J:BMC Cardiovasc Disord

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT74027 Creb1 Regulation of Jun 4 1 0.27 1.04 1.02
2 INT199189 Binding of Aldh2 and Ros1 1 4 0.06 0.3 0.88
3 INT213026 Hdl1 Positive_regulation of Nos3 5 1 0.16 7.92 0.73
4 INT199194 Ros1 Negative_regulation of Aldh2 1 1 0.07 0.27 0.3
5 INT199190 Ros1 Positive_regulation of Aldh2 1 1 0.08 0.27 0.3
6 INT186191 Binding of SCARB1 and TBP 1 3 0.03 2.57 0.24
7 INT336893 Epo Regulation of Epc2 1 1 0.00 0.69 0.23
8 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 1 0.08 0 0.19
9 INT199192 Gnat3 Positive_regulation of Hmox1 1 2 0.27 0.23 0.19
10 INT336892 Positive_regulation of Epc2 Positive_regulation of Localization of Spp1 1 1 0.00 0.62 0.19
11 INT336890 Positive_regulation of Epc2 Positive_regulation of Spp1 1 1 0.00 0.62 0.19
12 INT336891 Epo Negative_regulation of Transcription of Bax 1 1 0.10 0.68 0.16
13 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 2 0.24 0.12 0.14
14 INT199204 Gnat3 Positive_regulation of Gnat3 Positive_regulation of Hmox1 1 1 0.18 0.15 0.11
15 INT192358 CRP Regulation of Positive_regulation of HSPD1 1 2 0.15 2.46 0.1
16 INT192353 CRP Regulation of CP 1 2 0.20 2.46 0.1
17 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 1 0.02 1.18 0.1
18 INT171163 Creb1 Regulation of Sp1 1 1 0.03 0.62 0.1
19 INT171164 Agt Regulation of Positive_regulation of Rorb 1 1 0.02 0.64 0.1
20 INT192352 CRP Regulation of HSPD1 1 2 0.15 2.46 0.1
21 INT213023 Hdl1 Regulation of Nos3 2 2 0.09 4.06 0.09
22 INT199193 Gnat3 Positive_regulation of Gene_expression of Ros1 1 1 0.08 0.18 0.08
23 INT171165 Agt Positive_regulation of Positive_regulation of Nfkb1 1 1 0.23 1.09 0.08
24 INT184889 Binding of ALOX5 and MCRS1 1 2 0.06 1.34 0.07
25 INT186188 Binding of SCARB1 and PDZK1 1 1 0.53 0.54 0.05
26 INT260565 T2dm2 Regulation of SUGT1 1 1 0.00 1.43 0.05
27 INT186185 Binding of SCARB1 and SCARB2 1 1 0.22 0.58 0.05
28 INT186192 Binding of SCARB2 and TBP 1 1 0.02 0.58 0.05
29 INT186183 Binding of SCARB2 and SASH3 1 1 0.00 0.49 0.04
30 INT186187 LDLR Regulation of Gene_expression of SCARB1 1 2 0.17 1.71 0.04
31 INT199196 Gnat3 Positive_regulation of Aldh2 2 1 0.26 1.06 0.03
32 INT186186 LDLR Regulation of SCARB1 1 1 0.08 0.65 0.03
33 INT336894 Binding of Epo and Epc2 1 1 0.00 0.55 0.03
34 INT260600 Binding of Ppargc1a and Siglec1 1 1 0.14 1.25 0
35 INT192354 Binding of CRP and HSPD1 1 1 0.12 1.28 0
36 INT184887 MCRS1 Positive_regulation of ALOX5 1 1 0.11 0.64 0
37 INT186190 OLR1 Positive_regulation of SCARB1 1 1 0.01 0.67 0
38 INT187423 MTTP Regulation of Localization of Cd320 1 1 0.10 0.81 0
39 INT192356 Binding of CP and CRP 1 2 0.16 4.35 0
40 INT260601 Binding of ESR1 and Ppargc1a 1 1 0.01 0.48 0
41 INT186189 LDLR Positive_regulation of Gene_expression of SCARB1 1 2 0.14 1.27 0
42 INT192355 Binding of CP and FCGR3A 1 1 0.01 1.22 0
43 INT260564 Binding of Nos3 and T2dm2 1 3 0.05 3.96 0
44 INT336896 Binding of Epo and Epo Positive_regulation of Taok2 1 1 0.01 0.46 0
45 INT260563 Hdl1 Positive_regulation of Positive_regulation of Nos3 1 1 0.05 1.55 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
3 INT58061 Gene_expression of Trpv1 8 1117 0.78 451.54 637.59
4 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
5 INT64202 Positive_regulation of Trpv1 5 643 0.70 249.66 397.42
6 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
8 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
9 INT22548 Positive_regulation of Casp3 2 483 0.70 258.78 213.07
10 INT48955 Gene_expression of Nos2 6 753 0.78 403.87 208.08
11 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
12 INT15516 Gene_expression of Crp 3 711 0.77 615.33 173.09
13 INT15515 Positive_regulation of Crp 4 700 0.70 604.24 150.15
14 INT60126 Regulation of Trpv1 2 186 0.62 85.53 133.4
15 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
16 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
17 INT14151 Gene_expression of Casp3 1 311 0.78 140.26 120.68
18 INT17612 Gene_expression of CRP 13 676 0.78 580.61 119.03
19 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
20 INT170025 Gene_expression of Fig4 2 588 0.67 183.27 113.32
21 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
22 INT49171 Gene_expression of Nos1 1 241 0.78 140.7 104.76
23 INT69440 Gene_expression of ROS1 1 752 0.78 477.64 103.83
24 INT18009 Positive_regulation of CRP 9 518 0.70 553.03 103.74
25 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
26 INT82878 Gene_expression of Ccl2 3 201 0.78 164.95 101.35
27 INT48767 Negative_regulation of NOS1 6 312 0.59 154.25 90.32
28 INT48406 Gene_expression of Icam1 6 277 0.78 238.28 81.71
29 INT56291 Gene_expression of Ros1 8 503 0.63 274.12 81.5
30 INT64636 Positive_regulation of Gene_expression of Nos2 1 242 0.70 147.52 79.53
31 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
32 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
33 INT9484 Gene_expression of Jun 1 175 0.78 34.89 68.54
34 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
35 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
36 INT9408 Positive_regulation of Crp 2 296 0.69 242.27 57.35
37 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
38 INT49017 Negative_regulation of Gene_expression of Nos2 2 169 0.59 80.64 52.67
39 INT6796 Positive_regulation of Jun 1 165 0.70 37.18 49.64
40 INT671 Positive_regulation of Cea 3 221 0.69 164.5 47.79
41 INT48718 Positive_regulation of PRKCA 2 109 0.69 36.16 46.49
42 INT49105 Gene_expression of Vcam1 2 157 0.78 157.27 43.01
43 INT65245 Gene_expression of Nos3 2 121 0.78 98.14 41.56
44 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
45 INT385 Gene_expression of Agt 1 182 0.78 63.62 37.91
46 INT50673 Positive_regulation of Gene_expression of CPOX 1 156 0.54 97.31 37.03
47 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
48 INT51017 Positive_regulation of Icam1 1 113 0.70 81.16 35.55
49 INT1624 Gene_expression of Cea 1 212 0.76 180.44 34.21
50 INT17381 Gene_expression of Tbxa2r 4 146 0.78 65.01 34.15
51 INT74563 Positive_regulation of Gene_expression of ROS1 1 258 0.61 168.18 34.08
52 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
53 INT16714 Regulation of Creb1 2 64 0.62 22.23 33.56
54 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
55 INT1179 Negative_regulation of Ace 2 157 0.59 67.03 30.46
56 INT72923 Positive_regulation of MCRS1 6 72 0.50 99.19 30.36
57 INT9053 Negative_regulation of ALOX5 2 97 0.58 40.34 29.94
58 INT724 Negative_regulation of Alb 2 151 0.59 93.57 29.65
59 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
60 INT9650 Gene_expression of LPA 3 141 0.75 104.57 29
61 INT8698 Localization of Nka1 2 50 0.78 5.8 27.67
62 INT9296 Negative_regulation of PLEK 1 100 0.57 36.65 27.52
63 INT133876 Positive_regulation of Gene_expression of Ros1 3 141 0.32 75.55 27.45
64 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
65 INT145426 Positive_regulation of Ros1 6 185 0.56 106.76 27.21
66 INT111081 Gene_expression of CA1 1 19 0.75 51.09 26.64
67 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
68 INT100423 Gene_expression of Bax 3 141 0.75 98.43 24.48
69 INT147792 Gene_expression of COPD 1 230 0.70 287.13 24.1
70 INT70503 Regulation of Gene_expression of Nos2 2 71 0.62 44 24.01
71 INT3330 Gene_expression of AGT 2 149 0.76 98.65 22.73
72 INT23257 Regulation of CRP 7 127 0.62 100.05 21.87
73 INT3589 Positive_regulation of SCN5A 1 101 0.57 46.01 21.73
74 INT48407 Positive_regulation of Gene_expression of Icam1 2 61 0.70 57.91 21.54
75 INT49103 Positive_regulation of Vcam1 1 71 0.69 59.52 19.85
76 INT184895 Gene_expression of MCRS1 4 46 0.42 56.03 19.44
77 INT70970 Binding of COPD 1 144 0.42 180.34 18.29
78 INT17442 Gene_expression of ALOX5 1 110 0.75 51.55 18.29
79 INT84171 Negative_regulation of Gene_expression of Ccl2 1 30 0.58 26.37 18.28
80 INT80223 Positive_regulation of Hmox1 3 128 0.68 77.71 17.64
81 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
82 INT38056 Localization of Crp 1 71 0.78 53.14 17.03
83 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
84 INT1721 Negative_regulation of HP 8 148 0.42 86.82 16.89
85 INT22547 Regulation of Gene_expression of Casp3 1 23 0.62 8.04 16.78
86 INT61949 Regulation of Nos2 1 74 0.58 34.08 16.7
87 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
88 INT2383 Positive_regulation of CP 1 33 0.67 25.41 15.38
89 INT106745 Localization of CRP 2 65 0.81 66.44 15.21
90 INT2843 Gene_expression of Epo 10 100 0.78 62.01 14.66
91 INT17593 Regulation of Jun 2 37 0.60 5.5 14.35
92 INT9649 Positive_regulation of LPA 1 105 0.69 74.75 13.89
93 INT184890 Regulation of MCRS1 3 35 0.22 44.35 13.78
94 INT17565 Regulation of Gpt 1 85 0.60 43.64 13.68
95 INT52714 Regulation of PRKCA 1 28 0.61 7.73 13.66
96 INT24684 Localization of PLAT 1 30 0.78 26.21 13.56
97 INT14572 Binding of INS 2 205 0.48 175.43 13.38
98 INT55168 Binding of NFKB1 1 55 0.48 22.94 13.15
99 INT13823 Gene_expression of Egf 1 97 0.78 39.99 12.99
100 INT8210 Positive_regulation of Gene_expression of INS 1 188 0.68 146.57 12.83
101 INT4199 Binding of Agt 1 76 0.48 21.06 12.66
102 INT83201 Gene_expression of NOS3 3 93 0.78 47.16 12.48
103 INT21987 Positive_regulation of Rorb 2 30 0.33 12.7 12.24
104 INT9083 Gene_expression of Nppb 3 74 0.78 70.96 12.19
105 INT117502 Positive_regulation of Adipoq 1 70 0.63 40.43 12.03
106 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
107 INT9084 Positive_regulation of Nppb 2 74 0.70 69.77 11.85
108 INT3602 Negative_regulation of Shbg 7 148 0.53 69.05 11.65
109 INT49142 Gene_expression of SELP 2 94 0.75 54.61 11.64
110 INT1190 Positive_regulation of F2 2 53 0.70 46.41 11.64
111 INT73431 Positive_regulation of Nos3 2 82 0.65 53.22 11.61
112 INT14962 Gene_expression of Pf4 3 27 0.76 22.48 10.88
113 INT8065 Binding of AGT 1 54 0.48 20.54 10.85
114 INT36453 Binding of ABCA1 1 48 0.45 19.9 10.84
115 INT18412 Binding of PLEK 1 49 0.47 17.82 10.72
116 INT62895 Gene_expression of NOSTRIN 1 51 0.75 28.8 10.68
117 INT1180 Gene_expression of Ren 1 63 0.77 27.33 10.51
118 INT111335 Gene_expression of HSPD1 1 57 0.75 55.51 10.38
119 INT39712 Binding of pad 5 82 0.48 110.92 10.33
120 INT72924 Negative_regulation of MCRS1 2 27 0.19 33.59 10.29
121 INT110110 Gene_expression of ACCS 9 85 0.58 75.88 10.2
122 INT99505 Gene_expression of Bcl2l1 2 42 0.77 33.12 10.15
123 INT56450 Negative_regulation of Gene_expression of Icam1 1 33 0.52 27.21 10.15
124 INT158863 Negative_regulation of Ros1 3 84 0.35 40.3 10.14
125 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
126 INT11859 Positive_regulation of Tbxa2r 1 44 0.61 22.62 9.61
127 INT144689 Regulation of RCT 1 49 0.53 25.91 9.6
128 INT68373 Negative_regulation of FLNA 1 59 0.57 60.46 9.55
129 INT18145 Positive_regulation of Gene_expression of Tbxa2r 2 30 0.66 18.91 9.52
130 INT102106 Positive_regulation of Bax 2 48 0.67 30.62 9.28
131 INT56292 Negative_regulation of Gene_expression of Ros1 1 70 0.38 36.14 9.17
132 INT68133 Localization of Fgf2 1 36 0.81 15.37 9.14
133 INT102698 Binding of ACCS 8 54 0.42 66.73 9.06
134 INT57549 Gene_expression of GNPTAB 2 49 0.65 57.5 9.05
135 INT82685 Gene_expression of Pecam1 1 36 0.76 27.95 9.01
136 INT35366 Binding of AR 2 87 0.47 30.52 8.9
137 INT7105 Gene_expression of pad 1 54 0.77 63.68 8.8
138 INT22798 Regulation of Shbg 2 64 0.60 26.71 8.76
139 INT175554 Binding of MCRS1 3 21 0.23 25.2 8.59
140 INT2921 Positive_regulation of F8 1 53 0.59 41.56 8.56
141 INT15723 Gene_expression of Fn1 1 47 0.78 37.59 8.51
142 INT8637 Negative_regulation of Dbp 1 112 0.50 33.28 8.4
143 INT44003 Gene_expression of F3 1 40 0.75 27.92 8.29
144 INT389 Gene_expression of Ace 1 21 0.67 10.31 8.1
145 INT2093 Gene_expression of GAST 4 50 0.78 32.32 7.98
146 INT76091 Positive_regulation of NOS3 3 48 0.61 18.4 7.92
147 INT1925 Gene_expression of PLAT 4 47 0.75 34.76 7.88
148 INT48404 Regulation of Gene_expression of Icam1 1 21 0.62 15.1 7.81
149 INT15918 Gene_expression of Serpine1 2 60 0.62 41.73 7.72
150 INT124297 Gene_expression of Sod2 2 112 0.77 65.65 7.64
151 INT65246 Negative_regulation of Nos3 1 36 0.50 25.65 7.62
152 INT52937 Gene_expression of Cd68 1 37 0.67 31.33 7.54
153 INT171146 Negative_regulation of Gene_expression of Fig4 1 38 0.37 11.41 7.42
154 INT102107 Negative_regulation of Gene_expression of Bax 2 30 0.57 29.48 7.33
155 INT6906 Negative_regulation of SCN5A 1 64 0.43 20.64 7.3
156 INT11858 Localization of Tbxa2r 2 39 0.80 21.24 7.09
157 INT3098 Positive_regulation of Epo 1 46 0.70 28.27 7
158 INT78182 Positive_regulation of ACCS 3 43 0.43 46.39 6.78
159 INT110987 Transcription of ESR1 1 45 0.71 24.16 6.72
160 INT34767 Gene_expression of PTGIR 1 36 0.42 14.79 6.69
161 INT3309 Binding of CP 1 25 0.47 17.87 6.62
162 INT1926 Positive_regulation of PLAT 3 54 0.66 31.42 6.49
163 INT171691 Protein_catabolism of Ecm1 1 31 0.20 11.57 6.38
164 INT3738 Regulation of Epo 1 25 0.61 13.73 6.18
165 INT16359 Positive_regulation of Gene_expression of AGT 1 30 0.49 28.27 6.14
166 INT99506 Negative_regulation of Bcl2l1 1 25 0.58 15.7 6.09
167 INT3520 Binding of Csf2 1 27 0.43 9.68 6.08
168 INT64111 Negative_regulation of Gene_expression of Nos1 1 22 0.57 8.96 6.02
169 INT143357 Binding of Ros1 3 48 0.36 27.76 6
170 INT141751 Localization of Syt1 3 21 0.78 11.19 5.98
171 INT63177 Regulation of HP 4 71 0.44 39.48 5.86
172 INT71764 Positive_regulation of Mri1 1 24 0.44 12.31 5.67
173 INT17056 Gene_expression of DLD 5 37 0.57 13.15 5.47
174 INT28164 Regulation of ALOX5 2 25 0.60 12.76 5.47
175 INT28165 Positive_regulation of ALOX5 6 38 0.47 10.8 5.37
176 INT233 Binding of Gast 1 31 0.42 17.07 5.21
177 INT19934 Negative_regulation of Ptgis 1 18 0.32 6.18 5.03
178 INT15652 Positive_regulation of ENO2 1 37 0.68 33.39 5.02
179 INT61950 Regulation of Positive_regulation of Nos2 1 17 0.43 9.01 4.87
180 INT136754 Gene_expression of SCARB1 54 64 0.77 43.28 4.82
181 INT11030 Binding of LPA 3 70 0.48 40.35 4.81
182 INT113948 Gene_expression of FLNA 1 32 0.73 36.06 4.81
183 INT45613 Positive_regulation of pad 4 23 0.50 24.18 4.8
184 INT18011 Positive_regulation of HP 1 60 0.50 31.88 4.75
185 INT69396 Gene_expression of H2-K1 1 72 0.65 38.16 4.56
186 INT29231 Regulation of Dbp 1 44 0.53 10.08 4.47
187 INT45159 Regulation of Nppb 1 16 0.54 13.57 4.46
188 INT3097 Binding of Ren 2 12 0.48 3.15 4.4
189 INT39948 Binding of FLNA 2 45 0.42 58.05 4.27
190 INT5219 Negative_regulation of DBP 3 43 0.57 23.35 4.26
191 INT64338 Negative_regulation of Hmox1 1 16 0.56 12.72 4.2
192 INT34829 Positive_regulation of Gnat3 3 27 0.46 5.24 4.14
193 INT106274 Positive_regulation of Syt1 1 16 0.67 9.76 4.1
194 INT20672 Gene_expression of CDS1 1 19 0.76 8.19 4.08
195 INT104221 Regulation of Gene_expression of CRP 1 30 0.45 20.01 4.07
196 INT178037 Gene_expression of Del(7)Tyr<c-23DVT>-p 3 18 0.22 23.44 4.07
197 INT68189 Gene_expression of TNNT1 2 27 0.75 14.87 4.03
198 INT106805 Localization of ACCS 4 15 0.53 15.22 3.98
199 INT63880 Positive_regulation of FLNA 7 29 0.59 13.88 3.97
200 INT51831 Negative_regulation of ITGA2B 1 20 0.57 10.59 3.91
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