J:Autoimmune Diseases

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT276964 Binding of Tlr1 and Tlr2 11 1 0.24 4.22 0.89
2 INT276988 Binding of Tlr6 and Tlr2 11 1 0.26 4.89 0.79
3 INT350699 Binding of Casp8 and Stat3 1 1 0.04 1.81 0.58
4 INT350716 Binding of CD58 and Casp8 1 1 0.03 1.81 0.58
5 INT350693 Mir326 Positive_regulation of Regulation of thd 1 1 0.00 1.32 0.41
6 INT350698 Mir326 Regulation of Ets1 1 1 0.01 1.27 0.4
7 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 1 0.03 1.46 0.33
8 INT313915 Binding of Il12a and Il23a 2 1 0.16 0.44 0.31
9 INT350718 Mir106b Regulation of TGFB1 1 1 0.00 0.42 0.18
10 INT350603 MIR25 Regulation of TGFB1 1 1 0.01 0.42 0.18
11 INT350702 Rc3h1 Positive_regulation of Protein_catabolism of Icos 1 2 0.35 1.56 0.18
12 INT350717 MIR219-1 Negative_regulation of Zfp238 1 1 0.01 0.4 0.16
13 INT350719 MIR219-1 Negative_regulation of Foxj3 1 1 0.01 0.4 0.15
14 INT350713 MIR219-1 Negative_regulation of Pdgfra 1 1 0.00 0.4 0.15
15 INT350723 MIR219-1 Negative_regulation of Sox6 1 1 0.01 0.4 0.15
16 INT350711 Ifnb1 Negative_regulation of Gene_expression of DICER1 1 1 0.03 0.15 0.14
17 INT345280 Binding of Tlr2 and Tlr7 1 2 0.05 0.49 0.12
18 INT284309 Tlr4 Positive_regulation of Mir155 3 1 0.18 0.51 0.11
19 INT350694 Uts2r Negative_regulation of Negative_regulation of Rc3h1 1 1 0.05 0.79 0.1
20 INT350695 Mir101a Positive_regulation of Protein_catabolism of Icos 1 1 0.05 0.8 0.1
21 INT350700 Binding of Bcl6 and thd 1 1 0.00 0.21 0.08
22 INT350721 Binding of Hand1 and TBX21 1 1 0.13 0.22 0.08
23 INT350692 Binding of Bcl6 and Hand1 1 1 0.02 0.16 0.08
24 INT350720 Binding of Bcl6 and TBX21 1 1 0.07 0.22 0.08
25 INT350708 Foxp3 Regulation of Socs1 1 1 0.08 0.21 0.07
26 INT350704 Foxp3 Negative_regulation of Gene_expression of Mir142 1 1 0.02 0.13 0.04
27 INT350696 Mir31 Regulation of Gene_expression of Foxp3 1 1 0.04 0 0.03
28 INT345281 Binding of CASP1 and Nlrp3 1 1 0.02 0.31 0.03
29 INT345282 Binding of CASP1 and Pycard 1 1 0.01 0.3 0.03
30 INT350712 Binding of Gfi1 and MIR21 1 1 0.02 0.23 0
31 INT350710 Uts2r Negative_regulation of Gene_expression of MIR21 1 1 0.01 0 0
32 INT350706 Binding of Mef2c and Mir223 1 1 0.02 0.11 0
33 INT350715 Sfpi1 Positive_regulation of Transcription of MIR424 1 1 0.09 0.25 0
34 INT345283 Binding of Ads1 and BDNF-AS 1 1 0.00 0.26 0
35 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 2 0.03 0 0
36 INT350714 Gtf3a Negative_regulation of Gene_expression of MIR17 1 1 0.00 0.22 0
37 INT350722 Binding of Runx1 and Negative_regulation of Gene_expression of MIR17 1 1 0.01 0.22 0
38 INT350705 Sfpi1 Positive_regulation of Mir223 1 1 0.04 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
2 INT467 Gene_expression of POMC 2 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
4 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
5 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
6 INT812 Localization of INS 1 1026 0.81 515.6 145.31
7 INT118381 Gene_expression of Il17a 4 405 0.76 306.97 112.06
8 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
9 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
10 INT102546 Gene_expression of Ccl2 1 197 0.78 192.8 67.41
11 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
12 INT4509 Gene_expression of IGG 2 426 0.76 293.69 56.64
13 INT77855 Gene_expression of Pain1 2 55 0.75 67.42 54.1
14 INT118343 Positive_regulation of Eae1 2 121 0.39 136.06 34.87
15 INT49214 Gene_expression of Cd4 3 269 0.78 154.22 34.05
16 INT11325 Gene_expression of HLA-E 2 209 0.76 98.05 33.72
17 INT16428 Positive_regulation of Gtf3a 2 135 0.20 106.44 26.67
18 INT135411 Gene_expression of Il23a 1 76 0.72 72.87 26.15
19 INT93626 Gene_expression of Fasl 1 118 0.75 115.24 25.11
20 INT150022 Positive_regulation of Il17a 1 69 0.64 70.04 21.87
21 INT96156 Gene_expression of Cd40 1 144 0.77 56.95 21.7
22 INT160564 Gene_expression of Il22 1 64 0.55 59.29 20.9
23 INT137767 Gene_expression of Eae1 1 74 0.34 89.32 20.48
24 INT70145 Gene_expression of Trav6-3 1 136 0.76 69.6 18.05
25 INT113602 Positive_regulation of Gene_expression of Ccl2 2 48 0.70 48.71 17.85
26 INT10721 Gene_expression of BDNF-AS 8 119 0.76 72.8 16.29
27 INT9220 Gene_expression of Ighg1 1 125 0.77 85.74 15.92
28 INT161515 Positive_regulation of Gene_expression of Il17a 2 50 0.64 41.52 13.82
29 INT3796 Gene_expression of Ighm 1 130 0.77 69.61 13.78
30 INT20381 Localization of Il2 2 71 0.77 34.23 13.03
31 INT94464 Negative_regulation of Hand1 1 44 0.41 31.5 12.39
32 INT87239 Localization of Il12a 1 51 0.75 31.95 12.05
33 INT149985 Gene_expression of Tlr9 1 32 0.75 29.83 11.86
34 INT151168 Gene_expression of Pten 2 60 0.78 35.63 10.54
35 INT58449 Binding of Mthfd1 1 47 0.47 22.02 10.29
36 INT133210 Positive_regulation of Runx1 1 33 0.69 18.25 10.12
37 INT71174 Gene_expression of CASP1 1 44 0.75 30.3 9.37
38 INT155944 Gene_expression of Foxp3 4 66 0.66 24.37 9.12
39 INT1118 Gene_expression of C6orf25 1 73 0.77 47.24 9.1
40 INT25381 Localization of Csf2 1 62 0.76 47.48 9.03
41 INT20371 Gene_expression of Cd8a 2 125 0.60 67.59 8.97
42 INT20205 Binding of IgG 5 108 0.46 66.68 8.57
43 INT19185 Negative_regulation of Cd4 1 80 0.51 61.32 8.51
44 INT53487 Gene_expression of TSC1 1 81 0.58 77.71 7.94
45 INT101189 Transcription of Gtf3a 2 49 0.17 24.39 7.93
46 INT154094 Negative_regulation of Eae1 2 25 0.18 30.42 7.89
47 INT75841 Binding of Trav6-3 1 66 0.47 29.14 7.63
48 INT173639 Positive_regulation of INCENP 1 40 0.14 20.97 6.7
49 INT207892 Binding of Tlr9 3 35 0.46 26.66 6.61
50 INT48239 Binding of Gtf3a 1 52 0.33 23.14 6.45
51 INT169596 Transcription of Runx1 2 12 0.71 5.55 6.27
52 INT53871 Gene_expression of Socs1 2 32 0.71 22.83 6.21
53 INT3819 Positive_regulation of Apc 1 36 0.69 27.03 6.02
54 INT254269 Gene_expression of Il17f 1 12 0.48 13.29 6.02
55 INT81049 Positive_regulation of CASP1 2 44 0.67 19.97 5.69
56 INT145888 Negative_regulation of Mthfd1 2 27 0.41 8.98 5.4
57 INT174688 Binding of Tlr2 1 45 0.42 36.65 5.25
58 INT2144 Localization of COL7A1 1 36 0.74 20.92 4.67
59 INT36221 Positive_regulation of Nlrp3 3 25 0.68 19.7 4.5
60 INT19449 Binding of FANCB 1 22 0.47 7.4 4.27
61 INT296054 Positive_regulation of Il22 1 13 0.33 17.97 4.06
62 INT42994 Binding of BDNF-AS 5 21 0.35 14.17 4
63 INT174160 Binding of Il12a 1 19 0.24 12.61 3.4
64 INT188355 Binding of Cd28 1 25 0.34 8.29 3.38
65 INT215923 Positive_regulation of Mog 1 8 0.19 9.86 3.17
66 INT163269 Binding of Il23a 1 11 0.44 7.2 3.14
67 INT260424 Negative_regulation of Tlr9 1 8 0.41 8.19 2.92
68 INT284265 Gene_expression of Mir155 3 29 0.64 10.7 2.84
69 INT204524 Binding of TLR9 2 17 0.43 11.69 2.76
70 INT39469 Negative_regulation of Alb 1 21 0.41 13.33 2.68
71 INT190280 Gene_expression of DICER1 4 12 0.65 9.54 2.67
72 INT284274 Positive_regulation of Mir155 7 10 0.50 7.68 2.67
73 INT96151 Negative_regulation of Gene_expression of Cd40 1 20 0.58 6.06 2.58
74 INT49930 Binding of Ighg1 1 21 0.37 13.27 2.43
75 INT184054 Negative_regulation of Gene_expression of Socs1 2 7 0.53 9.18 2.22
76 INT181396 Transcription of Csf2 1 15 0.48 6.38 2.17
77 INT201652 Positive_regulation of Tnfsf10 1 26 0.68 26.79 2.14
78 INT224615 Negative_regulation of Gene_expression of Pten 1 7 0.59 2.99 2.09
79 INT236951 Gene_expression of Cxcr5 1 5 0.66 6.2 2.04
80 INT154922 Gene_expression of Icos 1 11 0.65 4.64 1.96
81 INT350632 Positive_regulation of Il17f 1 2 0.29 6.22 1.96
82 INT92476 Gene_expression of Gzmb 1 19 0.58 7.78 1.94
83 INT89253 Regulation of Mthfd1 3 14 0.23 8.1 1.94
84 INT245529 Binding of Runx1 1 9 0.48 4.42 1.9
85 INT188678 Binding of Tlr7 1 14 0.32 6.6 1.89
86 INT102839 Gene_expression of Pdc 1 15 0.52 6.3 1.87
87 INT228401 Positive_regulation of Cd86 1 24 0.53 6.46 1.8
88 INT236159 Gene_expression of Mir326 4 2 0.11 4.93 1.65
89 INT316709 Positive_regulation of Gene_expression of Pain1 1 3 0.49 2.39 1.5
90 INT300370 Positive_regulation of MIR34A 4 8 0.45 8.13 1.44
91 INT226175 Regulation of thd 1 8 0.14 6.8 1.42
92 INT22434 Gene_expression of Ads1 6 10 0.75 9.16 1.4
93 INT220177 Binding of Apc 1 21 0.37 15.34 1.37
94 INT237772 Localization of Il23a 1 5 0.42 4.16 1.34
95 INT16854 Gene_expression of Uts2r 1 17 0.26 3.1 1.31
96 INT194611 Gene_expression of Klrk1 1 28 0.44 19.31 1.28
97 INT338411 Positive_regulation of Gene_expression of Il17f 1 5 0.29 4.58 1.21
98 INT236158 Positive_regulation of Mir326 3 3 0.06 2.79 1.21
99 INT105984 Positive_regulation of Transcription of Gtf3a 1 4 0.06 2 1.19
100 INT15896 Gene_expression of FANCB 2 18 0.65 6.44 1.18
101 INT330526 Positive_regulation of Gene_expression of DICER1 1 5 0.30 3.34 1.18
102 INT34056 Regulation of Gene_expression of C6orf25 1 9 0.08 3.86 1.16
103 INT284257 Positive_regulation of Gene_expression of Mir155 1 13 0.57 3.34 1.08
104 INT53639 Positive_regulation of Gene_expression of Ads1 3 1 0.40 1.85 0.93
105 INT268582 Gene_expression of MIR17 8 8 0.58 9.99 0.9
106 INT252313 Positive_regulation of Cd47 2 4 0.22 3.95 0.87
107 INT184015 Positive_regulation of Stat5a 2 9 0.46 3.32 0.86
108 INT98017 Protein_catabolism of Gtf3a 1 10 0.11 6.16 0.83
109 INT105880 Regulation of Gene_expression of BDNF-AS 1 4 0.06 2.44 0.82
110 INT21604 Localization of BDNF-AS 2 12 0.73 9.5 0.79
111 INT68247 Gene_expression of Ighg3 1 6 0.65 1.76 0.79
112 INT217157 Gene_expression of MIR34A 2 9 0.58 9.36 0.77
113 INT128497 Regulation of Gene_expression of CASP1 1 4 0.38 2.02 0.72
114 INT284266 Negative_regulation of Mir155 1 8 0.42 2.44 0.65
115 INT297286 Positive_regulation of Foxp3 1 7 0.58 3.05 0.63
116 INT217168 Gene_expression of MIR21 1 30 0.55 30.86 0.62
117 INT184017 Positive_regulation of Gene_expression of Socs1 1 7 0.63 2.47 0.62
118 INT29259 Gene_expression of Ifnb1 1 4 0.65 1.32 0.62
119 INT65235 Negative_regulation of Ads1 1 4 0.57 0.87 0.49
120 INT252308 Positive_regulation of Cd80 1 9 0.51 1.24 0.45
121 INT350675 Gene_expression of MIR650 1 1 0.05 0.92 0.45
122 INT350681 Positive_regulation of MIR650 1 1 0.04 0.94 0.45
123 INT236165 Regulation of Gene_expression of Mir326 1 2 0.04 1.41 0.43
124 INT265208 Negative_regulation of thd 1 7 0.01 1.99 0.42
125 INT271576 Gene_expression of MIR125B1 1 3 0.58 1.02 0.42
126 INT188345 Regulation of Foxp3 1 3 0.18 1.59 0.42
127 INT350641 Negative_regulation of Gene_expression of Mir326 1 1 0.08 1.4 0.42
128 INT288184 Binding of Tlr1 1 8 0.29 4.73 0.4
129 INT213887 Gene_expression of MICB 2 10 0.19 15.33 0.39
130 INT350671 Gene_expression of Ets1 1 1 0.10 1.25 0.39
131 INT350672 Protein_catabolism of RNASE1 1 1 0.07 1.24 0.38
132 INT350630 Negative_regulation of Gene_expression of Cd47 1 1 0.20 0.8 0.37
133 INT350627 Gene_expression of Cd47 1 1 0.28 0.79 0.36
134 INT330525 Positive_regulation of DICER1 2 2 0.17 1.34 0.34
135 INT268553 Positive_regulation of Gene_expression of MIR17 2 3 0.09 3.37 0.32
136 INT276369 Positive_regulation of MIR9-1 2 2 0.49 1.8 0.31
137 INT350642 Gene_expression of Mirg 1 1 0.01 0.79 0.31
138 INT219134 Negative_regulation of Positive_regulation of Nlrp3 1 2 0.41 1.42 0.3
139 INT130581 Negative_regulation of Mier1 1 2 0.20 0.56 0.3
140 INT252322 Positive_regulation of Icos 1 3 0.23 1.74 0.27
141 INT350651 Positive_regulation of Mir146 2 1 0.45 1.03 0.27
142 INT34058 Gene_expression of FMR1 1 5 0.75 5.11 0.26
143 INT324677 Gene_expression of Tirap 1 3 0.47 0.21 0.26
144 INT350691 Localization of DICER1 2 1 0.08 1.18 0.23
145 INT181036 Positive_regulation of Sfpi1 1 3 0.49 0.96 0.21
146 INT217214 Negative_regulation of MIR17 1 2 0.24 1.37 0.2
147 INT216144 Positive_regulation of MIR21 2 4 0.19 2.59 0.19
148 INT170886 Gene_expression of AIRE 2 2 0.49 4.63 0.19
149 INT350663 Negative_regulation of Mir106b 1 1 0.02 0.37 0.18
150 INT300383 Regulation of MIR17 1 4 0.26 3.62 0.17
151 INT350629 Protein_catabolism of Icos 2 1 0.45 1.52 0.17
152 INT189925 Binding of Scpep1 1 5 0.18 1.86 0.16
153 INT350624 Positive_regulation of Mir147 1 1 0.03 0.6 0.16
154 INT350667 Positive_regulation of Transcription of Stat5a 2 1 0.29 0.47 0.16
155 INT350659 Negative_regulation of Mir126 1 1 0.05 0.48 0.16
156 INT350637 Transcription of Stat5a 2 1 0.40 0.46 0.16
157 INT217814 Gene_expression of MIR181A1 10 9 0.58 7.94 0.15
158 INT224838 Positive_regulation of Transcription of Csf2 1 4 0.42 1.49 0.15
159 INT262796 Positive_regulation of Pycard 3 12 0.22 6.5 0.14
160 INT350685 Negative_regulation of Gene_expression of DICER1 1 1 0.05 0.15 0.14
161 INT350687 Positive_regulation of MIR17 1 1 0.05 0.44 0.14
162 INT350676 Regulation of Gene_expression of DICER1 1 1 0.07 0.16 0.14
163 INT350645 Negative_regulation of Mir497 1 1 0.10 0.43 0.13
164 INT137529 Positive_regulation of MICA 1 5 0.30 3.73 0.12
165 INT187059 Positive_regulation of Ads1 2 3 0.67 2.07 0.12
166 INT284263 Positive_regulation of Positive_regulation of Mir155 1 3 0.41 0.52 0.11
167 INT332984 Negative_regulation of Gene_expression of Ads1 1 2 0.42 1.9 0.11
168 INT350674 Negative_regulation of Gene_expression of MIR125B1 1 1 0.42 0.53 0.11
169 INT350660 Negative_regulation of Gene_expression of Cxcr5 1 1 0.20 0.24 0.1
170 INT350655 Gene_expression of Mir101a 1 1 0.14 0.78 0.1
171 INT350631 Regulation of Gene_expression of Mir101a 1 1 0.10 0.79 0.1
172 INT350634 Gene_expression of 2010001M09Rik 2 1 0.04 1.22 0.1
173 INT350668 Positive_regulation of Rc3h1 1 1 0.49 0.79 0.1
174 INT350640 Negative_regulation of Rc3h1 1 1 0.41 0.73 0.1
175 INT350639 Positive_regulation of Protein_catabolism of Icos 1 1 0.23 0.79 0.1
176 INT350653 Positive_regulation of Mir101a 1 1 0.11 0.79 0.1
177 INT350635 Transcription of Bcl6 1 1 0.09 0.16 0.08
178 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 1 0.25 0.23 0.08
179 INT350649 Negative_regulation of Transcription of Bcl6 1 1 0.06 0.16 0.08
180 INT290988 Gene_expression of MIR93 1 3 0.58 1.59 0.07
181 INT321710 Regulation of Slc10a3 1 2 0.05 0.63 0.07
182 INT350688 Negative_regulation of Gene_expression of MIR181A1 1 1 0.42 0.41 0.07
183 INT90820 Gene_expression of MICA 1 11 0.24 7.64 0.06
184 INT350648 Binding of Dgcr8 3 4 0.22 0.4 0.05
185 INT350638 Gene_expression of Mir142 1 1 0.05 0.13 0.04
186 INT180359 Localization of AIRE 1 3 0.54 3.94 0.03
187 INT337529 Positive_regulation of MICB 1 2 0.13 1.67 0.03
188 INT217120 Gene_expression of Mir181a-2 8 3 0.58 2.52 0
189 INT268567 Negative_regulation of Gene_expression of MIR17 1 2 0.05 0.7 0
190 INT345270 Negative_regulation of Tirap 1 1 0.02 0.15 0
191 INT350678 Gene_expression of MIR20A 2 1 0.75 0.74 0
192 INT345271 Localization of Ads1 2 1 0.05 2.18 0
193 INT350643 Positive_regulation of Mir150 1 1 0.06 0.07 0
194 INT345276 Binding of Ads1 6 1 0.03 2.5 0
195 INT350689 Negative_regulation of Gene_expression of MIR93 1 1 0.05 0.53 0
196 INT350661 Binding of Eif2c2 1 1 0.18 0.15 0
197 INT350682 Gene_expression of MIR9-1 1 1 0.75 0.06 0
198 INT350684 Transcription of MIR424 1 1 0.08 0.25 0
199 INT350647 Positive_regulation of Transcription of Csf1r 1 1 0.08 0.15 0
200 INT350662 Regulation of Inpp5d 1 1 0.06 0.16 0
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