J:BMC Gastroenterol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT181490 Tryptase Positive_regulation of F2rl1 1 2 0.13 1.83 1.21
2 INT175553 Binding of CASR and CP 1 1 0.11 1.65 1.03
3 INT301079 Binding of GNAT1 and INPP5E 1 1 0.00 0.59 0.89
4 INT186672 IL8 Positive_regulation of Transcription of PTH 1 2 0.01 1.83 0.85
5 INT186674 Binding of BGLAP and CYP27A1 1 4 0.01 1.91 0.71
6 INT170832 Cftr Regulation of Scnn1a 2 1 0.16 1.2 0.67
7 INT181491 Tryptase Positive_regulation of HTR1A 1 1 0.02 0.93 0.61
8 INT170835 Cftr Positive_regulation of Cftr Negative_regulation of Slc10a2 1 1 0.55 0.31 0.56
9 INT170833 Cftr Negative_regulation of Slc10a2 1 1 0.47 0.31 0.56
10 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 2 0.23 1.98 0.51
11 INT341622 Binding of F2 and CTRC 1 1 0.06 1.22 0.46
12 INT341625 Binding of SPINK1 and CTRC 1 1 0.41 1.22 0.46
13 INT341623 Binding of CFTR and CTRC 1 1 0.35 1.22 0.46
14 INT341624 Binding of CFTR and PRSS1 1 1 0.39 1.01 0.45
15 INT185191 Binding of Car9 and Pif 1 2 0.01 2.33 0.45
16 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 1 0.01 0.92 0.42
17 INT324525 PGE Positive_regulation of Positive_regulation of Egfr 1 1 0.41 1.05 0.33
18 INT324522 PGE Positive_regulation of Phosphorylation of Egfr 1 1 0.56 1.04 0.33
19 INT324524 PGE Positive_regulation of Egfr 1 1 0.38 1.05 0.33
20 INT324527 PGE Positive_regulation of Egfr Positive_regulation of Phosphorylation of Egfr 1 1 0.38 1.05 0.33
21 INT175552 Binding of CASR and UPF1 1 1 0.01 0.89 0.33
22 INT190683 Binding of A2M and INS 4 4 0.11 4.97 0.32
23 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 1 0.03 1.35 0.29
24 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 1 0.06 1.36 0.29
25 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 1 0.06 1.36 0.29
26 INT185092 CRP Positive_regulation of ESR1 1 2 0.06 2.83 0.28
27 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 1 0.03 0.3 0.26
28 INT200637 Binding of Abpa and Ace 1 4 0.01 4.62 0.22
29 INT170834 Cftr Regulation of Slc10a2 1 1 0.58 0.37 0.22
30 INT301083 Binding of BCS1L and MYH7 1 1 0.36 1.53 0.19
31 INT199128 Ctsb Positive_regulation of Prss1 1 1 0.02 0.9 0.15
32 INT199129 Ctsb Positive_regulation of PRSS1 1 1 0.01 0.9 0.15
33 INT355867 Binding of Afp and HCC 1 1 0.01 2.25 0.14
34 INT174917 Negative_regulation of PLG Negative_regulation of Positive_regulation of FUT1 1 1 0.01 0.68 0.13
35 INT195896 Egf Positive_regulation of Nos1 1 1 0.10 0.57 0.12
36 INT327188 Gnat3 Regulation of PAEP 1 2 0.25 1.38 0.11
37 INT171645 Negative_regulation of CTSB Positive_regulation of PRSS1 1 1 0.44 0.36 0.1
38 INT171644 CTSB Positive_regulation of PRSS1 1 1 0.52 0.36 0.1
39 INT171648 Binding of CTSB and PRSS1 1 1 0.27 0.42 0.1
40 INT190684 Binding of A2M and IGF1 1 1 0.16 1.54 0.1
41 INT199130 PRSS1 Positive_regulation of Prss1 1 1 0.15 0.8 0.09
42 INT185279 Binding of CCND1 and CDK4 4 1 0.13 2.05 0.08
43 INT185278 Binding of CCND1 and CDK6 3 1 0.13 1.62 0.08
44 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 1 0.04 0.75 0.08
45 INT327189 Gnat3 Regulation of Positive_regulation of PAEP 1 1 0.25 0.72 0.07
46 INT200634 Binding of Agtr2 and Ace2 1 1 0.00 0.91 0.06
47 INT200641 Binding of ACE and Agtr1a 1 1 0.12 0.92 0.06
48 INT200638 Binding of ACE and Agtr2 1 1 0.10 0.93 0.06
49 INT200635 Binding of Ace and Spink1 1 1 0.37 1.4 0.05
50 INT296749 PTGER2 Positive_regulation of PTGER1 1 1 0.25 0 0.05
51 INT199212 Binding of IGFBP1 and INS 1 1 0.05 1.77 0.04
52 INT186502 Binding of AMELX and HLA-A 1 1 0.00 0.71 0
53 INT324016 Binding of Dclk1 and Tff2 1 1 0.34 0.92 0
54 INT299946 Binding of Tlr4 and Synj2bp 1 1 0.00 0.28 0
55 INT185281 Binding of CDK6 and CDKN2A 1 1 0.29 0.87 0
56 INT171646 PRSS1 Positive_regulation of NXF1 1 1 0.34 0.53 0
57 INT185277 CDK6 Negative_regulation of Binding of CDK4 and CDK6 1 1 0.20 0.87 0
58 INT301082 Binding of BCS1L and TARM1 1 2 0.17 1.21 0
59 INT324015 Binding of Dclk1 and Spem1 1 1 0.06 0.92 0
60 INT185280 Binding of CDK4 and CDK6 1 1 0.20 0.87 0
61 INT355864 EXT1 Positive_regulation of Positive_regulation of Afp 1 1 0.05 0.93 0
62 INT185276 CDK4 Negative_regulation of Binding of CDK4 and CDK6 1 1 0.20 0.87 0
63 INT355865 EXT1 Positive_regulation of Cm3 1 1 0.04 0.99 0
64 INT171647 CTSB Positive_regulation of NXF1 1 1 0.23 0.47 0
65 INT175548 Mdk Positive_regulation of Rps6ka1 1 1 0.08 0.71 0
66 INT355866 Binding of EXT1 and Afp 1 3 0.04 3.56 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
3 INT6580 Negative_regulation of Ptgs1 4 929 0.59 381.53 376.26
4 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
5 INT9158 Gene_expression of Tnf 5 722 0.78 522.01 277.68
6 INT10832 Gene_expression of IL8 4 1050 0.78 698.72 270
7 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
8 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
9 INT16868 Gene_expression of Il6 4 807 0.78 499.48 256.57
10 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
11 INT22548 Positive_regulation of Casp3 2 483 0.70 258.78 213.07
12 INT48955 Gene_expression of Nos2 1 753 0.78 403.87 208.08
13 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
14 INT50670 Gene_expression of CPOX 1 763 0.76 442.13 195.02
15 INT24326 Gene_expression of Ngf 1 346 0.78 218.67 184.71
16 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
17 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
18 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
19 INT66280 Gene_expression of Nos2 3 534 0.78 330.78 157.07
20 INT120811 Gene_expression of Gopc 2 1174 0.59 428.49 150.55
21 INT9852 Positive_regulation of Gpt 7 563 0.70 364.64 146.82
22 INT812 Localization of INS 2 1026 0.81 515.6 145.31
23 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
24 INT48895 Gene_expression of Il10 1 333 0.78 221.2 138.52
25 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
26 INT49439 Gene_expression of Cpox 11 508 0.73 326.97 130.17
27 INT65600 Positive_regulation of Casp3 5 376 0.70 198.44 128.03
28 INT65054 Positive_regulation of Nfkb1 2 285 0.70 149.33 126.73
29 INT5008 Localization of Calca 2 204 0.81 80.35 125.16
30 INT7533 Gene_expression of Tlr4 10 720 0.78 343.22 121.57
31 INT14151 Gene_expression of Casp3 2 311 0.78 140.26 120.68
32 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
33 INT17612 Gene_expression of CRP 7 676 0.78 580.61 119.03
34 INT12339 Localization of IL8 20 437 0.81 251.87 117.39
35 INT62124 Gene_expression of NOS1 7 444 0.78 218.08 114.85
36 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
37 INT170025 Gene_expression of Fig4 2 588 0.67 183.27 113.32
38 INT90 Localization of Gast 2 400 0.81 137.67 113
39 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
40 INT49171 Gene_expression of Nos1 3 241 0.78 140.7 104.76
41 INT18009 Positive_regulation of CRP 8 518 0.70 553.03 103.74
42 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
43 INT10838 Positive_regulation of IL8 2 381 0.70 295.51 101.62
44 INT397 Localization of SST 1 232 0.81 58.05 101.19
45 INT1760 Gene_expression of PTGER2 4 524 0.57 226.94 96.4
46 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
47 INT48767 Negative_regulation of NOS1 5 312 0.59 154.25 90.32
48 INT92434 Phosphorylation of Mapk1 1 287 0.82 91.65 83.46
49 INT48406 Gene_expression of Icam1 5 277 0.78 238.28 81.71
50 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
51 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
52 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
53 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
54 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
55 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
56 INT2055 Regulation of Gnrh1 2 185 0.62 23.65 71.26
57 INT10837 Positive_regulation of Gene_expression of IL8 3 294 0.70 190.08 70.34
58 INT171145 Positive_regulation of Fig4 3 274 0.59 93.55 69.81
59 INT4637 Binding of Adarb1 1 132 0.41 14.48 67.76
60 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
61 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
62 INT2056 Negative_regulation of Gnrh1 7 175 0.59 33.43 63.32
63 INT1951 Positive_regulation of Tlr4 4 345 0.70 176.99 62.42
64 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
65 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
66 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
67 INT17564 Gene_expression of Gpt 5 322 0.75 208.51 60.36
68 INT14740 Gene_expression of TGFB1 1 272 0.78 168.48 60.18
69 INT546 Binding of ALB 1 311 0.48 85.98 60.14
70 INT3920 Localization of Ldha 1 241 0.81 83.08 58.72
71 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
72 INT31116 Gene_expression of Casp3 3 192 0.78 78.21 57.43
73 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
74 INT31186 Negative_regulation of Insrr 1 81 0.37 24.91 55.94
75 INT251 Regulation of INS 2 398 0.62 232.47 55.04
76 INT82650 Gene_expression of Bcl2 3 312 0.78 211.71 55.03
77 INT96914 Phosphorylation of Mapk14 2 168 0.82 108.46 53.32
78 INT48952 Negative_regulation of Nos2 2 204 0.59 101.73 53.15
79 INT49017 Negative_regulation of Gene_expression of Nos2 1 169 0.59 80.64 52.67
80 INT72182 Gene_expression of Mcpt1 1 167 0.75 123.7 52.15
81 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
82 INT8490 Negative_regulation of CALCA 1 87 0.59 29.73 51.34
83 INT2197 Gene_expression of Gnrh1 2 184 0.78 40.04 50.57
84 INT53083 Gene_expression of Ptgs2 2 153 0.78 90.04 50.39
85 INT106525 Phosphorylation of Akt1 3 436 0.82 183.81 47.82
86 INT2463 Localization of CCK 1 101 0.81 37.54 47.59
87 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
88 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
89 INT170646 Negative_regulation of Fig4 3 213 0.37 81.29 46.92
90 INT110023 Negative_regulation of Mapk14 2 127 0.59 84.27 45.42
91 INT16364 Gene_expression of HLA-DRA 4 234 0.78 118.81 45.01
92 INT6979 Positive_regulation of CA2 1 206 0.67 50.79 44.97
93 INT49552 Negative_regulation of Positive_regulation of Casp3 2 76 0.55 36.04 44.78
94 INT27493 Negative_regulation of Casp3 1 114 0.56 56.89 44.63
95 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
96 INT613 Gene_expression of Alb 2 268 0.78 149.84 42.78
97 INT157666 Positive_regulation of GOPC 2 335 0.60 120.19 42.75
98 INT50957 Negative_regulation of Il6 1 134 0.59 79.08 42.67
99 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
100 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
101 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
102 INT65245 Gene_expression of Nos3 2 121 0.78 98.14 41.56
103 INT92437 Positive_regulation of Phosphorylation of Mapk1 1 113 0.70 32.19 40.29
104 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
105 INT3252 Negative_regulation of INS 5 428 0.59 271.65 39.52
106 INT173693 Localization of Gopc 1 249 0.65 70.49 38.81
107 INT3758 Gene_expression of ALB 5 326 0.78 184.65 38.75
108 INT20210 Localization of Ngf 1 69 0.79 46.22 38.57
109 INT77307 Gene_expression of Bcl2 8 399 0.77 319.77 38
110 INT48222 Positive_regulation of Localization of IL8 5 123 0.59 78.04 37.2
111 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
112 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
113 INT3253 Negative_regulation of Localization of INS 2 205 0.59 130.39 36.61
114 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
115 INT23330 Binding of Chrna7 2 79 0.48 10.06 35.5
116 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
117 INT1624 Gene_expression of Cea 1 212 0.76 180.44 34.21
118 INT67039 Positive_regulation of Cpox 4 144 0.65 98.4 33.77
119 INT666 Gene_expression of Jun 4 124 0.78 54.61 33.67
120 INT6302 Binding of IFNA1 1 196 0.48 133.85 32.73
121 INT81530 Gene_expression of Nfkb1 1 93 0.78 48.58 32.58
122 INT51685 Gene_expression of LTB4R 2 87 0.58 68.69 31.72
123 INT56809 Binding of Tlr4 3 184 0.48 106.02 31.18
124 INT86780 Positive_regulation of Hmox1 5 145 0.70 117.09 31.18
125 INT19396 Regulation of Rac1 1 66 0.53 37.41 30.01
126 INT9053 Negative_regulation of ALOX5 4 97 0.58 40.34 29.94
127 INT6660 Positive_regulation of Jun 1 148 0.69 67.58 29.73
128 INT2389 Regulation of PTGS1 1 86 0.61 31.23 28.95
129 INT23463 Positive_regulation of Gene_expression of CALCA 1 47 0.70 18.14 28.76
130 INT15610 Localization of GOPC 1 223 0.65 68.26 28.7
131 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
132 INT177581 Regulation of Fig4 2 113 0.41 39.26 27.75
133 INT5135 Negative_regulation of GNRH1 1 106 0.58 36.63 27.71
134 INT1765 Positive_regulation of Gene_expression of PTGER2 2 140 0.51 68.68 27
135 INT90313 Negative_regulation of Gene_expression of Casp3 1 57 0.57 22.23 26.77
136 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
137 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
138 INT52801 Regulation of Gene_expression of Tnf 1 55 0.62 48.74 26.59
139 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
140 INT5650 Gene_expression of Mpo 1 117 0.77 80.27 26.42
141 INT19856 Gene_expression of CD8A 2 240 0.75 147.86 26.39
142 INT1761 Positive_regulation of PTGER2 1 135 0.49 90.17 26.26
143 INT93626 Gene_expression of Fasl 1 118 0.75 115.24 25.11
144 INT17625 Localization of GCG 1 210 0.80 55.69 24.97
145 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
146 INT47459 Gene_expression of Rac1 4 101 0.68 45.27 24.33
147 INT4781 Gene_expression of TH 2 68 0.73 26.92 24.01
148 INT91891 Gene_expression of Kit 4 268 0.78 158.89 22.67
149 INT4369 Gene_expression of Ldha 3 157 0.76 88.12 22.45
150 INT83797 Gene_expression of Bcl2l1 1 124 0.77 94.55 22.39
151 INT69993 Positive_regulation of Gene_expression of Cpox 3 93 0.55 69.4 22.05
152 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
153 INT23257 Regulation of CRP 2 127 0.62 100.05 21.87
154 INT78057 Localization of Tlr4 1 140 0.77 67.75 21.72
155 INT70504 Regulation of Gene_expression of NOS1 2 30 0.51 21.72 21.72
156 INT7535 Negative_regulation of Tlr4 2 111 0.56 56.84 21.37
157 INT52106 Negative_regulation of Localization of IL8 3 57 0.52 22.81 20.8
158 INT96269 Positive_regulation of Mcpt1 2 71 0.61 52.38 20.4
159 INT27018 Gene_expression of PTGER1 7 68 0.75 31.76 20.12
160 INT7253 Negative_regulation of Localization of Gast 2 70 0.59 21.06 20.06
161 INT20129 Regulation of Il1 1 53 0.53 44.14 19.89
162 INT12243 Positive_regulation of PRSS1 22 91 0.70 52.87 19.48
163 INT74286 Regulation of Il10 1 42 0.44 28.06 19.44
164 INT23533 Gene_expression of CA2 1 110 0.75 30.81 19.4
165 INT1278 Negative_regulation of Ldha 1 93 0.59 37.66 19.36
166 INT5398 Positive_regulation of ALPP 1 178 0.70 110.52 19.18
167 INT66755 Transcription of Tnf 1 45 0.72 37.1 19.11
168 INT20260 Positive_regulation of Chkb 1 41 0.64 21.48 18.53
169 INT93734 Positive_regulation of Gene_expression of Bcl2 3 76 0.70 61.95 18.46
170 INT56749 Gene_expression of PCNA 6 219 0.77 111.25 18.42
171 INT1060 Negative_regulation of Pla2g1b 1 50 0.57 22.91 18.12
172 INT667 Negative_regulation of Hrh2 1 38 0.58 18.11 18.01
173 INT111531 Negative_regulation of Phosphorylation of Mapk14 3 37 0.50 20 17.68
174 INT168263 Gene_expression of IL23A 1 57 0.58 47.1 17.67
175 INT35487 Localization of PTGER2 1 103 0.46 51.24 17.45
176 INT86673 Positive_regulation of Bcl2 1 77 0.70 57.74 17.37
177 INT109316 Negative_regulation of Mapk8 3 72 0.59 50.59 17.24
178 INT76406 Gene_expression of Hmox1 9 140 0.78 85.86 17.15
179 INT1721 Negative_regulation of HP 1 148 0.42 86.82 16.89
180 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
181 INT59365 Gene_expression of HTR1A 1 41 0.75 16.31 16.57
182 INT22900 Positive_regulation of Cd4 1 126 0.67 82.77 16.43
183 INT48238 Regulation of Gene_expression of Ngf 1 25 0.62 11.48 16.42
184 INT10721 Gene_expression of BDNF-AS 1 119 0.76 72.8 16.29
185 INT899 Gene_expression of F13A1 1 122 0.70 78.02 16.26
186 INT3400 Positive_regulation of pr 1 57 0.68 36.9 16.24
187 INT1214 Gene_expression of PGE 6 70 0.72 29.07 16.22
188 INT2243 Localization of GAST 1 67 0.81 34.54 16.19
189 INT98647 Positive_regulation of Mdk 8 65 0.59 32.93 15.67
190 INT43906 Regulation of Tlr4 1 71 0.53 35.18 15.49
191 INT75434 Gene_expression of Il13 1 27 0.52 26.19 15.4
192 INT2383 Positive_regulation of CP 3 33 0.67 25.41 15.38
193 INT81627 Gene_expression of Fas 1 120 0.78 115.51 15.36
194 INT36554 Gene_expression of PRSS1 8 70 0.78 50.25 15.33
195 INT615 Regulation of Alb 2 66 0.62 33.43 15.33
196 INT1154 Negative_regulation of CCK 1 24 0.59 9.3 15.32
197 INT16167 Negative_regulation of DMD 1 186 0.57 108.71 15.25
198 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
199 INT34590 Gene_expression of ALPP 2 199 0.75 89.85 15.1
200 INT23212 Positive_regulation of Rac1 1 46 0.55 32.85 15.1
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