J:Arch Int Pharmacodyn Ther

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT29837 Gnrh1 Positive_regulation of LH 6 1 0.67 0 3.53
2 INT40408 Positive_regulation of Gnrh1 Positive_regulation of LH 2 1 0.58 0 2.21
3 INT27788 Gnrh1 Positive_regulation of Positive_regulation of LH 3 1 0.55 0.17 1.72
4 INT1066 Gm5720 Positive_regulation of MBD2 1 1 0.00 0.73 0.42
5 INT47600 Ccno Regulation of MBD2 1 1 0.00 0.22 0.24
6 INT56650 Binding of Olfr1417 and Gm14673 1 1 0.15 0.09 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 5 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 3 1902 0.78 275.47 1057.59
3 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
4 INT3439 Localization of Abat 6 1017 0.78 112.39 727.06
5 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
6 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
7 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
8 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
9 INT287 Localization of Cck 1 518 0.81 86.84 364.04
10 INT439 Localization of Gnrh1 3 976 0.81 100.96 363.25
11 INT477 Localization of Avp 3 813 0.81 131.58 300.4
12 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
13 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
14 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
15 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
16 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
17 INT528 Gene_expression of Prl 1 693 0.78 217.18 192.2
18 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
19 INT3440 Negative_regulation of Localization of Abat 2 221 0.57 33.94 180.36
20 INT1114 Localization of Ins1 3 748 0.80 192.95 165.48
21 INT5513 Negative_regulation of Pomc 2 295 0.59 60.9 158.63
22 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
23 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
24 INT1044 Negative_regulation of Localization of LH 1 358 0.59 25.95 151.31
25 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
26 INT1047 Negative_regulation of LH 4 314 0.59 53.71 135.89
27 INT416 Regulation of LH 2 253 0.62 31.48 125.55
28 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
29 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
30 INT9012 Localization of Vip 1 283 0.81 31.71 106.16
31 INT5940 Negative_regulation of Avp 5 236 0.59 67.86 101.2
32 INT4822 Localization of Ca2 2 417 0.80 99.57 96.45
33 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
34 INT3537 Positive_regulation of Car2 1 413 0.56 103.51 94.35
35 INT2122 Negative_regulation of Localization of Gnrh1 1 226 0.59 26.92 92.04
36 INT3441 Regulation of Localization of Abat 1 117 0.38 8.67 87.59
37 INT1472 Positive_regulation of Ins1 2 349 0.69 146.2 86.36
38 INT403 Localization of Trh 3 241 0.81 28.55 81.45
39 INT2055 Regulation of Gnrh1 1 185 0.62 23.65 71.26
40 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
41 INT1988 Positive_regulation of Localization of Ins1 2 254 0.69 59.25 68.37
42 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
43 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
44 INT2212 Binding of Abat 1 89 0.48 18.36 63.99
45 INT480 Negative_regulation of Localization of Avp 2 151 0.59 27.64 63.72
46 INT2056 Negative_regulation of Gnrh1 2 175 0.59 33.43 63.32
47 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
48 INT46 Localization of Ren 6 233 0.81 46.15 62.44
49 INT1169 Negative_regulation of Bche 3 322 0.59 149.22 61.27
50 INT546 Binding of ALB 1 311 0.48 85.98 60.14
51 INT770 Regulation of Localization of Gnrhr 1 127 0.61 17.91 58.23
52 INT20266 Positive_regulation of Bdkrb1 1 60 0.69 63.64 56.59
53 INT1316 Positive_regulation of Acot1 1 129 0.60 18.86 56.13
54 INT314 Positive_regulation of Ren 7 212 0.70 66.68 55.56
55 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
56 INT654 Localization of REN 8 250 0.81 75.12 47.86
57 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
58 INT17561 Localization of Car2 1 303 0.79 60.95 44.52
59 INT8824 Regulation of Vip 1 95 0.62 15.7 43.63
60 INT989 Negative_regulation of Trh 1 90 0.59 15.45 43.63
61 INT1295 Binding of Pomc 1 85 0.48 12.92 42.8
62 INT5539 Negative_regulation of Mme 2 75 0.59 28.91 41.84
63 INT390 Positive_regulation of Agt 1 170 0.70 61.47 36.08
64 INT49 Negative_regulation of Ren 4 129 0.59 37.48 35.62
65 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
66 INT1116 Regulation of Ren 3 103 0.62 27.66 33.26
67 INT1159 Negative_regulation of Agt 4 133 0.59 40.14 31.67
68 INT5069 Negative_regulation of Mthfs 2 69 0.57 22.54 31.36
69 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
70 INT2229 Positive_regulation of Man2a2 2 50 0.69 7.47 30.33
71 INT1079 Positive_regulation of Ache 9 104 0.70 23.52 30.28
72 INT50 Negative_regulation of Localization of Ren 2 87 0.59 14.94 30.22
73 INT64918 Gene_expression of Gria2 1 108 0.74 29.95 29.67
74 INT660 Negative_regulation of REN 2 194 0.59 82.06 29.46
75 INT7035 Regulation of CGA 1 87 0.45 29.04 28.45
76 INT1166 Negative_regulation of Dbh 3 56 0.59 12.54 28.26
77 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
78 INT4735 Gene_expression of Acot1 1 80 0.71 13.22 26.68
79 INT29107 Regulation of Oprk1 1 31 0.45 6.16 26.61
80 INT605 Regulation of Acot1 2 61 0.62 10.7 26.34
81 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
82 INT13838 Positive_regulation of Drd1a 1 48 0.70 9.83 23.42
83 INT11077 Positive_regulation of Htr3a 1 63 0.67 15.61 22.7
84 INT23564 Negative_regulation of Car2 1 103 0.50 27.28 21.86
85 INT3593 Gene_expression of ADRA1D 2 70 0.75 29.48 20.87
86 INT3030 Gene_expression of Adra2a 1 37 0.68 5.58 19.76
87 INT2660 Negative_regulation of Fabp6 1 58 0.49 33.74 18.27
88 INT48 Positive_regulation of Localization of Ren 4 69 0.70 12.47 18.03
89 INT2158 Negative_regulation of Positive_regulation of LH 1 41 0.58 4.52 17.75
90 INT14419 Negative_regulation of Localization of Trh 1 40 0.59 2.04 17.42
91 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
92 INT653 Negative_regulation of Localization of REN 2 67 0.59 20.33 16.7
93 INT3400 Positive_regulation of pr 1 57 0.68 36.9 16.24
94 INT3926 Regulation of Bdkrb1 1 22 0.61 16.72 16.1
95 INT7531 Positive_regulation of Eef1a1 3 29 0.62 8.16 15.41
96 INT4851 Positive_regulation of Chat 9 53 0.70 9.21 15.11
97 INT11945 Regulation of Chat 1 38 0.62 7.75 14.97
98 INT7523 Regulation of ADRA1D 1 42 0.45 11.63 14.52
99 INT7587 Localization of GAL 1 27 0.78 4.79 14.29
100 INT5806 Regulation of Edn1 3 63 0.62 23.46 13.88
101 INT110 Regulation of Adrb3 1 33 0.60 8.09 13.84
102 INT18658 Regulation of Adra1a 3 34 0.62 5.69 13.78
103 INT655 Positive_regulation of Localization of REN 2 86 0.70 32.41 13.56
104 INT7465 Negative_regulation of Mbp 2 53 0.58 19.12 13.27
105 INT3387 Negative_regulation of Gene_expression of LH 1 23 0.43 3.14 12.37
106 INT3104 Negative_regulation of CGA 1 76 0.54 29.81 12.23
107 INT27507 Positive_regulation of Dio1 1 23 0.44 3.43 12.11
108 INT8533 Regulation of Sorbs1 1 9 0.27 3.01 11.98
109 INT2586 Positive_regulation of Gcg 1 35 0.70 9.25 11.75
110 INT481 Regulation of Localization of Ren 1 37 0.62 5.95 11.61
111 INT10874 Negative_regulation of Twist1 2 89 0.50 36.84 11.32
112 INT14124 Negative_regulation of Adra1a 2 34 0.59 7.48 10.85
113 INT1372 Regulation of Localization of REN 4 50 0.62 5.76 9.81
114 INT11788 Positive_regulation of Rrsv 3 36 0.46 10.08 9.68
115 INT3954 Regulation of Fabp6 1 33 0.52 15.64 9.27
116 INT26487 Positive_regulation of Npr1 1 17 0.70 10.01 8.78
117 INT21438 Binding of Trim13 1 10 0.47 0.26 8.76
118 INT3658 Regulation of Gcg 1 28 0.53 12.89 8.58
119 INT43820 Positive_regulation of Twist1 2 75 0.59 42.15 8.47
120 INT3401 Positive_regulation of Hp 1 22 0.69 16.33 7.97
121 INT18393 Negative_regulation of Ryr1 1 15 0.43 3.63 7.57
122 INT3928 Localization of Bdkrb1 5 15 0.75 4.06 7.23
123 INT10104 Negative_regulation of Edn1 1 43 0.59 15.63 7.2
124 INT800 Negative_regulation of Grhpr 2 21 0.42 10.3 7.17
125 INT29583 Positive_regulation of Agtr2 1 30 0.45 21.47 7.04
126 INT717 Regulation of F2 1 29 0.61 17.46 6.99
127 INT19806 Regulation of Avp 1 29 0.53 14.17 6.94
128 INT19146 Negative_regulation of Apoa2 2 19 0.36 5.34 6.73
129 INT1280 Negative_regulation of Pebp1 1 7 0.28 2.12 6.45
130 INT2217 Positive_regulation of Positive_regulation of Ins1 1 21 0.69 7.66 6.32
131 INT3645 Positive_regulation of Grhpr 5 17 0.42 3.64 6.06
132 INT19805 Negative_regulation of Avp 1 18 0.59 4.57 5.87
133 INT56803 Positive_regulation of Bcl2a1a 2 12 0.47 7.29 5.65
134 INT19541 Gene_expression of Ptgir 1 22 0.65 15.42 5.39
135 INT5411 Positive_regulation of G6pd 1 20 0.70 4.74 5.11
136 INT10606 Localization of Ltc4s 1 16 0.75 10.14 5.05
137 INT4577 Negative_regulation of Thra 1 24 0.56 3.75 4.73
138 INT50657 Positive_regulation of HTR2B 1 8 0.67 3.95 4.71
139 INT37652 Positive_regulation of Pgr 2 29 0.59 9.09 4.67
140 INT1375 Negative_regulation of Pde4dl1 2 13 0.57 5.54 4.63
141 INT3128 Negative_regulation of PON1 1 30 0.59 26.19 4.57
142 INT3097 Binding of Ren 3 12 0.48 3.15 4.4
143 INT205 Negative_regulation of Cbr1 2 10 0.58 4.23 4.29
144 INT3722 Negative_regulation of Acot1 1 19 0.42 4.88 4.21
145 INT12577 Negative_regulation of H7 1 5 0.57 0.45 4.21
146 INT13134 Binding of ADRA2C 4 11 0.46 0.73 3.86
147 INT40712 Gene_expression of EPX 3 9 0.78 5.93 3.6
148 INT64919 Gene_expression of Prdm16 1 6 0.75 11.63 3.5
149 INT18396 Positive_regulation of Ryr1 1 10 0.58 2.45 3.38
150 INT7408 Negative_regulation of FGFR3 1 12 0.43 2.38 3.33
151 INT30131 Positive_regulation of Negative_regulation of Avp 1 5 0.50 1.94 3.3
152 INT4479 Negative_regulation of Positive_regulation of REN 1 17 0.56 6.1 3.27
153 INT27100 Binding of Adrb3 1 10 0.47 3.44 3.07
154 INT4057 Negative_regulation of Ptgfr 1 9 0.32 3.28 3
155 INT3644 Regulation of Grhpr 3 7 0.28 0.92 3
156 INT35548 Regulation of Mme 1 9 0.45 10.62 2.97
157 INT3682 Binding of Ppr1 1 10 0.42 1.87 2.96
158 INT39856 Binding of Neurod1 1 8 0.47 1.44 2.88
159 INT34814 Negative_regulation of Trh 1 5 0.43 0.36 2.8
160 INT31451 Negative_regulation of Gene_expression of Adra2a 1 4 0.43 1.03 2.72
161 INT21740 Localization of TAC3 1 7 0.73 1.46 2.6
162 INT4704 Positive_regulation of Negative_regulation of Th 1 4 0.50 0.06 2.56
163 INT101 Negative_regulation of HRH1 1 8 0.57 3.48 2.55
164 INT1815 Positive_regulation of Negative_regulation of Ren 3 6 0.47 1.32 2.54
165 INT3608 Regulation of Cbr1 1 6 0.45 2.28 2.44
166 INT27835 Regulation of Positive_regulation of Ren 1 10 0.44 2.27 2.38
167 INT22605 Regulation of Pgr 2 22 0.62 7.1 2.26
168 INT3798 Negative_regulation of GNS 1 5 0.26 3.18 2.21
169 INT13368 Binding of Hils1 1 5 0.23 0.46 2.14
170 INT3723 Binding of PON1 3 9 0.46 5.83 2.13
171 INT39134 Positive_regulation of Ace2 2 3 0.14 0.57 2.13
172 INT38374 Regulation of MBD2 2 8 0.10 0.72 2.09
173 INT13837 Negative_regulation of Positive_regulation of Drd1a 1 2 0.43 1.43 2.01
174 INT8035 Regulation of Olr1746 1 6 0.44 1.27 1.93
175 INT10976 Negative_regulation of ENPP3 1 13 0.42 5.11 1.92
176 INT50658 Positive_regulation of HTR2C 1 5 0.67 2.3 1.9
177 INT39133 Binding of Ace2 2 3 0.30 0.8 1.89
178 INT34864 Binding of Cp 1 23 0.47 5.17 1.78
179 INT19576 Negative_regulation of Tspo 1 3 0.42 1.02 1.75
180 INT40713 Negative_regulation of EPX 1 7 0.37 2.21 1.73
181 INT56801 Positive_regulation of Ugt2a2 2 1 0.17 1.41 1.62
182 INT56802 Regulation of Bcl2a1a 1 3 0.43 1.8 1.47
183 INT32184 Negative_regulation of Col2a1 2 9 0.42 3.05 1.43
184 INT30023 Regulation of PAF1 1 7 0.17 1.84 1.38
185 INT35641 Negative_regulation of Positive_regulation of Rrsv 1 2 0.18 0.74 1.38
186 INT10975 Gene_expression of ENPP3 1 16 0.76 3.28 1.36
187 INT55329 Localization of Lynx1 1 2 0.80 0.32 1.35
188 INT56804 Regulation of Ugt2a2 1 2 0.15 1.35 1.19
189 INT57708 Negative_regulation of Gstp2 1 1 0.37 0 1.11
190 INT57709 Positive_regulation of Gstp2 1 2 0.60 0.87 1.1
191 INT36859 Positive_regulation of ACOT2 2 1 0.01 0.41 1.1
192 INT34692 Negative_regulation of Positive_regulation of ras 2 5 0.45 3.86 1.08
193 INT39703 Regulation of Ccl4 2 3 0.39 0.39 1.08
194 INT27938 Negative_regulation of Pgr 1 12 0.38 1.98 1.05
195 INT2142 Regulation of Ptgir 1 7 0.42 3.35 1.02
196 INT3927 Negative_regulation of Localization of Bdkrb1 1 2 0.42 0.31 1.02
197 INT3402 Positive_regulation of Positive_regulation of Hp 1 2 0.49 1.05 1
198 INT37084 Positive_regulation of Ctnnal1 1 1 0.50 0.17 0.96
199 INT64920 Gene_expression of Boc 1 2 0.65 0 0.84
200 INT40928 Regulation of Binding of ADRA2C 2 1 0.43 0 0.82
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