J:Arzneimittelforschung

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT20411 Ghrh Positive_regulation of Gh1 6 1 0.56 0.62 2.47
2 INT167819 IFNA1 Positive_regulation of Fst 1 1 0.39 0 1.07
3 INT31260 Sst Negative_regulation of Gh1 2 1 0.11 0 0.66
4 INT80752 Binding of Il1b and El4 1 1 0.49 0.08 0.54
5 INT80751 Negative_regulation of Binding of Il1b and El4 1 1 0.60 0.08 0.54
6 INT72264 Binding of Hrh1 and Hrh3 1 1 0.11 0.16 0.34
7 INT37157 Pir Positive_regulation of Kncn 1 1 0.01 0.38 0.3
8 INT25169 GHRH Positive_regulation of Localization of Gh 1 2 0.12 0 0.29
9 INT22820 ADRA1D Regulation of ELANE 1 2 0.21 0 0.15
10 INT46268 MAPKAP1 Regulation of PTGS1 1 1 0.13 0 0.13
11 INT25285 CBS Negative_regulation of Localization of IL1RL1 1 1 0.05 0 0.09
12 INT10986 Nfasc Regulation of Hal 1 1 0.00 0.07 0.07
13 INT35137 SPANXC Positive_regulation of Negative_regulation of SERPINF2 1 1 0.00 0 0
14 INT65036 Fgf1 Regulation of Anxa5 1 1 0.01 0.35 0
15 INT65035 Fgf1 Regulation of F2 1 1 0.07 0.34 0
16 INT35138 SPANXC Regulation of ANGPTL5 1 1 0.00 0 0
17 INT35139 SPANXC Regulation of PLG 1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
2 INT3439 Localization of Abat 4 1017 0.78 112.39 727.06
3 INT6580 Negative_regulation of Ptgs1 10 929 0.59 381.53 376.26
4 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
5 INT287 Localization of Cck 1 518 0.81 86.84 364.04
6 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
7 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
8 INT5660 Binding of Oprd1 5 477 0.48 71.86 342.06
9 INT876 Localization of Gh1 10 843 0.80 67.75 340.82
10 INT34869 Negative_regulation of PTGS2 3 778 0.59 366.76 319.85
11 INT1352 Localization of Acot1 2 728 0.80 73.01 296.01
12 INT1893 Localization of Gh 3 1041 0.79 340.23 256.58
13 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
14 INT1902 Gene_expression of Cck 1 348 0.78 70.33 241.92
15 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
16 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
17 INT4937 Negative_regulation of Oprd1 1 224 0.59 44.51 171.11
18 INT4829 Positive_regulation of Localization of Abat 2 199 0.55 20.91 150.48
19 INT880 Positive_regulation of Localization of Gh1 1 304 0.70 14.79 150.23
20 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
21 INT9852 Positive_regulation of Gpt 2 563 0.70 364.64 146.82
22 INT425 Localization of PRL 1 455 0.81 189.64 144.8
23 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
24 INT695 Binding of POMC 1 304 0.48 56.66 126.85
25 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
26 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
27 INT8413 Gene_expression of Ptgs1 4 248 0.78 110.17 108.58
28 INT940 Negative_regulation of Ptgs1 5 219 0.59 104.34 95.97
29 INT5865 Positive_regulation of Localization of Gh 2 282 0.69 84.86 93.5
30 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
31 INT4289 Positive_regulation of Localization of Gnrh1 1 202 0.70 12.3 84.01
32 INT2155 Negative_regulation of Sst 2 111 0.59 16.58 77.74
33 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
34 INT1353 Negative_regulation of Localization of Acot1 1 153 0.53 15.05 75.17
35 INT7534 Gene_expression of Ifng 1 193 0.78 111.02 68.6
36 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
37 INT5095 Localization of Ghrh 2 185 0.81 28.09 62.08
38 INT1169 Negative_regulation of Bche 2 322 0.59 149.22 61.27
39 INT2761 Regulation of Gabrg1 1 119 0.61 18.8 60.52
40 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
41 INT546 Binding of ALB 6 311 0.48 85.98 60.14
42 INT6623 Gene_expression of NA 1 231 0.78 45.78 59.36
43 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
44 INT314 Positive_regulation of Ren 2 212 0.70 66.68 55.56
45 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
46 INT5098 Negative_regulation of Localization of Sst 1 70 0.58 3.56 51.17
47 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
48 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
49 INT873 Gene_expression of Gh1 1 130 0.76 26.15 46.75
50 INT89 Positive_regulation of Gast 5 187 0.70 80.49 42.07
51 INT30 Gene_expression of Gast 2 158 0.78 99 41.45
52 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
53 INT48075 Positive_regulation of Il1b 2 71 0.67 48.63 40.48
54 INT13501 Binding of Drd2 1 65 0.48 23.76 35.6
55 INT316 Regulation of Cebpz 2 105 0.00 27.21 35.41
56 INT5743 Localization of NA 1 104 0.59 14.35 35.29
57 INT326 Gene_expression of Gnrhr 1 105 0.76 35.87 34.93
58 INT2330 Regulation of CB 1 78 0.10 20.46 32.6
59 INT10453 Positive_regulation of Gad1 1 65 0.70 10.75 31.9
60 INT7082 Gene_expression of CRH 7 180 0.78 64.66 31.74
61 INT5418 Negative_regulation of Alox5 7 108 0.57 42.09 31.17
62 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
63 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
64 INT1079 Positive_regulation of Ache 2 104 0.70 23.52 30.28
65 INT5100 Positive_regulation of Ghrh 1 100 0.64 24.2 30.21
66 INT28 Regulation of Gast 1 106 0.62 26.37 29.85
67 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
68 INT894 Binding of Avp 1 84 0.48 29.16 29.63
69 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
70 INT2532 Negative_regulation of Cebpz 1 98 0.00 53.06 28.57
71 INT57692 Positive_regulation of Gene_expression of Il1b 1 50 0.67 43.54 28.29
72 INT5653 Positive_regulation of ELANE 1 136 0.70 72.78 27.94
73 INT6382 Regulation of Binding of Oprd1 1 36 0.61 7 26.48
74 INT6179 Binding of Oprk1 2 37 0.48 9.24 24.83
75 INT6385 Regulation of Man2a2 1 48 0.61 7.8 24.68
76 INT2140 Regulation of REN 1 104 0.62 28.24 24.49
77 INT12441 Positive_regulation of Gpr156 1 29 0.67 5.7 24.44
78 INT11746 Positive_regulation of Il1a 1 65 0.63 42.94 23.54
79 INT825 Negative_regulation of ADRA1D 1 54 0.58 20.25 22.78
80 INT21503 Binding of Ptgs1 1 45 0.48 15.6 22.29
81 INT35711 Positive_regulation of Sdcbp 1 110 0.60 50.45 22.11
82 INT5905 Negative_regulation of ELANE 7 113 0.59 47.43 22.09
83 INT1561 Negative_regulation of Dnahc8 2 59 0.59 18.12 20.99
84 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
85 INT49774 Binding of DRD2 1 48 0.48 17.42 20.73
86 INT45840 Positive_regulation of Gene_expression of Ptgs1 1 35 0.50 16.07 20.49
87 INT48144 Gene_expression of Fgf2 7 117 0.78 43 20.48
88 INT7994 Gene_expression of Lta 1 113 0.67 69.81 19.59
89 INT40811 Binding of OPRL1 1 26 0.48 2.76 18.68
90 INT55335 Binding of Cpox 4 49 0.34 15.48 18.46
91 INT6791 Binding of NA 1 55 0.46 5.36 17.59
92 INT32515 Negative_regulation of B4GALNT1 1 82 0.43 28.1 17.46
93 INT8037 Negative_regulation of Man2a2 1 39 0.42 5.15 17.44
94 INT24209 Negative_regulation of Ifng 1 37 0.57 16.52 17.15
95 INT3206 Positive_regulation of Got1 1 39 0.69 19.36 17.02
96 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
97 INT1721 Negative_regulation of HP 4 148 0.42 86.82 16.89
98 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
99 INT3926 Regulation of Bdkrb1 1 22 0.61 16.72 16.1
100 INT12617 Regulation of ADCY1 1 41 0.61 7.38 15.94
101 INT6381 Negative_regulation of Chat 1 51 0.59 19.68 15.86
102 INT1850 Binding of OXA1L 2 77 0.48 7.61 15.22
103 INT4851 Positive_regulation of Chat 1 53 0.70 9.21 15.11
104 INT3545 Positive_regulation of Mtx1 1 27 0.42 11.97 14.83
105 INT22276 Gene_expression of TBXA2R 3 65 0.77 23.22 14.21
106 INT23344 Gene_expression of Alox5 6 60 0.75 28.2 13.82
107 INT7997 Gene_expression of Ltc4s 1 51 0.76 34.28 13.8
108 INT16530 Gene_expression of Ghrh 2 45 0.77 6.22 13.44
109 INT4460 Regulation of Mpo 2 44 0.62 31.16 12.11
110 INT11429 Gene_expression of ADCY1 1 26 0.74 5.89 11.93
111 INT12992 Negative_regulation of Gene_expression of Ptgs1 1 33 0.42 20.47 11.77
112 INT744 Positive_regulation of PTH 1 130 0.70 95.02 11.7
113 INT2260 Gene_expression of Tyr 1 30 0.49 7.05 11.31
114 INT2956 Binding of H2-Ab1 4 19 0.37 3.1 11.18
115 INT14334 Negative_regulation of Il2 1 31 0.58 18.63 11.08
116 INT93129 Negative_regulation of KCNH2 1 42 0.54 9.63 10.85
117 INT19010 Negative_regulation of Localization of Ghrh 1 27 0.57 4.85 10.5
118 INT6574 Negative_regulation of Pla2g1b 1 35 0.59 11.4 10.44
119 INT17421 Negative_regulation of Alox5 1 41 0.57 15.23 10.05
120 INT7995 Positive_regulation of Lta 1 28 0.66 14.98 9.8
121 INT35164 Negative_regulation of IGHE 1 96 0.58 76.3 9.74
122 INT12367 Binding of PRLR 1 17 0.03 2.05 9.69
123 INT336 Negative_regulation of Gad1 1 19 0.58 7.71 9.51
124 INT46273 Gene_expression of PRNP 1 103 0.78 110.34 9.25
125 INT2339 Positive_regulation of CB 1 30 0.29 10.68 9.12
126 INT42971 Binding of Hivep3 1 14 0.42 3.92 8.99
127 INT22285 Negative_regulation of Mtx1 1 16 0.49 7.84 8.98
128 INT7090 Gene_expression of pcp 1 50 0.66 13.54 8.96
129 INT860 Regulation of ALB 1 48 0.60 25.11 8.95
130 INT9889 Gene_expression of Alox5 1 34 0.63 20.83 8.85
131 INT26487 Positive_regulation of Npr1 2 17 0.70 10.01 8.78
132 INT8637 Negative_regulation of Dbp 1 112 0.50 33.28 8.4
133 INT15481 Positive_regulation of asa 3 13 0.39 6.12 8.24
134 INT36173 Positive_regulation of Gs 2 17 0.43 7.48 8.19
135 INT62452 Regulation of Il2 1 14 0.61 12.11 7.64
136 INT4022 Negative_regulation of PLA2G1B 1 30 0.59 10.41 7.58
137 INT8684 Positive_regulation of ANGPTL5 1 45 0.69 36.29 7.47
138 INT14166 Positive_regulation of Ahr 3 32 0.61 20.78 7.47
139 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
140 INT2802 Negative_regulation of Asrgl1 1 14 0.59 2.69 7.37
141 INT10924 Positive_regulation of Sysbp1 2 25 0.04 11.12 7.35
142 INT22275 Negative_regulation of TBXA2R 2 25 0.54 8.67 7.34
143 INT5308 Regulation of Il1a 1 17 0.44 10.8 7.31
144 INT3928 Localization of Bdkrb1 3 15 0.75 4.06 7.23
145 INT2605 Regulation of ELANE 3 39 0.61 18.22 7.11
146 INT717 Regulation of F2 1 29 0.61 17.46 6.99
147 INT2733 Negative_regulation of Tbxas1 2 33 0.57 12.12 6.97
148 INT17143 Regulation of Cyp2c22 1 18 0.60 3.02 6.7
149 INT35712 Regulation of Sdcbp 2 19 0.23 5.3 6.58
150 INT9951 Gene_expression of ANGPTL5 1 45 0.53 37.2 6.44
151 INT38807 Negative_regulation of PLA2G6 1 29 0.59 10.1 6.42
152 INT20389 Localization of LYZ 1 19 0.79 4.58 6.25
153 INT4561 Gene_expression of PLG 1 32 0.75 17.59 6.21
154 INT55034 Positive_regulation of Adm 1 27 0.61 14.1 6.13
155 INT71230 Regulation of asa 4 11 0.55 4.75 5.97
156 INT25123 Negative_regulation of COL7A1 1 42 0.58 19.98 5.96
157 INT80750 Binding of Il1b 1 11 0.47 7.97 5.95
158 INT63177 Regulation of HP 1 71 0.44 39.48 5.86
159 INT7996 Gene_expression of Ptgds 1 18 0.64 6.47 5.51
160 INT51411 Negative_regulation of EDAR 2 8 0.41 1.05 5.49
161 INT1849 Binding of SUPT7L 1 14 0.47 0.95 5.44
162 INT10916 Positive_regulation of BDNF-AS 1 39 0.49 25.88 5.28
163 INT22907 Positive_regulation of Ggt1 1 33 0.67 17.82 5.28
164 INT18661 Localization of Ghsr 1 32 0.78 3.19 5.2
165 INT27415 Negative_regulation of Positive_regulation of Got1 1 15 0.51 10.99 5.14
166 INT6577 Regulation of Alox5 1 18 0.47 9.19 5.06
167 INT22825 Regulation of Gtf3a 1 36 0.25 19.93 5.03
168 INT50311 Binding of Htas2 1 9 0.47 1.19 4.91
169 INT20059 Protein_catabolism of Ache 1 15 0.98 3.73 4.87
170 INT10694 Binding of Bche 1 19 0.48 8.03 4.85
171 INT12104 Positive_regulation of PLG 2 45 0.68 28.94 4.81
172 INT8786 Negative_regulation of ALDH7A1 1 27 0.52 12.81 4.76
173 INT30355 Positive_regulation of Gene_expression of Alox5 4 10 0.67 14.61 4.69
174 INT24910 Negative_regulation of Enpp3 3 20 0.57 8.23 4.67
175 INT15995 Positive_regulation of Alox5 1 18 0.49 3.94 4.63
176 INT1983 Negative_regulation of Cbr1 1 4 0.58 4.44 4.52
177 INT29668 Regulation of PTGER1 1 9 0.45 5.52 4.5
178 INT6881 Binding of Tspo 1 12 0.46 5.03 4.38
179 INT387 Regulation of Ace 1 18 0.45 5.24 4.24
180 INT14165 Negative_regulation of Ahr 1 14 0.51 8.35 4.17
181 INT34829 Positive_regulation of Gnat3 1 27 0.46 5.24 4.14
182 INT13190 Gene_expression of Pbk 1 10 0.31 1.97 4.14
183 INT4075 Positive_regulation of Gene_expression of Gast 2 24 0.68 19.99 4.02
184 INT484 Negative_regulation of ADRB2 1 13 0.59 2.85 3.94
185 INT57724 Regulation of Cux1 1 10 0.39 1.81 3.92
186 INT9748 Negative_regulation of Sysbp1 3 28 0.35 8.93 3.87
187 INT54886 Negative_regulation of ANGPT2 1 25 0.42 9.33 3.79
188 INT48143 Gene_expression of Fgf1 2 32 0.78 8.2 3.72
189 INT40034 Localization of Maoa 1 7 0.80 2.17 3.69
190 INT25136 Localization of Gnat3 2 23 0.75 5.01 3.65
191 INT10586 Localization of B2M 1 15 0.68 8.67 3.46
192 INT5400 Positive_regulation of DBH 3 6 0.70 2.02 3.38
193 INT22823 Positive_regulation of Positive_regulation of ELANE 1 12 0.45 6.89 3.35
194 INT22274 Negative_regulation of Gene_expression of TBXA2R 1 12 0.58 3.32 3.28
195 INT26312 Positive_regulation of PLA2G6 1 26 0.70 7.41 3.2
196 INT35143 Negative_regulation of ANGPTL5 2 28 0.54 18.59 3.14
197 INT14086 Binding of SERPINB1 1 18 0.34 4.32 3.13
198 INT27446 Negative_regulation of CTSA 3 11 0.57 5.58 3.08
199 INT7909 Positive_regulation of Positive_regulation of Got1 1 8 0.49 6.44 3.06
200 INT65033 Negative_regulation of Fgf2 1 21 0.59 12.36 2.94
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