J:Arthritis Res Ther

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT51205 Binding of OPRK1 and PDYN 7 1 0.00 2.01 7.8
2 INT149117 Binding of CD80 and CTLA4 31 6 0.52 12.7 7.73
3 INT188692 Binding of Cd40 and Cd40lg 32 11 0.34 22.95 6.62
4 INT84921 Binding of NGF and NTRK1 13 1 0.50 6.39 6.1
5 INT155484 Binding of CD86 and CTLA4 15 5 0.52 8.85 6.09
6 INT176477 Binding of CXCR3 and CXCL10 14 2 0.25 10.61 5.87
7 INT182124 Binding of IRF6 and TLR4 14 8 0.10 16.11 4.65
8 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 2 0.59 9.37 4.48
9 INT182194 Binding of IL8 and CXCR2 10 1 0.56 7.14 4.16
10 INT101942 Binding of CD40 and CD40LG 16 4 0.23 15.24 4.01
11 INT127128 Binding of CNR1 and CNR2 8 1 0.39 3.98 3.97
12 INT69032 IL18 Positive_regulation of IFNA1 12 7 0.23 7.87 3.83
13 INT121651 Binding of CXCL12 and CXCR4 13 3 0.48 17.61 3.52
14 INT194647 Binding of CD28 and CD80 15 3 0.40 4.9 3.22
15 INT186126 Binding of CD28 and CTLA4 9 1 0.52 4.13 3.12
16 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 4 0.35 13.11 3.11
17 INT208572 Binding of IL8 and CXCR1 6 1 0.33 5.2 3.08
18 INT130721 Binding of IL1B and IL1RN 6 4 0.05 5.29 2.85
19 INT220062 Binding of NGF and TNFRSF1B 1 2 0.10 2.21 2.81
20 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 6 0.06 1.79 2.79
21 INT31513 Crh Regulation of POMC 3 4 0.29 5.06 2.78
22 INT186128 Binding of CD2 and CD58 8 1 0.10 7.59 2.76
23 INT69030 IL18 Positive_regulation of IL12A 3 5 0.31 5.57 2.72
24 INT220061 Binding of TRPV1 and TRPA1 1 2 0.15 1.7 2.69
25 INT29446 Crh Positive_regulation of Localization of POMC 8 1 0.38 1.87 2.58
26 INT299783 Binding of Cd28 and Cd80 7 8 0.14 6.49 2.49
27 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 2 0.19 3.22 2.35
28 INT103548 Binding of TRPV1 and TRPV3 3 1 0.37 1.82 2.28
29 INT126717 Binding of Il6 and Il6st 3 3 0.21 3.35 2.22
30 INT194646 Binding of CD28 and CD86 7 3 0.40 2.69 2.21
31 INT209924 IL1B Negative_regulation of PPARA 1 15 0.20 4.38 2.17
32 INT184262 Binding of AGER and HMGB1 1 5 0.34 4.49 2.17
33 INT239037 Binding of Cd28 and Cd86 9 5 0.16 3.69 2.14
34 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 11 0.06 4.35 2.14
35 INT240131 Binding of Crp and Nppb 7 8 0.07 11.53 2.12
36 INT182200 Binding of CXCR5 and CXCL13 1 3 0.37 2.89 2.07
37 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 1 0.51 0.48 1.92
38 INT183781 Binding of IL6 and INS 6 1 0.22 8.97 1.87
39 INT203044 Binding of PDCD1 and DTHD1 1 3 0.02 3.19 1.87
40 INT201940 Binding of IL8 and CXCL10 2 2 0.28 2.46 1.86
41 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 10 0.13 5.83 1.8
42 INT136273 NGF Regulation of Gene_expression of BDNF 2 1 0.41 1.14 1.78
43 INT203149 Binding of Mif and Osm 1 2 0.02 2.93 1.78
44 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 4 0.22 3.23 1.72
45 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 1 0.50 4.37 1.69
46 INT194863 Binding of IL1R1 and IL1RN 5 3 0.09 2.23 1.64
47 INT187175 Binding of BSG and PPIA 1 3 0.14 2.23 1.64
48 INT174503 Binding of HLA-B and KIR3DL1 6 5 0.37 3.48 1.61
49 INT209853 TNF Regulation of Gene_expression of CD36 1 6 0.61 3.41 1.59
50 INT254243 Binding of HOMER1 and MRI1 1 2 0.03 1.99 1.57
51 INT254205 Binding of Myd88 and Tlr4 12 1 0.19 3.17 1.54
52 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 2 0.17 3.36 1.53
53 INT174508 Binding of CD4 and HLA-B 1 4 0.14 4.68 1.53
54 INT69031 IL12A Positive_regulation of IFNA1 9 4 0.13 4.23 1.52
55 INT240057 Binding of RHOB and NME8 1 5 0.41 4.11 1.5
56 INT126718 Binding of Il6 and Il6r 3 2 0.09 2.33 1.49
57 INT174450 Positive_regulation of Binding of Cxcr3 and Smcp 1 2 0.18 2.83 1.49
58 INT159657 Binding of INSRR and NGF 3 2 0.00 1.65 1.48
59 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 1 0.12 1.31 1.48
60 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 1 0.11 1.31 1.48
61 INT59547 Avp Positive_regulation of Crh 2 2 0.14 1.13 1.47
62 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 2 0.12 2.17 1.47
63 INT201946 IFNA1 Positive_regulation of DPP4 1 2 0.17 2.16 1.46
64 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 1 0.08 1.11 1.39
65 INT55837 Binding of HLA-B and PHB2 3 2 0.20 3.52 1.37
66 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 1 0.16 4.47 1.35
67 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 3 0.16 2.53 1.35
68 INT250934 Binding of BDNF and NGF 3 3 0.39 0.62 1.34
69 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 2 0.07 3.19 1.33
70 INT194513 Timp1 Negative_regulation of Cpox 1 2 0.00 0.9 1.31
71 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 2 0.49 1.2 1.3
72 INT201942 DPP4 Negative_regulation of CXCL10 1 2 0.33 0.9 1.3
73 INT186393 Binding of TNF and Tnfrsf1a 9 1 0.37 8.55 1.29
74 INT107858 PRSS1 Positive_regulation of F2RL1 6 1 0.12 4.23 1.29
75 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 2 0.49 1.14 1.27
76 INT159655 Binding of BDNF and INSRR 2 5 0.00 1.25 1.26
77 INT254355 PF4 Positive_regulation of IFNA1 1 2 0.04 1.23 1.26
78 INT254210 Binding of Cxcr2 and Ccl2 1 2 0.08 2.39 1.25
79 INT202042 CAMK2N2 Negative_regulation of MMP9 1 1 0.01 0.73 1.25
80 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 1 0.00 0.74 1.25
81 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 1 0.12 3 1.24
82 INT202039 CAMK2N2 Negative_regulation of MMP1 1 1 0.00 0.73 1.24
83 INT202036 CAMK2N2 Negative_regulation of MMP3 1 1 0.00 0.73 1.24
84 INT202040 CAMK2N2 Negative_regulation of MMP7 1 1 0.00 0.73 1.24
85 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 2 0.01 1.94 1.23
86 INT240095 Binding of PDYN and Oprk1 1 1 0.52 1.3 1.22
87 INT187174 RPS3AP9 Negative_regulation of MMP2 1 2 0.00 0.9 1.22
88 INT224410 Binding of CRP and CIMT 3 2 0.42 10.46 1.2
89 INT194861 Binding of IL1B and IL1R1 2 1 0.01 1.55 1.2
90 INT209926 IL1B Regulation of PPARA 1 4 0.21 2.45 1.2
91 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 2 0.24 2.23 1.2
92 INT187172 RPS3AP9 Negative_regulation of MMP9 1 2 0.00 0.89 1.2
93 INT184402 Binding of HLA-DRB4 and HLA-E 1 3 0.00 3.1 1.19
94 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 2 0.05 2.88 1.18
95 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 3 0.03 2.4 1.18
96 INT182159 Binding of HGF and DCPS 1 2 0.01 2.5 1.17
97 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.19 1.61 1.17
98 INT43509 Avp Positive_regulation of Localization of POMC 2 2 0.13 1.26 1.16
99 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 3 0.26 4.75 1.15
100 INT160540 Binding of NGF and PSIP1 2 2 0.29 1.43 1.12
101 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 2 0.02 1.31 1.12
102 INT224728 Col7a1 Positive_regulation of Cia1 1 2 0.00 2.9 1.12
103 INT207437 Binding of PLA2G7 and ERAL1 1 4 0.14 3.64 1.11
104 INT333966 Binding of Il6r and Il6st 1 2 0.01 1.74 1.1
105 INT187176 Binding of BSG and MMP1 1 1 0.09 1.18 1.08
106 INT186125 Negative_regulation of Binding of CD2 and CD58 3 1 0.12 3.04 1.06
107 INT176474 Binding of CXCR3 and CXCL9 3 2 0.22 1.9 1.05
108 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 1 0.17 1.5 1.05
109 INT312097 ELANE Regulation of ALOX5 1 5 0.08 1.75 1.05
110 INT264324 Olr614 Regulation of IL-17 1 2 0.02 2.3 1.03
111 INT160541 Binding of BDNF and PSIP1 4 1 0.49 1.94 1.02
112 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 4 0.01 1.98 1.02
113 INT174468 IL7 Positive_regulation of Gene_expression of IL4 1 4 0.40 1.88 1.02
114 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 1 0.06 1.86 1
115 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 2 0.12 1.07 0.99
116 INT209923 IL17A Negative_regulation of PPARA 1 3 0.14 2.46 0.99
117 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 1 0.78 1.23 0.98
118 INT203040 Binding of PDCD1 and PDCD1LG2 3 2 0.40 4.86 0.98
119 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 1 0.08 1 0.98
120 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 3 0.06 1.56 0.98
121 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 3 0.43 0.61 0.98
122 INT346204 Binding of S100A10 and TPPP 1 1 0.02 1.62 0.97
123 INT187111 TIMP2 Regulation of MMP9 1 2 0.23 1.47 0.97
124 INT278292 Binding of CRP and ESR1 6 2 0.09 10.92 0.96
125 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 1 0.48 1.26 0.96
126 INT240123 MIR885 Negative_regulation of IL1B 1 2 0.01 1.57 0.96
127 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 1 0.03 3.42 0.95
128 INT182203 Binding of CXCL1 and CXCR2 1 1 0.14 1.25 0.95
129 INT182190 Binding of IL8 and CXCR4 1 1 0.26 1.25 0.95
130 INT182207 Binding of CXCR2 and CXCL13 1 1 0.42 1.26 0.95
131 INT182208 Binding of CXCR2 and CXCL12 1 1 0.29 1.26 0.95
132 INT182210 Binding of CXCR4 and CXCL13 1 1 0.32 1.25 0.95
133 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 1 0.67 1.91 0.94
134 INT182193 Binding of CXCR2 and CXCL5 1 1 0.30 1.25 0.94
135 INT182206 Binding of CXCR5 and IL8 1 1 0.30 1.25 0.94
136 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 2 0.04 1.47 0.94
137 INT182188 Binding of CXCR5 and CXCL5 1 1 0.34 1.24 0.94
138 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 3 0.05 1.58 0.94
139 INT182199 Binding of CXCR5 and CXCL1 1 1 0.16 1.24 0.94
140 INT182197 Binding of CXCR2 and CCL16 1 1 0.00 1.24 0.94
141 INT182205 Binding of CXCL5 and CXCR4 1 1 0.29 1.24 0.94
142 INT182198 Binding of CXCR5 and CXCL12 1 1 0.33 1.25 0.94
143 INT182195 Binding of CXCL1 and CXCR4 1 1 0.13 1.25 0.94
144 INT126766 Binding of PTGDS and PTGDR2 4 1 0.40 1.62 0.93
145 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 4 0.15 1.73 0.93
146 INT182189 Binding of CXCL1 and CXCL13 1 1 0.14 1.24 0.93
147 INT182209 Binding of CXCL12 and CXCL13 1 1 0.30 1.24 0.93
148 INT182196 Binding of IL8 and CXCL13 1 1 0.27 1.24 0.93
149 INT182204 Binding of CXCL5 and CXCL13 1 1 0.30 1.24 0.93
150 INT107001 F2 Positive_regulation of PAR1 4 1 0.05 2.15 0.92
151 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 1 0.04 0 0.92
152 INT250976 Binding of FMOD and IL8 1 1 0.08 1.26 0.91
153 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 1 0.14 1.24 0.91
154 INT141965 Binding of ADM and CALCRL 5 1 0.33 3.6 0.89
155 INT346266 MTX1 Regulation of IL17A 1 1 0.08 1.33 0.89
156 INT203101 Binding of Aes and Mtx1 2 1 0.25 0.24 0.88
157 INT224583 CSF2 Positive_regulation of IL1RN 1 1 0.02 1.3 0.88
158 INT209928 IL1B Positive_regulation of MAPK14 2 3 0.15 1.69 0.87
159 INT231716 Binding of IL6 and DIP 1 2 0.24 1.55 0.87
160 INT224585 IL1B Positive_regulation of IL1RN 1 1 0.02 1.3 0.87
161 INT207439 Binding of HCRT and ERAL1 1 3 0.00 3.06 0.87
162 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 1 0.00 1.56 0.87
163 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 3 0.27 1.92 0.87
164 INT209881 Binding of TNFRSF11B and TNFSF11 8 3 0.36 8.92 0.86
165 INT323698 Gene_expression of MIR146A Regulation of FAF1 1 2 0.16 1.82 0.86
166 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 1 0.01 0.73 0.85
167 INT182636 Binding of TNFSF11 and TNFRSF11A 16 10 0.29 17.5 0.84
168 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 3 0.04 1.51 0.84
169 INT221034 IL10 Positive_regulation of Localization of CCL18 1 3 0.19 1.3 0.84
170 INT174509 Binding of CD4 and CD28 1 2 0.26 1.68 0.84
171 INT184114 Tlr4 Positive_regulation of Socs3 2 1 0.65 1.14 0.83
172 INT187290 Binding of HEY1 and Gtf3a 1 2 0.00 6.18 0.83
173 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 2 0.05 1.28 0.82
174 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 1 0.04 0.96 0.82
175 INT187232 Vip Positive_regulation of Gene_expression of Il10 1 1 0.16 0.95 0.81
176 INT231693 Binding of IGKV2-19 and BDNF-AS 1 3 0.00 2.39 0.81
177 INT201945 Binding of CXCR1 and CXCR2 3 1 0.14 0.84 0.8
178 INT220056 Binding of NTF3 and NTRK1 1 1 0.07 1.12 0.78
179 INT188531 Binding of TNF and PDXK 1 2 0.03 1.99 0.78
180 INT239064 Binding of Mbl1 and IgG 1 2 0.03 2.59 0.78
181 INT220063 Binding of NTF3 and NTRK2 1 1 0.09 1.13 0.78
182 INT346133 RAMP2 Regulation of ADM 1 1 0.13 2.06 0.78
183 INT203164 PTGER2 Regulation of ALOX5 1 1 0.00 0.9 0.78
184 INT187229 Binding of Tnfsf11 and Insrr 1 2 0.00 2.06 0.78
185 INT184116 Il10 Positive_regulation of Stat3 2 2 0.18 1.15 0.77
186 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 2 0.05 1.19 0.77
187 INT203171 PTGER2 Negative_regulation of ALOX5 1 1 0.01 0.89 0.77
188 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 2 0.20 1.83 0.77
189 INT346234 MAP2K6 Positive_regulation of MAPK14 1 2 0.44 1.65 0.77
190 INT194644 Tlr4 Positive_regulation of TNF 6 1 0.58 2.42 0.76
191 INT183698 Binding of Cxcr2 and Cxcl1 3 1 0.33 3.26 0.76
192 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 1 0.57 1.4 0.76
193 INT224463 TPSAB1 Positive_regulation of F2RL1 2 1 0.03 1.49 0.76
194 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 1 0.43 1.34 0.76
195 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 2 0.11 1.82 0.76
196 INT220057 Binding of NTS and TNFRSF1B 1 1 0.08 1.23 0.76
197 INT178576 CNTN2 Positive_regulation of DPYD 1 1 0.05 2.18 0.76
198 INT178581 CNTN2 Positive_regulation of PTHLH 1 1 0.24 2.16 0.75
199 INT178577 CNTN2 Positive_regulation of IL2RA 1 1 0.03 2.16 0.75
200 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 1 0.05 1.1 0.75

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
3 INT6483 Gene_expression of TNF 520 3152 0.78 2515.62 929.82
4 INT58061 Gene_expression of Trpv1 10 1117 0.78 451.54 637.59
5 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
6 INT155 Positive_regulation of Prl 2 1233 0.70 317.93 457.82
7 INT443 Localization of POMC 13 1020 0.81 284.52 443.17
8 INT50058 Negative_regulation of Cpox 9 907 0.58 426.28 428.29
9 INT9238 Gene_expression of IL6 110 1575 0.78 1135.66 424.22
10 INT64202 Positive_regulation of Trpv1 12 643 0.70 249.66 397.42
11 INT467 Gene_expression of POMC 17 1048 0.78 332.8 394.16
12 INT18357 Gene_expression of TRPV1 1 825 0.78 307.11 382.81
13 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
14 INT439 Localization of Gnrh1 3 976 0.81 100.96 363.25
15 INT720 Positive_regulation of POMC 11 807 0.70 237.37 353.83
16 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
17 INT876 Localization of Gh1 1 843 0.80 67.75 340.82
18 INT5235 Negative_regulation of TNF 167 924 0.59 772.91 331.98
19 INT5235 Negative_regulation of TNF 5 924 0.59 772.91 331.98
20 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
21 INT5059 Positive_regulation of TNF 152 1050 0.70 896.51 322.81
22 INT34869 Negative_regulation of PTGS2 10 778 0.59 366.76 319.85
23 INT46460 Gene_expression of NAV1 1 288 0.78 135.51 305.75
24 INT4941 Positive_regulation of Oprd1 1 345 0.70 74.26 304.41
25 INT9131 Positive_regulation of Prkcg 3 431 0.70 130.8 302.41
26 INT477 Localization of Avp 2 813 0.81 131.58 300.4
27 INT63932 Positive_regulation of Ephb1 5 537 0.70 259.67 296.14
28 INT886 Gene_expression of Pomc 21 676 0.78 129.87 295.98
29 INT5379 Gene_expression of Fos 2 656 0.78 255.5 292.54
30 INT9158 Gene_expression of Tnf 3 722 0.78 522.01 277.68
31 INT9381 Positive_regulation of TRPV1 3 523 0.70 187.4 276.05
32 INT49750 Negative_regulation of CPOX 79 735 0.58 360.06 274.19
33 INT6852 Localization of TNF 117 883 0.81 705.95 270.84
34 INT10832 Gene_expression of IL8 71 1050 0.78 698.72 270
35 INT9659 Gene_expression of Il6 111 991 0.78 715.11 265.57
36 INT5972 Gene_expression of IL1B 211 948 0.78 510.91 263.97
37 INT68684 Gene_expression of VEGFA 134 2371 0.78 1742.52 259.2
38 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
39 INT1893 Localization of Gh 3 1041 0.79 340.23 256.58
40 INT16868 Gene_expression of Il6 39 807 0.78 499.48 256.57
41 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
42 INT1562 Localization of Crh 13 499 0.81 126.74 236.68
43 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
44 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
45 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
46 INT6481 Binding of TNF 127 624 0.48 510.2 214.82
47 INT767 Localization of Gnrhr 5 565 0.80 106.68 214.57
48 INT4893 Gene_expression of Tacr1 17 366 0.78 129.67 213.92
49 INT22548 Positive_regulation of Casp3 3 483 0.70 258.78 213.07
50 INT6482 Positive_regulation of Gene_expression of TNF 107 659 0.70 569.88 210
51 INT48955 Gene_expression of Nos2 20 753 0.78 403.87 208.08
52 INT2651 Positive_regulation of Pomc 6 403 0.70 95.72 206.24
53 INT2391 Negative_regulation of PTGS1 3 501 0.59 207.62 205.6
54 INT9132 Negative_regulation of Prkcg 5 279 0.59 88.05 203.47
55 INT11313 Positive_regulation of Il6 10 526 0.70 331.27 201.59
56 INT50670 Gene_expression of CPOX 62 763 0.76 442.13 195.02
57 INT528 Gene_expression of Prl 3 693 0.78 217.18 192.2
58 INT6488 Gene_expression of Tnf 3 484 0.78 339.61 191.58
59 INT63934 Phosphorylation of Ephb1 2 377 0.82 150.52 188.66
60 INT10194 Positive_regulation of IL6 35 702 0.70 600.62 183.38
61 INT49441 Negative_regulation of Cpox 2 494 0.59 303.22 177.46
62 INT1429 Gene_expression of PDYN 9 308 0.78 61.33 175.65
63 INT19472 Gene_expression of Il1 121 554 0.76 419.75 175.35
64 INT15516 Gene_expression of Crp 48 711 0.77 615.33 173.09
65 INT438 Gene_expression of Crh 5 376 0.78 159.11 169.17
66 INT867 Gene_expression of IFNA1 194 930 0.78 594.85 168.03
67 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
68 INT55879 Gene_expression of CCL2 35 421 0.78 240.74 166.02
69 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
70 INT5513 Negative_regulation of Pomc 2 295 0.59 60.9 158.63
71 INT51921 Gene_expression of Cpox 23 501 0.73 229.81 157.81
72 INT66280 Gene_expression of Nos2 6 534 0.78 330.78 157.07
73 INT120811 Gene_expression of Gopc 7 1174 0.59 428.49 150.55
74 INT15515 Positive_regulation of Crp 27 700 0.70 604.24 150.15
75 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
76 INT5116 Gene_expression of IL2 29 670 0.78 291.13 146.69
77 INT812 Localization of INS 1 1026 0.81 515.6 145.31
78 INT60694 Gene_expression of Il10 16 567 0.78 369.48 143.69
79 INT9660 Regulation of TNF 68 363 0.62 312.94 139.99
80 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
81 INT48895 Gene_expression of Il10 5 333 0.78 221.2 138.52
82 INT60126 Regulation of Trpv1 1 186 0.62 85.53 133.4
83 INT48953 Positive_regulation of Nos2 20 486 0.70 239.85 131.87
84 INT5497 Positive_regulation of Crh 4 299 0.70 125.54 131.14
85 INT49439 Gene_expression of Cpox 2 508 0.73 326.97 130.17
86 INT115386 Gene_expression of Ppara 8 779 0.77 549.99 128.36
87 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
88 INT1878 Binding of HLA-B 33 440 0.48 321.16 127.36
89 INT1878 Binding of HLA-B 1 440 0.48 321.16 127.36
90 INT695 Binding of POMC 6 304 0.48 56.66 126.85
91 INT4824 Positive_regulation of Tacr1 12 169 0.70 66.1 123.46
92 INT252 Localization of GH1 6 529 0.80 227.4 122.05
93 INT6128 Positive_regulation of Localization of POMC 5 256 0.70 68.77 121.64
94 INT7533 Gene_expression of Tlr4 22 720 0.78 343.22 121.57
95 INT14151 Gene_expression of Casp3 1 311 0.78 140.26 120.68
96 INT64201 Negative_regulation of Trpv1 1 203 0.59 79.18 119.75
97 INT8243 Positive_regulation of Il6 29 451 0.70 358.24 119.28
98 INT17612 Gene_expression of CRP 67 676 0.78 580.61 119.03
99 INT9235 Negative_regulation of Gene_expression of TNF 41 346 0.59 252.98 118.61
100 INT50674 Gene_expression of PTGS2 4 459 0.78 253.33 118.51
101 INT12339 Localization of IL8 10 437 0.81 251.87 117.39
102 INT4207 Regulation of Avp 2 267 0.62 63.72 115.33
103 INT62124 Gene_expression of NOS1 47 444 0.78 218.08 114.85
104 INT48593 Positive_regulation of NOS1 21 420 0.68 226.15 114.71
105 INT20374 Gene_expression of Il4 39 515 0.76 306.15 114.12
106 INT170025 Gene_expression of Fig4 12 588 0.67 183.27 113.32
107 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
108 INT118381 Gene_expression of Il17a 67 405 0.76 306.97 112.06
109 INT11051 Positive_regulation of Gene_expression of IL6 24 415 0.69 319.21 109.3
110 INT27096 Positive_regulation of Nfkb1 3 325 0.70 195.11 109.06
111 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
112 INT60526 Gene_expression of IL10 63 449 0.78 292.71 107.84
113 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
114 INT12082 Localization of IL6 18 365 0.81 241.78 105.78
115 INT69440 Gene_expression of ROS1 41 752 0.78 477.64 103.83
116 INT18009 Positive_regulation of CRP 38 518 0.70 553.03 103.74
117 INT90091 Gene_expression of GOPC 54 967 0.67 366.22 103.6
118 INT1898 Regulation of Crh 3 220 0.62 61.33 102.64
119 INT89054 Positive_regulation of Gene_expression of Trpv1 3 156 0.70 90.78 102.03
120 INT10838 Positive_regulation of IL8 26 381 0.70 295.51 101.62
121 INT11381 Positive_regulation of IL1B 36 330 0.70 209.31 100.9
122 INT97701 Phosphorylation of Mapk14 4 191 0.82 115.33 100.46
123 INT7944 Positive_regulation of Fos 3 193 0.70 60.69 98.31
124 INT874 Positive_regulation of Gh1 2 244 0.70 27.17 97.98
125 INT1760 Gene_expression of PTGER2 103 524 0.57 226.94 96.4
126 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
127 INT74058 Gene_expression of Nos1 25 260 0.78 80.04 95.71
128 INT11587 Gene_expression of CSF2 6 645 0.78 544.38 93.89
129 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
130 INT86024 Gene_expression of PPARA 40 736 0.78 497.93 91.14
131 INT38731 Localization of Trpv1 1 138 0.81 52.73 90.49
132 INT48767 Negative_regulation of NOS1 6 312 0.59 154.25 90.32
133 INT1160 Positive_regulation of Rbm39 2 122 0.57 28.19 90.28
134 INT12763 Phosphorylation of Prkcg 1 167 0.82 38.91 89.63
135 INT71789 Positive_regulation of MAPK1 43 396 0.70 234.44 89.27
136 INT96917 Positive_regulation of Mapk14 5 261 0.70 173.29 88.79
137 INT48408 Gene_expression of ICAM1 28 494 0.78 340.08 88.6
138 INT15898 Positive_regulation of Prkaca 3 199 0.70 50.89 87.54
139 INT54571 Positive_regulation of NFKB1 2 263 0.70 138.99 87.32
140 INT54571 Positive_regulation of NFKB1 2 263 0.70 138.99 87.32
141 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
142 INT914 Positive_regulation of GH1 8 292 0.69 100.7 84.91
143 INT4857 Regulation of Tacr1 1 115 0.62 39.01 84.52
144 INT82448 Gene_expression of S100a8 10 246 0.77 236.72 84.02
145 INT92434 Phosphorylation of Mapk1 1 287 0.82 91.65 83.46
146 INT84546 Positive_regulation of Ppara 2 481 0.70 334.21 83.45
147 INT75999 Gene_expression of BDNF 64 344 0.78 114.19 83.12
148 INT48406 Gene_expression of Icam1 9 277 0.78 238.28 81.71
149 INT68682 Positive_regulation of VEGFA 22 640 0.70 454.14 81.65
150 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
151 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
152 INT55944 Positive_regulation of Cpox 17 214 0.57 105.14 81.4
153 INT1498 Gene_expression of Gh 4 521 0.75 220.84 81.16
154 INT99070 Gene_expression of Mapk14 1 147 0.78 103.99 79.59
155 INT64636 Positive_regulation of Gene_expression of Nos2 8 242 0.70 147.52 79.53
156 INT920 Localization of PLOD1 2 223 0.81 42.25 78.7
157 INT12476 Negative_regulation of TRPV1 2 124 0.59 47.95 77.98
158 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
159 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
160 INT749 Gene_expression of HLA-B 35 341 0.75 224.12 77.37
161 INT24958 Gene_expression of Nkx1-1 4 106 0.74 51.29 76.88
162 INT62374 Gene_expression of NGF 37 158 0.78 77.87 76.45
163 INT60691 Gene_expression of Il12a 9 331 0.78 208.03 75.96
164 INT16654 Gene_expression of Insrr 5 138 0.46 58.96 75.68
165 INT1497 Negative_regulation of Gh 1 415 0.59 192.95 74.71
166 INT5056 Gene_expression of IFNG 2 216 0.78 137.52 74.57
167 INT1724 Negative_regulation of ACE 4 437 0.59 315.64 74.48
168 INT48244 Gene_expression of Il4 2 172 0.76 132.38 73.42
169 INT63936 Positive_regulation of Phosphorylation of Ephb1 1 131 0.70 49.38 73.16
170 INT9236 Regulation of Gene_expression of TNF 32 204 0.62 162.66 72.99
171 INT56298 Gene_expression of IL4 58 306 0.78 182.18 72.92
172 INT442 Localization of PDYN 2 99 0.81 11.87 72.75
173 INT39565 Gene_expression of Ptger2 17 424 0.75 229.28 72.68
174 INT11380 Negative_regulation of IL1B 42 215 0.59 125.62 72.35
175 INT4153 Binding of Insrr 1 109 0.40 17.99 72.15
176 INT12720 Positive_regulation of Il1 49 246 0.70 195.97 72.05
177 INT49111 Negative_regulation of Prkaca 1 102 0.59 27.44 71.77
178 INT5969 Gene_expression of Il1a 28 221 0.75 96.31 71.38
179 INT10837 Positive_regulation of Gene_expression of IL8 21 294 0.70 190.08 70.34
180 INT8346 Gene_expression of Qrfp 9 136 0.70 19.49 70.21
181 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
182 INT79494 Positive_regulation of Gene_expression of VEGFA 30 577 0.70 442.94 69.73
183 INT170332 Gene_expression of IFN1@ 23 477 0.75 275.21 69.65
184 INT6849 Localization of IL1B 30 229 0.81 112.56 69.63
185 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
186 INT53964 Negative_regulation of Prkaca 4 131 0.58 38.76 69.52
187 INT8357 Gene_expression of KNG1 2 153 0.75 77.26 68.66
188 INT7534 Gene_expression of Ifng 2 193 0.78 111.02 68.6
189 INT5861 Gene_expression of Egr1 1 203 0.78 49.35 68.13
190 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
191 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
192 INT19511 Localization of Il6 10 212 0.81 118.17 67.67
193 INT55224 Gene_expression of DRGX 3 99 0.31 67.55 67.63
194 INT8388 Positive_regulation of Vip 1 142 0.70 39.72 67.61
195 INT102546 Gene_expression of Ccl2 3 197 0.78 192.8 67.41
196 INT5374 Gene_expression of Esr1 43 412 0.77 263.89 67.34
197 INT9489 Gene_expression of SFTPA1 5 112 0.66 55.38 66.45
198 INT4960 Positive_regulation of CSF2 3 285 0.70 256.73 65.73
199 INT3375 Gene_expression of IGHE 3 535 0.77 387.47 65.46
200 INT1425 Gene_expression of Rbm39 5 143 0.58 51.32 65.44
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