J:Anesth. Analg.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT135830 Gch1 Regulation of Nos2 1 2 0.65 0 1.29
2 INT134454 EGF Positive_regulation of EGFR 3 1 0.56 1.32 0.88
3 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 1 0.35 0.35 0.88
4 INT149983 Binding of Cpox and Nos2 1 2 0.30 0.54 0.69
5 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 2 0.46 0.98 0.66
6 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 2 0.64 0.98 0.66
7 INT135829 Cat2 Regulation of Nos2 1 1 0.47 0 0.65
8 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 2 0.46 1 0.63
9 INT150536 OPRM1 Positive_regulation of Positive_regulation of IL6 1 1 0.04 0.38 0.48
10 INT150537 OPRM1 Positive_regulation of Negative_regulation of IL6 1 2 0.04 0.38 0.48
11 INT150539 OPRM1 Positive_regulation of IL6 1 1 0.04 0.38 0.48
12 INT150534 OPRM1 Positive_regulation of TNF 1 1 0.03 0.38 0.48
13 INT150535 OPRM1 Positive_regulation of Positive_regulation of TNF 1 1 0.08 0.38 0.48
14 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 1 0.00 0.09 0.26
15 INT149357 Trib3 Negative_regulation of Raf1 1 1 0.01 0.08 0.25
16 INT149356 Prkaca Negative_regulation of Raf1 1 1 0.10 0.08 0.25
17 INT136497 Binding of TAM and ECT 1 1 0.34 0.65 0.11
18 INT152135 TDRD7 Positive_regulation of Gene_expression of SELP 1 1 0.26 0 0
19 INT150538 OPRM1 Positive_regulation of Negative_regulation of TNF 1 1 0.08 0 0
20 INT149982 Negative_regulation of Cpox Negative_regulation of Gene_expression of FLII 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 54 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
3 INT6483 Gene_expression of TNF 14 3152 0.78 2515.62 929.82
4 INT7114 Positive_regulation of Ltp 3 1192 0.62 290.76 755.77
5 INT1912 Gene_expression of Calca 5 1152 0.78 453.25 739.84
6 INT5202 Positive_regulation of Gene_expression of Fos 14 1163 0.70 319.28 684
7 INT58061 Gene_expression of Trpv1 3 1117 0.78 451.54 637.59
8 INT2543 Positive_regulation of Calca 2 787 0.70 331.13 592.08
9 INT5228 Positive_regulation of Fos 10 934 0.70 209.8 503.87
10 INT50058 Negative_regulation of Cpox 17 907 0.58 426.28 428.29
11 INT9238 Gene_expression of IL6 17 1575 0.78 1135.66 424.22
12 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
13 INT6056 Negative_regulation of Gene_expression of Fos 16 601 0.59 193.05 386.84
14 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
15 INT6580 Negative_regulation of Ptgs1 10 929 0.59 381.53 376.26
16 INT5660 Binding of Oprd1 4 477 0.48 71.86 342.06
17 INT16260 Gene_expression of Bdnf 3 671 0.78 283.44 339.1
18 INT5235 Negative_regulation of TNF 8 924 0.59 772.91 331.98
19 INT2649 Regulation of Calca 3 433 0.62 146.05 330.95
20 INT5059 Positive_regulation of TNF 3 1050 0.70 896.51 322.81
21 INT34869 Negative_regulation of PTGS2 14 778 0.59 366.76 319.85
22 INT5680 Gene_expression of Ngf 2 530 0.78 264.29 310.56
23 INT886 Gene_expression of Pomc 3 676 0.78 129.87 295.98
24 INT11624 Gene_expression of OPRM1 1 445 0.78 72.36 294.36
25 INT5379 Gene_expression of Fos 5 656 0.78 255.5 292.54
26 INT9158 Gene_expression of Tnf 9 722 0.78 522.01 277.68
27 INT9381 Positive_regulation of TRPV1 1 523 0.70 187.4 276.05
28 INT49750 Negative_regulation of CPOX 2 735 0.58 360.06 274.19
29 INT6852 Localization of TNF 3 883 0.81 705.95 270.84
30 INT5591 Regulation of Gene_expression of Fos 19 425 0.62 129.06 265.78
31 INT16868 Gene_expression of Il6 8 807 0.78 499.48 256.57
32 INT11377 Positive_regulation of Ngf 1 331 0.70 206.5 238
33 INT11009 Phosphorylation of Creb1 2 458 0.82 111.34 221.97
34 INT6293 Gene_expression of Oprm1 2 312 0.78 48.73 215.61
35 INT22548 Positive_regulation of Casp3 3 483 0.70 258.78 213.07
36 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
37 INT16259 Positive_regulation of Bdnf 1 336 0.70 183.48 209.82
38 INT48955 Gene_expression of Nos2 5 753 0.78 403.87 208.08
39 INT11313 Positive_regulation of Il6 16 526 0.70 331.27 201.59
40 INT50670 Gene_expression of CPOX 3 763 0.76 442.13 195.02
41 INT63934 Phosphorylation of Ephb1 1 377 0.82 150.52 188.66
42 INT94952 Positive_regulation of Mapk14 6 305 0.70 197.83 186.61
43 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
44 INT10194 Positive_regulation of IL6 7 702 0.70 600.62 183.38
45 INT49441 Negative_regulation of Cpox 3 494 0.59 303.22 177.46
46 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
47 INT1114 Localization of Ins1 4 748 0.80 192.95 165.48
48 INT4768 Positive_regulation of OPRM1 1 212 0.70 31.09 164.28
49 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
50 INT51921 Gene_expression of Cpox 6 501 0.73 229.81 157.81
51 INT66280 Gene_expression of Nos2 7 534 0.78 330.78 157.07
52 INT1303 Negative_regulation of Npr1 7 278 0.55 35.1 156.78
53 INT6042 Binding of Oprm1 2 248 0.48 31.77 154.34
54 INT13353 Positive_regulation of Tnf 10 332 0.70 248.75 148.1
55 INT3300 Positive_regulation of Gene_expression of Calca 3 179 0.70 77.76 144.2
56 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
57 INT90910 Phosphorylation of Grin1 5 150 0.82 68.23 139.24
58 INT48895 Gene_expression of Il10 6 333 0.78 221.2 138.52
59 INT11012 Positive_regulation of Creb1 4 258 0.70 84.4 132
60 INT48953 Positive_regulation of Nos2 8 486 0.70 239.85 131.87
61 INT5380 Positive_regulation of Gene_expression of Fos 2 243 0.70 105.65 131.05
62 INT65054 Positive_regulation of Nfkb1 4 285 0.70 149.33 126.73
63 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
64 INT14151 Gene_expression of Casp3 6 311 0.78 140.26 120.68
65 INT218 Positive_regulation of Th 1 245 0.70 40.5 120.1
66 INT64201 Negative_regulation of Trpv1 2 203 0.59 79.18 119.75
67 INT9235 Negative_regulation of Gene_expression of TNF 4 346 0.59 252.98 118.61
68 INT7341 Positive_regulation of Grin1 4 169 0.70 65.86 118.38
69 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
70 INT48593 Positive_regulation of NOS1 2 420 0.68 226.15 114.71
71 INT16253 Positive_regulation of Gene_expression of Bdnf 1 196 0.70 92.67 113.01
72 INT49651 Gene_expression of Creb1 5 276 0.78 114.77 111.96
73 INT48923 Gene_expression of Ephb1 1 211 0.77 106.23 109.9
74 INT11051 Positive_regulation of Gene_expression of IL6 7 415 0.69 319.21 109.3
75 INT8413 Gene_expression of Ptgs1 5 248 0.78 110.17 108.58
76 INT60526 Gene_expression of IL10 3 449 0.78 292.71 107.84
77 INT7627 Negative_regulation of Positive_regulation of Ltp 2 162 0.50 41.2 106.27
78 INT89054 Positive_regulation of Gene_expression of Trpv1 1 156 0.70 90.78 102.03
79 INT97701 Phosphorylation of Mapk14 2 191 0.82 115.33 100.46
80 INT52651 Positive_regulation of Prkaca 3 136 0.67 40.82 99.16
81 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
82 INT94953 Negative_regulation of Mapk14 2 156 0.59 104.77 91.51
83 INT77435 Positive_regulation of Nos2 4 343 0.70 208.49 91.43
84 INT10166 Localization of Tnf 3 237 0.81 153.95 88.64
85 INT7180 Negative_regulation of Trib3 4 180 0.51 68.48 88.01
86 INT1472 Positive_regulation of Ins1 3 349 0.69 146.2 86.36
87 INT5610 Positive_regulation of Insr 3 140 0.69 37.26 86.24
88 INT73340 Negative_regulation of Faah 3 134 0.59 38.67 85.03
89 INT10534 Positive_regulation of Trib3 2 209 0.60 78.75 81.48
90 INT7528 Regulation of OPRM1 1 100 0.62 20.63 80.57
91 INT99070 Gene_expression of Mapk14 2 147 0.78 103.99 79.59
92 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
93 INT48244 Gene_expression of Il4 3 172 0.76 132.38 73.42
94 INT79506 Gene_expression of Grin2b 4 122 0.78 43.71 73.42
95 INT63936 Positive_regulation of Phosphorylation of Ephb1 1 131 0.70 49.38 73.16
96 INT9236 Regulation of Gene_expression of TNF 6 204 0.62 162.66 72.99
97 INT10359 Gene_expression of Ifng 3 159 0.78 79.6 72.14
98 INT49111 Negative_regulation of Prkaca 3 102 0.59 27.44 71.77
99 INT58400 Negative_regulation of Tnf 4 182 0.59 129.97 71
100 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
101 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
102 INT19511 Localization of Il6 2 212 0.81 118.17 67.67
103 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
104 INT10706 Regulation of Il6 4 150 0.62 93.23 62.34
105 INT1169 Negative_regulation of Bche 9 322 0.59 149.22 61.27
106 INT9196 Gene_expression of PTGS1 2 215 0.77 96.99 60.5
107 INT546 Binding of ALB 1 311 0.48 85.98 60.14
108 INT55344 Gene_expression of Ros1 7 396 0.54 217.64 59.98
109 INT1536 Negative_regulation of NA 2 244 0.55 52.67 59.79
110 INT90911 Positive_regulation of Phosphorylation of Grin1 2 62 0.70 27.45 59.26
111 INT6477 Gene_expression of IL1RN 3 213 0.77 114.69 58.62
112 INT7340 Regulation of Grin1 2 87 0.62 30.37 57.93
113 INT48901 Negative_regulation of IL6 4 186 0.57 136.33 57.87
114 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
115 INT647 Gene_expression of SGCG 5 211 0.75 78.46 55.82
116 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
117 INT314 Positive_regulation of Ren 6 212 0.70 66.68 55.56
118 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
119 INT82650 Gene_expression of Bcl2 4 312 0.78 211.71 55.03
120 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
121 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
122 INT4891 Transcription of Calca 1 81 0.72 35.27 53.75
123 INT48952 Negative_regulation of Nos2 5 204 0.59 101.73 53.15
124 INT9234 Negative_regulation of Gene_expression of IL6 4 171 0.59 101.61 53.15
125 INT5759 Positive_regulation of Ptgs1 3 127 0.69 53.45 53.04
126 INT929 Positive_regulation of Oprl1 1 64 0.70 14.67 52.84
127 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
128 INT49017 Negative_regulation of Gene_expression of Nos2 1 169 0.59 80.64 52.67
129 INT22546 Positive_regulation of Gene_expression of Casp3 3 97 0.70 47.89 51.92
130 INT52264 Gene_expression of IK 3 180 0.77 90.87 51.87
131 INT48920 Negative_regulation of Ephb1 1 107 0.57 43.6 51.02
132 INT35975 Regulation of Cpox 4 109 0.39 57.88 49.69
133 INT6796 Positive_regulation of Jun 1 165 0.70 37.18 49.64
134 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
135 INT671 Positive_regulation of Cea 7 221 0.69 164.5 47.79
136 INT375 Positive_regulation of REN 3 293 0.70 152.46 47.55
137 INT2275 Negative_regulation of Localization of Ins1 2 183 0.59 51.02 44.94
138 INT8465 Regulation of Ptgs1 2 100 0.57 36.03 44.41
139 INT88617 Positive_regulation of Gene_expression of Creb1 2 90 0.69 51.69 44.29
140 INT5307 Regulation of Tnf 9 87 0.62 78.71 43.4
141 INT50957 Negative_regulation of Il6 4 134 0.59 79.08 42.67
142 INT85943 Negative_regulation of Nos2 3 161 0.59 108.56 42.65
143 INT48929 Regulation of Ephb1 1 71 0.62 24.42 42.11
144 INT64440 Gene_expression of Pnoc 1 66 0.78 13.61 41.76
145 INT16194 Binding of CNR1 1 82 0.48 20.75 39.59
146 INT2429 Negative_regulation of Mpo 2 128 0.59 93.76 39.57
147 INT11560 Positive_regulation of CASP3 2 236 0.70 184.33 39.38
148 INT1596 Negative_regulation of Oprl1 2 61 0.57 13.5 38.41
149 INT11439 Positive_regulation of Csf2 2 105 0.69 62.63 37.77
150 INT50673 Positive_regulation of Gene_expression of CPOX 2 156 0.54 97.31 37.03
151 INT9239 Regulation of Gene_expression of IL6 5 106 0.61 75.24 36.53
152 INT12029 Gene_expression of Car1 2 143 0.67 29.69 36.39
153 INT390 Positive_regulation of Agt 2 170 0.70 61.47 36.08
154 INT84260 Positive_regulation of Mapk8 1 124 0.69 72.84 35.98
155 INT53577 Negative_regulation of Localization of TNF 2 110 0.59 59.28 35.23
156 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
157 INT1163 Negative_regulation of Rbm39 1 64 0.29 16.8 34.74
158 INT7675 Gene_expression of ENG 2 146 0.77 45.35 34.6
159 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
160 INT2330 Regulation of CB 16 78 0.10 20.46 32.6
161 INT92837 Negative_regulation of Gene_expression of Nos2 2 116 0.59 59.67 31.82
162 INT1159 Negative_regulation of Agt 6 133 0.59 40.14 31.67
163 INT8027 Regulation of Gene_expression of Ngf 2 34 0.62 26.32 31.16
164 INT151111 Gene_expression of Pain1 1 33 0.40 33.6 30.73
165 INT719 Negative_regulation of SGCG 2 96 0.57 47.91 30.22
166 INT52690 Positive_regulation of Ptgs2 3 65 0.68 39.51 30.02
167 INT67912 Gene_expression of GRIN1 5 75 0.77 28.99 29.28
168 INT5300 Regulation of Insr 1 54 0.60 11.33 29.26
169 INT106540 Negative_regulation of Phosphorylation of Grin1 2 15 0.58 9.32 29.13
170 INT11010 Regulation of Phosphorylation of Creb1 1 52 0.62 7.26 29.04
171 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
172 INT67620 Negative_regulation of Gene_expression of Bdnf 2 53 0.59 22.45 28.5
173 INT9199 Positive_regulation of CEBPZ 2 111 0.67 30.99 28.45
174 INT7779 Negative_regulation of Adra2a 3 47 0.58 9.45 28
175 INT74726 Negative_regulation of Slc6a4 1 61 0.59 21.01 27.84
176 INT5923 Negative_regulation of Rtn4 4 50 0.36 24.19 27.2
177 INT90313 Negative_regulation of Gene_expression of Casp3 1 57 0.57 22.23 26.77
178 INT3760 Positive_regulation of ALB 4 142 0.70 87.46 26.7
179 INT52801 Regulation of Gene_expression of Tnf 1 55 0.62 48.74 26.59
180 INT5378 Regulation of Gene_expression of Fos 2 47 0.60 14.47 26.41
181 INT22066 Gene_expression of Phax 1 40 0.78 22.51 25.91
182 INT11159 Gene_expression of EGFR 1 698 0.78 548.93 25.69
183 INT100423 Gene_expression of Bax 4 141 0.75 98.43 24.48
184 INT89854 Regulation of Nos2 3 49 0.61 42.58 24.1
185 INT9155 Gene_expression of Glul 2 60 0.77 17.97 23.95
186 INT13145 Positive_regulation of Car1 3 60 0.70 16.32 23.23
187 INT29704 Regulation of Casp3 2 51 0.56 22.13 22.79
188 INT11077 Positive_regulation of Htr3a 1 63 0.67 15.61 22.7
189 INT106175 Positive_regulation of Positive_regulation of Creb1 2 37 0.70 13.89 22.46
190 INT66753 Negative_regulation of Positive_regulation of Tnf 1 45 0.59 35.28 22.33
191 INT15326 Phosphorylation of Trib3 2 83 0.55 30.96 22.27
192 INT2911 Positive_regulation of Glul 1 36 0.70 11.09 22.07
193 INT11893 Positive_regulation of Ptger2 3 96 0.69 31.49 21.92
194 INT72060 Positive_regulation of Gene_expression of Ros1 1 127 0.41 76.76 20.91
195 INT3593 Gene_expression of ADRA1D 3 70 0.75 29.48 20.87
196 INT102281 Positive_regulation of Gene_expression of Grin2b 2 27 0.70 10.38 20.84
197 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
198 INT17848 Binding of PTGS2 1 70 0.46 32.1 20.6
199 INT61159 Regulation of Gene_expression of Creb1 3 46 0.62 24.07 20.52
200 INT66281 Transcription of Nos2 3 81 0.71 39.49 20.37
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