J:BMC Nephrol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT173059 Binding of KDR and VEGFA 43 1 0.43 29.63 1.1
2 INT241853 Binding of SLC40A1 and HAMP 3 3 0.41 5.35 0.43
3 INT184543 Agt Positive_regulation of Ccl2 1 2 0.16 3.18 0.43
4 INT193492 Binding of Icam1 and Sele 1 1 0.06 1.05 0.34
5 INT184540 Agt Regulation of Gene_expression of Ccl2 1 1 0.08 1.66 0.18
6 INT177714 Binding of GALNT3 and REN 1 1 0.01 2.36 0.12
7 INT184537 Ccl2 Positive_regulation of Spp1 1 1 0.34 1.37 0.09
8 INT184542 Positive_regulation of Ccl2 Positive_regulation of Gpbar1 1 1 0.10 1.39 0.09
9 INT184538 Positive_regulation of Ccl2 Positive_regulation of Spp1 1 1 0.34 1.38 0.09
10 INT184541 Ccl2 Positive_regulation of Gpbar1 1 1 0.10 1.37 0.09
11 INT184539 Spp1 Positive_regulation of Gpbar1 1 1 0.03 1.37 0.09
12 INT341043 Avp Regulation of Camp 1 1 0.10 0.47 0.03
13 INT214902 Binding of Pcna and Trib3 1 1 0.00 1.51 0
14 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 1 0.17 0.31 0
15 INT214918 Gtf3a Positive_regulation of CDKN1A 1 1 0.01 0.66 0
16 INT214890 GOPC Positive_regulation of CDKN1A 1 1 0.06 0.57 0
17 INT214891 HGF Positive_regulation of CDKN1A 1 3 0.25 1.15 0
18 INT214919 Pkd1 Positive_regulation of CDKN1A 1 3 0.51 2.6 0
19 INT177566 Binding of Gtayu6 and Syf2 1 2 0.00 0.13 0
20 INT214917 Pkd1 Positive_regulation of Negative_regulation of CDKN1A 1 1 0.37 1.46 0
21 INT183750 Binding of EPO and TF 1 1 0.42 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
3 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
4 INT477 Localization of Avp 5 813 0.81 131.58 300.4
5 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
6 INT68684 Gene_expression of VEGFA 4 2371 0.78 1742.52 259.2
7 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
8 INT6482 Positive_regulation of Gene_expression of TNF 3 659 0.70 569.88 210
9 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
10 INT2451 Positive_regulation of Avp 3 355 0.70 102.66 147.69
11 INT1273 Gene_expression of Avp 5 356 0.78 90.56 138.7
12 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 7 1138 0.72 311.58 119.18
13 INT4207 Regulation of Avp 3 267 0.62 63.72 115.33
14 INT170025 Gene_expression of Fig4 5 588 0.67 183.27 113.32
15 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
16 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
17 INT18009 Positive_regulation of CRP 4 518 0.70 553.03 103.74
18 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
19 INT82878 Gene_expression of Ccl2 10 201 0.78 164.95 101.35
20 INT5940 Negative_regulation of Avp 3 236 0.59 67.86 101.2
21 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
22 INT214 Localization of AVP 2 370 0.81 208.51 91.09
23 INT7180 Negative_regulation of Trib3 3 180 0.51 68.48 88.01
24 INT48406 Gene_expression of Icam1 3 277 0.78 238.28 81.71
25 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
26 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
27 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
28 INT171145 Positive_regulation of Fig4 1 274 0.59 93.55 69.81
29 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
30 INT46 Localization of Ren 1 233 0.81 46.15 62.44
31 INT55344 Gene_expression of Ros1 4 396 0.54 217.64 59.98
32 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
33 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
34 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
35 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
36 INT83199 Gene_expression of Nos3 16 193 0.78 100.72 51.57
37 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
38 INT17915 Gene_expression of Insr 1 141 0.75 47.45 48.59
39 INT654 Localization of REN 5 250 0.81 75.12 47.86
40 INT375 Positive_regulation of REN 1 293 0.70 152.46 47.55
41 INT20345 Gene_expression of Dbi 1 136 0.78 56.41 46.2
42 INT935 Localization of Gtf3a 2 124 0.70 35.72 43.3
43 INT49105 Gene_expression of Vcam1 3 157 0.78 157.27 43.01
44 INT613 Gene_expression of Alb 3 268 0.78 149.84 42.78
45 INT82883 Positive_regulation of Ccl2 13 105 0.69 84.96 42.27
46 INT3758 Gene_expression of ALB 3 326 0.78 184.65 38.75
47 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
48 INT234 Binding of Alb 1 151 0.48 52.34 32.97
49 INT65698 Localization of CCL2 1 118 0.81 77.54 32.69
50 INT84170 Positive_regulation of Gene_expression of Ccl2 3 58 0.69 48.79 32.43
51 INT48693 Regulation of VEGFA 2 268 0.62 191.88 31.52
52 INT99688 Negative_regulation of Gene_expression of VEGFA 3 274 0.58 201.8 31.1
53 INT724 Negative_regulation of Alb 1 151 0.59 93.57 29.65
54 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
55 INT82882 Localization of Ccl2 3 61 0.80 41.96 28
56 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
57 INT100861 Binding of CRP 5 179 0.48 175.2 26.45
58 INT68758 Positive_regulation of Ros1 2 125 0.46 82.72 25.27
59 INT7678 Localization of Alb 6 142 0.81 80.93 22.49
60 INT127435 Gene_expression of Per1 1 89 0.77 13.94 22.31
61 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
62 INT72060 Positive_regulation of Gene_expression of Ros1 1 127 0.41 76.76 20.91
63 INT12951 Negative_regulation of Cat 2 126 0.57 64.39 20.61
64 INT89396 Phosphorylation of AKT1 2 225 0.82 111.66 19.61
65 INT756 Gene_expression of C3 2 138 0.75 100.6 19.2
66 INT89594 Gene_expression of Ccl5 5 44 0.54 24.08 18.62
67 INT28215 Gene_expression of CDKN1A 20 196 0.76 113.9 18.3
68 INT83198 Positive_regulation of Nos3 3 78 0.64 35.69 17.71
69 INT2120 Gene_expression of CD79A 2 159 0.78 111.69 17.16
70 INT61513 Positive_regulation of Gpx1 1 71 0.64 37.91 17.07
71 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 1 95 0.43 24.83 15.69
72 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
73 INT615 Regulation of Alb 1 66 0.62 33.43 15.33
74 INT75502 Positive_regulation of CDKN1A 15 123 0.68 70.75 14.74
75 INT2843 Gene_expression of Epo 4 100 0.78 62.01 14.66
76 INT18012 Gene_expression of EPO 21 169 0.78 108.36 13.75
77 INT655 Positive_regulation of Localization of REN 5 86 0.70 32.41 13.56
78 INT91703 Negative_regulation of Myoz1 1 78 0.58 53.78 13.5
79 INT83200 Positive_regulation of Gene_expression of Nos3 5 48 0.70 24.75 12.99
80 INT174844 Binding of Fig4 1 81 0.41 18.03 12.87
81 INT61946 Positive_regulation of HGF 1 57 0.69 38.93 11.99
82 INT41313 Gene_expression of Gpx1 2 68 0.78 34.24 11.77
83 INT481 Regulation of Localization of Ren 1 37 0.62 5.95 11.61
84 INT661 Gene_expression of REN 1 100 0.78 48.21 11.36
85 INT95271 Negative_regulation of Nos3 3 46 0.53 24.1 9.71
86 INT57162 Positive_regulation of Gene_expression of CDKN1A 1 64 0.68 35.3 9.69
87 INT70134 Negative_regulation of TXK 2 124 0.23 81.96 9.59
88 INT56985 Gene_expression of MEFV 3 56 0.71 46.71 9.47
89 INT48978 Negative_regulation of FOS 1 41 0.57 11.94 9.14
90 INT55342 Negative_regulation of Gene_expression of Ros1 2 49 0.37 31.62 8.93
91 INT55597 Negative_regulation of Gpx1 1 59 0.55 28.3 8.83
92 INT86705 Gene_expression of BTG3 1 41 0.65 37.29 8.29
93 INT30638 Positive_regulation of Gene_expression of Dbi 1 17 0.69 4.63 8.28
94 INT725 Negative_regulation of IgG 1 62 0.41 37.21 8.16
95 INT62944 Regulation of Icam1 1 33 0.47 23.52 7.94
96 INT48404 Regulation of Gene_expression of Icam1 1 21 0.62 15.1 7.81
97 INT81399 Regulation of Vcam1 1 24 0.46 23.53 7.68
98 INT82881 Regulation of Ccl2 2 19 0.57 15.29 7.19
99 INT93664 Gene_expression of TIMP2 1 33 0.67 36.67 7.14
100 INT83531 Gene_expression of KITLG 2 54 0.65 26 7.07
101 INT60196 Binding of FOS 1 33 0.47 13.11 6.95
102 INT15872 Positive_regulation of EPO 10 74 0.70 45.35 6.67
103 INT7205 Positive_regulation of HBG1 2 65 0.69 40.35 6.37
104 INT934 Regulation of Gtf3a 2 25 0.35 11.35 6.34
105 INT6512 Gene_expression of PTH 1 103 0.77 76.29 6.33
106 INT17913 Regulation of HSD11B1 1 87 0.60 93.23 6.04
107 INT91159 Negative_regulation of Ros1 1 35 0.44 26.12 5.97
108 INT104330 Negative_regulation of CDKN1A 23 57 0.58 39.93 5.88
109 INT71727 Negative_regulation of Icam1 1 25 0.45 17.76 5.73
110 INT83290 Regulation of Gene_expression of Ccl2 1 8 0.59 9.06 5.56
111 INT160055 Localization of CDKN1A 3 15 0.78 12.56 4.83
112 INT94433 Negative_regulation of TIMP2 1 16 0.55 9.38 4.78
113 INT69215 Gene_expression of Col1a1 1 38 0.68 17.39 4.77
114 INT24889 Negative_regulation of CABIN1 2 36 0.48 16.76 4.73
115 INT8773 Gene_expression of HBG1 1 58 0.76 37.6 4.59
116 INT4679 Negative_regulation of RAPGEF5 2 55 0.57 47.51 4.55
117 INT14026 Positive_regulation of Igh-6 1 24 0.68 10.84 4.32
118 INT7083 Positive_regulation of HBM 5 35 0.66 20.96 4.3
119 INT56404 Gene_expression of EDA 1 16 0.75 7.09 4.24
120 INT109450 Positive_regulation of Phosphorylation of AKT1 1 62 0.64 25.18 4.21
121 INT10542 Gene_expression of DLL1 1 16 0.71 3.7 4.21
122 INT19847 Positive_regulation of Localization of Alb 2 21 0.70 13.89 4.16
123 INT75688 Binding of KITLG 1 24 0.30 11.73 4.06
124 INT41942 Gene_expression of A2m 9 9 0.36 9.98 3.96
125 INT181922 Binding of RENBP 2 16 0.36 13.92 3.71
126 INT89592 Localization of Ccl5 1 10 0.61 7.65 3.62
127 INT117518 Transcription of Ccl2 3 12 0.68 11.12 3.61
128 INT45818 Gene_expression of C4A 1 35 0.75 26.4 3.52
129 INT53584 Regulation of Gpx1 1 19 0.62 14.38 3.48
130 INT150395 Binding of MEFV 5 55 0.44 31.18 3.42
131 INT82796 Regulation of CDKN1A 1 22 0.53 9.83 3.33
132 INT82879 Regulation of Ccl5 2 9 0.30 6.19 3.17
133 INT28094 Binding of PTH 2 29 0.37 13.57 3.09
134 INT88130 Gene_expression of Spp1 5 13 0.74 12.96 3.07
135 INT90289 Positive_regulation of Gene_expression of Gpx1 1 10 0.17 8.07 3.05
136 INT43907 Binding of CD79A 1 28 0.48 28.11 3.04
137 INT45503 Binding of EPO 1 42 0.48 24.85 2.88
138 INT41721 Negative_regulation of MTOR 2 40 0.58 32.49 2.83
139 INT8112 Regulation of EPO 9 38 0.58 22.04 2.76
140 INT90675 Negative_regulation of Gene_expression of Nos3 1 15 0.46 11.11 2.7
141 INT81411 Negative_regulation of Sele 1 8 0.38 7 2.7
142 INT74216 Binding of Icam1 1 16 0.48 10.11 2.69
143 INT177551 Negative_regulation of Tg(CAG-EGFP)D4Nagy 4 31 0.37 11.16 2.65
144 INT8111 Localization of EPO 2 32 0.81 19.53 2.54
145 INT84599 Gene_expression of Aqp2 8 31 0.77 22.58 2.54
146 INT117519 Positive_regulation of Transcription of Ccl2 1 5 0.49 6.01 2.54
147 INT132315 Positive_regulation of DLL1 1 6 0.67 3.4 2.45
148 INT99524 Gene_expression of IFIH1 1 34 0.64 23.38 2.24
149 INT72865 Localization of Icam1 1 12 0.68 8.18 2.24
150 INT2544 Localization of PTH 1 39 0.81 30.55 2.22
151 INT23667 Gene_expression of Hgfac 1 10 0.03 6.74 2.19
152 INT27989 Positive_regulation of Gene_expression of REN 1 18 0.55 12.69 2.11
153 INT146793 Positive_regulation of Tp53 1 30 0.70 32.93 1.94
154 INT174653 Localization of MEFV 2 15 0.70 12.06 1.93
155 INT16205 Localization of ras 1 25 0.73 18.99 1.85
156 INT148326 Gene_expression of Pkd1 2 7 0.76 5.38 1.85
157 INT15742 Negative_regulation of EPO 6 37 0.59 17.44 1.84
158 INT183753 Regulation of HBM 1 24 0.39 13.13 1.79
159 INT84595 Negative_regulation of Aqp2 5 11 0.58 4.88 1.78
160 INT109294 Negative_regulation of PRKD1 1 3 0.06 2.05 1.74
161 INT104331 Negative_regulation of Gene_expression of CDKN1A 6 24 0.57 13.68 1.63
162 INT98687 Gene_expression of Calr 1 38 0.61 7.03 1.59
163 INT88136 Positive_regulation of Gene_expression of Spp1 1 8 0.66 4.5 1.57
164 INT114862 Gene_expression of BEST1 1 16 0.65 12.14 1.53
165 INT37485 Regulation of RAPGEF5 1 10 0.44 6.64 1.51
166 INT933 Regulation of Localization of Gtf3a 1 6 0.11 2.3 1.47
167 INT27762 Positive_regulation of Gene_expression of EPO 3 18 0.70 17.67 1.45
168 INT183755 Localization of GYPC 1 4 0.56 3.91 1.42
169 INT47734 Positive_regulation of RAPGEF5 1 19 0.56 13.16 1.41
170 INT179644 Gene_expression of RENBP 5 26 0.35 13.74 1.38
171 INT88133 Positive_regulation of Spp1 5 8 0.66 10.07 1.33
172 INT41944 Positive_regulation of Gene_expression of A2m 2 2 0.23 2.56 1.29
173 INT148321 Positive_regulation of Gene_expression of Pkd1 1 5 0.68 2.93 1.21
174 INT45666 Positive_regulation of IFNB1 1 4 0.50 3.12 1.2
175 INT135556 Localization of AKT1 1 38 0.69 12.78 1.17
176 INT79557 Localization of Aqp2 5 5 0.73 2 1.13
177 INT188774 Binding of RAPGEF5 2 12 0.29 13.55 1.04
178 INT184547 Localization of Spp1 1 4 0.58 4.44 1.02
179 INT112717 Negative_regulation of Binding of VEGFA 1 21 0.56 11.07 0.99
180 INT187026 Positive_regulation of Gene_expression of TIMP2 1 3 0.47 2.05 0.96
181 INT153329 Gene_expression of Cm9 2 6 0.67 4.35 0.95
182 INT115471 Binding of Sele 1 5 0.36 4.06 0.94
183 INT4681 Localization of RAPGEF5 1 12 0.68 8.69 0.93
184 INT55052 Binding of Cat 1 10 0.36 5.46 0.92
185 INT84598 Regulation of Aqp2 6 13 0.45 4.28 0.86
186 INT108348 Positive_regulation of Aqp2 2 10 0.68 4.94 0.82
187 INT173100 Binding of KDR 2 39 0.39 22.48 0.81
188 INT146521 Negative_regulation of Positive_regulation of CDKN1A 1 6 0.42 3.29 0.79
189 INT177716 Gene_expression of GALNT3 3 7 0.53 6.91 0.75
190 INT129174 Gene_expression of PKD1 1 24 0.67 14.91 0.74
191 INT149238 Positive_regulation of Gene_expression of Aqp2 1 5 0.66 3.07 0.73
192 INT153297 Regulation of MEFV 2 6 0.40 11.09 0.71
193 INT193486 Negative_regulation of Negative_regulation of Nos3 1 3 0.34 2.21 0.68
194 INT41106 Gene_expression of Camp 3 2 0.75 0.24 0.64
195 INT177557 Positive_regulation of Calr 1 12 0.48 5.47 0.61
196 INT188775 Binding of IFIH1 4 11 0.16 12.4 0.61
197 INT187050 Localization of RENBP 2 8 0.35 6.92 0.61
198 INT65701 Localization of KITLG 1 13 0.65 2.46 0.58
199 INT103638 Negative_regulation of MEFV 1 7 0.39 5.88 0.54
200 INT62266 Phosphorylation of Rb1 2 4 0.71 2.68 0.54
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