J:Annals of the Rheumatic Diseases

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
2 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
3 INT155484 Binding of CD86 and CTLA4 15 1 0.52 8.85 6.09
4 INT194647 Binding of CD28 and CD80 15 1 0.40 4.9 3.22
5 INT186126 Binding of CD28 and CTLA4 9 1 0.52 4.13 3.12
6 INT350148 Binding of IL12A and ERAL1 1 5 0.21 8.23 2.26
7 INT194646 Binding of CD28 and CD86 7 1 0.40 2.69 2.21
8 INT197092 TNF Regulation of VEGFA 4 1 0.21 2.78 1.22
9 INT329956 Binding of IL2 and IL23R 1 2 0.33 4.58 1.21
10 INT329962 Binding of C5 and HEPACAM 1 2 0.03 2.25 1.06
11 INT353741 Binding of IGHE and Aia1 1 2 0.00 1.16 1.06
12 INT329959 Binding of TRAF1 and HEPACAM 1 2 0.03 2.25 1.06
13 INT248271 IL6 Regulation of Gene_expression of Crp 3 1 0.27 1.7 0.73
14 INT248244 Binding of IL8 and SDC2 1 1 0.02 1.57 0.72
15 INT329957 Binding of STAT4 and HEPACAM 1 1 0.03 1.41 0.7
16 INT329297 Binding of Cd226 and Aff3 1 3 0.18 1.54 0.64
17 INT329961 Binding of IL2RA and PTPN22 1 1 0.35 1.87 0.63
18 INT329963 Binding of IL21 and IL23R 1 1 0.30 2.28 0.6
19 INT350147 Binding of LPP and SH2B3 1 1 0.36 1.82 0.55
20 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 1 0.47 0.57 0.55
21 INT350144 Binding of LPP and NAA25 1 1 0.25 1.83 0.55
22 INT350169 Binding of DMD and MRI1 1 3 0.11 3.08 0.54
23 INT350150 Binding of LPP and ATXN2 1 1 0.35 1.82 0.54
24 INT149121 Binding of CD80 and Cd28 2 1 0.04 0.95 0.46
25 INT248310 Crx Regulation of MATN3 1 1 0.07 0.65 0.45
26 INT329960 Binding of C5 and TRAF1 1 2 0.32 1.04 0.42
27 INT248239 Binding of FN1 and SDC3 1 1 0.00 0.77 0.42
28 INT248242 Binding of COL7A1 and SDC1 1 1 0.00 0.76 0.41
29 INT353730 Binding of FCGR2A and FCGR3A 1 1 0.33 0.5 0.41
30 INT329958 Binding of C5 and STAT4 1 1 0.33 0.93 0.41
31 INT248236 Binding of FN1 and SDC1 1 1 0.00 0.76 0.41
32 INT248243 Binding of COL7A1 and SDC3 1 1 0.00 0.76 0.41
33 INT329955 Binding of STAT4 and TRAF1 1 1 0.38 0.93 0.4
34 INT329954 Binding of PRKCQ and SNRNP70 1 1 0.07 0.65 0.33
35 INT328224 Col2a1 Positive_regulation of Gene_expression of Mmp13 1 1 0.04 0.8 0.29
36 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 1 0.07 0.69 0.29
37 INT350145 Binding of SNRNP70 and ERAL1 1 1 0.05 1.29 0.28
38 INT328222 Mmp2 Regulation of Positive_regulation of Mmp13 1 1 0.05 0.69 0.28
39 INT248318 RETN Regulation of VEGFA 1 1 0.00 0.43 0.26
40 INT248238 Binding of SDC2 and SDC3 1 1 0.01 0.36 0.26
41 INT328205 Binding of PSG5 and PSORS4 1 1 0.01 0.5 0.25
42 INT328204 Binding of DSG3 and PSORS4 1 1 0.00 0.5 0.25
43 INT350146 Binding of IL12A and RS1 1 1 0.01 0.97 0.23
44 INT350151 Binding of SNRNP70 and SH2B3 1 1 0.13 1.22 0.2
45 INT350152 Binding of ATXN2 and SNRNP70 1 1 0.13 1.22 0.2
46 INT248237 Binding of IL8 and SDC3 1 1 0.02 0.52 0.18
47 INT350149 SH2B3 Regulation of CD8A 1 1 0.13 0.86 0.17
48 INT156195 Binding of GEM and Kir3dl1 1 1 0.01 0.17 0.17
49 INT156196 Binding of GEM and Kir3dl2 1 1 0.02 0.17 0.17
50 INT248259 Binding of HSPG2 and Gtf3a 1 1 0.00 0.33 0.12
51 INT350164 Binding of DURS1 and ELOVL1 1 1 0.00 1.47 0.11
52 INT350163 Regulation of Binding of DURS1 and ELOVL1 1 1 0.00 1.48 0.11
53 INT248240 SDC3 Positive_regulation of Localization of CD68 1 1 0.05 0 0
54 INT248298 Binding of Cd40 and Rf 1 1 0.08 0 0
55 INT350168 Binding of DMD and PROC 1 1 0.00 0.67 0
56 INT168385 Il6 Regulation of TNF 1 1 0.49 0.3 0
57 INT149120 Binding of CTLA4 and Cd28 1 1 0.03 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 22 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 23 1575 0.78 1135.66 424.22
3 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
4 INT5235 Negative_regulation of TNF 6 924 0.59 772.91 331.98
5 INT5059 Positive_regulation of TNF 11 1050 0.70 896.51 322.81
6 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
7 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
8 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
9 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
10 INT16868 Gene_expression of Il6 4 807 0.78 499.48 256.57
11 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
12 INT6481 Binding of TNF 7 624 0.48 510.2 214.82
13 INT6482 Positive_regulation of Gene_expression of TNF 8 659 0.70 569.88 210
14 INT11313 Positive_regulation of Il6 2 526 0.70 331.27 201.59
15 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
16 INT10194 Positive_regulation of IL6 10 702 0.70 600.62 183.38
17 INT49441 Negative_regulation of Cpox 7 494 0.59 303.22 177.46
18 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
19 INT15516 Gene_expression of Crp 29 711 0.77 615.33 173.09
20 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
21 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
22 INT15515 Positive_regulation of Crp 5 700 0.70 604.24 150.15
23 INT9660 Regulation of TNF 4 363 0.62 312.94 139.99
24 INT5497 Positive_regulation of Crh 1 299 0.70 125.54 131.14
25 INT49439 Gene_expression of Cpox 36 508 0.73 326.97 130.17
26 INT1878 Binding of HLA-B 5 440 0.48 321.16 127.36
27 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
28 INT17612 Gene_expression of CRP 5 676 0.78 580.61 119.03
29 INT9235 Negative_regulation of Gene_expression of TNF 6 346 0.59 252.98 118.61
30 INT11051 Positive_regulation of Gene_expression of IL6 4 415 0.69 319.21 109.3
31 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
32 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
33 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
34 INT9236 Regulation of Gene_expression of TNF 2 204 0.62 162.66 72.99
35 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
36 INT170332 Gene_expression of IFN1@ 2 477 0.75 275.21 69.65
37 INT15514 Negative_regulation of Crp 9 275 0.59 194.6 64.86
38 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
39 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
40 INT11318 Gene_expression of Gtf3a 2 274 0.52 183.82 60.89
41 INT48901 Negative_regulation of IL6 11 186 0.57 136.33 57.87
42 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
43 INT96937 Gene_expression of Mmp9 1 191 0.75 150.3 56.01
44 INT9234 Negative_regulation of Gene_expression of IL6 2 171 0.59 101.61 53.15
45 INT9210 Regulation of IL6 5 166 0.62 125.61 49.95
46 INT22454 Regulation of Crp 3 213 0.62 160.67 49.24
47 INT22454 Regulation of Crp 2 213 0.62 160.67 49.24
48 INT117598 Regulation of ACR 4 118 0.26 41.25 48.01
49 INT2774 Binding of Crp 4 241 0.48 195.89 44.39
50 INT4216 Gene_expression of CD40LG 3 328 0.78 256.02 44.23
51 INT69992 Negative_regulation of Hmox2 1 93 0.50 49.01 44.07
52 INT115384 Positive_regulation of Mmp9 1 121 0.68 94.74 43.02
53 INT50957 Negative_regulation of Il6 3 134 0.59 79.08 42.67
54 INT13354 Transcription of TNF 3 108 0.72 85.81 42.32
55 INT29496 Gene_expression of MMP3 2 136 0.75 49.49 41.78
56 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
57 INT163134 Gene_expression of ACR 3 78 0.65 30.39 38.48
58 INT9239 Regulation of Gene_expression of IL6 6 106 0.61 75.24 36.53
59 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
60 INT53475 Gene_expression of MRI1 1 116 0.59 77.68 33.98
61 INT67039 Positive_regulation of Cpox 4 144 0.65 98.4 33.77
62 INT132161 Gene_expression of MTX1 5 48 0.58 26.55 32.32
63 INT9655 Regulation of Il6 2 98 0.62 70.92 31.95
64 INT166203 Positive_regulation of Cia1 1 62 0.43 75.94 31.37
65 INT17886 Negative_regulation of Il1 3 95 0.57 70.91 31.25
66 INT145594 Gene_expression of Mtx1 1 64 0.57 35.33 30.35
67 INT145594 Gene_expression of Mtx1 4 64 0.57 35.33 30.35
68 INT169180 Binding of SNRNP70 8 204 0.47 119.1 29.3
69 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
70 INT3841 Gene_expression of FCGR3B 1 117 0.75 58.99 28.87
71 INT59449 Negative_regulation of Timp1 1 76 0.42 54.86 26.99
72 INT9647 Gene_expression of PROC 1 163 0.65 89.76 26.75
73 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
74 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
75 INT93717 Gene_expression of Mmp3 1 85 0.78 33.95 24.89
76 INT64185 Gene_expression of TNFRSF11A 1 131 0.76 75.15 24.73
77 INT86295 Gene_expression of Mmp2 2 114 0.76 73.68 24.25
78 INT25607 Binding of Il1 1 82 0.47 64.4 23.9
79 INT58288 Positive_regulation of Gene_expression of Crp 4 83 0.61 82.23 23.7
80 INT63419 Gene_expression of PTGES 2 109 0.77 40.83 23.67
81 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
82 INT48081 Localization of Il1b 2 46 0.80 21.59 22.4
83 INT69993 Positive_regulation of Gene_expression of Cpox 10 93 0.55 69.4 22.05
84 INT96156 Gene_expression of Cd40 10 144 0.77 56.95 21.7
85 INT170313 Gene_expression of Mmp1a 8 50 0.65 38.53 21.36
86 INT11346 Binding of Mtx1 1 39 0.41 24.88 21.21
87 INT116282 Gene_expression of Mmp13 19 83 0.75 45.4 20.18
88 INT76336 Negative_regulation of PDE5A 1 192 0.59 112.02 20.09
89 INT78990 Regulation of Cpox 1 72 0.57 35.22 18.16
90 INT4067 Negative_regulation of Esr1 3 97 0.50 43.45 17.52
91 INT2120 Gene_expression of CD79A 2 159 0.78 111.69 17.16
92 INT38056 Localization of Crp 2 71 0.78 53.14 17.03
93 INT10834 Binding of IL8 2 65 0.48 41.66 16.53
94 INT99898 Gene_expression of Mmp14 1 37 0.56 28.54 16.39
95 INT1214 Gene_expression of PGE 3 70 0.72 29.07 16.22
96 INT24670 Gene_expression of FGF2 1 121 0.78 85.64 15.12
97 INT16166 Positive_regulation of DMD 6 348 0.67 133.22 15.06
98 INT49532 Regulation of Gene_expression of Il6 1 43 0.61 25.8 14.99
99 INT1284 Negative_regulation of Mmp13 26 20 0.57 36.21 14.91
100 INT3545 Positive_regulation of Mtx1 3 27 0.42 11.97 14.83
101 INT180497 Binding of MRI1 1 45 0.42 28.35 14.77
102 INT16321 Gene_expression of Cd3e 2 111 0.72 49.9 14.21
103 INT91544 Gene_expression of CHI3L1 1 60 0.75 77.72 13.9
104 INT34904 Negative_regulation of Gtf3a 2 48 0.15 38.88 13.73
105 INT19399 Gene_expression of Rf 9 43 0.36 33.39 13.53
106 INT132178 Binding of CD80 1 41 0.47 15.55 12.98
107 INT195226 Positive_regulation of ACR 1 23 0.26 7.85 12.62
108 INT122812 Gene_expression of SNRNP70 2 130 0.75 67 12.5
109 INT12084 Regulation of Localization of IL6 1 36 0.61 20.32 12.34
110 INT176453 Negative_regulation of Cia1 1 23 0.14 28.27 12.33
111 INT520 Binding of Comt 1 24 0.48 8.98 12.21
112 INT148207 Gene_expression of CTLA4 1 53 0.77 29.13 12.07
113 INT83611 Negative_regulation of Gene_expression of Cpox 9 55 0.29 31.09 11.5
114 INT80756 Gene_expression of CD86 1 77 0.77 46.68 11.36
115 INT158070 Localization of Aes 4 23 0.65 19.93 10.9
116 INT94454 Gene_expression of CD68 1 73 0.72 63.94 10.43
117 INT19620 Binding of CD86 1 30 0.47 12.01 9.89
118 INT106510 Gene_expression of Ptges 27 70 0.75 36.18 9.75
119 INT140191 Positive_regulation of Gene_expression of Mmp13 1 25 0.67 13.47 9.71
120 INT11047 Positive_regulation of Positive_regulation of IL6 2 45 0.66 28.7 9.37
121 INT76860 Gene_expression of HSPG2 9 32 0.65 37.14 9.06
122 INT22285 Negative_regulation of Mtx1 1 16 0.49 7.84 8.98
123 INT92822 Negative_regulation of Gene_expression of Crp 2 36 0.49 29.5 8.83
124 INT12861 Gene_expression of Cish 1 40 0.57 23.01 8.48
125 INT132278 Binding of CTLA4 4 32 0.39 18.69 8.17
126 INT39301 Gene_expression of Chd7 1 50 0.26 27.06 8.13
127 INT150422 Positive_regulation of Aes 3 24 0.43 15.63 8
128 INT24232 Localization of Mtx1 3 24 0.65 8.06 7.99
129 INT15687 Regulation of ESR1 3 91 0.60 40.42 7.95
130 INT17996 Binding of Crp 1 40 0.37 31.4 7.8
131 INT93914 Gene_expression of CD80 1 70 0.75 36.35 7.74
132 INT48077 Positive_regulation of Localization of Il1b 1 17 0.69 8.8 7.68
133 INT65489 Regulation of Gene_expression of Crp 3 28 0.59 29.17 7.56
134 INT66318 Gene_expression of NR3C1 1 26 0.76 20 7.55
135 INT100497 Gene_expression of Aia1 1 9 0.25 11.78 7.51
136 INT74326 Gene_expression of Crhr1 1 25 0.66 9.7 7.48
137 INT153794 Gene_expression of Ctsk 4 51 0.77 24.99 7.28
138 INT93003 Binding of CD40 2 28 0.47 20.25 7.13
139 INT168381 Positive_regulation of Mmp3 2 24 0.58 19.12 7.03
140 INT1124 Negative_regulation of CD40LG 2 53 0.57 36.26 7
141 INT52180 Binding of Aes 1 38 0.42 23.16 6.7
142 INT166707 Protein_catabolism of Col7a1 1 24 0.74 20.47 6.39
143 INT168383 Positive_regulation of Mmp13 1 27 0.67 17.9 6.27
144 INT168383 Positive_regulation of Mmp13 1 27 0.67 17.9 6.27
145 INT172084 Positive_regulation of Binding of TNF 1 21 0.50 15.31 6.06
146 INT1126 Negative_regulation of CD79A 1 46 0.59 31.07 6
147 INT329292 Gene_expression of Aff3 2 3 0.54 3.24 5.87
148 INT52819 Negative_regulation of NR3C1 1 14 0.50 7.22 5.84
149 INT87470 Gene_expression of SDC1 5 27 0.78 24.86 5.81
150 INT3838 Regulation of FCGR3B 1 16 0.60 6.67 5.53
151 INT13396 Gene_expression of DMD 2 125 0.75 57.81 5.45
152 INT138157 Regulation of Mmp3 1 12 0.54 6.12 5.36
153 INT102547 Gene_expression of Cd68 3 25 0.75 14.47 5.22
154 INT85653 Regulation of Gene_expression of Cpox 4 24 0.24 20.55 5.22
155 INT143925 Negative_regulation of Ptges 1 18 0.42 10.5 5.18
156 INT67597 Negative_regulation of Das 4 17 0.37 9.95 5.05
157 INT25831 Gene_expression of NR4A2 1 20 0.74 2.73 4.92
158 INT211133 Negative_regulation of MTX1 1 8 0.19 3.86 4.87
159 INT62291 Gene_expression of PTGES2 1 14 0.68 8.34 4.75
160 INT100912 Regulation of Kdm5d 1 52 0.32 20.39 4.72
161 INT164171 Gene_expression of Cd163 4 18 0.49 12.45 4.63
162 INT9837 Negative_regulation of Rf 4 12 0.11 8.41 4.55
163 INT98251 Binding of IL12A 1 20 0.37 16.03 4.51
164 INT50309 Binding of Il1a 2 22 0.40 5.4 4.49
165 INT146355 Negative_regulation of Aes 3 15 0.51 7.83 4.25
166 INT139533 Binding of Il23r 2 17 0.47 7.67 4.14
167 INT76149 Gene_expression of Das 1 18 0.37 6.55 3.92
168 INT6507 Binding of C5 3 23 0.48 15.35 3.91
169 INT27303 Binding of FCGR3B 3 26 0.46 5.15 3.86
170 INT14778 Gene_expression of FCGR3A 2 25 0.75 16.25 3.86
171 INT86293 Positive_regulation of Gene_expression of Mmp2 1 21 0.64 11.69 3.79
172 INT136106 Gene_expression of DNMT3B 1 30 0.58 8.43 3.7
173 INT149332 Gene_expression of CD163 1 19 0.75 13.63 3.65
174 INT16165 Regulation of DMD 2 114 0.60 35.13 3.64
175 INT32464 Regulation of Mmp13 4 12 0.44 6.46 3.61
176 INT59900 Binding of MATN3 1 13 0.42 17.19 3.59
177 INT187819 Regulation of IFN1@ 1 25 0.60 12.89 3.55
178 INT83646 Binding of Il1rn 1 12 0.37 4.41 3.51
179 INT79477 Binding of HLA-DMA 1 19 0.26 13.78 3.47
180 INT116281 Negative_regulation of Gene_expression of Mmp13 1 15 0.41 9.96 3.41
181 INT157342 Gene_expression of S100A9 1 19 0.60 21.27 3.37
182 INT171998 Binding of DMD 8 58 0.47 38.13 3.35
183 INT47949 Positive_regulation of ELOVL1 1 19 0.42 29.78 3.3
184 INT125237 Negative_regulation of Gene_expression of CD40LG 2 16 0.54 9.9 3.27
185 INT239495 Negative_regulation of Gene_expression of Mtx1 1 3 0.36 1.55 3.24
186 INT200443 Positive_regulation of AES 2 27 0.60 22.46 3.22
187 INT25906 Negative_regulation of Cish 1 6 0.29 5.41 3.17
188 INT146300 Binding of RS1 4 31 0.22 29.55 3.04
189 INT45673 Gene_expression of Serpina6 1 10 0.53 3.47 3
190 INT211132 Positive_regulation of Gene_expression of MTX1 1 4 0.23 2.71 2.94
191 INT159709 Binding of ERAP1 2 12 0.47 3.42 2.91
192 INT81129 Gene_expression of SDC3 7 13 0.40 5.81 2.81
193 INT64147 Gene_expression of C5 4 15 0.60 16.8 2.78
194 INT220858 Positive_regulation of Mmp1a 1 15 0.38 9.11 2.77
195 INT172797 Negative_regulation of Mmp1a 1 8 0.24 6.47 2.74
196 INT194892 Regulation of Mmp1a 2 5 0.22 4.93 2.67
197 INT75685 Regulation of CD86 1 12 0.58 3.55 2.66
198 INT231694 Negative_regulation of IGKV2-19 1 14 0.03 7.09 2.64
199 INT96151 Negative_regulation of Gene_expression of Cd40 3 20 0.58 6.06 2.58
200 INT182224 Binding of CCL21 2 6 0.34 5.91 2.54
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