J:BMC Evol Biol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT233785 Binding of SCT and VIPR1 1 1 0.08 0 0.27
2 INT233784 Binding of GCG and SCT 1 1 0.06 0 0.27
3 INT233781 Binding of PTH1R and SCT 1 1 0.18 0 0.27
4 INT233786 Binding of CALCR and SCT 1 1 0.05 0 0.27
5 INT233780 Binding of ADCYAP1 and SCT 1 1 0.16 0 0.27
6 INT233782 Binding of PTHLH and SCT 1 1 0.06 0 0.27
7 INT233783 Binding of SCT and VIPR2 1 1 0.13 0 0.27
8 INT207845 Binding of INS and Hypism 3 1 0.04 2.88 0.22
9 INT207846 Hypism Regulation of INS 1 1 0.06 1.14 0.04
10 INT227366 Binding of CES1 and PTER 1 1 0.24 0 0
11 INT227365 Binding of CES2 and PTER 1 1 0.25 0 0
12 INT227367 CES2 Negative_regulation of Localization of KDELC1 1 1 0.03 0 0
13 INT233779 PTH1R Regulation of Positive_regulation of PTH 1 1 0.08 0.34 0
14 INT227368 Binding of CES1 and CES2 1 1 0.36 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT738 Regulation of POMC 2 459 0.62 111.19 243.74
4 INT50670 Gene_expression of CPOX 2 763 0.76 442.13 195.02
5 INT812 Localization of INS 2 1026 0.81 515.6 145.31
6 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
7 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
8 INT3038 Gene_expression of INS 56 1583 0.78 1174.16 107.01
9 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
10 INT56130 Gene_expression of MC1R 10 259 0.78 62.7 97.55
11 INT21737 Binding of MC1R 7 129 0.48 45.45 56.54
12 INT251 Regulation of INS 9 398 0.62 232.47 55.04
13 INT62630 Positive_regulation of CNR1 1 86 0.70 40.34 51.51
14 INT1199 Positive_regulation of INS 12 579 0.70 399.64 50.43
15 INT3252 Negative_regulation of INS 6 428 0.59 271.65 39.52
16 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
17 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
18 INT7133 Negative_regulation of MME 1 85 0.59 29.22 33.1
19 INT8097 Gene_expression of EGF 2 122 0.77 75.94 28.47
20 INT62169 Positive_regulation of MC1R 4 72 0.69 14.56 27.52
21 INT1728 Negative_regulation of Cndp2 2 36 0.57 3.76 25.39
22 INT4877 Gene_expression of MME 4 184 0.78 122.82 24.78
23 INT184895 Gene_expression of MCRS1 1 46 0.42 56.03 19.44
24 INT22068 Binding of CALCRL 4 53 0.41 6.14 17.32
25 INT84712 Regulation of MC1R 4 36 0.62 9.34 16.91
26 INT42810 Gene_expression of CALCRL 2 53 0.77 10.87 15.42
27 INT184890 Regulation of MCRS1 1 35 0.22 44.35 13.78
28 INT14572 Binding of INS 3 205 0.48 175.43 13.38
29 INT8210 Positive_regulation of Gene_expression of INS 3 188 0.68 146.57 12.83
30 INT27242 Gene_expression of PGR 1 153 0.75 98.77 12.79
31 INT744 Positive_regulation of PTH 1 130 0.70 95.02 11.7
32 INT5464 Regulation of CALCRL 1 24 0.16 4.2 11.19
33 INT4605 Negative_regulation of Gene_expression of INS 2 220 0.58 139.66 10.75
34 INT82854 Gene_expression of MRGPRX1 8 61 0.75 10.14 10.65
35 INT5465 Positive_regulation of CALCRL 2 25 0.49 7.24 9.8
36 INT67612 Binding of PPARG 1 38 0.48 22.67 8.94
37 INT17701 Gene_expression of PTHLH 1 103 0.78 64.23 8.85
38 INT25585 Positive_regulation of DNAH8 1 39 0.70 17.96 7.85
39 INT80822 Positive_regulation of MRGPRX1 4 30 0.67 3.66 7.73
40 INT91609 Regulation of Gene_expression of MC1R 1 11 0.62 2.75 7.34
41 INT233812 Gene_expression of PTH1R 3 32 0.77 18.15 6.15
42 INT16687 Regulation of Cndp2 1 6 0.44 0.23 6.11
43 INT16688 Positive_regulation of Cndp2 1 11 0.49 1.12 5.86
44 INT190298 Binding of MRGPRX1 6 61 0.46 2.66 5.75
45 INT71418 Binding of CES1 3 42 0.40 29.78 5.01
46 INT51898 Binding of PECAM1 1 26 0.36 18.87 4.22
47 INT4360 Gene_expression of Hypism 1 29 0.22 38.1 4.07
48 INT175555 Gene_expression of CASR 2 17 0.78 14.83 3.73
49 INT154867 Gene_expression of CECR 21 28 0.57 6.97 3.72
50 INT2886 Gene_expression of SCT 3 13 0.78 4.55 3.57
51 INT1727 Gene_expression of Cndp2 3 22 0.74 4.28 3.34
52 INT66599 Gene_expression of MC4R 7 16 0.78 12.37 3.12
53 INT61136 Localization of MC1R 1 8 0.75 2.8 2.85
54 INT60750 Gene_expression of HNF4A 1 12 0.65 8.29 2.68
55 INT27230 Gene_expression of LTBR 1 10 0.75 8.57 2.34
56 INT35359 Negative_regulation of LCT 1 23 0.59 9.13 2.29
57 INT57360 Gene_expression of STAR 1 31 0.66 12.72 2.24
58 INT87323 Binding of ITGB2 2 16 0.47 9.91 2.24
59 INT26177 Regulation of Regulation of INS 3 19 0.44 11.32 2.18
60 INT64709 Gene_expression of VTN 1 11 0.67 11.01 1.97
61 INT117116 Positive_regulation of Positive_regulation of MC1R 1 7 0.49 1.57 1.91
62 INT3866 Positive_regulation of Positive_regulation of INS 2 30 0.59 21.58 1.86
63 INT3343 Regulation of PTH 1 24 0.62 11.18 1.62
64 INT49567 Regulation of DRD1 1 5 0.35 1.02 1.54
65 INT134338 Gene_expression of CD55 4 23 0.65 13.01 1.38
66 INT113567 Localization of PLAU 1 12 0.79 7.16 1.34
67 INT41521 Binding of Cndp2 2 4 0.36 0.74 1.34
68 INT71417 Binding of CES2 3 6 0.47 0.23 1.31
69 INT111473 Gene_expression of CES2 29 15 0.78 1.35 1.29
70 INT88396 Positive_regulation of CES1 4 6 0.49 2.93 1.29
71 INT152255 Gene_expression of ATM 1 14 0.71 12.53 1.26
72 INT34669 Localization of Hypism 1 8 0.25 10.79 1.2
73 INT15419 Gene_expression of IL31RA 1 6 0.65 5.02 1.19
74 INT23199 Binding of LDLR 1 22 0.47 17.08 1.16
75 INT75053 Gene_expression of MC3R 5 4 0.53 0.41 1.16
76 INT87233 Gene_expression of ECE1 6 12 0.65 3.54 1.12
77 INT56808 Positive_regulation of CECR 2 7 0.41 2.07 1.12
78 INT11063 Negative_regulation of CES1 3 16 0.53 6.92 1.11
79 INT233816 Negative_regulation of PTH1R 1 2 0.58 4.08 1.07
80 INT335619 Positive_regulation of MC3R 1 2 0.67 0.42 1.03
81 INT172616 Regulation of HNF4A 2 9 0.06 4.25 1.02
82 INT86800 Positive_regulation of Binding of CALCRL 1 3 0.37 0 1.01
83 INT66492 Negative_regulation of CES2 3 8 0.42 0.73 0.96
84 INT66491 Regulation of CES2 1 2 0.45 1.51 0.86
85 INT33097 Negative_regulation of PHEX 2 3 0.14 0.41 0.82
86 INT11657 Gene_expression of ALPI 1 11 0.71 5.13 0.74
87 INT106127 Negative_regulation of CASR 1 7 0.43 7.12 0.67
88 INT165813 Gene_expression of CES1 20 31 0.76 6.08 0.66
89 INT4878 Regulation of Gene_expression of MME 1 6 0.53 5.38 0.65
90 INT69283 Gene_expression of PHEX 2 25 0.75 7.81 0.64
91 INT167665 Gene_expression of KLRD1 1 14 0.25 8.35 0.58
92 INT32921 Positive_regulation of Msx1 1 4 0.47 0.99 0.57
93 INT28402 Negative_regulation of Negative_regulation of MME 1 3 0.43 1.51 0.57
94 INT125727 Positive_regulation of FGF23 1 5 0.69 4.04 0.53
95 INT87230 Localization of ECE1 1 5 0.80 1.51 0.53
96 INT191383 Gene_expression of GPRC6A 2 5 0.14 0 0.46
97 INT247307 Negative_regulation of Msx1 2 3 0.22 0.11 0.42
98 INT144535 Localization of CES1 6 11 0.73 4.33 0.39
99 INT144617 Gene_expression of RHO 3 13 0.75 1.74 0.38
100 INT159856 Positive_regulation of RHO 1 5 0.67 0.94 0.37
101 INT253844 Localization of FOXP2 2 1 0.10 0.19 0.37
102 INT171995 Binding of PTH1R 1 8 0.35 1.16 0.31
103 INT134342 Binding of CD55 1 7 0.35 1.83 0.28
104 INT106638 Negative_regulation of AVPR2 1 2 0.39 2.05 0.2
105 INT208476 Binding of Pkd1 1 13 0.39 7.23 0.17
106 INT251593 Binding of BET1 4 1 0.03 0.05 0.17
107 INT233805 Gene_expression of lgr 3 1 0.65 0 0.17
108 INT164050 Localization of CECR 1 4 0.64 1.01 0.12
109 INT224195 Localization of GPRC6A 1 1 0.15 0 0.12
110 INT165978 Localization of CD55 2 5 0.60 1.78 0.1
111 INT111475 Transcription of CES2 3 2 0.69 0.08 0.1
112 INT224191 Gene_expression of GIPR 1 1 0.01 0 0.1
113 INT226240 Gene_expression of Mmel1 1 1 0.65 0.28 0.1
114 INT233806 Gene_expression of Slc52a2 2 1 0.65 0.15 0.1
115 INT49260 Negative_regulation of ECE1 2 7 0.57 0.24 0.08
116 INT227384 Gene_expression of CES3 3 1 0.57 0 0.08
117 INT233814 Positive_regulation of Gene_expression of RHO 1 1 0.29 0 0.08
118 INT205973 Binding of SHH 1 3 0.35 1.03 0.07
119 INT233804 Binding of Slc52a2 2 1 0.36 0 0.07
120 INT212476 Binding of FNDC3A 1 1 0.03 0.06 0.07
121 INT233807 Positive_regulation of Gene_expression of Slc52a2 1 1 0.49 0 0.07
122 INT226245 Gene_expression of ECE2 2 1 0.07 0.55 0.06
123 INT233817 Gene_expression of MAS1L 1 2 0.13 15.97 0.05
124 INT261202 Regulation of MC3R 1 2 0.05 0.09 0.05
125 INT335615 Regulation of Regulation of MC3R 1 1 0.05 0.09 0.05
126 INT335618 Positive_regulation of Gene_expression of MC4R 1 1 0.13 0.08 0.05
127 INT233810 Regulation of Gene_expression of LPHN2 1 1 0.19 0.12 0.04
128 INT233820 Binding of LPHN2 1 1 0.20 0.11 0.04
129 INT233809 Regulation of LPHN1 1 1 0.04 0.12 0.04
130 INT233818 Gene_expression of LPHN3 1 1 0.37 0.12 0.04
131 INT233821 Regulation of Gene_expression of LPHN3 1 1 0.21 0.12 0.04
132 INT224192 Negative_regulation of Gene_expression of RHO 1 1 0.12 0.09 0.04
133 INT233813 Gene_expression of LPHN2 1 1 0.32 0.12 0.04
134 INT236072 Binding of DARC 1 8 0.03 6.01 0.03
135 INT221083 Localization of CES2 6 2 0.80 1.48 0.03
136 INT207842 Gene_expression of KL 2 3 0.34 2.88 0
137 INT174235 Positive_regulation of CES2 5 2 0.50 0.63 0
138 INT209455 Gene_expression of RRBP1 2 2 0.65 0.32 0
139 INT207843 Positive_regulation of Gene_expression of KL 1 2 0.26 1.1 0
140 INT185295 Gene_expression of RASL12 3 2 0.13 2.02 0
141 INT226250 Positive_regulation of ECEL1 1 1 0.15 0.28 0
142 INT296630 Gene_expression of ADH1B 1 1 0.64 0 0
143 INT226238 Negative_regulation of Negative_regulation of Kel 1 1 0.41 0 0
144 INT227394 Localization of KDELC1 1 1 0.05 0 0
145 INT227390 Localization of CES5A 1 1 0.56 0 0
146 INT226252 Negative_regulation of Negative_regulation of ECE2 1 1 0.05 0 0
147 INT226241 Negative_regulation of Negative_regulation of Cndp2 1 1 0.41 0 0
148 INT227381 Positive_regulation of Binding of CES2 1 1 0.50 0 0
149 INT226246 Negative_regulation of Negative_regulation of PHEX 1 1 0.10 0 0
150 INT253842 Gene_expression of Zfp386 1 1 0.58 0 0
151 INT226244 Negative_regulation of ECEL1 1 1 0.12 0 0
152 INT233803 Positive_regulation of Slc52a2 1 1 0.49 0 0
153 INT226251 Protein_catabolism of EDN3 1 1 0.02 0 0
154 INT227389 Binding of CES5A 1 1 0.32 0 0
155 INT251585 Gene_expression of Mpv17l 2 1 0.65 0.32 0
156 INT253839 Gene_expression of Trim8 5 1 0.65 0 0
157 INT227385 Gene_expression of CES4A 6 1 0.57 0 0
158 INT226249 Negative_regulation of ECE2 1 1 0.05 0 0
159 INT227386 Positive_regulation of Gene_expression of CES4A 1 1 0.37 0 0
160 INT342883 Gene_expression of Ots1 1 1 0.03 0.35 0
161 INT226237 Negative_regulation of Kel 1 1 0.41 0 0
162 INT226242 Localization of ECE2 1 1 0.08 0 0
163 INT233808 Positive_regulation of Binding of Slc52a2 1 1 0.49 0 0
164 INT251592 Localization of BET1 1 1 0.06 0 0
165 INT335614 Positive_regulation of Regulation of MC1R 1 1 0.23 0 0
166 INT251597 Regulation of Gene_expression of BET1 2 1 0.04 0 0
167 INT253840 Binding of Trim8 1 1 0.36 0 0
168 INT251595 Gene_expression of BET1 3 1 0.06 0 0
169 INT180815 Positive_regulation of Nhp2l1 1 1 0.49 0 0
170 INT227379 Negative_regulation of Gene_expression of CES2 2 1 0.42 0 0
171 INT227380 Transcription of DNASE1L1 1 1 0.05 0 0
172 INT296631 Positive_regulation of ADH1B 2 1 0.48 0 0
173 INT226248 Negative_regulation of Negative_regulation of ECE1 1 1 0.05 0 0
174 INT226239 Positive_regulation of Ecel1 1 1 0.08 0.28 0
175 INT227383 Positive_regulation of CES4A 1 1 0.42 0 0
176 INT227388 Binding of CES3 1 1 0.32 0 0
177 INT333351 Localization of Tes 1 1 0.07 0 0
178 INT335620 Localization of RASL12 1 1 0.13 0.32 0
179 INT226243 Gene_expression of ECEL1 2 1 0.20 0 0
180 INT253843 Gene_expression of ZFP112 1 1 0.41 0 0
181 INT226247 Negative_regulation of Negative_regulation of ECEL1 1 1 0.12 0 0
182 INT227387 Localization of CES4A 3 1 0.63 0 0
183 INT227393 Gene_expression of CES5A 3 1 0.58 0 0
184 INT335616 Positive_regulation of RASL12 2 1 0.08 0.9 0
185 INT251596 Localization of PHLPP1 2 1 0.03 0 0
186 INT227391 Transcription of CES1 1 1 0.52 0 0
187 INT227382 Positive_regulation of CES3 1 1 0.43 0 0
188 INT180816 Negative_regulation of Nhp2l1 2 1 0.42 0 0
189 INT233815 Positive_regulation of Regulation of PTH 1 1 0.11 0.32 0
190 INT253841 Localization of Trim8 1 1 0.68 0 0
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