J:BMC Complement Altern Med

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT15842 Crh Positive_regulation of Localization of Pomc 15 1 0.73 5 5.05
2 INT212658 KCNA1 Positive_regulation of Cort 1 4 0.00 2.58 3.36
3 INT29446 Crh Positive_regulation of Localization of POMC 8 1 0.38 1.87 2.58
4 INT212660 Nr3c1 Regulation of KCNA1 1 2 0.00 1.25 1.57
5 INT212662 KCNA1 Regulation of Localization of Cort 1 2 0.00 1.36 1.37
6 INT209409 Binding of CALM1 and NHS 2 4 0.27 0.58 1.32
7 INT212661 KCNA1 Positive_regulation of Scort1 1 1 0.00 0.91 1.03
8 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 4 0.02 0.93 0.57
9 INT356351 Binding of CALM1 and TNC 1 1 0.02 0 0.52
10 INT212659 KCNA1 Regulation of Cort 1 1 0.00 0.41 0.49
11 INT330598 Binding of Il6 and Fig4 1 1 0.11 1.78 0.4
12 INT350214 Binding of GPER and HSPG2 1 1 0.00 0.12 0.32
13 INT226989 Lias Regulation of Gene_expression of Lep 1 2 0.10 0.91 0.3
14 INT190826 ELANE Positive_regulation of Localization of MUC1 1 1 0.07 0 0.29
15 INT128644 Binding of Icam1 and Selp 2 1 0.39 0.57 0.25
16 INT190827 KCNA1 Regulation of Localization of MUC1 1 1 0.05 0.08 0.22
17 INT349475 Regulation of Bax Regulation of Bcl2 1 1 0.07 1.35 0.17
18 INT226988 Lias Positive_regulation of Localization of Lep 1 1 0.08 0.3 0.17
19 INT349476 Bax Regulation of Bcl2 1 1 0.07 1.33 0.15
20 INT213749 NHS Positive_regulation of Localization of CALM1 1 1 0.28 0.58 0.14
21 INT227485 pk Positive_regulation of Ptger2 1 2 0.06 0.91 0.14
22 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 1 0.05 0.09 0.09
23 INT350216 ITPR3 Regulation of Localization of TNIP3 1 1 0.01 0.08 0.09
24 INT190825 Cl Regulation of Gopc 1 1 0.00 0.52 0.09
25 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 1 0.05 0.09 0.09
26 INT192293 Binding of IGF1 and IL1B 1 1 0.15 0.08 0.08
27 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 1 0.04 0.09 0.08
28 INT182897 Mak Positive_regulation of Gene_expression of Il2 1 1 0.38 0.09 0.07
29 INT350219 ITPR3 Positive_regulation of CA2 1 1 0.22 0 0.05
30 INT183302 Tchol1 Negative_regulation of Lipg 1 2 0.00 0.52 0.05
31 INT190824 Binding of Cl and Bcl2 1 1 0.02 1.4 0.05
32 INT250226 Binding of Camp and Rngtt 1 1 0.14 0.85 0.03
33 INT353551 Pck1 Regulation of SLC17A5 1 1 0.00 0 0
34 INT353549 Pck1 Regulation of Gene_expression of Gpt 1 1 0.00 0 0
35 INT349174 Mapk14 Positive_regulation of Phosphorylation of Hspb1 1 1 0.35 0.2 0
36 INT323386 Negative_regulation of Binding of Lta and Coq10a 1 2 0.10 0.57 0
37 INT227486 pk Positive_regulation of Gene_expression of Ptgs1 1 1 0.03 0.17 0
38 INT353550 Pck1 Regulation of Gpt 1 1 0.00 0 0
39 INT349173 Positive_regulation of Stzid Positive_regulation of Positive_regulation of Hspb1 1 1 0.03 0.3 0
40 INT323385 Binding of Lta and Coq10a 1 3 0.09 0.56 0
41 INT227489 pk Regulation of Gene_expression of VEGFA 1 1 0.03 0.07 0
42 INT356140 Fshb Regulation of FSHR 1 1 0.04 0.28 0
43 INT227483 pk Positive_regulation of Gene_expression of Cpox 1 2 0.08 0.27 0
44 INT192292 OR5A1 Negative_regulation of IL1B 1 1 0.01 0.15 0
45 INT257547 HBEGF Positive_regulation of Phosphorylation of CDCP1 1 1 0.00 0.36 0
46 INT227488 pk Regulation of Gene_expression of Cpox 1 1 0.04 0.16 0
47 INT227487 pk Regulation of Gene_expression of Ptger2 1 1 0.04 0.08 0
48 INT227484 pk Regulation of Proc 1 1 0.00 0.27 0
49 INT227482 pk Regulation of Gene_expression of Egf 1 1 0.34 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 8 1020 0.81 284.52 443.17
2 INT50058 Negative_regulation of Cpox 8 907 0.58 426.28 428.29
3 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
4 INT467 Gene_expression of POMC 3 1048 0.78 332.8 394.16
5 INT720 Positive_regulation of POMC 7 807 0.70 237.37 353.83
6 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
7 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
8 INT477 Localization of Avp 1 813 0.81 131.58 300.4
9 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
10 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
11 INT5972 Gene_expression of IL1B 11 948 0.78 510.91 263.97
12 INT68684 Gene_expression of VEGFA 3 2371 0.78 1742.52 259.2
13 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
14 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
15 INT1562 Localization of Crh 8 499 0.81 126.74 236.68
16 INT1308 Localization of Pomc 2 457 0.81 66.83 217.5
17 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
18 INT48955 Gene_expression of Nos2 18 753 0.78 403.87 208.08
19 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
20 INT50670 Gene_expression of CPOX 2 763 0.76 442.13 195.02
21 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
22 INT49441 Negative_regulation of Cpox 4 494 0.59 303.22 177.46
23 INT19472 Gene_expression of Il1 1 554 0.76 419.75 175.35
24 INT438 Gene_expression of Crh 4 376 0.78 159.11 169.17
25 INT1114 Localization of Ins1 10 748 0.80 192.95 165.48
26 INT51921 Gene_expression of Cpox 3 501 0.73 229.81 157.81
27 INT66280 Gene_expression of Nos2 1 534 0.78 330.78 157.07
28 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
29 INT9852 Positive_regulation of Gpt 3 563 0.70 364.64 146.82
30 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
31 INT812 Localization of INS 1 1026 0.81 515.6 145.31
32 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
33 INT90910 Phosphorylation of Grin1 5 150 0.82 68.23 139.24
34 INT1273 Gene_expression of Avp 1 356 0.78 90.56 138.7
35 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
36 INT48953 Positive_regulation of Nos2 2 486 0.70 239.85 131.87
37 INT5497 Positive_regulation of Crh 3 299 0.70 125.54 131.14
38 INT49439 Gene_expression of Cpox 15 508 0.73 326.97 130.17
39 INT65600 Positive_regulation of Casp3 6 376 0.70 198.44 128.03
40 INT695 Binding of POMC 1 304 0.48 56.66 126.85
41 INT65054 Positive_regulation of Nfkb1 2 285 0.70 149.33 126.73
42 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
43 INT7533 Gene_expression of Tlr4 1 720 0.78 343.22 121.57
44 INT62124 Gene_expression of NOS1 3 444 0.78 218.08 114.85
45 INT48593 Positive_regulation of NOS1 6 420 0.68 226.15 114.71
46 INT20374 Gene_expression of Il4 6 515 0.76 306.15 114.12
47 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
48 INT11051 Positive_regulation of Gene_expression of IL6 2 415 0.69 319.21 109.3
49 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
50 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
51 INT69440 Gene_expression of ROS1 5 752 0.78 477.64 103.83
52 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
53 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
54 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
55 INT74058 Gene_expression of Nos1 3 260 0.78 80.04 95.71
56 INT96917 Positive_regulation of Mapk14 19 261 0.70 173.29 88.79
57 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
58 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
59 INT54571 Positive_regulation of NFKB1 1 263 0.70 138.99 87.32
60 INT1472 Positive_regulation of Ins1 4 349 0.69 146.2 86.36
61 INT914 Positive_regulation of GH1 1 292 0.69 100.7 84.91
62 INT92434 Phosphorylation of Mapk1 1 287 0.82 91.65 83.46
63 INT48406 Gene_expression of Icam1 3 277 0.78 238.28 81.71
64 INT56291 Gene_expression of Ros1 2 503 0.63 274.12 81.5
65 INT10534 Positive_regulation of Trib3 4 209 0.60 78.75 81.48
66 INT55944 Positive_regulation of Cpox 1 214 0.57 105.14 81.4
67 INT64636 Positive_regulation of Gene_expression of Nos2 6 242 0.70 147.52 79.53
68 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
69 INT3657 Gene_expression of Ins1 2 514 0.78 321.69 75.76
70 INT39565 Gene_expression of Ptger2 7 424 0.75 229.28 72.68
71 INT11380 Negative_regulation of IL1B 2 215 0.59 125.62 72.35
72 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
73 INT79494 Positive_regulation of Gene_expression of VEGFA 1 577 0.70 442.94 69.73
74 INT170332 Gene_expression of IFN1@ 11 477 0.75 275.21 69.65
75 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
76 INT8357 Gene_expression of KNG1 1 153 0.75 77.26 68.66
77 INT1988 Positive_regulation of Localization of Ins1 3 254 0.69 59.25 68.37
78 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
79 INT11807 Gene_expression of Il2 12 266 0.78 112 64.97
80 INT15514 Negative_regulation of Crp 3 275 0.59 194.6 64.86
81 INT822 Gene_expression of ESR1 4 529 0.78 302.16 63.64
82 INT67614 Positive_regulation of PPARA 1 438 0.68 293.28 63.61
83 INT1951 Positive_regulation of Tlr4 2 345 0.70 176.99 62.42
84 INT17401 Gene_expression of IGF1 59 475 0.78 232.18 62.07
85 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
86 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
87 INT55344 Gene_expression of Ros1 6 396 0.54 217.64 59.98
88 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
89 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
90 INT5453 Regulation of Localization of POMC 1 114 0.62 20.56 56.34
91 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
92 INT33567 Gene_expression of CALM1 82 139 0.67 48.85 56.14
93 INT82650 Gene_expression of Bcl2 18 312 0.78 211.71 55.03
94 INT12717 Binding of Pck1 7 85 0.47 12.49 54.81
95 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
96 INT5509 Positive_regulation of Localization of Crh 2 91 0.70 30.65 53.92
97 INT96914 Phosphorylation of Mapk14 16 168 0.82 108.46 53.32
98 INT48952 Negative_regulation of Nos2 2 204 0.59 101.73 53.15
99 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
100 INT49017 Negative_regulation of Gene_expression of Nos2 7 169 0.59 80.64 52.67
101 INT83199 Gene_expression of Nos3 1 193 0.78 100.72 51.57
102 INT12345 Gene_expression of Il2 4 142 0.78 59.17 51.21
103 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
104 INT35975 Regulation of Cpox 5 109 0.39 57.88 49.69
105 INT937 Positive_regulation of Oxt 2 195 0.70 37.82 49.3
106 INT51163 Gene_expression of Gal 4 119 0.78 67.48 49.23
107 INT55671 Gene_expression of Ik 3 151 0.27 80.1 48.49
108 INT17881 Gene_expression of LEP 1 278 0.78 221.61 48.31
109 INT170646 Negative_regulation of Fig4 6 213 0.37 81.29 46.92
110 INT531 Gene_expression of GH1 2 376 0.75 193.45 46.24
111 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
112 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
113 INT110023 Negative_regulation of Mapk14 1 127 0.59 84.27 45.42
114 INT6979 Positive_regulation of CA2 22 206 0.67 50.79 44.97
115 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
116 INT80124 Negative_regulation of VEGFA 2 450 0.58 311.19 44.53
117 INT613 Gene_expression of Alb 2 268 0.78 149.84 42.78
118 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
119 INT5502 Positive_regulation of Gene_expression of Crh 2 69 0.70 43.06 42.23
120 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
121 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
122 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
123 INT69437 Positive_regulation of ROS1 2 328 0.58 222.83 40.56
124 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
125 INT16194 Binding of CNR1 1 82 0.48 20.75 39.59
126 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
127 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
128 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
129 INT47939 Gene_expression of Selp 2 171 0.76 87.54 39.03
130 INT173693 Localization of Gopc 3 249 0.65 70.49 38.81
131 INT1931 Positive_regulation of Gene_expression of POMC 1 116 0.70 37.26 38.67
132 INT65889 Gene_expression of RETNLB 1 73 0.34 60.98 38.3
133 INT64558 Negative_regulation of Nos1 1 88 0.58 26.76 36.78
134 INT9082 Positive_regulation of ESR1 2 238 0.69 148.51 36.69
135 INT3971 Positive_regulation of Alb 2 175 0.70 98.46 36.45
136 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
137 INT51017 Positive_regulation of Icam1 1 113 0.70 81.16 35.55
138 INT48896 Positive_regulation of Gene_expression of Il10 1 73 0.70 43.14 35.5
139 INT65055 Negative_regulation of Nfkb1 2 83 0.58 44.85 34.94
140 INT74563 Positive_regulation of Gene_expression of ROS1 2 258 0.61 168.18 34.08
141 INT81289 Positive_regulation of Gene_expression of Tlr4 1 192 0.69 104.5 33.89
142 INT5489 Localization of CA2 17 172 0.80 39.46 33.56
143 INT65536 Negative_regulation of Positive_regulation of Nfkb1 1 77 0.59 38.86 33.33
144 INT10248 Gene_expression of KRT20 3 436 0.78 231.96 32.88
145 INT16290 Gene_expression of BSG 1 60 0.68 38.73 32.86
146 INT81530 Gene_expression of Nfkb1 2 93 0.78 48.58 32.58
147 INT22939 Gene_expression of Csf2 2 164 0.78 85.1 32.22
148 INT17886 Negative_regulation of Il1 1 95 0.57 70.91 31.25
149 INT5418 Negative_regulation of Alox5 1 108 0.57 42.09 31.17
150 INT99688 Negative_regulation of Gene_expression of VEGFA 1 274 0.58 201.8 31.1
151 INT65960 Gene_expression of BCL2 1 352 0.78 312.03 30.73
152 INT11650 Negative_regulation of Gpt 2 122 0.59 69.15 30.36
153 INT110020 Gene_expression of Mapk14 5 142 0.77 72.33 30.08
154 INT5117 Negative_regulation of Gene_expression of IL2 2 118 0.59 52.33 29.96
155 INT9053 Negative_regulation of ALOX5 1 97 0.58 40.34 29.94
156 INT64113 Positive_regulation of Gene_expression of NOS1 1 110 0.60 71.03 29.72
157 INT724 Negative_regulation of Alb 3 151 0.59 93.57 29.65
158 INT32165 Binding of CALM1 36 92 0.48 24.19 29.57
159 INT12319 Positive_regulation of Cort 3 52 0.61 22.55 29.35
160 INT65597 Negative_regulation of Casp3 1 69 0.59 39.19 29.32
161 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
162 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
163 INT65598 Negative_regulation of Positive_regulation of Casp3 3 45 0.59 18.36 28.59
164 INT6364 Gene_expression of Edn1 2 123 0.78 73.76 28.43
165 INT5653 Positive_regulation of ELANE 1 136 0.70 72.78 27.94
166 INT6717 Negative_regulation of YY1 1 45 0.57 15.35 27.8
167 INT133876 Positive_regulation of Gene_expression of Ros1 1 141 0.32 75.55 27.45
168 INT145426 Positive_regulation of Ros1 3 185 0.56 106.76 27.21
169 INT17331 Positive_regulation of JUN 1 132 0.69 60.4 27.03
170 INT129956 Gene_expression of MMP13 5 145 0.72 60.48 26.98
171 INT2609 Localization of ELANE 2 111 0.81 50.22 26.63
172 INT13995 Gene_expression of gr 2 96 0.74 48.21 26.54
173 INT9682 Positive_regulation of IGF1 8 238 0.70 120.03 26.36
174 INT65537 Positive_regulation of Positive_regulation of Nfkb1 1 52 0.67 30.6 26.35
175 INT47075 Positive_regulation of Ptger2 1 142 0.70 78.55 25.47
176 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
177 INT68758 Positive_regulation of Ros1 1 125 0.46 82.72 25.27
178 INT81496 Gene_expression of CNR2 1 68 0.75 30.04 24.92
179 INT100423 Gene_expression of Bax 14 141 0.75 98.43 24.48
180 INT22708 Gene_expression of MUC1 3 297 0.78 232.71 24.19
181 INT70503 Regulation of Gene_expression of Nos2 3 71 0.62 44 24.01
182 INT15390 Positive_regulation of Edn1 2 64 0.70 47.36 23.8
183 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
184 INT16721 Negative_regulation of Cat 4 56 0.59 44.44 22.84
185 INT76123 Gene_expression of Lep 29 193 0.78 94.17 22.76
186 INT11659 Gene_expression of COL2A1 7 164 0.78 78.49 22.58
187 INT823 Negative_regulation of ESR1 2 144 0.58 63.72 22.52
188 INT35711 Positive_regulation of Sdcbp 6 110 0.60 50.45 22.11
189 INT5905 Negative_regulation of ELANE 2 113 0.59 47.43 22.09
190 INT8580 Gene_expression of ELANE 3 132 0.75 62.98 21.79
191 INT1644 Regulation of FSHR 2 77 0.55 15.62 21.49
192 INT101517 Negative_regulation of PPARA 1 168 0.57 112.24 21.41
193 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
194 INT73593 Gene_expression of BAX 1 173 0.76 147.81 20.94
195 INT72060 Positive_regulation of Gene_expression of Ros1 3 127 0.41 76.76 20.91
196 INT171820 Localization of Fig4 2 144 0.65 27.38 20.88
197 INT66923 Localization of Ik 1 54 0.07 19.78 20.84
198 INT12951 Negative_regulation of Cat 1 126 0.57 64.39 20.61
199 INT105021 Binding of GOPC 1 187 0.40 60.39 20.38
200 INT9237 Regulation of Gene_expression of IL1B 1 49 0.62 30.69 20.34
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