J:BMC Med

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT176010 Binding of MTHFR and ZNF677 1 1 0.00 0.7 0.5
2 INT176009 Binding of GRHPR and ZNF677 1 1 0.00 0.57 0.36
3 INT287380 Binding of VEGFA and Kdr 12 1 0.18 11.97 0.34
4 INT319753 Mpo Positive_regulation of Timp1 1 1 0.14 2.13 0.29
5 INT320794 Binding of VEGFA and Flt4 4 2 0.08 3.04 0.27
6 INT352163 SNRPA Positive_regulation of Localization of IL10 1 1 0.06 0.87 0.23
7 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 1 0.01 1.21 0.15
8 INT230761 VEGFA Positive_regulation of Kdr 2 1 0.02 2.16 0.12
9 INT345370 Binding of Vegfa and Insrr 1 2 0.01 2.29 0.08
10 INT345371 Binding of Flt4 and Kdr 1 1 0.10 1.12 0.05
11 INT337386 Lipg Regulation of GK2 1 1 0.00 0.15 0.05
12 INT345375 VEGFA Positive_regulation of Gene_expression of Kdr 1 1 0.02 1.2 0
13 INT345374 VEGFA Positive_regulation of Flt4 1 2 0.01 2.95 0
14 INT337352 Binding of ARNT and HIF1A 1 1 0.14 0.61 0
15 INT345372 Col18a1 Positive_regulation of Kdr 1 1 0.20 1.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
3 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
4 INT68684 Gene_expression of VEGFA 10 2371 0.78 1742.52 259.2
5 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
6 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
7 INT9852 Positive_regulation of Gpt 5 563 0.70 364.64 146.82
8 INT17612 Gene_expression of CRP 4 676 0.78 580.61 119.03
9 INT7395 Localization of GNRH1 1 399 0.81 62.88 117.68
10 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
11 INT18009 Positive_regulation of CRP 5 518 0.70 553.03 103.74
12 INT11587 Gene_expression of CSF2 7 645 0.78 544.38 93.89
13 INT96917 Positive_regulation of Mapk14 1 261 0.70 173.29 88.79
14 INT16654 Gene_expression of Insrr 1 138 0.46 58.96 75.68
15 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
16 INT79494 Positive_regulation of Gene_expression of VEGFA 4 577 0.70 442.94 69.73
17 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
18 INT3375 Gene_expression of IGHE 1 535 0.77 387.47 65.46
19 INT9664 Binding of LBP 21 127 0.48 94.9 63.42
20 INT17564 Gene_expression of Gpt 4 322 0.75 208.51 60.36
21 INT789 Positive_regulation of YY1 3 69 0.67 14.07 47.06
22 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
23 INT80124 Negative_regulation of VEGFA 2 450 0.58 311.19 44.53
24 INT4216 Gene_expression of CD40LG 6 328 0.78 256.02 44.23
25 INT73502 Positive_regulation of IL10 2 154 0.69 124.87 43.5
26 INT4004 Gene_expression of IGHG3 18 321 0.71 221.03 42.33
27 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
28 INT5793 Binding of CTS 1 110 0.48 63.91 40.62
29 INT8905 Gene_expression of EDN1 1 215 0.78 157.1 34.19
30 INT53475 Gene_expression of MRI1 1 116 0.59 77.68 33.98
31 INT3913 Positive_regulation of ABAT 1 47 0.69 22.73 33.4
32 INT19759 Gene_expression of LBP 4 77 0.77 56.44 33.23
33 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
34 INT7975 Regulation of PLOD1 1 97 0.62 20.9 30.51
35 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
36 INT11554 Negative_regulation of CSF2 2 129 0.59 108.55 29.44
37 INT6364 Gene_expression of Edn1 1 123 0.78 73.76 28.43
38 INT59449 Negative_regulation of Timp1 1 76 0.42 54.86 26.99
39 INT78251 Positive_regulation of LBP 3 38 0.69 39.98 26.73
40 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
41 INT19856 Gene_expression of CD8A 2 240 0.75 147.86 26.39
42 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
43 INT2614 Gene_expression of CGA 5 187 0.78 105.89 24.77
44 INT58301 Positive_regulation of Mpo 1 87 0.70 80.19 23.99
45 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
46 INT15390 Positive_regulation of Edn1 1 64 0.70 47.36 23.8
47 INT4465 Gene_expression of CEL 1 116 0.77 98.35 23.58
48 INT8775 Binding of IGHE 1 167 0.48 102.61 23.54
49 INT5055 Positive_regulation of IFNG 2 89 0.69 64.03 23.05
50 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
51 INT1644 Regulation of FSHR 1 77 0.55 15.62 21.49
52 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
53 INT5328 Positive_regulation of CD4 1 191 0.69 133.43 21.31
54 INT4535 Localization of PROC 1 106 0.73 76.24 21.1
55 INT1792 Positive_regulation of CGA 4 123 0.70 64.73 20.79
56 INT50814 Positive_regulation of Mmp2 1 72 0.68 51.37 20.42
57 INT8662 Positive_regulation of EDN1 1 144 0.70 125.34 19.59
58 INT6993 Negative_regulation of Mpo 1 72 0.59 61.83 19.51
59 INT8075 Localization of Crh 1 64 0.81 25.41 19.45
60 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
61 INT56301 Positive_regulation of IL4 1 68 0.56 54.51 18.65
62 INT18010 Positive_regulation of CD40LG 2 122 0.70 100.8 18.46
63 INT70970 Binding of COPD 2 144 0.42 180.34 18.29
64 INT61519 Gene_expression of Mpo 3 112 0.78 89.29 18.22
65 INT25223 Positive_regulation of Gene_expression of IFNG 1 41 0.67 36.97 15.89
66 INT20336 Positive_regulation of CYP2E1 10 48 0.70 19.26 15.66
67 INT170335 Gene_expression of INCENP 1 176 0.54 91.62 15.31
68 INT9904 Gene_expression of CYP2E1 1 64 0.78 13.11 14.65
69 INT11340 Positive_regulation of SLC17A5 2 120 0.67 113.52 14.5
70 INT39507 Positive_regulation of TXNRD1 2 37 0.68 12.47 14.25
71 INT69435 Negative_regulation of ROS1 1 74 0.51 50.38 13.71
72 INT17565 Regulation of Gpt 4 85 0.60 43.64 13.68
73 INT56651 Binding of HLA-DRB1 1 58 0.48 52.25 13.68
74 INT1125 Positive_regulation of IGHG3 5 130 0.69 112.07 13.18
75 INT36263 Positive_regulation of CEL 1 53 0.69 34.88 12.87
76 INT635 Negative_regulation of MAOB 1 51 0.59 24.5 12.66
77 INT70905 Positive_regulation of EDNRA 1 49 0.67 24.33 11.79
78 INT14132 Negative_regulation of HTR1A 1 25 0.57 4.93 10.91
79 INT103923 Negative_regulation of Positive_regulation of Mapk14 1 23 0.53 13.95 10.64
80 INT16449 Binding of IGHG3 3 67 0.48 39.55 10.59
81 INT100379 Positive_regulation of HIF1A 2 69 0.69 57.31 10.4
82 INT85015 Gene_expression of ADM 2 29 0.73 30.75 10.21
83 INT134625 Gene_expression of Kdr 4 116 0.71 53.13 10.09
84 INT35164 Negative_regulation of IGHE 1 96 0.58 76.3 9.74
85 INT6361 Localization of Edn1 1 30 0.81 19.09 9.7
86 INT3988 Positive_regulation of Gene_expression of IGHE 1 98 0.68 91.46 9.61
87 INT144689 Regulation of RCT 1 49 0.53 25.91 9.6
88 INT20371 Gene_expression of Cd8a 2 125 0.60 67.59 8.97
89 INT132938 Phosphorylation of Insrr 1 21 0.03 10.55 8.88
90 INT2241 Negative_regulation of CEL 3 56 0.58 29.32 8.83
91 INT32624 Regulation of LBP 2 15 0.60 11.48 8.71
92 INT86705 Gene_expression of BTG3 2 41 0.65 37.29 8.29
93 INT127378 Localization of Mpo 1 21 0.78 26.36 8.28
94 INT87699 Positive_regulation of WAS 1 16 0.45 5.84 8.03
95 INT6884 Negative_regulation of pr 1 20 0.42 13.18 7.97
96 INT79168 Binding of TNC 1 39 0.47 16.51 7.55
97 INT147793 Localization of COPD 1 70 0.64 89.01 7.3
98 INT33105 Regulation of WAS 1 11 0.60 3.61 7.18
99 INT1124 Negative_regulation of CD40LG 1 53 0.57 36.26 7
100 INT78182 Positive_regulation of ACCS 1 43 0.43 46.39 6.78
101 INT13520 Binding of HLA-DRB4 4 30 0.42 32.65 6.74
102 INT23246 Gene_expression of HLA-DRB4 4 37 0.64 36.79 6.61
103 INT62950 Gene_expression of NPPB 3 73 0.75 65.91 6.54
104 INT138833 Binding of MTHFR 4 12 0.46 16.08 6.4
105 INT8683 Positive_regulation of F3 1 31 0.67 42.89 6.21
106 INT80657 Gene_expression of SLC17A5 3 50 0.75 39.98 5.44
107 INT21747 Localization of crf 1 8 0.47 5.32 5.06
108 INT198136 Positive_regulation of BCL2A1 1 7 0.67 5.72 5.05
109 INT130300 Gene_expression of Abcc3 2 14 0.70 5.34 4.96
110 INT87322 Binding of ITGAL 1 23 0.47 15.73 4.68
111 INT2065 Binding of BTG3 1 15 0.36 10.9 4.65
112 INT102583 Gene_expression of Gdf15 1 26 0.77 15.33 4.52
113 INT59041 Negative_regulation of CYP2E1 1 17 0.59 5.47 4.51
114 INT35765 Gene_expression of TXNRD1 1 47 0.56 9.16 4.43
115 INT114162 Localization of Srms 2 5 0.60 2.22 4.14
116 INT176208 Gene_expression of Nr1h2 2 27 0.59 22.75 3.84
117 INT3127 Gene_expression of SRI 1 38 0.68 26.29 3.82
118 INT62386 Negative_regulation of Gene_expression of IGHG3 2 12 0.20 7.94 3.62
119 INT159472 Localization of NPPB 4 32 0.79 33.67 3.59
120 INT115921 Positive_regulation of AHR 4 22 0.49 12.03 3.53
121 INT240127 Binding of Nppb 1 19 0.37 22.42 3.3
122 INT124606 Positive_regulation of Gene_expression of Mpo 1 14 0.49 12.66 3.24
123 INT200443 Positive_regulation of AES 1 27 0.60 22.46 3.22
124 INT102585 Positive_regulation of Gdf15 2 19 0.69 14.78 3.21
125 INT80656 Regulation of SLC17A5 3 15 0.26 6.89 3.19
126 INT176190 Gene_expression of Abcg8 54 1 0.78 10.4 3.19
127 INT109448 Negative_regulation of MTHFR 2 8 0.58 7.62 3.11
128 INT130603 Binding of Timp1 1 9 0.35 8.52 3.04
129 INT54740 Positive_regulation of Localization of Crh 1 10 0.47 7.27 3.01
130 INT78467 Negative_regulation of IL12A 1 18 0.38 11.29 2.98
131 INT53374 Binding of Edn1 1 17 0.43 11.66 2.98
132 INT53890 Transcription of YY1 2 8 0.67 1.53 2.88
133 INT71794 Binding of SERPINC1 1 17 0.39 10.5 2.64
134 INT56376 Negative_regulation of AMBP 1 29 0.35 21.49 2.59
135 INT178888 Gene_expression of CHDH 2 41 0.65 38.66 2.51
136 INT176205 Gene_expression of Cyp7a1 3 8 0.69 2.5 2.45
137 INT76094 Localization of NOS2 1 8 0.72 2.76 2.34
138 INT134626 Positive_regulation of Gene_expression of Kdr 1 20 0.63 14.63 2.29
139 INT28191 Positive_regulation of Positive_regulation of CYP2E1 2 5 0.49 3.5 2.25
140 INT108263 Negative_regulation of Gene_expression of Mpo 1 12 0.52 12.89 2.22
141 INT219180 Gene_expression of TLR7 1 13 0.68 9.51 2.21
142 INT132903 Gene_expression of Cd34 2 65 0.72 33.95 2.2
143 INT112784 Positive_regulation of Positive_regulation of IFNG 1 11 0.49 7.84 2.18
144 INT176177 Localization of Abcg8 16 1 0.81 3.79 2.14
145 INT62711 Binding of HGF 2 27 0.31 15.23 2.08
146 INT141968 Positive_regulation of ADM 2 12 0.65 11.19 2
147 INT46332 Binding of Mmp2 1 10 0.34 5.63 2
148 INT2982 Positive_regulation of Gene_expression of CGA 2 17 0.59 9.08 1.99
149 INT84264 Regulation of NPPB 1 22 0.61 21.18 1.94
150 INT134628 Gene_expression of Flt4 3 9 0.48 7.52 1.94
151 INT84510 Positive_regulation of Nf1 3 8 0.69 9.52 1.93
152 INT176173 Positive_regulation of Nr1h2 1 19 0.52 10.95 1.88
153 INT203541 Regulation of Binding of LBP 2 1 0.39 1.96 1.79
154 INT162636 Localization of PTX3 1 8 0.78 9.73 1.77
155 INT209366 Negative_regulation of GSX1 2 1 0.42 0.92 1.72
156 INT62712 Negative_regulation of HGF 1 19 0.58 7.21 1.67
157 INT26451 Gene_expression of KLK1 1 14 0.75 5.79 1.66
158 INT22329 Gene_expression of Ptprc 11 36 0.66 15.84 1.59
159 INT204563 Binding of Mpo 1 16 0.37 12.1 1.56
160 INT178889 Negative_regulation of CHDH 2 38 0.48 36.69 1.53
161 INT345367 Negative_regulation of Phosphorylation of Insrr 1 2 0.01 2.9 1.53
162 INT143443 Localization of HIF1A 1 14 0.78 10.93 1.49
163 INT178890 Localization of CHDH 1 12 0.62 15.76 1.49
164 INT55979 Protein_catabolism of PROC 1 8 0.22 2.8 1.49
165 INT21744 Positive_regulation of Localization of crf 1 3 0.12 3.47 1.48
166 INT11710 Positive_regulation of SERPINC1 1 6 0.59 6.15 1.47
167 INT36389 Binding of AHR 3 18 0.45 7.22 1.46
168 INT7812 Negative_regulation of SRI 2 10 0.59 4.28 1.46
169 INT135920 Binding of SRY 1 9 0.45 3.57 1.45
170 INT189392 Gene_expression of MFI2 1 6 0.57 7.69 1.45
171 INT115659 Gene_expression of ABCB6 1 29 0.75 13.59 1.43
172 INT73432 Gene_expression of Nppa 2 32 0.59 21.04 1.39
173 INT199567 Binding of Kdr 1 18 0.47 13.81 1.34
174 INT140647 Gene_expression of DSG1 1 45 0.75 27.95 1.33
175 INT219159 Positive_regulation of TLR7 1 8 0.55 2.37 1.32
176 INT176211 Negative_regulation of Abcg8 24 1 0.59 6.04 1.31
177 INT116903 Negative_regulation of Hmgcr 2 32 0.43 10.71 1.3
178 INT70615 Binding of TXNRD1 4 25 0.36 12.15 1.27
179 INT90771 Positive_regulation of Ptprc 9 20 0.48 8.43 1.27
180 INT254308 Negative_regulation of TNFSF13B 2 10 0.42 5.12 1.25
181 INT131645 Negative_regulation of Nf1 1 10 0.58 8.12 1.24
182 INT55599 Gene_expression of GSX1 1 3 0.65 3.72 1.23
183 INT79927 Localization of GSTK1 1 5 0.40 1.29 1.21
184 INT39711 Negative_regulation of FOXC1 1 4 0.41 4.29 1.2
185 INT81311 Gene_expression of FOXC1 1 9 0.44 3.46 1.18
186 INT37679 Positive_regulation of HLA-DRB4 1 12 0.34 11.93 1.16
187 INT3512 Gene_expression of Igha 1 9 0.60 7.71 1.13
188 INT176183 Gene_expression of Abcg5 22 1 0.77 5.01 1.08
189 INT199308 Gene_expression of Krt8 2 37 0.75 23.17 1.06
190 INT97994 Binding of Hmox2 1 4 0.32 1.98 1.04
191 INT197721 Positive_regulation of ARMC9 2 36 0.35 20.08 1.03
192 INT178483 Gene_expression of Col18a1 4 12 0.75 11.87 1.03
193 INT123536 Positive_regulation of MTHFR 1 7 0.57 4.74 1
194 INT133846 Binding of NPPB 2 14 0.42 11.52 0.98
195 INT147464 Binding of Ptprc 5 13 0.36 15.18 0.98
196 INT43131 Regulation of FOXC1 5 3 0.36 1.09 0.98
197 INT10303 Regulation of STH 3 16 0.60 16.14 0.95
198 INT23105 Gene_expression of MS4A1 1 5 0.75 5.17 0.95
199 INT139515 Positive_regulation of EDNRB 1 15 0.67 10.35 0.93
200 INT156351 Positive_regulation of Flt1 1 22 0.51 20.05 0.91
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