J:Ann. Neurol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT108727 Binding of ATP1A2 and CACNA1A 2 1 0.34 1.97 1.37
2 INT108729 Binding of CACNA1A and Cacna1a 3 1 0.13 1.21 0.95
3 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 1 0.10 0.97 0.64
4 INT48303 MBP Positive_regulation of PLP1 1 1 0.10 0.97 0.64
5 INT87605 Binding of FOS and Penk 1 1 0.07 0.78 0.4
6 INT87604 FOS Regulation of Penk 1 1 0.09 0.76 0.39
7 INT87603 Binding of FOS and Jund 1 1 0.03 0.77 0.39
8 INT60524 IFNGR2 Positive_regulation of FERMT2 1 1 0.04 1.87 0.25
9 INT60523 Binding of IL1B and TNFRSF1A 1 1 0.25 1.73 0.21
10 INT95125 Binding of KCNA6 and SGCG 1 1 0.40 2.73 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
3 INT797 Regulation of Penk 4 812 0.62 111.13 542.24
4 INT5228 Positive_regulation of Fos 1 934 0.70 209.8 503.87
5 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
6 INT1395 Negative_regulation of Penk 4 537 0.59 87.33 389.81
7 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
8 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
9 INT9158 Gene_expression of Tnf 4 722 0.78 522.01 277.68
10 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
11 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
12 INT5501 Regulation of Oprd1 1 283 0.62 55.1 249.9
13 INT5597 Gene_expression of Pdyn 1 433 0.78 62.97 235.47
14 INT1665 Positive_regulation of Pag1 1 270 0.68 186.63 229.87
15 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
16 INT1212 Binding of Oprl1 3 312 0.48 28.6 225.15
17 INT11009 Phosphorylation of Creb1 3 458 0.82 111.34 221.97
18 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
19 INT49441 Negative_regulation of Cpox 1 494 0.59 303.22 177.46
20 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
21 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
22 INT5050 Regulation of Localization of Calca 1 149 0.62 41.25 148.57
23 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
24 INT11012 Positive_regulation of Creb1 4 258 0.70 84.4 132
25 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
26 INT11011 Positive_regulation of Phosphorylation of Creb1 1 190 0.70 49.25 112.01
27 INT49651 Gene_expression of Creb1 1 276 0.78 114.77 111.96
28 INT27096 Positive_regulation of Nfkb1 2 325 0.70 195.11 109.06
29 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
30 INT114 Binding of Oprl1 4 139 0.48 23 103.35
31 INT4742 Gene_expression of Tac1 1 177 0.78 69.99 102.66
32 INT397 Localization of SST 3 232 0.81 58.05 101.19
33 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
34 INT97701 Phosphorylation of Mapk14 2 191 0.82 115.33 100.46
35 INT65500 Gene_expression of App 1 605 0.78 429.94 98.31
36 INT4860 Positive_regulation of CALCA 10 148 0.00 73.35 97.61
37 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
38 INT6437 Binding of YY1 1 154 0.47 26.3 90.46
39 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
40 INT2289 Gene_expression of PENK 6 203 0.78 55.62 79.49
41 INT3657 Gene_expression of Ins1 2 514 0.78 321.69 75.76
42 INT5056 Gene_expression of IFNG 4 216 0.78 137.52 74.57
43 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
44 INT5852 Gene_expression of Penk 1 167 0.78 44.44 71.13
45 INT49995 Positive_regulation of Gene_expression of Tnf 2 187 0.70 125.07 70.54
46 INT4960 Positive_regulation of CSF2 2 285 0.70 256.73 65.73
47 INT8347 Gene_expression of SST 1 181 0.78 104.59 65.45
48 INT83419 Gene_expression of Mors1 1 57 0.68 12.11 63.66
49 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
50 INT14740 Gene_expression of TGFB1 8 272 0.78 168.48 60.18
51 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
52 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
53 INT16258 Gene_expression of Ntf3 6 121 0.78 53.93 59.03
54 INT5356 Positive_regulation of FOS 1 153 0.69 54.21 56.74
55 INT1463 Binding of Pomc 2 129 0.48 15.89 56.27
56 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
57 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
58 INT5759 Positive_regulation of Ptgs1 1 127 0.69 53.45 53.04
59 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
60 INT789 Positive_regulation of YY1 1 69 0.67 14.07 47.06
61 INT108726 Binding of Mors1 1 38 0.33 7.08 43.62
62 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
63 INT68975 Gene_expression of Mmp9 4 111 0.78 79.57 38.55
64 INT13501 Binding of Drd2 1 65 0.48 23.76 35.6
65 INT59466 Gene_expression of ISYNA1 4 204 0.77 112.57 35.48
66 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
67 INT3913 Positive_regulation of ABAT 2 47 0.69 22.73 33.4
68 INT691 Binding of SST 1 67 0.48 24.66 32.67
69 INT7692 Positive_regulation of PENK 1 71 0.70 20.34 32.54
70 INT9993 Positive_regulation of Gene_expression of IL2 2 131 0.69 46.27 30.04
71 INT68973 Positive_regulation of Mmp9 3 89 0.52 58.56 30.04
72 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
73 INT1990 Positive_regulation of Ean5 1 35 0.41 38.05 28.8
74 INT87212 Negative_regulation of Positive_regulation of Nfkb1 2 74 0.57 38.21 28.31
75 INT5653 Positive_regulation of ELANE 2 136 0.70 72.78 27.94
76 INT17739 Gene_expression of S100B 1 226 0.78 132.7 26.4
77 INT76095 Positive_regulation of ISYNA1 1 117 0.55 79.73 25.86
78 INT9781 Binding of INSRR 4 64 0.31 19.1 25.2
79 INT17275 Gene_expression of HIVEP1 2 267 0.75 232.07 24.06
80 INT9292 Positive_regulation of SGCG 1 93 0.67 35.13 23.48
81 INT21344 Negative_regulation of Penk 3 34 0.57 8.83 23.32
82 INT100026 Gene_expression of Tnfrsf1b 2 73 0.72 43.26 23.23
83 INT61160 Negative_regulation of Gene_expression of Creb1 1 37 0.59 17.95 23.17
84 INT5055 Positive_regulation of IFNG 2 89 0.69 64.03 23.05
85 INT50970 Positive_regulation of Ntrk1 1 51 0.57 29.38 22.83
86 INT15326 Phosphorylation of Trib3 1 83 0.55 30.96 22.27
87 INT14731 Positive_regulation of TGFB1 2 78 0.67 52.57 22.23
88 INT14733 Positive_regulation of Gene_expression of TGFB1 1 71 0.69 49.89 22.2
89 INT693 Negative_regulation of Localization of SST 3 46 0.59 8.57 21.75
90 INT11161 Gene_expression of HLA-DRB1 1 121 0.78 75.33 20.96
91 INT125411 Negative_regulation of Phosphorylation of Mapk14 2 31 0.57 18.55 19.98
92 INT12031 Negative_regulation of Car1 4 44 0.59 20.46 19.36
93 INT11243 Localization of NPY 1 33 0.78 11.18 19.24
94 INT56301 Positive_regulation of IL4 1 68 0.56 54.51 18.65
95 INT78024 Gene_expression of ACLY 2 73 0.75 59.15 18.54
96 INT7056 Positive_regulation of Gene_expression of PENK 1 35 0.70 14.31 18.21
97 INT3364 Binding of SGCG 1 87 0.47 31.93 17.24
98 INT7580 Positive_regulation of Mbp 1 54 0.70 23.37 17.14
99 INT8530 Transcription of Penk 1 48 0.70 11.67 16.34
100 INT6110 Negative_regulation of Gene_expression of Ins1 2 83 0.56 60.59 16.07
101 INT2383 Positive_regulation of CP 1 33 0.67 25.41 15.38
102 INT16166 Positive_regulation of DMD 1 348 0.67 133.22 15.06
103 INT7413 Positive_regulation of Localization of SST 1 37 0.69 5.64 13.94
104 INT18012 Gene_expression of EPO 1 169 0.78 108.36 13.75
105 INT73594 Positive_regulation of Gene_expression of ISYNA1 2 61 0.55 31.35 13.45
106 INT1125 Positive_regulation of IGHG3 2 130 0.69 112.07 13.18
107 INT75224 Positive_regulation of Gene_expression of Ntf3 1 23 0.69 11.79 13.08
108 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
109 INT5987 Positive_regulation of Positive_regulation of Oprl1 1 11 0.49 2.81 12.57
110 INT1612 Regulation of Binding of Oprl1 1 19 0.62 2.34 12.45
111 INT541 Positive_regulation of MBP 7 31 0.67 28.56 12.24
112 INT13409 Gene_expression of NEUROD1 1 52 0.75 14.17 12.23
113 INT107539 Gene_expression of Csad 1 7 0.66 8.32 12.13
114 INT16255 Negative_regulation of Ntf3 2 21 0.51 12.92 11.93
115 INT15238 Positive_regulation of NPY 2 24 0.67 11.86 11.26
116 INT19944 Negative_regulation of IFNG 1 39 0.58 22.35 10.91
117 INT91932 Positive_regulation of Scn10a 1 18 0.67 10.39 10.9
118 INT5854 Regulation of Gene_expression of Penk 1 22 0.61 6.91 10.03
119 INT17283 Positive_regulation of CSF1 2 37 0.59 24.16 10.01
120 INT74812 Negative_regulation of Positive_regulation of Cpox 1 17 0.34 10.1 9.94
121 INT36212 Positive_regulation of Csad 2 11 0.61 12.31 9.94
122 INT17741 Gene_expression of MBP 2 67 0.78 23.67 9.65
123 INT21214 Negative_regulation of Gene_expression of PENK 2 21 0.58 9.14 9.53
124 INT71878 Protein_catabolism of Nfkb1 1 24 0.65 10.85 9.46
125 INT4929 Binding of Mbp 3 25 0.48 18.01 9.41
126 INT20664 Binding of ACE 2 60 0.48 35.27 9.16
127 INT1118 Gene_expression of C6orf25 1 73 0.77 47.24 9.1
128 INT23264 Negative_regulation of Positive_regulation of Ptgs1 1 16 0.39 8.47 8.9
129 INT70017 Positive_regulation of BCL2 2 87 0.67 66.62 8.68
130 INT80872 Protein_catabolism of Nfkbia 1 28 0.92 10.56 8.62
131 INT67037 Gene_expression of Sod1 4 121 0.78 59.32 7.99
132 INT42707 Gene_expression of Tbce 1 24 0.65 12.92 7.93
133 INT73323 Negative_regulation of Scn10a 1 13 0.58 5.77 7.85
134 INT87623 Gene_expression of PPT1 1 9 0.75 5.32 7.65
135 INT74629 Gene_expression of Mmp7 1 17 0.55 12.78 7.58
136 INT73508 Negative_regulation of Gene_expression of ISYNA1 2 32 0.51 19.67 7.57
137 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 1 21 0.54 8.92 7.38
138 INT81541 Negative_regulation of Nfkbia 1 12 0.51 5.73 6.79
139 INT60527 Transcription of IL10 1 16 0.56 13.57 6.42
140 INT48541 Positive_regulation of Kcna5 1 12 0.69 5.51 6.35
141 INT92662 Negative_regulation of Gene_expression of Ntf3 3 9 0.57 7.44 6.22
142 INT48313 Binding of NTRK1 2 19 0.47 14.44 6.12
143 INT24724 Positive_regulation of Gene_expression of SST 1 11 0.67 7.51 6.12
144 INT48308 Binding of PLP1 1 7 0.48 9.59 6.09
145 INT12631 Positive_regulation of Binding of INSRR 1 11 0.45 6.13 6.04
146 INT8910 Negative_regulation of Qrfp 1 10 0.53 2.8 6.02
147 INT33612 Binding of NTS 1 16 0.46 4.65 6
148 INT15132 Gene_expression of TNFRSF1A 1 33 0.75 20.09 5.93
149 INT185 Regulation of Cyp1a1 1 18 0.54 2.71 5.56
150 INT56299 Transcription of IL4 1 15 0.64 10.2 5.44
151 INT58972 Gene_expression of BHLHE23 1 10 0.65 2.97 5.1
152 INT48307 Positive_regulation of PLP1 4 5 0.66 8.42 5.09
153 INT186 Positive_regulation of Cyp1a1 1 30 0.70 5 5.02
154 INT104356 Negative_regulation of Pgp 1 15 0.43 6.64 4.89
155 INT1991 Gene_expression of Ean5 2 7 0.60 6.97 4.84
156 INT24889 Negative_regulation of CABIN1 1 36 0.48 16.76 4.73
157 INT20055 Gene_expression of CRTAC1 1 19 0.58 15.49 4.73
158 INT48246 Gene_expression of PLP1 2 18 0.64 10.33 4.73
159 INT59464 Regulation of ISYNA1 1 21 0.43 12.15 4.63
160 INT78659 Gene_expression of Thim 1 17 0.28 14.34 4.4
161 INT15275 Binding of Pmp2 1 11 0.37 6.43 4.32
162 INT42317 Negative_regulation of Dlat 1 21 0.43 3.13 4.11
163 INT78023 Gene_expression of DDX41 3 13 0.65 23.55 3.84
164 INT23088 Phosphorylation of Tnf 1 15 0.79 9.85 3.82
165 INT52227 Gene_expression of CD9 1 11 0.75 6.23 3.71
166 INT536 Binding of MBP 1 17 0.48 6.52 3.56
167 INT56300 Negative_regulation of Gene_expression of TGFB1 1 13 0.41 4.87 3.5
168 INT68974 Localization of Mmp9 1 10 0.80 4.84 3.35
169 INT52899 Positive_regulation of TNFRSF1A 1 16 0.46 19.04 3.34
170 INT51607 Positive_regulation of DES 1 33 0.67 32.24 3.29
171 INT22949 Gene_expression of CCBE1 1 8 0.19 4.27 3.25
172 INT81955 Positive_regulation of SPTLC1 1 12 0.70 10.25 3.12
173 INT33857 Negative_regulation of NTS 1 6 0.42 4.98 3.07
174 INT108728 Regulation of ATP1A2 1 4 0.45 3.65 3.04
175 INT85572 Gene_expression of Cacna1a 2 11 0.66 5.72 3.02
176 INT64386 Binding of Cyp11a1 1 13 0.46 5.09 3.01
177 INT9130 Negative_regulation of TGFB1 1 16 0.41 12.21 2.92
178 INT45503 Binding of EPO 2 42 0.48 24.85 2.88
179 INT15555 Localization of PLP1 1 6 0.60 3.35 2.75
180 INT5757 Gene_expression of SCN4A 2 6 0.75 1.73 2.73
181 INT62487 Localization of HIVEP1 1 35 0.73 36.24 2.72
182 INT93401 Positive_regulation of Protein_catabolism of Nfkbia 1 11 0.46 3.89 2.7
183 INT80319 Negative_regulation of Negative_regulation of Car1 2 3 0.59 2 2.58
184 INT8111 Localization of EPO 2 32 0.81 19.53 2.54
185 INT12485 Binding of DNAH8 1 17 0.48 4.24 2.54
186 INT133262 Negative_regulation of Csad 2 5 0.50 2.03 2.51
187 INT56918 Negative_regulation of TAT 1 11 0.57 5.92 2.44
188 INT9159 Negative_regulation of Regulation of Penk 2 7 0.43 3.05 2.41
189 INT21726 Gene_expression of Tfrc 1 10 0.74 7.38 2.36
190 INT5756 Gene_expression of KCNN1 3 7 0.59 1.07 2.29
191 INT3151 Localization of MBP 2 27 0.80 7.58 2.28
192 INT74628 Positive_regulation of Mmp7 1 8 0.25 4.19 2.27
193 INT101937 Negative_regulation of Protein_catabolism of Nfkb1 1 6 0.19 3.21 2.21
194 INT30137 Negative_regulation of TPP1 1 5 0.37 0.96 2.2
195 INT95128 Positive_regulation of KCNA1 1 8 0.41 4.28 2.19
196 INT25265 Transcription of HIVEP1 2 30 0.45 28.12 2.08
197 INT19409 Binding of Cyp1a1 1 12 0.48 2.58 1.97
198 INT106153 Gene_expression of HJURP 1 5 0.04 2.33 1.85
199 INT5758 Transcription of KCNN1 4 5 0.67 0.76 1.85
200 INT24173 Negative_regulation of FCGR3A 1 6 0.40 2.69 1.81
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