J:BMC Cancer

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 5 0.56 7.14 4.16
2 INT208572 Binding of IL8 and CXCR1 6 2 0.33 5.2 3.08
3 INT192161 Mmp14 Positive_regulation of Mmp2 2 1 0.19 1.23 1.81
4 INT113844 CDKN1A Negative_regulation of CDK2 4 1 0.49 1.18 1.27
5 INT314037 THL Negative_regulation of Localization of Plau 1 3 0.17 1.64 0.99
6 INT249347 Binding of FOS and JUN 4 2 0.19 6.15 0.89
7 INT188196 LIF Regulation of MAPK1 1 4 0.21 2.26 0.87
8 INT188214 OSM Regulation of MAPK1 1 4 0.20 2.27 0.87
9 INT192158 Binding of Mmp2 and Mmp9 1 1 0.21 0.94 0.83
10 INT94331 IFNG Positive_regulation of CXCL10 4 1 0.11 1.31 0.82
11 INT228255 Binding of Akt1 and Pten 2 1 0.43 1.78 0.8
12 INT209043 Binding of Fn1 and Slc11a1 3 1 0.03 1.91 0.78
13 INT258644 Binding of CCL2 and CCL5 1 1 0.36 1.6 0.74
14 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 1 0.49 1.61 0.74
15 INT318737 Binding of CXCR1 and CXCL6 1 2 0.25 1.37 0.67
16 INT318738 Binding of CXCR2 and CXCL6 1 2 0.32 1.39 0.67
17 INT220148 Binding of IGF1 and IGFBP3 12 2 0.36 5.56 0.66
18 INT193218 Binding of PTGER1 and PTGER2 3 1 0.12 2.31 0.66
19 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 4 0.11 2.87 0.66
20 INT192332 UBR7 Negative_regulation of TXK 1 3 0.00 1.38 0.63
21 INT314051 THL Negative_regulation of Localization of Mmp2 1 2 0.14 1.1 0.62
22 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 1 0.27 2.73 0.6
23 INT342624 VEGFA Negative_regulation of Mmp2 1 2 0.09 1.54 0.58
24 INT342619 Mmp2 Negative_regulation of Timp2 1 2 0.42 1.48 0.57
25 INT342621 VEGFA Negative_regulation of Timp2 1 2 0.09 1.53 0.57
26 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 1 0.28 0.88 0.56
27 INT144035 IL6 Positive_regulation of STAT3 4 1 0.31 2.58 0.56
28 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 2 0.66 2.42 0.54
29 INT192160 Cxcl9 Negative_regulation of Furin 1 1 0.02 0.8 0.54
30 INT314043 THL Negative_regulation of Mmp2 1 2 0.22 2.11 0.53
31 INT192162 Furin Positive_regulation of Mmp14 1 1 0.10 0.79 0.53
32 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 1 0.02 1.01 0.52
33 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 2 0.02 0.2 0.47
34 INT191686 Igh-Dex Positive_regulation of Sgk1 1 2 0.04 1.79 0.46
35 INT191691 Igh-Dex Positive_regulation of Dusp1 1 2 0.02 1.8 0.46
36 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 1 0.48 1.85 0.45
37 INT314044 THL Negative_regulation of Transcription of Mmp9 1 1 0.20 0.81 0.45
38 INT314050 THL Negative_regulation of Transcription of Mmp2 1 1 0.16 0.81 0.44
39 INT304281 IL8 Positive_regulation of TBK1 1 1 0.01 2.35 0.44
40 INT193217 Binding of PTGER2 and PTGER3 2 1 0.10 1.31 0.43
41 INT188194 OSM Regulation of IL6 1 2 0.16 1.12 0.43
42 INT188205 OSM Regulation of LIF 1 2 0.09 1.12 0.43
43 INT188211 IL6 Regulation of MAPK1 1 2 0.16 1.13 0.43
44 INT188207 LIF Regulation of IL6 1 2 0.17 1.12 0.43
45 INT196348 PTGER2 Negative_regulation of Negative_regulation of MMP2 1 1 0.01 0.29 0.43
46 INT314042 THL Negative_regulation of Gene_expression of Mmp2 1 3 0.19 2.97 0.42
47 INT337047 Art2b Positive_regulation of Gene_expression of S100a8 1 1 0.00 1.03 0.42
48 INT191690 Igh-Dex Positive_regulation of Gene_expression of exf 1 1 0.01 0.79 0.41
49 INT314046 THL Negative_regulation of Localization of Mmp9 1 1 0.13 0.95 0.39
50 INT183645 Ppp1r14b Positive_regulation of Macf1 1 1 0.00 1.23 0.38
51 INT183647 Dss1 Positive_regulation of Macf1 1 1 0.01 1.23 0.38
52 INT183646 Negative_regulation of Ppp1r14b Positive_regulation of Macf1 1 1 0.00 1.29 0.38
53 INT342622 Binding of MMP14 and Mmp2 1 1 0.39 1.15 0.37
54 INT342623 Binding of VEGFA and Col18a1 1 1 0.02 1.15 0.37
55 INT342606 Binding of MMP14 and VEGFA 1 1 0.08 1.16 0.37
56 INT342617 Binding of Col18a1 and Mmp2 1 1 0.11 1.15 0.37
57 INT172213 Binding of BAX and BCL2L1 3 2 0.22 4.02 0.35
58 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 2 0.28 0.54 0.34
59 INT188204 Negative_regulation of IL6 Positive_regulation of STAT3 1 2 0.28 0.54 0.34
60 INT156831 EGF Positive_regulation of MAPK1 2 2 0.45 0.27 0.33
61 INT304277 CCNE1 Positive_regulation of IL1RN 1 1 0.00 1.93 0.31
62 INT259132 KLK7 Positive_regulation of Binding of DSG2 1 1 0.51 0.91 0.31
63 INT304278 CCNE1 Positive_regulation of IL8 1 1 0.02 1.93 0.31
64 INT259130 KLK7 Positive_regulation of Binding of DSG1 1 1 0.51 0.91 0.31
65 INT259133 KLK7 Positive_regulation of DSG2 1 1 0.51 0.91 0.31
66 INT304280 CCNE1 Positive_regulation of IL6 1 1 0.00 1.93 0.31
67 INT259131 KLK7 Positive_regulation of DSG1 1 1 0.51 0.91 0.31
68 INT342625 Binding of IFN1@ and Vps54 1 1 0.03 1.18 0.3
69 INT222301 Binding of ERBB2 and ESR1 5 3 0.36 5.07 0.29
70 INT191692 Binding of Bag1 and gr 1 1 0.07 0.76 0.29
71 INT71904 Binding of ESR1 and PGR 6 1 0.34 3.79 0.27
72 INT318551 Binding of VEGFA and Adamts1 1 2 0.13 1.13 0.27
73 INT188209 OSM Positive_regulation of MAPK1 1 2 0.35 0.47 0.27
74 INT314040 THL Regulation of Mapk1 1 1 0.28 0.67 0.26
75 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 1 0.14 0.71 0.25
76 INT314045 THL Negative_regulation of Phosphorylation of Mapk3 1 1 0.13 0.7 0.25
77 INT191687 Igh-Dex Positive_regulation of Gene_expression of Xiap 1 1 0.01 0.63 0.24
78 INT191689 Igh-Dex Positive_regulation of Xiap 1 1 0.01 0.63 0.24
79 INT192331 UBR7 Negative_regulation of INSRR 1 2 0.00 0.54 0.23
80 INT188200 IL6ST Positive_regulation of STAT3 1 1 0.25 0.38 0.23
81 INT188195 GOPC Positive_regulation of MAPK1 2 1 0.21 0.32 0.22
82 INT223570 Binding of Mri1 and Uhrf2 1 1 0.02 0.56 0.22
83 INT223569 Binding of cy and Mri1 1 1 0.00 0.57 0.22
84 INT188203 EGF Positive_regulation of Protein_catabolism of OSM 1 1 0.30 0.17 0.21
85 INT188201 OSM Positive_regulation of Phosphorylation of STAT3 1 1 0.40 0.24 0.21
86 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 1 0.05 0.84 0.21
87 INT257989 PTGER2 Positive_regulation of RASGRP1 1 2 0.01 0.61 0.21
88 INT191693 Igh-Dex Regulation of Bag1 Regulation of gr 1 1 0.01 1.31 0.21
89 INT191685 Bag1 Regulation of gr 1 1 0.08 1.1 0.21
90 INT254687 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Mmp13 1 1 0.06 0.2 0.2
91 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 1 0.33 0.93 0.2
92 INT257985 PTGER2 Positive_regulation of MAPK1 1 2 0.04 0.61 0.2
93 INT220146 Binding of IGF1 and IGFBP1 2 1 0.10 1.57 0.19
94 INT314049 THL Negative_regulation of Gene_expression of Plau 1 2 0.20 2.91 0.19
95 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 1 0.11 1.26 0.18
96 INT201212 FGF2 Regulation of FGFR1 2 1 0.09 1.01 0.18
97 INT254683 Positive_regulation of Map2k1 Positive_regulation of Gene_expression of Plaur 1 1 0.01 0.07 0.18
98 INT254691 Gopc Positive_regulation of Positive_regulation of Map2k2 1 1 0.07 0.07 0.18
99 INT254698 Gopc Positive_regulation of Positive_regulation of Map2k1 1 1 0.06 0.07 0.18
100 INT314038 THL Negative_regulation of Pik3r1 1 1 0.14 0.78 0.18
101 INT254685 Map2k2 Positive_regulation of Mmp3 1 1 0.04 0.08 0.18
102 INT222300 Binding of ERBB2 and PGR 2 2 0.34 1.89 0.17
103 INT334423 Binding of SPINK1 and Cea 1 3 0.02 2.53 0.17
104 INT304279 ETS1 Positive_regulation of MMP2 1 1 0.05 1.83 0.17
105 INT304282 ETS1 Positive_regulation of Gene_expression of MMP2 1 1 0.05 1.83 0.17
106 INT181144 Raf1 Positive_regulation of Gene_expression of El4 1 1 0.06 0.35 0.17
107 INT191688 Igh-Dex Regulation of Gene_expression of Bag1 1 1 0.04 1.21 0.16
108 INT257986 Binding of PTGER2 and GOPC 1 1 0.04 0.42 0.16
109 INT188199 IL6 Positive_regulation of MAPK1 1 1 0.27 0.25 0.16
110 INT259135 Gene_expression of KLK7 Positive_regulation of DSG2 1 1 0.47 1.21 0.16
111 INT314054 Gtf3a Positive_regulation of Gene_expression of VEGFA 1 1 0.00 1.7 0.16
112 INT301121 Tgm7 Regulation of Gene_expression of Mmp2 1 2 0.52 2.53 0.16
113 INT316249 DBT Regulation of TRPM8 1 2 0.08 1.28 0.15
114 INT307813 Ace Positive_regulation of Ace Positive_regulation of Agt 1 2 0.27 3.05 0.15
115 INT307814 Ace Positive_regulation of Ace Positive_regulation of Ang 1 2 0.30 3.05 0.15
116 INT307807 Ace Positive_regulation of ras 1 2 0.38 3 0.15
117 INT314039 THL Negative_regulation of Binding of Mmp2 1 1 0.16 1.62 0.14
118 INT314041 THL Negative_regulation of Gene_expression of Mmp9 1 1 0.13 1.86 0.14
119 INT223084 Binding of Pdgfa and Pdgfb 2 1 0.17 0.83 0.13
120 INT184953 Binding of CDC6 and PCNA 1 1 0.05 0.19 0.13
121 INT326246 Prkcg Positive_regulation of ras 1 1 0.01 0.62 0.13
122 INT326249 Prkcg Positive_regulation of EPHB2 1 1 0.06 0.63 0.13
123 INT339116 CNA1 Regulation of RSF1 1 1 0.00 0.3 0.13
124 INT326252 EPHB2 Positive_regulation of ras 1 1 0.03 0.62 0.13
125 INT326247 Prkcg Positive_regulation of Prkaca 1 1 0.00 0.62 0.13
126 INT326248 Prkaca Positive_regulation of ras 1 1 0.00 0.62 0.13
127 INT304187 Ang Negative_regulation of Gene_expression of VEGFA 1 1 0.05 0.16 0.13
128 INT192330 UBR7 Negative_regulation of Positive_regulation of PDGFRB 1 1 0.01 0.54 0.12
129 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 2 0.06 0.6 0.12
130 INT253328 Binding of IL8 and Scrib 1 1 0.04 0.79 0.12
131 INT188197 LIF Positive_regulation of STAT3 1 1 0.35 0.27 0.12
132 INT188198 OSM Positive_regulation of STAT3 1 1 0.52 0.24 0.12
133 INT341828 Binding of BTC and EGFR 1 1 0.22 0.95 0.12
134 INT341827 Binding of ESR1 and TNC 1 1 0.14 0.63 0.11
135 INT188202 HBE1 Positive_regulation of MAPK1 1 1 0.01 0.14 0.11
136 INT221683 Binding of Mki67 and FRTS 1 3 0.01 1.18 0.11
137 INT314055 THL Negative_regulation of Localization of VEGFA 1 3 0.04 3.73 0.11
138 INT257976 Positive_regulation of EGFR Positive_regulation of PTGER2 Positive_regulation of RASGRP1 1 1 0.00 0.31 0.11
139 INT221684 Binding of Bcl2 and FRTS 1 3 0.01 1.19 0.11
140 INT188192 HBE1 Positive_regulation of LY6E 1 1 0.00 0.14 0.11
141 INT302883 Binding of TXN and Alb 1 3 0.06 4.13 0.1
142 INT175561 NAA50 Negative_regulation of PRELID1 1 1 0.00 0.83 0.1
143 INT234626 IGFBP3 Regulation of IGF2 1 2 0.15 1.31 0.1
144 INT259129 KLK7 Regulation of DSG2 1 1 0.24 0.61 0.09
145 INT341826 Binding of ERBB2 and TNC 1 1 0.18 0.63 0.09
146 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 5 0.21 2.07 0.09
147 INT341825 Binding of TNC and PGR 1 1 0.14 0.63 0.09
148 INT185279 Binding of CCND1 and CDK4 4 1 0.13 2.05 0.08
149 INT185278 Binding of CCND1 and CDK6 3 1 0.13 1.62 0.08
150 INT276141 Binding of Gh and Igf1 2 1 0.34 0.66 0.08
151 INT314011 VEGFA Regulation of IL19 1 1 0.04 1.11 0.08
152 INT301921 UCK2 Regulation of Gene_expression of FGF2 1 2 0.01 1.22 0.08
153 INT244449 CS Regulation of Gene_expression of ATF4 1 2 0.15 0.83 0.08
154 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 1 0.06 0.74 0.08
155 INT179872 Binding of HGF and MET 7 1 0.09 4.69 0.07
156 INT339111 Binding of ERBB2 and JUP 1 1 0.38 0.62 0.07
157 INT188210 EGF Positive_regulation of OSM 1 1 0.28 0 0.07
158 INT301122 Tgm7 Negative_regulation of Akt1 1 5 0.38 2.78 0.07
159 INT188208 EGF Regulation of STAT3 1 1 0.46 0 0.07
160 INT307805 Ace Positive_regulation of Ang 1 1 0.32 1.52 0.07
161 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 1 0.01 0.79 0.07
162 INT223085 Binding of Pdgfb and Insrr 1 2 0.01 0.91 0.07
163 INT339108 Binding of ESR1 and JUP 1 1 0.38 0.62 0.07
164 INT298006 CHDM Positive_regulation of Gene_expression of PDGFRB 1 1 0.16 1.08 0.07
165 INT192329 UBR7 Negative_regulation of Phosphorylation of PDGFRB 1 1 0.01 0.06 0.07
166 INT211875 Binding of CDS1 and SMUG1 1 2 0.03 1.04 0.07
167 INT307806 Ace Positive_regulation of Agt 1 1 0.28 1.51 0.07
168 INT245296 Trp53 Regulation of Gadd45a 1 1 0.05 0.43 0.07
169 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 1 0.02 0.43 0.07
170 INT122480 Binding of SERPINE1 and PLAU 4 2 0.40 2.75 0.06
171 INT304186 Ang Positive_regulation of Gene_expression of VEGFA 2 2 0.05 2.5 0.06
172 INT339101 ERBB2 Positive_regulation of TGFA 1 1 0.33 0.68 0.06
173 INT339099 ERBB2 Positive_regulation of IGF2R 1 1 0.33 0.67 0.06
174 INT314056 THL Negative_regulation of VEGFA 1 1 0.03 0.85 0.06
175 INT339105 ERBB2 Positive_regulation of EGFR 1 1 0.37 0.68 0.06
176 INT339110 ERBB2 Positive_regulation of GATA6 1 1 0.31 0.67 0.06
177 INT234619 IGF1 Regulation of IGF1R 1 1 0.11 0.39 0.05
178 INT185037 INHBA Negative_regulation of Inhba 1 1 0.26 0.32 0.05
179 INT234624 Binding of IGF1 and IGF1R 1 1 0.09 0.39 0.05
180 INT306510 INCENP Regulation of Gene_expression of Clu 1 2 0.00 1.92 0.05
181 INT314048 THL Negative_regulation of Gene_expression of Gopc 1 1 0.09 1.05 0.05
182 INT326253 Prkaca Negative_regulation of ARAF 1 1 0.00 0 0.05
183 INT326251 Prkaca Positive_regulation of ARAF 1 1 0.00 0 0.05
184 INT326250 Prkcg Positive_regulation of ARAF 1 1 0.00 0 0.05
185 INT234620 Regulation of Binding of IGF1 and IGF1R 1 1 0.07 0.39 0.05
186 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 1 0.34 0.17 0.05
187 INT244461 CS Positive_regulation of ESR1 1 1 0.06 1.15 0.05
188 INT257988 PTGER2 Regulation of Gene_expression of PTGER1 1 1 0.15 0.4 0.05
189 INT332795 Negative_regulation of Vhl Positive_regulation of Positive_regulation of Cxcr4 1 1 0.02 1.64 0.05
190 INT207700 ADM Regulation of MSMB 1 1 0.18 0.69 0.04
191 INT207760 Fkbp1a Regulation of MSMB 1 1 0.12 0.69 0.04
192 INT258006 PTGER2 Positive_regulation of Phosphorylation of Prkaca 1 1 0.03 0.13 0.04
193 INT301128 Binding of Tgm7 and Gm9662 1 1 0.01 0.12 0.04
194 INT258005 Binding of PTGER3 and Prkaca 1 1 0.03 0.52 0.04
195 INT172214 BAX Positive_regulation of TP53 1 1 0.09 0.37 0.04
196 INT339112 Binding of ERBB2 and TAB2 1 1 0.00 0.05 0.04
197 INT223086 Binding of Pdgfb and Pdgfrb 1 1 0.33 0.46 0.04
198 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 1 0.17 0.37 0.04
199 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 1 0.09 0.37 0.04
200 INT207702 CCND1 Regulation of MSMB 1 1 0.22 0.69 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
2 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
3 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
4 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
5 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
6 INT5680 Gene_expression of Ngf 3 530 0.78 264.29 310.56
7 INT97367 Gene_expression of Nav1 32 243 0.78 132.97 286.66
8 INT49750 Negative_regulation of CPOX 4 735 0.58 360.06 274.19
9 INT10832 Gene_expression of IL8 40 1050 0.78 698.72 270
10 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
11 INT5972 Gene_expression of IL1B 3 948 0.78 510.91 263.97
12 INT68684 Gene_expression of VEGFA 78 2371 0.78 1742.52 259.2
13 INT1893 Localization of Gh 5 1041 0.79 340.23 256.58
14 INT95787 Positive_regulation of Mapk1 7 568 0.70 226.51 220.94
15 INT6665 Gene_expression of FOS 18 520 0.77 165.31 217.66
16 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
17 INT2391 Negative_regulation of PTGS1 2 501 0.59 207.62 205.6
18 INT9132 Negative_regulation of Prkcg 1 279 0.59 88.05 203.47
19 INT50670 Gene_expression of CPOX 2 763 0.76 442.13 195.02
20 INT10194 Positive_regulation of IL6 6 702 0.70 600.62 183.38
21 INT49441 Negative_regulation of Cpox 8 494 0.59 303.22 177.46
22 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
23 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
24 INT867 Gene_expression of IFNA1 3 930 0.78 594.85 168.03
25 INT55879 Gene_expression of CCL2 2 421 0.78 240.74 166.02
26 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
27 INT51921 Gene_expression of Cpox 5 501 0.73 229.81 157.81
28 INT66280 Gene_expression of Nos2 8 534 0.78 330.78 157.07
29 INT120811 Gene_expression of Gopc 24 1174 0.59 428.49 150.55
30 INT5116 Gene_expression of IL2 5 670 0.78 291.13 146.69
31 INT48895 Gene_expression of Il10 3 333 0.78 221.2 138.52
32 INT49439 Gene_expression of Cpox 6 508 0.73 326.97 130.17
33 INT115386 Gene_expression of Ppara 2 779 0.77 549.99 128.36
34 INT65600 Positive_regulation of Casp3 5 376 0.70 198.44 128.03
35 INT5842 Gene_expression of Gfap 1 372 0.78 153.71 127.71
36 INT8243 Positive_regulation of Il6 1 451 0.70 358.24 119.28
37 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 4 1138 0.72 311.58 119.18
38 INT50674 Gene_expression of PTGS2 5 459 0.78 253.33 118.51
39 INT12339 Localization of IL8 9 437 0.81 251.87 117.39
40 INT170025 Gene_expression of Fig4 4 588 0.67 183.27 113.32
41 INT90 Localization of Gast 3 400 0.81 137.67 113
42 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
43 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
44 INT90091 Gene_expression of GOPC 18 967 0.67 366.22 103.6
45 INT10838 Positive_regulation of IL8 15 381 0.70 295.51 101.62
46 INT1760 Gene_expression of PTGER2 23 524 0.57 226.94 96.4
47 INT17459 Positive_regulation of Gene_expression of FOS 5 182 0.67 53.45 96.38
48 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
49 INT77435 Positive_regulation of Nos2 5 343 0.70 208.49 91.43
50 INT86024 Gene_expression of PPARA 14 736 0.78 497.93 91.14
51 INT71789 Positive_regulation of MAPK1 22 396 0.70 234.44 89.27
52 INT96917 Positive_regulation of Mapk14 2 261 0.70 173.29 88.79
53 INT15898 Positive_regulation of Prkaca 1 199 0.70 50.89 87.54
54 INT54571 Positive_regulation of NFKB1 3 263 0.70 138.99 87.32
55 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
56 INT82448 Gene_expression of S100a8 2 246 0.77 236.72 84.02
57 INT92434 Phosphorylation of Mapk1 6 287 0.82 91.65 83.46
58 INT84546 Positive_regulation of Ppara 1 481 0.70 334.21 83.45
59 INT68682 Positive_regulation of VEGFA 16 640 0.70 454.14 81.65
60 INT56291 Gene_expression of Ros1 3 503 0.63 274.12 81.5
61 INT403 Localization of Trh 3 241 0.81 28.55 81.45
62 INT55944 Positive_regulation of Cpox 2 214 0.57 105.14 81.4
63 INT1498 Gene_expression of Gh 4 521 0.75 220.84 81.16
64 INT12001 Regulation of Ngf 1 97 0.62 54.64 76.25
65 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
66 INT16654 Gene_expression of Insrr 12 138 0.46 58.96 75.68
67 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
68 INT48244 Gene_expression of Il4 2 172 0.76 132.38 73.42
69 INT56298 Gene_expression of IL4 2 306 0.78 182.18 72.92
70 INT39565 Gene_expression of Ptger2 6 424 0.75 229.28 72.68
71 INT10837 Positive_regulation of Gene_expression of IL8 11 294 0.70 190.08 70.34
72 INT1377 Positive_regulation of Trh 3 172 0.70 40.55 69.83
73 INT79494 Positive_regulation of Gene_expression of VEGFA 9 577 0.70 442.94 69.73
74 INT170332 Gene_expression of IFN1@ 4 477 0.75 275.21 69.65
75 INT53964 Negative_regulation of Prkaca 1 131 0.58 38.76 69.52
76 INT39777 Regulation of Prkcg 1 90 0.62 31.52 68.17
77 INT5374 Gene_expression of Esr1 29 412 0.77 263.89 67.34
78 INT11807 Gene_expression of Il2 1 266 0.78 112 64.97
79 INT15514 Negative_regulation of Crp 1 275 0.59 194.6 64.86
80 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
81 INT822 Gene_expression of ESR1 44 529 0.78 302.16 63.64
82 INT67614 Positive_regulation of PPARA 12 438 0.68 293.28 63.61
83 INT17401 Gene_expression of IGF1 1 475 0.78 232.18 62.07
84 INT6761 Binding of CALCA 1 100 0.48 26.71 62.05
85 INT11318 Gene_expression of Gtf3a 6 274 0.52 183.82 60.89
86 INT39153 Positive_regulation of PTGS2 3 182 0.70 96.16 60.6
87 INT5058 Positive_regulation of IFNA1 2 356 0.70 245.75 60.52
88 INT9196 Gene_expression of PTGS1 4 215 0.77 96.99 60.5
89 INT103924 Positive_regulation of Akt1 6 359 0.69 158.94 60.34
90 INT97368 Negative_regulation of Nav1 12 62 0.59 41.56 60.27
91 INT14740 Gene_expression of TGFB1 2 272 0.78 168.48 60.18
92 INT50672 Positive_regulation of CPOX 1 205 0.44 125.93 60.06
93 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
94 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
95 INT169926 Positive_regulation of Gopc 6 416 0.46 157.8 58.67
96 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
97 INT73048 Gene_expression of MMP9 29 268 0.77 159.75 57.81
98 INT46637 Gene_expression of CXCL10 1 172 0.78 121.94 57.74
99 INT48232 Gene_expression of MMP1 1 245 0.78 96.31 57.72
100 INT31116 Gene_expression of Casp3 3 192 0.78 78.21 57.43
101 INT5356 Positive_regulation of FOS 3 153 0.69 54.21 56.74
102 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
103 INT96937 Gene_expression of Mmp9 7 191 0.75 150.3 56.01
104 INT647 Gene_expression of SGCG 17 211 0.75 78.46 55.82
105 INT117223 Gene_expression of TLR4 1 348 0.78 206.18 54.42
106 INT52611 Negative_regulation of Ptgs2 2 142 0.59 66.31 52.71
107 INT52264 Gene_expression of IK 1 180 0.77 90.87 51.87
108 INT122041 Binding of Ppara 3 308 0.48 189.17 51.48
109 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
110 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
111 INT53083 Gene_expression of Ptgs2 2 153 0.78 90.04 50.39
112 INT9210 Regulation of IL6 2 166 0.62 125.61 49.95
113 INT35975 Regulation of Cpox 1 109 0.39 57.88 49.69
114 INT6796 Positive_regulation of Jun 5 165 0.70 37.18 49.64
115 INT2323 Gene_expression of Trh 2 146 0.78 29.92 49.5
116 INT22454 Regulation of Crp 1 213 0.62 160.67 49.24
117 INT12471 Regulation of Insrr 2 52 0.35 17.8 48.31
118 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
119 INT671 Positive_regulation of Cea 7 221 0.69 164.5 47.79
120 INT6864 Positive_regulation of Gene_expression of Gfap 1 110 0.70 59.01 47.07
121 INT170646 Negative_regulation of Fig4 1 213 0.37 81.29 46.92
122 INT26500 Gene_expression of MMP2 5 201 0.78 110.57 46.9
123 INT71786 Phosphorylation of MAPK1 27 256 0.82 110.09 46.17
124 INT20492 Gene_expression of MMP12 1 89 0.76 81.36 46.12
125 INT81498 Positive_regulation of Gene_expression of CCL2 1 107 0.70 53.89 45.22
126 INT6979 Positive_regulation of CA2 4 206 0.67 50.79 44.97
127 INT3361 Positive_regulation of Esr1 7 273 0.69 208.53 44.81
128 INT80124 Negative_regulation of VEGFA 7 450 0.58 311.19 44.53
129 INT4216 Gene_expression of CD40LG 1 328 0.78 256.02 44.23
130 INT117675 Transcription of Nav1 9 46 0.72 30.23 44.01
131 INT1894 Negative_regulation of Localization of Gh 2 168 0.58 64.12 43.56
132 INT66383 Phosphorylation of Prkaca 12 143 0.80 30.85 43.38
133 INT25383 Gene_expression of Csf2 2 222 0.76 152.93 43.32
134 INT115384 Positive_regulation of Mmp9 1 121 0.68 94.74 43.02
135 INT52531 Gene_expression of Nfkb1 2 153 0.75 82.84 42.9
136 INT613 Gene_expression of Alb 11 268 0.78 149.84 42.78
137 INT157666 Positive_regulation of GOPC 4 335 0.60 120.19 42.75
138 INT85943 Negative_regulation of Nos2 2 161 0.59 108.56 42.65
139 INT170054 Negative_regulation of Gopc 6 280 0.38 117.89 42.4
140 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
141 INT89 Positive_regulation of Gast 1 187 0.70 80.49 42.07
142 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
143 INT29496 Gene_expression of MMP3 4 136 0.75 49.49 41.78
144 INT114751 Gene_expression of Mapk1 7 137 0.76 60.14 39.98
145 INT11560 Positive_regulation of CASP3 3 236 0.70 184.33 39.38
146 INT77434 Positive_regulation of Gene_expression of Nos2 2 151 0.69 96.76 38.94
147 INT173693 Localization of Gopc 5 249 0.65 70.49 38.81
148 INT16323 Gene_expression of pr 4 62 0.66 36.14 38.26
149 INT97366 Regulation of Nav1 5 38 0.62 23.63 38.17
150 INT77307 Gene_expression of Bcl2 17 399 0.77 319.77 38
151 INT14009 Gene_expression of Sst 5 66 0.77 19.6 37.3
152 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
153 INT80690 Positive_regulation of MAPK8 2 223 0.68 125.63 36.75
154 INT9082 Positive_regulation of ESR1 18 238 0.69 148.51 36.69
155 INT9239 Regulation of Gene_expression of IL6 1 106 0.61 75.24 36.53
156 INT101992 Localization of VEGFA 14 413 0.81 258.23 36.15
157 INT70437 Negative_regulation of Mdk 5 115 0.57 41.03 35.72
158 INT48896 Positive_regulation of Gene_expression of Il10 1 73 0.70 43.14 35.5
159 INT59466 Gene_expression of ISYNA1 3 204 0.77 112.57 35.48
160 INT60710 Gene_expression of Col7a1 1 217 0.78 113.2 35.2
161 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
162 INT6484 Binding of IL1B 1 122 0.47 75.84 35.07
163 INT103094 Binding of PPARA 3 308 0.47 177.26 34.75
164 INT6105 Positive_regulation of IL2 2 133 0.69 82.76 34.67
165 INT1624 Gene_expression of Cea 13 212 0.76 180.44 34.21
166 INT14559 Gene_expression of Igf1 3 254 0.78 112 34.17
167 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
168 INT67039 Positive_regulation of Cpox 3 144 0.65 98.4 33.77
169 INT666 Gene_expression of Jun 2 124 0.78 54.61 33.67
170 INT5489 Localization of CA2 2 172 0.80 39.46 33.56
171 INT52350 Gene_expression of CD14 1 184 0.75 71.37 33.13
172 INT7133 Negative_regulation of MME 11 85 0.59 29.22 33.1
173 INT9694 Positive_regulation of Csf2 2 102 0.68 70.09 33.07
174 INT234 Binding of Alb 3 151 0.48 52.34 32.97
175 INT10248 Gene_expression of KRT20 6 436 0.78 231.96 32.88
176 INT16290 Gene_expression of BSG 1 60 0.68 38.73 32.86
177 INT99610 Localization of MMP9 7 126 0.79 48.46 32.67
178 INT8915 Gene_expression of Igf1 4 199 0.78 78.58 32.51
179 INT14823 Gene_expression of MET 12 103 0.75 51.92 32.48
180 INT13897 Localization of Sst 1 65 0.81 14.91 32.24
181 INT73982 Gene_expression of Hmox1 24 141 0.78 119.43 32.17
182 INT92837 Negative_regulation of Gene_expression of Nos2 2 116 0.59 59.67 31.82
183 INT114881 Gene_expression of Akt1 19 227 0.78 102.49 31.81
184 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
185 INT48693 Regulation of VEGFA 13 268 0.62 191.88 31.52
186 INT47764 Binding of Jun 3 106 0.48 22.62 31.39
187 INT117112 Negative_regulation of Mapk1 1 87 0.56 40.34 31.18
188 INT99688 Negative_regulation of Gene_expression of VEGFA 5 274 0.58 201.8 31.1
189 INT65960 Gene_expression of BCL2 18 352 0.78 312.03 30.73
190 INT34729 Positive_regulation of IFN1@ 2 233 0.67 128.04 30.38
191 INT77652 Negative_regulation of Gene_expression of IL8 4 99 0.59 67.57 30.21
192 INT110020 Gene_expression of Mapk14 3 142 0.77 72.33 30.08
193 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
194 INT65597 Negative_regulation of Casp3 2 69 0.59 39.19 29.32
195 INT169180 Binding of SNRNP70 2 204 0.47 119.1 29.3
196 INT86437 Binding of IL6 2 154 0.48 121.22 29.3
197 INT15174 Gene_expression of Itgam 1 238 0.73 104.92 29.26
198 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
199 INT3841 Gene_expression of FCGR3B 1 117 0.75 58.99 28.87
200 INT28361 Gene_expression of TP53 29 443 0.78 384.86 28.8
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