J:BMC Med Genomics

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT222185 Binding of Ccr1 and Ccl3 4 2 0.23 2.7 1.47
2 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 4 0.02 3.96 1.4
3 INT222182 Binding of ESR1 and HLA-DRB2 1 2 0.00 3.1 1.35
4 INT222181 TFAM Positive_regulation of XCR1 1 2 0.00 1.89 0.68
5 INT222211 TFAM Positive_regulation of Ccr1 1 2 0.02 1.89 0.68
6 INT222183 Binding of HDLBP and PLA2G15 1 1 0.01 0.7 0.57
7 INT222180 Binding of HNF1B and TFAM 1 1 0.01 1.48 0.4
8 INT222212 TFAM Negative_regulation of Cd28 1 1 0.02 1.17 0.39
9 INT222214 TFAM Positive_regulation of Cxcr1 1 1 0.03 1.13 0.37
10 INT249090 FOXL1 Regulation of Regulation of ICAM1 1 1 0.12 1.03 0.37
11 INT237745 Binding of Lgals3 and Lgals3bp 1 1 0.24 1.36 0.28
12 INT237750 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3 1 1 0.30 1.36 0.28
13 INT237752 Lgals3bp Positive_regulation of Binding of Lgals3 and Lgals3bp 1 1 0.26 1.36 0.28
14 INT237753 Lgals3 Positive_regulation of Binding of Lgals3 and Lgals3bp 1 1 0.30 1.36 0.28
15 INT300779 STAT3 Positive_regulation of CRP 1 1 0.41 0.62 0.26
16 INT300778 STAT3 Positive_regulation of Transcription of CRP 1 1 0.38 0.62 0.26
17 INT237749 Prkcg Regulation of Transcription of Pcgf1 1 2 0.14 0.68 0.25
18 INT222178 SERPINB1 Regulation of ELANE 1 1 0.00 1.04 0.23
19 INT222184 SERPINB1 Regulation of PRTN3 1 1 0.00 1.04 0.23
20 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 1 0.25 1.01 0.22
21 INT222179 CDC5L Regulation of TFAM 1 1 0.01 0.26 0.13
22 INT237746 Prkcg Regulation of Pcgf1 1 1 0.14 0.34 0.12
23 INT249111 SAI1 Regulation of Cora1 1 1 0.00 0.15 0.08
24 INT338019 Egf Positive_regulation of AR 1 1 0.07 1.02 0.05
25 INT240586 IRF7 Positive_regulation of Positive_regulation of IFNA1 1 1 0.01 0.44 0.03
26 INT338018 Binding of AR and Flna 1 1 0.11 0.33 0
27 INT338013 Binding of Ngfrap1 and Ngfr 1 1 0.06 1.3 0
28 INT338022 Cuedc2 Positive_regulation of Protein_catabolism of AR 1 1 0.23 0.29 0
29 INT338021 Binding of Flna and Regulation of Transcription of AR 1 1 0.14 0.33 0
30 INT338023 Psma7 Positive_regulation of AR 1 1 0.17 0.38 0
31 INT338020 Binding of AR and Ddr1 1 1 0.03 0.45 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
3 INT5235 Negative_regulation of TNF 4 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
5 INT5379 Gene_expression of Fos 1 656 0.78 255.5 292.54
6 INT10832 Gene_expression of IL8 4 1050 0.78 698.72 270
7 INT5972 Gene_expression of IL1B 4 948 0.78 510.91 263.97
8 INT6665 Gene_expression of FOS 6 520 0.77 165.31 217.66
9 INT22548 Positive_regulation of Casp3 2 483 0.70 258.78 213.07
10 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
11 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
12 INT867 Gene_expression of IFNA1 1 930 0.78 594.85 168.03
13 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
14 INT17612 Gene_expression of CRP 5 676 0.78 580.61 119.03
15 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
16 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
17 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
18 INT18009 Positive_regulation of CRP 6 518 0.70 553.03 103.74
19 INT1760 Gene_expression of PTGER2 2 524 0.57 226.94 96.4
20 INT60691 Gene_expression of Il12a 1 331 0.78 208.03 75.96
21 INT39153 Positive_regulation of PTGS2 1 182 0.70 96.16 60.6
22 INT5058 Positive_regulation of IFNA1 2 356 0.70 245.75 60.52
23 INT14740 Gene_expression of TGFB1 4 272 0.78 168.48 60.18
24 INT46637 Gene_expression of CXCL10 3 172 0.78 121.94 57.74
25 INT17458 Negative_regulation of Gene_expression of FOS 2 98 0.57 36.77 55.69
26 INT251 Regulation of INS 1 398 0.62 232.47 55.04
27 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
28 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
29 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
30 INT16364 Gene_expression of HLA-DRA 2 234 0.78 118.81 45.01
31 INT13354 Transcription of TNF 1 108 0.72 85.81 42.32
32 INT82883 Positive_regulation of Ccl2 6 105 0.69 84.96 42.27
33 INT61619 Gene_expression of IL12A 9 194 0.77 146.07 41.97
34 INT52732 Negative_regulation of CRP 3 169 0.59 138.47 40.33
35 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
36 INT63349 Gene_expression of PECAM1 3 199 0.75 166.03 36.76
37 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
38 INT7675 Gene_expression of ENG 1 146 0.77 45.35 34.6
39 INT8905 Gene_expression of EDN1 3 215 0.78 157.1 34.19
40 INT84825 Gene_expression of CD36 1 121 0.78 43.73 33.23
41 INT52350 Gene_expression of CD14 4 184 0.75 71.37 33.13
42 INT99610 Localization of MMP9 1 126 0.79 48.46 32.67
43 INT8097 Gene_expression of EGF 1 122 0.77 75.94 28.47
44 INT5298 Negative_regulation of MTHFS 1 70 0.57 27.07 28.11
45 INT5206 Gene_expression of AR 5 316 0.78 113.83 27.29
46 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
47 INT1761 Positive_regulation of PTGER2 2 135 0.49 90.17 26.26
48 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
49 INT141612 Gene_expression of Ccr1 4 92 0.77 72.09 24.14
50 INT134651 Binding of TLR4 1 89 0.48 66.96 23.19
51 INT94335 Positive_regulation of CXCL10 1 71 0.58 50.69 23
52 INT49196 Gene_expression of SELE 1 105 0.78 107.29 22.92
53 INT14733 Positive_regulation of Gene_expression of TGFB1 2 71 0.69 49.89 22.2
54 INT5905 Negative_regulation of ELANE 2 113 0.59 47.43 22.09
55 INT23257 Regulation of CRP 4 127 0.62 100.05 21.87
56 INT14700 Regulation of IFNA1 1 111 0.45 66.16 21.52
57 INT170313 Gene_expression of Mmp1a 3 50 0.65 38.53 21.36
58 INT85952 Positive_regulation of AR 8 168 0.67 64.36 20.66
59 INT46016 Gene_expression of Ngfr 1 69 0.77 41.22 19.8
60 INT1764 Negative_regulation of Gene_expression of PTGER2 1 81 0.34 34.74 19.45
61 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
62 INT756 Gene_expression of C3 6 138 0.75 100.6 19.2
63 INT16445 Gene_expression of IL1A 1 60 0.78 44.46 19.19
64 INT61626 Transcription of IL6 1 73 0.72 42.04 17.86
65 INT107454 Positive_regulation of Stat3 2 43 0.68 19.63 17.69
66 INT36054 Transcription of IL1B 1 53 0.72 32.64 17.31
67 INT52107 Transcription of IL8 2 63 0.72 41.66 16.06
68 INT68913 Gene_expression of Cd14 2 55 0.76 38.99 15.67
69 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
70 INT106745 Localization of CRP 2 65 0.81 66.44 15.21
71 INT55740 Gene_expression of Timp1 1 53 0.75 28.63 13.85
72 INT27739 Positive_regulation of EGF 1 49 0.70 28.31 13.68
73 INT78472 Gene_expression of CDKN2A 1 223 0.78 173.76 13.61
74 INT20066 Gene_expression of Mdk 3 38 0.76 21.41 13.4
75 INT61624 Positive_regulation of Gene_expression of IL12A 2 50 0.56 33.07 13.07
76 INT4137 Positive_regulation of C3 1 73 0.69 48.57 12.63
77 INT27268 Localization of Gtf3a 1 71 0.21 56.93 12.51
78 INT83201 Gene_expression of NOS3 1 93 0.78 47.16 12.48
79 INT24876 Gene_expression of CD34 4 172 0.78 91.02 12.39
80 INT178338 Gene_expression of Tbx15 1 50 0.65 38.65 12.19
81 INT3057 Gene_expression of Ptgfr 1 60 0.58 14.54 11.73
82 INT69029 Gene_expression of PTPRC 1 127 0.75 74.26 11.57
83 INT1762 Negative_regulation of PTGER2 2 64 0.43 28.21 11.27
84 INT76138 Transcription of Oprk1 1 21 0.72 5.79 11.25
85 INT56448 Regulation of ICAM1 2 52 0.60 55.1 10.96
86 INT23177 Negative_regulation of Gene_expression of HLA-DRA 1 50 0.44 16.99 10.55
87 INT104441 Binding of NOVA2 1 72 0.42 16.41 10.51
88 INT94454 Gene_expression of CD68 2 73 0.72 63.94 10.43
89 INT150540 Binding of TLR2 1 50 0.45 35.86 10.43
90 INT95565 Positive_regulation of IL12A 2 47 0.56 33.96 10.16
91 INT73223 Gene_expression of UPF1 4 78 0.41 31.44 9.94
92 INT115648 Gene_expression of Camk2n1 1 13 0.64 2.61 9.54
93 INT159116 Gene_expression of Gnb2l1 1 12 0.77 2.79 9.49
94 INT48978 Negative_regulation of FOS 2 41 0.57 11.94 9.14
95 INT69264 Gene_expression of KIT 1 207 0.78 179.41 8.95
96 INT35366 Binding of AR 4 87 0.47 30.52 8.9
97 INT97331 Positive_regulation of Timp1 2 20 0.45 13.32 8.57
98 INT174422 Binding of Cxcr3 1 24 0.47 26.09 8.34
99 INT48310 Binding of Ngfr 1 25 0.48 9.72 8.16
100 INT61363 Positive_regulation of TFAM 3 43 0.69 26.43 8.14
101 INT8694 Binding of Lgals3 4 38 0.48 14.82 8.05
102 INT153300 Negative_regulation of Gene_expression of CRP 1 48 0.58 39.97 7.58
103 INT4022 Negative_regulation of PLA2G1B 1 30 0.59 10.41 7.58
104 INT4606 Regulation of Gene_expression of INS 1 67 0.61 54.69 7.53
105 INT92138 Binding of CDKN2A 1 28 0.37 25.64 7.47
106 INT26462 Gene_expression of DNAH8 1 44 0.78 19.36 7.31
107 INT35486 Regulation of PTGER2 4 39 0.36 19.03 6.75
108 INT24907 Gene_expression of PAPPA 1 42 0.75 28.32 6.63
109 INT103847 Positive_regulation of Ccr5 1 11 0.55 6.04 5.79
110 INT32458 Gene_expression of VWF 2 57 0.78 28.97 5.56
111 INT15284 Positive_regulation of Lgals3 1 21 0.47 8.88 5.52
112 INT97145 Positive_regulation of TBK1 1 14 0.12 15.32 5.43
113 INT70193 Gene_expression of Slc6a12 2 10 0.78 3.73 5.39
114 INT181022 Binding of Ccr1 2 15 0.37 10.69 5.37
115 INT76313 Gene_expression of CD38 2 30 0.64 20.74 5.27
116 INT3165 Gene_expression of LYZ 3 25 0.65 16.72 5.16
117 INT92234 Regulation of CXCL10 2 15 0.42 8.37 5.09
118 INT99091 Regulation of AR 3 70 0.45 31.68 5.05
119 INT22825 Regulation of Gtf3a 2 36 0.25 19.93 5.03
120 INT62822 Positive_regulation of Gene_expression of SELE 1 22 0.66 28.04 4.97
121 INT85415 Positive_regulation of IL9 1 10 0.28 6.93 4.71
122 INT35254 Negative_regulation of SERPINB1 1 22 0.48 11.42 4.7
123 INT153269 Binding of Ccl3 2 10 0.48 8.87 4.69
124 INT87632 Positive_regulation of Gene_expression of PECAM1 1 32 0.45 29.47 4.66
125 INT107605 Gene_expression of MMP14 2 26 0.64 25.88 4.49
126 INT67144 Gene_expression of Cd44 1 17 0.76 8.94 4.48
127 INT103155 Gene_expression of KDR 3 78 0.66 50.53 4.38
128 INT24278 Gene_expression of FUT4 1 33 0.75 26.7 4.29
129 INT57642 Gene_expression of PCSK1 1 26 0.76 5.09 4.28
130 INT171252 Gene_expression of BMI1 1 21 0.70 26.98 4.11
131 INT99608 Transcription of MMP9 1 18 0.65 9.67 4.11
132 INT115853 Transcription of Trpm8 1 15 0.68 7.72 4.1
133 INT55741 Negative_regulation of Timp1 1 15 0.51 8.12 4.09
134 INT104221 Regulation of Gene_expression of CRP 2 30 0.45 20.01 4.07
135 INT97128 Localization of SPP1 2 32 0.80 21.75 4.02
136 INT158573 Negative_regulation of Jak3 1 3 0.43 8.2 3.99
137 INT97139 Gene_expression of CD83 4 43 0.70 22.05 3.91
138 INT153666 Gene_expression of CAV1 3 156 0.77 120.99 3.9
139 INT15133 Regulation of HLA-DRA 2 19 0.34 5.84 3.9
140 INT52227 Gene_expression of CD9 3 11 0.75 6.23 3.71
141 INT5204 Positive_regulation of Gene_expression of AR 1 60 0.67 23.54 3.53
142 INT141148 Gene_expression of BMP7 4 24 0.71 14.34 3.44
143 INT139366 Gene_expression of PROM1 1 98 0.77 67.84 3.39
144 INT17511 Negative_regulation of PRTN3 1 19 0.41 12 3.3
145 INT25122 Binding of PTGER2 1 31 0.31 13.83 3.12
146 INT109411 Gene_expression of SAT1 31 61 0.77 67.99 3.08
147 INT97393 Localization of Stat3 2 11 0.75 7.33 3.01
148 INT92335 Gene_expression of TBK1 1 11 0.28 8.98 3
149 INT134798 Gene_expression of ANXA1 2 15 0.75 13.94 2.99
150 INT64437 Gene_expression of IL1R1 1 9 0.65 6.22 2.99
151 INT181848 Negative_regulation of CD14 1 16 0.43 8.14 2.95
152 INT130705 Gene_expression of TFAM 2 50 0.77 38.85 2.79
153 INT95105 Gene_expression of TGFBR2 5 15 0.64 16.36 2.74
154 INT204124 Transcription of CRP 1 14 0.69 20.79 2.71
155 INT15543 Gene_expression of CASP8 2 32 0.75 25.6 2.61
156 INT144822 Negative_regulation of Gene_expression of CD14 1 18 0.56 4.48 2.5
157 INT185927 Positive_regulation of Positive_regulation of AR 1 12 0.34 6.35 2.5
158 INT92141 Negative_regulation of CDKN2A 1 53 0.57 44.23 2.48
159 INT2731 Negative_regulation of LTBR 2 7 0.58 5.35 2.44
160 INT68781 Negative_regulation of TFAM 1 15 0.58 10.01 2.42
161 INT127549 Gene_expression of Marcksl1 1 6 0.70 1.95 2.42
162 INT109655 Binding of TFAM 4 11 0.08 7.9 2.41
163 INT27230 Gene_expression of LTBR 1 10 0.75 8.57 2.34
164 INT22605 Regulation of Pgr 1 22 0.62 7.1 2.26
165 INT43612 Regulation of SERPINB1 2 12 0.11 3.26 2.21
166 INT151878 Gene_expression of CAV2 1 18 0.66 9.26 2.17
167 INT79816 Localization of Pla2g2a 1 13 0.74 8.08 2.06
168 INT172554 Positive_regulation of Gene_expression of Mmp1a 1 7 0.16 4.48 2.05
169 INT173851 Localization of FN1 1 20 0.76 13.95 1.97
170 INT28830 Localization of Klkb1 1 9 0.61 0.6 1.96
171 INT173116 Regulation of VCAM1 1 14 0.33 11.85 1.92
172 INT148702 Positive_regulation of UPF1 1 29 0.31 12.9 1.91
173 INT209890 Positive_regulation of Gene_expression of CD83 1 11 0.62 9.04 1.88
174 INT153719 Gene_expression of TEK 2 10 0.49 9.82 1.88
175 INT107607 Negative_regulation of MMP14 1 10 0.37 6.05 1.83
176 INT222997 Positive_regulation of Localization of FN1 1 4 0.14 4.26 1.78
177 INT108790 Gene_expression of RGS1 7 2 0.58 4.36 1.76
178 INT97333 Regulation of Gene_expression of Timp1 1 6 0.54 4.8 1.71
179 INT84722 Regulation of Gene_expression of AR 1 20 0.61 7.73 1.69
180 INT206586 Gene_expression of Artmd1 1 15 0.30 6.64 1.67
181 INT105248 Negative_regulation of Vegfa 1 8 0.47 6.19 1.61
182 INT20982 Positive_regulation of SERPINB1 1 7 0.28 7.27 1.61
183 INT98476 Gene_expression of Ddr1 1 3 0.58 1.28 1.6
184 INT99720 Positive_regulation of SAT1 8 21 0.69 26.55 1.56
185 INT39969 Localization of Kcne2 1 4 0.61 1.11 1.56
186 INT311253 Localization of Acpp 1 3 0.30 2.8 1.53
187 INT117033 Gene_expression of JAG1 2 13 0.65 11.46 1.52
188 INT68094 Negative_regulation of SERPINB3 1 12 0.43 10.55 1.49
189 INT173716 Positive_regulation of Cd44 3 7 0.44 4.65 1.45
190 INT95566 Positive_regulation of Positive_regulation of IL12A 2 10 0.41 7.47 1.43
191 INT213442 Gene_expression of CXCL3 2 8 0.57 6.3 1.41
192 INT159175 Gene_expression of HBD 7 11 0.54 15.66 1.37
193 INT82932 Transcription of AR 2 14 0.67 5.75 1.34
194 INT97394 Regulation of Stat3 1 6 0.41 2.52 1.34
195 INT140647 Gene_expression of DSG1 1 45 0.75 27.95 1.33
196 INT69723 Gene_expression of SERPINB2 3 7 0.60 4.54 1.28
197 INT39144 Gene_expression of RIPK2 3 5 0.75 2.56 1.27
198 INT37253 Negative_regulation of PTPRC 1 12 0.37 6.13 1.26
199 INT155992 Gene_expression of THBD 1 16 0.66 17 1.24
200 INT165994 Gene_expression of NANS 1 12 0.65 3.47 1.22
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