J:BMC Bioinformatics

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT333457 Binding of PPARA and TGFB1 1 1 0.04 0 0.34
2 INT333453 Binding of PPARA and RXRA 1 1 0.02 0 0.31
3 INT342057 Binding of gr and Esrrb 1 1 0.00 0 0.2
4 INT333449 Binding of SMAD2 and SMAD4 1 1 0.23 0 0.17
5 INT333447 Binding of SMAD2 and RXRA 1 1 0.04 0 0.16
6 INT352067 Binding of B4GALNT1 and HPGDS 1 1 0.01 0.12 0.16
7 INT209706 Binding of GTPBP4 and MRGPRX1 1 2 0.01 0 0.08
8 INT352066 Binding of PTGS2 and PTGES2 1 1 0.04 0 0
9 INT333456 ATM Positive_regulation of CHEK2 1 1 0.20 0 0
10 INT333446 ATM Positive_regulation of CHEK1 1 2 0.20 0 0
11 INT333455 ATM Positive_regulation of TP53 1 1 0.18 0 0
12 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 1 0.14 0 0
13 INT232595 Binding of BRCA1 and HEPACAM 1 1 0.02 0.89 0
14 INT333448 RB1 Positive_regulation of TFDP1 1 1 0.05 0 0
15 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 1 0.18 0 0
16 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 1 0.14 0 0
17 INT352064 Binding of PTGS2 and HPGDS 1 1 0.20 0 0
18 INT333458 ATM Positive_regulation of MDM2 1 1 0.25 0 0
19 INT221124 Binding of KRT1 and IGKV1-22 1 1 0.02 0 0
20 INT352065 Binding of PTGDS and PTGS2 1 1 0.28 0 0
21 INT209708 Binding of GABBR1 and GTPBP4 1 1 0.00 0 0
22 INT333459 TP53 Positive_regulation of CHEK1 1 1 0.09 0 0
23 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 1 0.18 0 0
24 INT232594 CDH1 Regulation of HEPACAM 1 1 0.01 1.02 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
2 INT1912 Gene_expression of Calca 6 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 1 787 0.70 331.13 592.08
4 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
5 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
6 INT5680 Gene_expression of Ngf 5 530 0.78 264.29 310.56
7 INT11624 Gene_expression of OPRM1 1 445 0.78 72.36 294.36
8 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
9 INT7628 Gene_expression of Ltp 4 273 0.77 70.21 147.87
10 INT2541 Binding of Calca 3 200 0.48 67.14 134.62
11 INT50674 Gene_expression of PTGS2 2 459 0.78 253.33 118.51
12 INT49651 Gene_expression of Creb1 1 276 0.78 114.77 111.96
13 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
14 INT16254 Positive_regulation of Gene_expression of Ngf 1 144 0.70 80.61 82.08
15 INT7528 Regulation of OPRM1 1 100 0.62 20.63 80.57
16 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
17 INT6656 Gene_expression of YY1 1 135 0.75 24.73 72.16
18 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
19 INT67614 Positive_regulation of PPARA 1 438 0.68 293.28 63.61
20 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
21 INT4891 Transcription of Calca 4 81 0.72 35.27 53.75
22 INT19078 Binding of Ngf 1 78 0.48 31.03 44.33
23 INT27798 Gene_expression of Ntrk2 1 111 0.78 56.08 42.68
24 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
25 INT1705 Gene_expression of pCA 1 126 0.65 88.65 34.81
26 INT103094 Binding of PPARA 1 308 0.47 177.26 34.75
27 INT7082 Gene_expression of CRH 1 180 0.78 64.66 31.74
28 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
29 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
30 INT17825 Gene_expression of Flvcr2 1 44 0.68 12.58 28.08
31 INT32826 Positive_regulation of Gene_expression of Ltp 1 52 0.45 10.34 26.8
32 INT50490 Regulation of PTGS2 1 80 0.48 39.51 25.85
33 INT6441 Positive_regulation of CRH 1 98 0.69 57.22 24.12
34 INT4809 Gene_expression of PTGDS 1 103 0.76 52.94 24.01
35 INT63419 Gene_expression of PTGES 1 109 0.77 40.83 23.67
36 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
37 INT23224 Gene_expression of tf 2 99 0.56 60.22 22.03
38 INT63340 Positive_regulation of Gene_expression of ICAM1 1 109 0.70 90.82 20.61
39 INT17848 Binding of PTGS2 16 70 0.46 32.1 20.6
40 INT11803 Positive_regulation of Il2 1 62 0.70 31.44 18.93
41 INT22068 Binding of CALCRL 1 53 0.41 6.14 17.32
42 INT10214 Gene_expression of VIM 2 153 0.78 115.88 16.29
43 INT216751 Gene_expression of ADORA2B 2 36 0.60 3.42 15.6
44 INT92354 Localization of ESR1 1 77 0.75 33.04 15.51
45 INT61893 Gene_expression of Ghrl 1 125 0.75 71.49 15.14
46 INT60197 Gene_expression of JUN 2 90 0.78 42.32 14.61
47 INT22276 Gene_expression of TBXA2R 1 65 0.77 23.22 14.21
48 INT17035 Positive_regulation of TFPI 2 55 0.61 34.88 14.18
49 INT65697 Positive_regulation of GRIN3B 1 23 0.69 12.52 13.78
50 INT15921 Positive_regulation of Serpine1 2 85 0.68 81.24 13.4
51 INT65109 Negative_regulation of Transcription of Calca 2 16 0.59 8.63 12.84
52 INT59080 Negative_regulation of Gene_expression of PTGS2 1 55 0.58 22.92 12.39
53 INT10847 Gene_expression of LAMC2 1 39 0.75 27 12.09
54 INT69029 Gene_expression of PTPRC 1 127 0.75 74.26 11.57
55 INT5464 Regulation of CALCRL 1 24 0.16 4.2 11.19
56 INT8021 Gene_expression of Enpp1 1 43 0.78 31.46 10.8
57 INT82854 Gene_expression of MRGPRX1 7 61 0.75 10.14 10.65
58 INT53201 Negative_regulation of gr 1 35 0.50 17.76 10.62
59 INT17584 Regulation of tf 1 12 0.50 4.69 10.39
60 INT105816 Gene_expression of P2RY2 1 53 0.78 16.47 9.67
61 INT69321 Regulation of Gene_expression of PTGS2 1 27 0.61 13.27 9.53
62 INT66819 Binding of CYP2C9 2 41 0.48 8.23 8.76
63 INT119831 Gene_expression of PTEN 2 55 0.75 40.37 8.57
64 INT22481 Gene_expression of CADM1 1 28 0.65 30.26 8.5
65 INT17996 Binding of Crp 1 40 0.37 31.4 7.8
66 INT11568 Gene_expression of ADORA2A 2 14 0.73 1.51 7.79
67 INT14043 Binding of HP 1 52 0.30 26.56 7.76
68 INT80822 Positive_regulation of MRGPRX1 4 30 0.67 3.66 7.73
69 INT15918 Gene_expression of Serpine1 2 60 0.62 41.73 7.72
70 INT78371 Gene_expression of IGKV2D-29 1 29 0.75 6.95 7.66
71 INT76892 Gene_expression of FGFR1 1 45 0.69 23.6 7.56
72 INT57922 Gene_expression of CYP2C9 1 65 0.78 22.24 7.53
73 INT212758 Binding of Hmgb1 2 40 0.44 35.6 7.41
74 INT92755 Regulation of MRGPRX1 2 26 0.27 3.63 7.37
75 INT103909 Gene_expression of NOD2 2 37 0.77 21.9 7.36
76 INT77756 Positive_regulation of GTPBP4 3 16 0.11 2.6 7.29
77 INT83006 Gene_expression of AGTR1 2 59 0.75 54.46 7.27
78 INT25 Positive_regulation of LAMC2 1 19 0.67 8.64 7.06
79 INT36726 Regulation of Gene_expression of Ltp 1 14 0.46 4.81 7.05
80 INT264641 Binding of AES 4 25 0.42 18.56 6.98
81 INT39516 Gene_expression of Alb 1 81 0.75 30.08 6.59
82 INT93061 Binding of gr 2 31 0.48 10.93 6.45
83 INT49566 Positive_regulation of LMOD1 1 16 0.61 5.74 5.92
84 INT63772 Gene_expression of LMOD1 2 26 0.75 3.77 5.84
85 INT190298 Binding of MRGPRX1 33 61 0.46 2.66 5.75
86 INT41892 Gene_expression of HBM 1 48 0.64 28.32 5.64
87 INT58489 Gene_expression of Rorb 1 51 0.41 4.7 5.39
88 INT28084 Positive_regulation of VIM 1 49 0.67 35.12 5.15
89 INT14753 Binding of GRP 1 15 0.48 2.28 5.09
90 INT49568 Regulation of LMOD1 1 6 0.43 2.57 5
91 INT114311 Negative_regulation of Gene_expression of Gpt 1 33 0.38 17.83 4.94
92 INT57125 Gene_expression of AP1B1 2 8 0.18 3.8 4.91
93 INT240934 Gene_expression of Sirt1 1 24 0.75 18.77 4.68
94 INT62684 Negative_regulation of TP53 1 66 0.58 66.09 4.62
95 INT103155 Gene_expression of KDR 2 78 0.66 50.53 4.38
96 INT74815 Binding of Grm5 1 11 0.36 3.62 4.25
97 INT107620 Binding of PTGES 1 25 0.48 5.49 4.24
98 INT4148 Gene_expression of HRH1 1 11 0.77 2.71 4.22
99 INT119063 Gene_expression of BRCA1 1 24 0.67 30.04 4.17
100 INT47686 Regulation of Gene_expression of Ntrk2 1 5 0.44 5.24 4.14
101 INT7560 Transcription of gr 1 14 0.69 4.21 4.09
102 INT111477 Gene_expression of KRT7 2 90 0.74 86.76 4.07
103 INT108086 Negative_regulation of AKR1C3 1 17 0.58 7.7 3.99
104 INT140542 Gene_expression of SSTR2 1 18 0.65 13.58 3.94
105 INT6956 Gene_expression of PTGIS 3 29 0.76 12.1 3.8
106 INT24983 Binding of MPO 1 18 0.42 17.56 3.29
107 INT134413 Gene_expression of HPGDS 1 20 0.77 8.93 3.28
108 INT102451 Localization of CALCRL 2 9 0.69 0 3.25
109 INT118978 Gene_expression of MRGPRX4 1 7 0.25 3.57 2.96
110 INT103910 Binding of NOD2 2 19 0.47 12.24 2.93
111 INT57123 Localization of AP1B1 1 5 0.24 1.29 2.91
112 INT144955 Binding of Grm8 2 8 0.22 1.82 2.83
113 INT19235 Negative_regulation of PDE1B 1 11 0.14 2.38 2.81
114 INT78146 Gene_expression of AKR1C3 2 24 0.77 5.71 2.77
115 INT54495 Binding of GABBR1 2 9 0.35 1.82 2.76
116 INT172186 Gene_expression of IL6ST 1 20 0.75 11.63 2.67
117 INT97452 Positive_regulation of MOCS1 1 20 0.39 11.4 2.59
118 INT25119 Binding of PTGDS 1 9 0.35 3.86 2.54
119 INT140206 Binding of GRM5 1 6 0.36 1.85 2.52
120 INT60279 Gene_expression of VHL 2 70 0.78 75.21 2.21
121 INT209594 Positive_regulation of Positive_regulation of GRIN3B 1 4 0.05 1.06 2.17
122 INT46109 Binding of SERPINF2 1 6 0.37 1.08 2.06
123 INT7562 Positive_regulation of Transcription of gr 1 8 0.48 2.47 1.97
124 INT57122 Positive_regulation of Localization of AP1B1 2 3 0.16 0.39 1.93
125 INT221127 Positive_regulation of IGKV1-22 1 2 0.17 4.7 1.93
126 INT167035 Regulation of Cd8a 1 25 0.41 16.78 1.9
127 INT57618 Binding of GTPBP4 1 9 0.43 1.61 1.87
128 INT9189 Regulation of PTGFR 1 6 0.45 2.6 1.8
129 INT98580 Positive_regulation of CADM1 1 11 0.49 10.16 1.78
130 INT173324 Positive_regulation of Gene_expression of MRGPRX1 3 13 0.48 1.49 1.75
131 INT16314 Gene_expression of NR0B1 2 25 0.65 7.99 1.71
132 INT164010 Gene_expression of CNBP 2 7 0.53 9.13 1.71
133 INT140241 Phosphorylation of MRGPRX1 1 8 0.79 0.42 1.68
134 INT96823 Positive_regulation of Positive_regulation of GTPBP4 1 3 0.05 0.41 1.67
135 INT14405 Gene_expression of SERPINF2 7 14 0.65 3 1.64
136 INT110906 Binding of Rorb 1 14 0.48 2.88 1.62
137 INT14404 Negative_regulation of SERPINF2 2 11 0.47 3.15 1.47
138 INT131457 Gene_expression of FCGR1A 1 11 0.75 4.88 1.45
139 INT50010 Negative_regulation of CHR 2 5 0.42 3.64 1.41
140 INT115502 Gene_expression of SAGE1 4 12 0.65 6.07 1.39
141 INT173208 Binding of CNBP 2 9 0.25 11.01 1.23
142 INT169363 Negative_regulation of PTGIS 1 4 0.20 3.35 1.22
143 INT162831 Regulation of ARSD 2 13 0.35 6.17 1.19
144 INT119832 Positive_regulation of Gene_expression of PTEN 2 12 0.49 7.12 1.19
145 INT20100 Binding of Serpine1 8 16 0.29 6.78 1.18
146 INT28083 Negative_regulation of Gene_expression of VIM 2 9 0.41 7.23 1.17
147 INT50012 Regulation of CHR 1 3 0.28 1.82 1.16
148 INT157765 Negative_regulation of CDH1 2 32 0.53 35.72 1.15
149 INT15919 Positive_regulation of Gene_expression of Serpine1 1 6 0.41 4.5 1.15
150 INT62981 Protein_catabolism of PTGS2 1 5 0.78 1.09 1.11
151 INT60720 Localization of Esrrb 1 6 0.70 0.61 1.1
152 INT97777 Positive_regulation of CNBP 2 7 0.37 9.85 1.09
153 INT173350 Localization of MRGPRX1 1 6 0.63 1.95 1.03
154 INT101841 Localization of SERPINF2 2 4 0.68 1.27 1.01
155 INT10855 Positive_regulation of Gene_expression of LAMC2 1 4 0.67 2.05 0.88
156 INT83948 Transcription of PECAM1 1 2 0.09 2.97 0.87
157 INT184678 Regulation of Uts2r 1 7 0.14 2.57 0.85
158 INT223653 Transcription of Grm5 1 4 0.69 1.4 0.83
159 INT201596 Regulation of H2-D1 4 2 0.03 0.4 0.82
160 INT193060 Gene_expression of CHRM2 1 9 0.51 2.09 0.79
161 INT221129 Gene_expression of IGKV1-22 1 5 0.22 1.73 0.78
162 INT11919 Regulation of KRT1 1 9 0.10 4.97 0.77
163 INT87734 Regulation of ARAF 1 4 0.23 2.44 0.76
164 INT50501 Negative_regulation of TBXAS1 1 3 0.30 1.26 0.74
165 INT160736 Negative_regulation of KRT7 1 9 0.41 10.08 0.68
166 INT268377 Phosphorylation of SMAD2 1 7 0.80 0.85 0.65
167 INT44478 Negative_regulation of PTEN 2 32 0.57 27.45 0.63
168 INT132262 Binding of SLC3A2 1 3 0.03 1.75 0.58
169 INT31402 Gene_expression of AFM 1 5 0.49 0.34 0.56
170 INT93647 Regulation of P2RY1 1 7 0.36 2.13 0.55
171 INT97901 Regulation of FGFR1 1 5 0.24 2.56 0.55
172 INT177864 Negative_regulation of HPGDS 1 6 0.49 1.92 0.54
173 INT335635 Localization of H2-D1 1 1 0.06 0.12 0.49
174 INT71019 Negative_regulation of SMAD4 1 12 0.42 6.88 0.43
175 INT134412 Binding of HPGDS 1 9 0.42 1.7 0.43
176 INT285391 Binding of RXRA 1 2 0.03 0.08 0.36
177 INT212757 Regulation of Bmp8b 1 1 0.03 0.42 0.36
178 INT212763 Regulation of CHRM4 1 1 0.02 0.42 0.36
179 INT212761 Regulation of SQLE 1 2 0.23 1.21 0.35
180 INT183240 Negative_regulation of NOD2 2 6 0.43 1.52 0.33
181 INT216733 Localization of P2RY12 1 2 0.70 0.32 0.33
182 INT216121 Gene_expression of NOX3 2 1 0.63 2.04 0.33
183 INT193065 Regulation of Binding of MRGPRX1 1 3 0.43 0 0.31
184 INT335634 Gene_expression of Gm6509 2 1 0.01 0.2 0.31
185 INT172189 Gene_expression of CHR 1 6 0.30 1.81 0.29
186 INT96569 Negative_regulation of CHEK1 1 4 0.32 3.08 0.29
187 INT202728 Localization of Map3k8 1 4 0.54 1.19 0.28
188 INT209719 Phosphorylation of AP1B1 1 1 0.10 0.07 0.28
189 INT232598 Gene_expression of NR1H2 1 5 0.45 1.05 0.27
190 INT172978 Negative_regulation of SMAD2 1 4 0.42 0.89 0.27
191 INT216120 Negative_regulation of SMO 1 2 0.49 3.05 0.27
192 INT212762 Regulation of FLT1 1 21 0.58 2.95 0.26
193 INT34058 Gene_expression of FMR1 1 5 0.75 5.11 0.26
194 INT202723 Positive_regulation of Surf2 1 1 0.34 0.09 0.26
195 INT148717 Binding of NR0B1 3 6 0.34 5.4 0.25
196 INT226575 Regulation of OXER1 1 2 0.09 0.16 0.23
197 INT209722 Regulation of LAMB1 1 1 0.00 0 0.2
198 INT277935 Binding of SMAD4 1 4 0.28 1.12 0.17
199 INT268365 Binding of SMAD2 1 2 0.47 0.56 0.17
200 INT183242 Negative_regulation of Gene_expression of PTEN 2 6 0.55 3.81 0.16
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