J:Arch. Pharm. Res.

This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT140032	Tnf Positive_regulation of Gene_expression of Ifng	2	1	0.43	2.23	2
2	INT140030	Il1b Positive_regulation of Gene_expression of Ifng	2	1	0.48	2.23	2
3	INT140026	Il1b Positive_regulation of Gene_expression of Tnf	2	1	0.49	2.23	2
4	INT120723	Positive_regulation of Trpv1 Positive_regulation of Localization of Calca	3	1	0.51	0.48	1.92
5	INT105112	Plat Positive_regulation of JUN	1	3	0.01	1.55	1.58
6	INT112607	DNAJC15 Negative_regulation of Positive_regulation of Casp3	1	1	0.03	0.14	1.12
7	INT112608	DNAJC15 Regulation of Gene_expression of Fos	1	1	0.02	0.14	1.12
8	INT105113	Plat Positive_regulation of NFKB1	1	2	0.03	1.06	1.06
9	INT105109	Cxcl12 Positive_regulation of JUN	1	2	0.01	1.07	1.05
10	INT128943	Pomc Regulation of Npy	1	1	0.23	0.61	0.81
11	INT121966	HRAS Positive_regulation of RAC1	1	1	0.75	0.41	0.67
12	INT150754	GTS Negative_regulation of Gene_expression of Prkaca	1	1	0.32	0.08	0.65
13	INT150755	GTS Negative_regulation of Phosphorylation of Atf6b	1	1	0.13	0.08	0.64
14	INT105111	Negative_regulation of Plat Positive_regulation of NFKB1	1	1	0.03	0.53	0.54
15	INT105110	Cxcl12 Positive_regulation of NFKB1	1	1	0.06	0.54	0.53
16	INT105107	Cxcl12 Positive_regulation of Cxcl12 Positive_regulation of NFKB1	1	1	0.01	0.54	0.53
17	INT105108	Negative_regulation of Cxcl12 Positive_regulation of NFKB1	1	1	0.05	0.54	0.53
18	INT105106	Plat Positive_regulation of Cxcl12 Positive_regulation of NFKB1	1	1	0.01	0.54	0.53
19	INT129551	Sag Negative_regulation of Gene_expression of Ptgs1	1	1	0.08	0.88	0.48
20	INT121974	Lrdd Positive_regulation of Fos	1	1	0.04	0	0.39
21	INT121972	Sub1 Positive_regulation of Fos	1	1	0.38	0	0.39
22	INT90593	Binding of Eif3h and Man2a2	1	1	0.01	0.32	0.38
23	INT166664	Mpzl2 Negative_regulation of Mmp9	1	1	0.31	0.32	0.25
24	INT166662	Mpzl2 Negative_regulation of Positive_regulation of Mmp9	1	1	0.31	0.32	0.25
25	INT166663	Mpzl2 Negative_regulation of Positive_regulation of Ptgs2	1	1	0.29	0.3	0.24
26	INT121973	Sub1 Regulation of Gene_expression of Fos	1	1	0.32	0	0.21

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Reported in Journal	Documents	TM Confidence	Disease Relevance	Pain Relevance
1	INT2542	Localization of Calca	10	2008	0.81	518.3	1408.65
2	INT6483	Gene_expression of TNF	4	3152	0.78	2515.62	929.82
3	INT58061	Gene_expression of Trpv1	7	1117	0.78	451.54	637.59
4	INT2543	Positive_regulation of Calca	1	787	0.70	331.13	592.08
5	INT50058	Negative_regulation of Cpox	4	907	0.58	426.28	428.29
6	INT9238	Gene_expression of IL6	3	1575	0.78	1135.66	424.22
7	INT4758	Positive_regulation of Localization of Calca	4	557	0.70	138.55	411.04
8	INT64202	Positive_regulation of Trpv1	4	643	0.70	249.66	397.42
9	INT6580	Negative_regulation of Ptgs1	1	929	0.59	381.53	376.26
10	INT34869	Negative_regulation of PTGS2	1	778	0.59	366.76	319.85
11	INT886	Gene_expression of Pomc	2	676	0.78	129.87	295.98
12	INT5379	Gene_expression of Fos	16	656	0.78	255.5	292.54
13	INT9158	Gene_expression of Tnf	2	722	0.78	522.01	277.68
14	INT6852	Localization of TNF	2	883	0.81	705.95	270.84
15	INT5972	Gene_expression of IL1B	6	948	0.78	510.91	263.97
16	INT16868	Gene_expression of Il6	1	807	0.78	499.48	256.57
17	INT48955	Gene_expression of Nos2	4	753	0.78	403.87	208.08
18	INT2651	Positive_regulation of Pomc	1	403	0.70	95.72	206.24
19	INT6488	Gene_expression of Tnf	3	484	0.78	339.61	191.58
20	INT19472	Gene_expression of Il1	2	554	0.76	419.75	175.35
21	INT66280	Gene_expression of Nos2	2	534	0.78	330.78	157.07
22	INT49134	Gene_expression of Grin1	1	270	0.78	84.78	148.61
23	INT5050	Regulation of Localization of Calca	1	149	0.62	41.25	148.57
24	INT6108	Gene_expression of Npy	5	292	0.78	110.65	148.21
25	INT9852	Positive_regulation of Gpt	3	563	0.70	364.64	146.82
26	INT60126	Regulation of Trpv1	1	186	0.62	85.53	133.4
27	INT48953	Positive_regulation of Nos2	2	486	0.70	239.85	131.87
28	INT5380	Positive_regulation of Gene_expression of Fos	6	243	0.70	105.65	131.05
29	INT65600	Positive_regulation of Casp3	3	376	0.70	198.44	128.03
30	INT64201	Negative_regulation of Trpv1	2	203	0.59	79.18	119.75
31	INT50674	Gene_expression of PTGS2	1	459	0.78	253.33	118.51
32	INT20374	Gene_expression of Il4	2	515	0.76	306.15	114.12
33	INT5283	Positive_regulation of Npy	4	191	0.70	66.77	109.2
34	INT8413	Gene_expression of Ptgs1	1	248	0.78	110.17	108.58
35	INT12082	Localization of IL6	1	365	0.81	241.78	105.78
36	INT69440	Gene_expression of ROS1	2	752	0.78	477.64	103.83
37	INT7944	Positive_regulation of Fos	3	193	0.70	60.69	98.31
38	INT203	Positive_regulation of Pomc	1	257	0.70	90.56	92.84
39	INT54571	Positive_regulation of NFKB1	3	263	0.70	138.99	87.32
40	INT4830	Binding of Trpv1	1	158	0.48	45.11	84.2
41	INT2520	Negative_regulation of Ca2	1	271	0.57	72.13	83.71
42	INT2431	Positive_regulation of Mpo	1	275	0.70	211.99	78.47
43	INT15769	Gene_expression of Il1b	3	146	0.78	114.51	75.35
44	INT11380	Negative_regulation of IL1B	1	215	0.59	125.62	72.35
45	INT57380	Phosphorylation of Creb1	1	213	0.82	66.8	71.26
46	INT49995	Positive_regulation of Gene_expression of Tnf	1	187	0.70	125.07	70.54
47	INT6849	Localization of IL1B	1	229	0.81	112.56	69.63
48	INT7534	Gene_expression of Ifng	3	193	0.78	111.02	68.6
49	INT6489	Positive_regulation of Gene_expression of Tnf	1	140	0.70	92.31	67.85
50	INT55224	Gene_expression of DRGX	1	99	0.31	67.55	67.63
51	INT15613	Negative_regulation of Ptgs2	1	160	0.59	71.08	65.08
52	INT17564	Gene_expression of Gpt	1	322	0.75	208.51	60.36
53	INT48901	Negative_regulation of IL6	1	186	0.57	136.33	57.87
54	INT31116	Gene_expression of Casp3	1	192	0.78	78.21	57.43
55	INT52692	Gene_expression of Ptgs2	1	160	0.78	85.06	55.73
56	INT48952	Negative_regulation of Nos2	1	204	0.59	101.73	53.15
57	INT9234	Negative_regulation of Gene_expression of IL6	2	171	0.59	101.61	53.15
58	INT5759	Positive_regulation of Ptgs1	1	127	0.69	53.45	53.04
59	INT52611	Negative_regulation of Ptgs2	4	142	0.59	66.31	52.71
60	INT49017	Negative_regulation of Gene_expression of Nos2	2	169	0.59	80.64	52.67
61	INT22112	Positive_regulation of Localization of TNF	1	164	0.70	115.66	52.18
62	INT5338	Regulation of Npy	1	92	0.62	25.54	51.24
63	INT53083	Gene_expression of Ptgs2	2	153	0.78	90.04	50.39
64	INT35975	Regulation of Cpox	1	109	0.39	57.88	49.69
65	INT7093	Negative_regulation of CYP2B6	1	146	0.58	37.3	48.39
66	INT374	Positive_regulation of Ldha	4	212	0.70	107.08	47.43
67	INT57021	Positive_regulation of Gene_expression of Grin1	1	62	0.70	24.77	47.31
68	INT5337	Negative_regulation of Npy	2	87	0.59	19.6	46.75
69	INT6979	Positive_regulation of CA2	2	206	0.67	50.79	44.97
70	INT115384	Positive_regulation of Mmp9	1	121	0.68	94.74	43.02
71	INT85943	Negative_regulation of Nos2	1	161	0.59	108.56	42.65
72	INT11180	Binding of RYBP	1	52	0.46	13.86	42.53
73	INT13354	Transcription of TNF	1	108	0.72	85.81	42.32
74	INT9039	Negative_regulation of Htr1a	1	69	0.57	9.56	41.84
75	INT9233	Negative_regulation of Gene_expression of IL1B	1	114	0.59	56.99	41.82
76	INT69437	Positive_regulation of ROS1	1	328	0.58	222.83	40.56
77	INT58062	Negative_regulation of Gene_expression of Trpv1	3	66	0.59	22.34	38.02
78	INT80075	Regulation of Gene_expression of Trpv1	4	55	0.62	32.42	36.88
79	INT10796	Gene_expression of CYP2B6	1	131	0.77	30.14	35.27
80	INT96624	Positive_regulation of Positive_regulation of Trpv1	4	62	0.70	20.5	34.28
81	INT74563	Positive_regulation of Gene_expression of ROS1	1	258	0.61	168.18	34.08
82	INT5489	Localization of CA2	3	172	0.80	39.46	33.56
83	INT3117	Regulation of Oxt	1	103	0.61	17.93	32.28
84	INT6177	Binding of Htr1a	8	65	0.47	17.65	30.59
85	INT11650	Negative_regulation of Gpt	1	122	0.59	69.15	30.36
86	INT57379	Positive_regulation of Phosphorylation of Creb1	1	79	0.69	28.24	30.25
87	INT18489	Binding of Man2a2	1	59	0.48	11.27	29.38
88	INT65597	Negative_regulation of Casp3	4	69	0.59	39.19	29.32
89	INT65598	Negative_regulation of Positive_regulation of Casp3	1	45	0.59	18.36	28.59
90	INT57692	Positive_regulation of Gene_expression of Il1b	1	50	0.67	43.54	28.29
91	INT7565	Transcription of Pomc	1	69	0.72	14.46	27.41
92	INT5923	Negative_regulation of Rtn4	1	50	0.36	24.19	27.2
93	INT80470	Negative_regulation of Gene_expression of Grin1	1	33	0.59	10.22	27.15
94	INT17331	Positive_regulation of JUN	2	132	0.69	60.4	27.03
95	INT3760	Positive_regulation of ALB	2	142	0.70	87.46	26.7
96	INT5378	Regulation of Gene_expression of Fos	3	47	0.60	14.47	26.41
97	INT17925	Transcription of Npy	3	53	0.72	15.75	25.56
98	INT61953	Transcription of Nos2	3	101	0.72	46.64	25.49
99	INT9886	Gene_expression of Ptgs1	1	92	0.77	40.66	25.31
100	INT8380	Positive_regulation of Gene_expression of Npy	2	49	0.70	19.62	24.13
101	INT89854	Regulation of Nos2	2	49	0.61	42.58	24.1
102	INT5511	Negative_regulation of Gene_expression of Pomc	1	47	0.59	12.08	23.02
103	INT66208	Positive_regulation of Positive_regulation of NFKB1	1	45	0.68	20.17	22.62
104	INT4369	Gene_expression of Ldha	2	157	0.76	88.12	22.45
105	INT89056	Phosphorylation of Trpv1	1	46	0.82	13.52	22.16
106	INT39914	Negative_regulation of Cyp1a2	1	44	0.58	10.04	22
107	INT2978	Gene_expression of Tbxa2r	1	76	0.77	28.4	21.27
108	INT52693	Positive_regulation of Gene_expression of Ptgs2	1	57	0.70	25.51	21.18
109	INT4535	Localization of PROC	1	106	0.73	76.24	21.1
110	INT45840	Positive_regulation of Gene_expression of Ptgs1	1	35	0.50	16.07	20.49
111	INT8765	Positive_regulation of Cyp3a23/3a1	1	63	0.67	22.28	20.39
112	INT7487	Gene_expression of Htr1a	1	36	0.75	11.08	20.05
113	INT20305	Gene_expression of Cyp2e1	1	53	0.78	19.75	19.54
114	INT1278	Negative_regulation of Ldha	2	93	0.59	37.66	19.36
115	INT66755	Transcription of Tnf	2	45	0.72	37.1	19.11
116	INT3952	Negative_regulation of ALB	1	116	0.59	72.18	18.35
117	INT1060	Negative_regulation of Pla2g1b	3	50	0.57	22.91	18.12
118	INT61626	Transcription of IL6	1	73	0.72	42.04	17.86
119	INT5922	Gene_expression of Rtn4	2	27	0.48	12.7	17.86
120	INT36054	Transcription of IL1B	1	53	0.72	32.64	17.31
121	INT17313	Positive_regulation of HSPG2	1	57	0.67	55.78	16.65
122	INT71634	Gene_expression of SLC6A3	1	45	0.78	13.48	15.23
123	INT32706	Gene_expression of Cyp3a23/3a1	4	51	0.65	19.48	15.06
124	INT52696	Positive_regulation of Ptgs2	2	48	0.70	27.65	14.44
125	INT77619	Gene_expression of Prkaca	1	43	0.75	8.55	14.13
126	INT53070	Regulation of Rtn4	1	15	0.22	9.35	13.77
127	INT67855	Negative_regulation of PPIG	1	64	0.57	17.83	13.54
128	INT12281	Negative_regulation of Gene_expression of Npy	2	23	0.59	7.45	13.41
129	INT18191	Negative_regulation of Cyp3a23/3a1	4	48	0.57	10.21	13.38
130	INT55168	Binding of NFKB1	1	55	0.48	22.94	13.15
131	INT7532	Negative_regulation of Gene_expression of Ifng	2	33	0.59	18.56	13.14
132	INT28420	Gene_expression of Ptgds	6	59	0.78	31.72	12.67
133	INT69436	Negative_regulation of Gene_expression of ROS1	1	81	0.38	46.58	12.22
134	INT20457	Regulation of Ptgs1	1	23	0.48	11.63	11.56
135	INT55886	Negative_regulation of Gene_expression of Il4	1	47	0.57	26.04	11.42
136	INT70877	Gene_expression of PPIG	1	72	0.75	22.39	10.93
137	INT25613	Gene_expression of Il1f5	1	32	0.77	13.29	10.44
138	INT53081	Negative_regulation of Gene_expression of Ptgs2	1	29	0.59	15.83	10.39
139	INT17421	Negative_regulation of Alox5	1	41	0.57	15.23	10.05
140	INT85535	Negative_regulation of Gene_expression of Ptgs2	1	27	0.51	16.04	10.01
141	INT8527	Positive_regulation of Positive_regulation of Fos	2	20	0.70	6.87	9.62
142	INT23535	Positive_regulation of Localization of CA2	1	41	0.41	13.52	9.43
143	INT57665	Negative_regulation of Cyp2e1	2	35	0.59	8.05	9.29
144	INT860	Regulation of ALB	1	48	0.60	25.11	8.95
145	INT10208	Negative_regulation of Binding of Htr1a	10	18	0.57	13.98	8.91
146	INT66213	Localization of RELA	1	63	0.78	14.71	8.77
147	INT51922	Localization of Cpox	2	24	0.68	12.05	8.59
148	INT5340	Negative_regulation of Positive_regulation of Npy	1	12	0.55	3.83	8.23
149	INT135120	Phosphorylation of Atf6b	1	13	0.61	4.01	8.03
150	INT58625	Gene_expression of Ugt2b1	1	19	0.77	1.95	7.05
151	INT26489	Negative_regulation of Npr1	1	15	0.59	5.7	6.79
152	INT53773	Positive_regulation of Transcription of Npy	1	11	0.70	3.75	6.29
153	INT67060	Negative_regulation of Transcription of TNF	1	17	0.59	12.94	5.88
154	INT28015	Regulation of Cyp3a23/3a1	1	19	0.40	6.32	5.79
155	INT47976	Protein_catabolism of NFKBIA	1	17	0.88	7.57	5.79
156	INT52695	Regulation of Ptgs2	2	20	0.42	8.72	5.71
157	INT78728	Negative_regulation of Binding of NFKB1	2	18	0.58	6.89	5.39
158	INT6577	Regulation of Alox5	1	18	0.47	9.19	5.06
159	INT186	Positive_regulation of Cyp1a1	1	30	0.70	5	5.02
160	INT19639	Negative_regulation of Gene_expression of Tbxa2r	1	17	0.55	7.69	5.01
161	INT65514	Gene_expression of Cyp1a2	2	25	0.77	6.12	4.6
162	INT47766	Transcription of Fos	2	25	0.69	8.78	4.42
163	INT107771	Localization of HSPG2	1	10	0.78	8.47	4.3
164	INT89784	Regulation of Transcription of Nos2	2	14	0.42	8.39	4.24
165	INT1701	Localization of Neu1	1	11	0.69	6.36	4.18
166	INT123752	Regulation of Bax	1	19	0.60	16.45	4
167	INT142240	Positive_regulation of Phosphorylation of Atf6b	1	6	0.49	1.54	3.87
168	INT50143	Negative_regulation of Gene_expression of Ptgds	2	10	0.48	5.82	3.54
169	INT1970	Localization of Gusb	1	11	0.75	3.46	3.42
170	INT121967	Regulation of RAC1	1	9	0.45	6.14	3.41
171	INT61952	Negative_regulation of Transcription of Nos2	1	17	0.54	5.1	3.34
172	INT1972	Negative_regulation of Localization of Gusb	1	8	0.55	3.24	3.27
173	INT53388	Negative_regulation of Cyp2c11	2	18	0.53	2.66	3.11
174	INT66519	Positive_regulation of Binding of Htr1a	3	5	0.67	3.61	2.81
175	INT47770	Positive_regulation of Transcription of Fos	1	9	0.49	1.87	2.71
176	INT47974	Negative_regulation of Protein_catabolism of NFKBIA	1	7	0.49	2.38	2.69
177	INT39266	Negative_regulation of Localization of Neu1	1	6	0.30	4.66	2.6
178	INT21516	Negative_regulation of Positive_regulation of Ldha	1	13	0.43	4.73	2.53
179	INT16089	Gene_expression of Ltc4s	6	11	0.77	3.37	2.29
180	INT128941	Gene_expression of Mir343	1	2	0.42	0.46	2.27
181	INT63440	Regulation of Transcription of Npy	1	5	0.39	1.53	2.25
182	INT66929	Positive_regulation of Localization of Cpox	1	6	0.25	4.68	1.98
183	INT63672	Negative_regulation of Ugt2b1	1	7	0.57	1.07	1.9
184	INT85302	Negative_regulation of Cyp2b21	1	6	0.20	8.94	1.8
185	INT24283	Regulation of Positive_regulation of CA2	1	8	0.30	3.06	1.74
186	INT39229	Regulation of Alox5	1	6	0.57	3.2	1.72
187	INT113684	Negative_regulation of Gene_expression of Cyp3a23/3a1	1	5	0.36	2.04	1.71
188	INT67504	Binding of Niacr1	1	3	0.48	0.78	1.7
189	INT123755	Negative_regulation of 4933400C05Rik	2	1	0.02	3.08	1.51
190	INT121970	Negative_regulation of Transcription of Fos	1	4	0.42	2.52	1.48
191	INT1851	Regulation of OXA1L	1	7	0.40	0.59	1.42
192	INT123754	Gene_expression of Bcl2l2	1	4	0.65	4.36	1.38
193	INT123751	Negative_regulation of Gene_expression of Bcl2l2	1	2	0.12	2.35	1.35
194	INT115608	Negative_regulation of Gene_expression of Htr1a	1	4	0.57	1.19	1.32
195	INT50031	Negative_regulation of Gene_expression of CYP2B6	1	5	0.57	2.37	1.29
196	INT66214	Regulation of Binding of NFKB1	1	2	0.35	0.55	1.28
197	INT49013	Gene_expression of Por	2	6	0.75	2.19	1.22
198	INT57169	Gene_expression of Cyp2b1	1	5	0.72	1.39	1.2
199	INT53285	Gene_expression of Cyp2c11	2	20	0.76	5.43	1.17
200	INT115831	Transcription of Hmox1	3	16	0.66	5.31	1.14