive_regulation of PLA2G1B 1 1 0.15 0.47 0.26
200 INT156207 Negative_regulation of Phosphorylation of MTOR 2 5 0.58 2.33 0.25
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