J:BMC Endocr Disord

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT316544 BCL2L11 Regulation of INS 1 1 0.00 1.36 0.77
2 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 2 0.22 3.78 0.69
3 INT316546 Binding of GH1 and SST 2 1 0.03 0.55 0.54
4 INT173475 Bcar1 Regulation of Isl1 1 1 0.01 0 0.47
5 INT78444 Binding of GH1 and IGF1 4 1 0.16 2.82 0.37
6 INT316545 Binding of IGF1 and SST 1 1 0.06 0.45 0.37
7 INT173476 Th Regulation of Gene_expression of Bcar1 1 1 0.10 0 0.34
8 INT173478 Th Regulation of Localization of Ins1 1 1 0.13 0 0.34
9 INT355103 Binding of Ins2 and Ins1 1 4 0.12 2 0.21
10 INT316543 GH1 Regulation of Gene_expression of IGF1 1 1 0.03 1.32 0.09
11 INT316552 Binding of SST and Sst1 1 1 0.03 0.53 0.09
12 INT218614 INS Positive_regulation of Binding of IGF1 1 1 0.39 0.79 0.05
13 INT173477 Bcar1 Regulation of Localization of Ins1 1 1 0.16 0.07 0.05
14 INT218616 Binding of IGFBP3 and INS 1 1 0.07 0.68 0.05
15 INT239605 Ghrh Negative_regulation of Gh 1 1 0.01 0.53 0.04
16 INT202231 Binding of IGF1 and INS 2 1 0.28 1.38 0.03
17 INT296954 NRIP1 Negative_regulation of Gene_expression of UCP1 1 1 0.30 1.05 0
18 INT296960 Binding of NRIP1 and MLST8 1 2 0.03 2.65 0
19 INT296956 NRIP1 Regulation of Gene_expression of CIDEA 1 1 0.44 0.76 0
20 INT296959 NRIP1 Regulation of SLC2A4 1 1 0.22 0.54 0
21 INT17529 Igf1 Regulation of Gh 1 1 0.01 0.07 0
22 INT296955 Binding of CIDEA and MLST8 1 1 0.02 0.97 0
23 INT218615 Negative_regulation of INS Negative_regulation of Gene_expression of IGF1 1 1 0.33 0.89 0
24 INT256400 GLP1R Positive_regulation of Localization of GCG 1 1 0.02 0.15 0
25 INT296957 NRIP1 Regulation of Transcription of CIDEA 1 1 0.44 0.91 0
26 INT296958 NRIP1 Regulation of Gene_expression of MLST8 1 1 0.04 0.76 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 6 1020 0.81 284.52 443.17
3 INT1893 Localization of Gh 7 1041 0.79 340.23 256.58
4 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
5 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
6 INT739 Negative_regulation of POMC 2 358 0.59 102.28 166.77
7 INT1114 Localization of Ins1 33 748 0.80 192.95 165.48
8 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
9 INT4740 Gene_expression of Th 3 298 0.78 61.27 154.03
10 INT812 Localization of INS 3 1026 0.81 515.6 145.31
11 INT425 Localization of PRL 7 455 0.81 189.64 144.8
12 INT252 Localization of GH1 10 529 0.80 227.4 122.05
13 INT6128 Positive_regulation of Localization of POMC 3 256 0.70 68.77 121.64
14 INT218 Positive_regulation of Th 4 245 0.70 40.5 120.1
15 INT1530 Regulation of Gh 4 382 0.61 115.96 112.47
16 INT7327 Regulation of Th 5 164 0.62 29.67 110.14
17 INT3038 Gene_expression of INS 7 1583 0.78 1174.16 107.01
18 INT915 Positive_regulation of PRL 1 342 0.70 141.96 104.31
19 INT5865 Positive_regulation of Localization of Gh 2 282 0.69 84.86 93.5
20 INT86024 Gene_expression of PPARA 2 736 0.78 497.93 91.14
21 INT1472 Positive_regulation of Ins1 8 349 0.69 146.2 86.36
22 INT914 Positive_regulation of GH1 2 292 0.69 100.7 84.91
23 INT1498 Gene_expression of Gh 5 521 0.75 220.84 81.16
24 INT3657 Gene_expression of Ins1 8 514 0.78 321.69 75.76
25 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
26 INT1724 Negative_regulation of ACE 26 437 0.59 315.64 74.48
27 INT1988 Positive_regulation of Localization of Ins1 9 254 0.69 59.25 68.37
28 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
29 INT8347 Gene_expression of SST 16 181 0.78 104.59 65.45
30 INT217 Negative_regulation of Th 3 134 0.59 26.83 62.63
31 INT17401 Gene_expression of IGF1 21 475 0.78 232.18 62.07
32 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
33 INT55344 Gene_expression of Ros1 3 396 0.54 217.64 59.98
34 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
35 INT1200 Negative_regulation of Ins1 9 274 0.58 155.17 56.14
36 INT1579 Gene_expression of PRL 2 279 0.78 119.2 55.41
37 INT251 Regulation of INS 7 398 0.62 232.47 55.04
38 INT2276 Regulation of Ins1 11 234 0.61 103.78 54.05
39 INT921 Regulation of GH1 6 172 0.60 52.88 51.04
40 INT1199 Positive_regulation of INS 2 579 0.70 399.64 50.43
41 INT1197 Negative_regulation of Localization of POMC 3 109 0.59 28.29 48.02
42 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
43 INT531 Gene_expression of GH1 20 376 0.75 193.45 46.24
44 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
45 INT2275 Negative_regulation of Localization of Ins1 8 183 0.59 51.02 44.94
46 INT18522 Positive_regulation of Gene_expression of IFNA1 2 248 0.67 160.85 44.87
47 INT1474 Regulation of Localization of Ins1 7 132 0.61 25.96 43.07
48 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
49 INT5454 Localization of CRH 1 124 0.79 79.18 41.53
50 INT350 Localization of Th 1 79 0.80 10.26 41.17
51 INT3252 Negative_regulation of INS 3 428 0.59 271.65 39.52
52 INT916 Regulation of Localization of PRL 1 92 0.62 22.98 38.13
53 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
54 INT248 Positive_regulation of Localization of GH1 3 137 0.69 49.25 32.92
55 INT6302 Binding of IFNA1 1 196 0.48 133.85 32.73
56 INT691 Binding of SST 7 67 0.48 24.66 32.67
57 INT8915 Gene_expression of Igf1 2 199 0.78 78.58 32.51
58 INT985 Negative_regulation of GH1 5 213 0.57 89.53 32.39
59 INT6558 Positive_regulation of Gene_expression of Th 2 56 0.70 9.64 30.89
60 INT719 Negative_regulation of SGCG 1 96 0.57 47.91 30.22
61 INT7412 Positive_regulation of SST 2 71 0.70 24.44 29.48
62 INT86437 Binding of IL6 2 154 0.48 121.22 29.3
63 INT5300 Regulation of Insr 2 54 0.60 11.33 29.26
64 INT9682 Positive_regulation of IGF1 6 238 0.70 120.03 26.36
65 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
66 INT956 Negative_regulation of PRL 2 94 0.59 42.72 23.01
67 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
68 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
69 INT16303 Negative_regulation of Localization of GH1 3 89 0.59 37.31 22.15
70 INT72060 Positive_regulation of Gene_expression of Ros1 2 127 0.41 76.76 20.91
71 INT14701 Negative_regulation of IFNA1 2 118 0.54 84.19 20.08
72 INT28951 Negative_regulation of IGF1 2 133 0.59 75.77 18.9
73 INT84464 Gene_expression of DPP4 1 101 0.78 56.15 17.53
74 INT1578 Negative_regulation of Localization of PRL 2 52 0.59 20.62 17.18
75 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
76 INT28950 Positive_regulation of Gene_expression of IGF1 4 99 0.69 46.9 16.47
77 INT6110 Negative_regulation of Gene_expression of Ins1 1 83 0.56 60.59 16.07
78 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
79 INT20665 Gene_expression of ACE 3 87 0.78 51.71 14.19
80 INT14572 Binding of INS 2 205 0.48 175.43 13.38
81 INT17539 Positive_regulation of Igf1 5 68 0.69 28.47 13.02
82 INT2578 Binding of Ins1 3 74 0.48 33.57 12.92
83 INT35467 Gene_expression of DIO2 3 37 0.65 9.56 12.61
84 INT11288 Negative_regulation of CRH 1 44 0.00 16.69 12.37
85 INT28952 Negative_regulation of Gene_expression of IGF1 4 75 0.58 41.11 12.32
86 INT8065 Binding of AGT 1 54 0.48 20.54 10.85
87 INT63773 Gene_expression of DRD2 1 25 0.78 10.41 10.8
88 INT952 Negative_regulation of GHRH 1 57 0.56 25.3 10.34
89 INT31780 Binding of DIO2 1 17 0.36 10.07 10
90 INT11729 Regulation of IGF1 8 71 0.61 44.58 9.71
91 INT27882 Gene_expression of HSP90B2P 5 52 0.75 36.51 9.59
92 INT132036 Negative_regulation of DPP4 12 126 0.59 63.24 9.51
93 INT26492 Negative_regulation of Localization of GCG 1 73 0.58 22.2 9.48
94 INT20664 Binding of ACE 5 60 0.48 35.27 9.16
95 INT11510 Negative_regulation of Positive_regulation of Gh 1 28 0.52 12.71 9.16
96 INT55342 Negative_regulation of Gene_expression of Ros1 1 49 0.37 31.62 8.93
97 INT34777 Localization of IGF1 4 82 0.80 42.68 8.62
98 INT12292 Negative_regulation of Positive_regulation of GH1 1 22 0.58 5.02 8.28
99 INT3803 Negative_regulation of Igf1 1 45 0.58 15.95 7.98
100 INT34741 Positive_regulation of Gene_expression of GH1 8 58 0.67 35.06 7.8
101 INT73992 Gene_expression of Hspa1b 10 41 0.78 37.26 6.88
102 INT20922 Positive_regulation of Localization of CRH 1 18 0.67 11.12 6.79
103 INT5455 Negative_regulation of Localization of CRH 1 16 0.49 7.31 6.41
104 INT15803 Regulation of IFNG 1 21 0.44 12.57 5.98
105 INT8916 Regulation of Igf1 2 45 0.60 13.06 5.81
106 INT67195 Negative_regulation of Gene_expression of SST 1 7 0.42 6.98 4.88
107 INT55434 Positive_regulation of Gene_expression of HSP90B2P 1 14 0.38 10.91 4.83
108 INT4378 Regulation of Gene_expression of GH1 3 26 0.47 10.2 4.61
109 INT6021 Binding of PRL 1 18 0.48 12.55 4.3
110 INT84700 Positive_regulation of HSP90B2P 2 34 0.67 30.22 4.07
111 INT14930 Regulation of Gene_expression of SST 1 12 0.45 6.86 3.89
112 INT34054 Regulation of Gene_expression of IFNG 1 8 0.42 3.69 3.76
113 INT9677 Negative_regulation of Gene_expression of GH1 3 46 0.48 23.32 3.68
114 INT73991 Positive_regulation of Hspa1b 3 20 0.69 11.4 3.45
115 INT48726 Gene_expression of IGFBP1 1 27 0.67 9.45 3.36
116 INT4479 Negative_regulation of Positive_regulation of REN 1 17 0.56 6.1 3.27
117 INT131187 Regulation of Gene_expression of IGF1 2 18 0.62 11.18 3.05
118 INT73990 Positive_regulation of Gene_expression of Hspa1b 3 19 0.70 13.94 3.03
119 INT16130 Binding of IGF1 4 67 0.48 27.43 2.95
120 INT1631 Binding of Hdl1 1 42 0.36 49.22 2.92
121 INT10267 Regulation of Positive_regulation of Ins1 1 11 0.24 2.74 2.63
122 INT122557 Localization of Chdh 1 6 0.74 4.44 2.6
123 INT61378 Positive_regulation of Bcar1 1 13 0.45 2.84 2.45
124 INT66544 Binding of Igf1 1 23 0.46 8.33 2.44
125 INT26177 Regulation of Regulation of INS 2 19 0.44 11.32 2.18
126 INT14010 Gene_expression of SLC2A1 1 19 0.78 15.22 2.12
127 INT84702 Positive_regulation of Positive_regulation of HSP90B2P 1 6 0.49 1.34 2.03
128 INT132971 Negative_regulation of Localization of IGF1 2 5 0.42 3.98 1.94
129 INT77656 Gene_expression of Hsp90aa1 2 12 0.78 24.27 1.81
130 INT23881 Gene_expression of Bcar1 1 8 0.52 2.48 1.69
131 INT43425 Positive_regulation of Hspa9 2 2 0.13 1 1.61
132 INT242212 Gene_expression of GLP1R 3 29 0.65 11.36 1.52
133 INT90377 Gene_expression of HBA1 1 26 0.75 7.34 1.51
134 INT29667 Positive_regulation of CRHR1 1 6 0.54 1.09 1.5
135 INT87062 Positive_regulation of Binding of IL6 2 10 0.49 11.8 1.42
136 INT8067 Negative_regulation of Binding of AGT 1 12 0.25 10.33 1.39
137 INT53775 Gene_expression of Hspd1 9 21 0.78 31.25 1.38
138 INT81922 Regulation of Gene_expression of HSP90B2P 1 5 0.44 4.25 1.34
139 INT84701 Binding of HSP90B2P 2 8 0.47 7.37 1.29
140 INT10266 Negative_regulation of Regulation of Ins1 1 9 0.43 3.68 1.28
141 INT53776 Positive_regulation of Hspd1 4 17 0.70 10.64 1.23
142 INT48728 Negative_regulation of IGFBP3 1 28 0.59 14.84 1.21
143 INT145960 Positive_regulation of GLP1R 3 19 0.58 7.25 1.19
144 INT32354 Negative_regulation of Regulation of Insr 1 3 0.33 0.13 1.08
145 INT147880 Regulation of SRGN 1 28 0.33 13.99 0.9
146 INT173472 Positive_regulation of Isl1 5 1 0.03 0.2 0.83
147 INT167833 Positive_regulation of Ins2 10 4 0.50 6.52 0.82
148 INT208334 Localization of Hdl1 1 22 0.54 18.94 0.74
149 INT316547 Binding of Sst1 1 2 0.10 0.84 0.74
150 INT296992 Gene_expression of MLST8 10 19 0.07 18.39 0.73
151 INT117245 Gene_expression of CRHR1 4 3 0.51 3.45 0.73
152 INT259902 Regulation of Gene_expression of ACE 1 3 0.45 1.87 0.7
153 INT84068 Negative_regulation of Gene_expression of IGFBP1 1 3 0.42 2.74 0.69
154 INT312830 Regulation of Ins2 2 2 0.39 1.45 0.66
155 INT186790 Regulation of NRIP1 5 4 0.45 6.68 0.64
156 INT173234 Gene_expression of Sst1 1 2 0.14 0.88 0.63
157 INT72446 Negative_regulation of Binding of ACE 1 4 0.42 2.48 0.62
158 INT44079 Regulation of HBA1 1 3 0.12 0.98 0.62
159 INT242210 Positive_regulation of Gene_expression of GLP1R 1 6 0.58 3.59 0.61
160 INT53774 Positive_regulation of Gene_expression of Hspd1 2 7 0.70 6.99 0.6
161 INT106343 Positive_regulation of Positive_regulation of Igf1 1 2 0.69 1.45 0.59
162 INT53778 Regulation of Gene_expression of Hspd1 3 2 0.58 3.61 0.52
163 INT9426 Negative_regulation of IGFBP1 1 5 0.37 1.35 0.51
164 INT116460 Negative_regulation of HBA1 1 11 0.42 5.6 0.47
165 INT123338 Regulation of HSP90B2P 1 4 0.26 1.52 0.47
166 INT173474 Localization of Bcar1 1 2 0.35 0 0.47
167 INT312821 Binding of Ins2 2 2 0.37 2.13 0.46
168 INT92145 Transcription of Hspa1b 1 3 0.50 1.28 0.44
169 INT145928 Negative_regulation of SERPINA4 1 5 0.07 2.05 0.43
170 INT186786 Positive_regulation of NRIP1 3 3 0.50 4.81 0.42
171 INT236143 Transcription of Hdl1 1 2 0.06 1.85 0.41
172 INT230478 Gene_expression of Hspa9 9 1 0.22 5.45 0.41
173 INT92143 Regulation of Positive_regulation of Hspa1b 1 2 0.56 1 0.39
174 INT296969 Gene_expression of NRIP1 29 1 0.78 26.23 0.38
175 INT355101 Negative_regulation of Transcription of Hdl1 2 1 0.02 1.61 0.38
176 INT63222 Negative_regulation of MGAM 1 8 0.43 4.33 0.37
177 INT17937 Gene_expression of Isl1 1 4 0.27 0.48 0.36
178 INT77655 Regulation of Gene_expression of Hspa1b 3 4 0.38 3.7 0.33
179 INT230486 Regulation of Positive_regulation of HSP90B2P 1 2 0.19 1.38 0.33
180 INT77654 Regulation of Gene_expression of Hsp90aa1 1 4 0.62 2.41 0.28
181 INT143489 Gene_expression of Ggt6 1 3 0.24 1.67 0.28
182 INT62808 Positive_regulation of SLC2A4 3 7 0.50 3.3 0.24
183 INT230475 Positive_regulation of Gene_expression of Hspa9 5 1 0.20 2.52 0.24
184 INT229317 Gene_expression of SLC2A4 5 10 0.69 6.88 0.2
185 INT230483 Protein_catabolism of Akt1 1 2 0.10 1.11 0.2
186 INT344691 Negative_regulation of Binding of Hdl1 1 2 0.31 2.95 0.19
187 INT296978 Negative_regulation of MLST8 2 3 0.04 5.26 0.18
188 INT291813 Negative_regulation of HSD17B4 1 3 0.42 0.62 0.17
189 INT78741 Negative_regulation of Gene_expression of Hspa1b 3 2 0.43 2.83 0.17
190 INT230470 Regulation of Imgt1 1 1 0.00 0.65 0.17
191 INT277389 Positive_regulation of Gene_expression of SLC2A4 1 4 0.61 2.87 0.14
192 INT296990 Positive_regulation of MLST8 1 2 0.05 2.89 0.13
193 INT255072 Regulation of Negative_regulation of DPP4 1 2 0.44 1.22 0.13
194 INT296995 Regulation of MLST8 1 2 0.03 3.1 0.13
195 INT230484 Localization of Hspa9 4 1 0.22 2.67 0.12
196 INT256404 Positive_regulation of Positive_regulation of GLP1R 1 2 0.58 1.31 0.1
197 INT296963 Positive_regulation of ESRRA 1 2 0.33 1.17 0.09
198 INT355099 Localization of Ins2 1 1 0.44 0.83 0.09
199 INT173473 Positive_regulation of Positive_regulation of Isl1 1 1 0.02 0.06 0.09
200 INT296984 Positive_regulation of UCP1 7 1 0.42 5.95 0.09
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