J:BMC Neurol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT103548 Binding of TRPV1 and TRPV3 3 1 0.37 1.82 2.28
2 INT212301 NGF Regulation of Gene_expression of TRPV1 1 2 0.23 2.37 2.13
3 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 1 0.04 1.21 1.38
4 INT190130 Binding of CPOX and MRXS5 1 2 0.00 1.4 1.23
5 INT219154 Binding of HMGB1 and TLR4 2 2 0.17 4.45 0.93
6 INT209250 TRPV1 Positive_regulation of Localization of DRGX 1 1 0.06 0.82 0.68
7 INT206206 Binding of Mcf2l and Obfc1 1 2 0.02 1.11 0.64
8 INT189197 RASGRP1 Positive_regulation of JUN 1 2 0.07 1.26 0.43
9 INT345006 CSF2 Regulation of GSN 1 1 0.16 0.82 0.39
10 INT345007 CSF2 Regulation of DBP 1 1 0.14 0.82 0.39
11 INT345012 GSN Regulation of CCBE1 1 1 0.00 0.82 0.36
12 INT345010 GSN Regulation of DBP 1 1 0.26 0.81 0.36
13 INT345009 DBP Regulation of CCBE1 1 1 0.00 0.81 0.36
14 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 1 0.02 0.71 0.34
15 INT344238 MCRS1 Regulation of TREX1 1 1 0.08 1.02 0.34
16 INT130128 Binding of Ocln and Tjp1 2 8 0.38 0.98 0.29
17 INT174311 Binding of Krit1 and Rap1a 1 2 0.04 1.08 0.28
18 INT189200 Binding of CA2 and ITPR3 3 1 0.03 1.9 0.27
19 INT180246 Binding of Tbca and Uchl1 1 1 0.00 0.47 0.27
20 INT180245 Binding of Plp1 and Uchl1 1 1 0.03 0.47 0.27
21 INT345008 Binding of ACTN1 and CSF2 1 1 0.02 0.53 0.26
22 INT189199 JUN Positive_regulation of KRT16 1 1 0.31 0.58 0.22
23 INT180247 Binding of Gad1 and Tbca 1 1 0.02 0.22 0.22
24 INT180248 Binding of Gad1 and Plp1 1 1 0.08 0.22 0.21
25 INT336946 Binding of ITGA4 and VCAM1 1 1 0.03 2.02 0.21
26 INT189196 RASGRP1 Positive_regulation of SP1 1 1 0.05 0.63 0.21
27 INT355226 VEGFA Positive_regulation of Akt1 1 1 0.04 0.27 0.14
28 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 1 0.03 0.75 0.14
29 INT345011 Binding of GSN and PTAFR 1 1 0.09 0.83 0.12
30 INT209400 Binding of F13A1 and FGG 1 2 0.01 1.72 0.09
31 INT189195 Binding of C4A and C4B 1 2 0.14 2.45 0.09
32 INT174104 Binding of HSPG2 and Ache 1 2 0.16 0.98 0.09
33 INT171616 Sh2d1b2 Negative_regulation of Pitm1 1 1 0.01 0.47 0.08
34 INT221878 Binding of Ltp and Ctrcts 1 4 0.00 1.94 0.07
35 INT193564 Binding of STMN1 and MRI1 1 1 0.07 0.06 0.07
36 INT189202 Binding of C4B and HAS2 1 1 0.02 1.25 0.05
37 INT355224 Phosphorylation of Ocln Negative_regulation of Binding of Tjp2 1 1 0.06 0.09 0.04
38 INT355219 Phosphorylation of Ocln Positive_regulation of Binding of Tjp2 1 1 0.07 0.09 0.04
39 INT189198 Binding of C4A and SERPINF1 1 1 0.12 1.17 0.04
40 INT355220 Negative_regulation of Binding of Ocln and Tjp1 1 3 0.21 0.14 0
41 INT180294 Positive_regulation of Binding of CPB1 and S100B 1 1 0.09 0 0
42 INT189203 CHGB Regulation of CA2 1 1 0.04 0.95 0
43 INT189201 CHGB Regulation of Localization of CA2 1 1 0.04 0.95 0
44 INT180295 Binding of CPB1 and S100B 1 2 0.08 0 0
45 INT180302 Positive_regulation of Binding of S100B and Tg(EGFR)0Jlj 1 1 0.05 0 0
46 INT180303 Binding of S100B and Tg(EGFR)0Jlj 1 1 0.03 0 0
47 INT355221 Binding of Espn and Ocln 1 1 0.01 0 0
48 INT355223 Binding of Espn and Tjp2 1 1 0.01 0 0
49 INT355225 Binding of Ocln and Tjp2 1 1 0.07 0 0
50 INT355222 Positive_regulation of Binding of Ocln and Tjp1 1 1 0.18 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 2 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 2 2008 0.81 518.3 1408.65
3 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
4 INT7114 Positive_regulation of Ltp 1 1192 0.62 290.76 755.77
5 INT5202 Positive_regulation of Gene_expression of Fos 1 1163 0.70 319.28 684
6 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
7 INT4758 Positive_regulation of Localization of Calca 1 557 0.70 138.55 411.04
8 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
9 INT18357 Gene_expression of TRPV1 22 825 0.78 307.11 382.81
10 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
11 INT2649 Regulation of Calca 1 433 0.62 146.05 330.95
12 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
13 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
14 INT9381 Positive_regulation of TRPV1 6 523 0.70 187.4 276.05
15 INT49750 Negative_regulation of CPOX 3 735 0.58 360.06 274.19
16 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
17 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
18 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
19 INT6481 Binding of TNF 9 624 0.48 510.2 214.82
20 INT50670 Gene_expression of CPOX 12 763 0.76 442.13 195.02
21 INT94952 Positive_regulation of Mapk14 1 305 0.70 197.83 186.61
22 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
23 INT7506 Negative_regulation of Ltp 2 267 0.46 91.01 176.8
24 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
25 INT867 Gene_expression of IFNA1 6 930 0.78 594.85 168.03
26 INT7628 Gene_expression of Ltp 3 273 0.77 70.21 147.87
27 INT9852 Positive_regulation of Gpt 1 563 0.70 364.64 146.82
28 INT425 Localization of PRL 2 455 0.81 189.64 144.8
29 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
30 INT14843 Gene_expression of Gabrg1 9 301 0.77 62.63 139.16
31 INT695 Binding of POMC 1 304 0.48 56.66 126.85
32 INT6323 Positive_regulation of Gabrg1 1 213 0.70 45.08 124.34
33 INT7533 Gene_expression of Tlr4 1 720 0.78 343.22 121.57
34 INT17612 Gene_expression of CRP 4 676 0.78 580.61 119.03
35 INT62124 Gene_expression of NOS1 2 444 0.78 218.08 114.85
36 INT65731 Gene_expression of Cnr1 1 234 0.78 63.82 109.34
37 INT7627 Negative_regulation of Positive_regulation of Ltp 1 162 0.50 41.2 106.27
38 INT915 Positive_regulation of PRL 2 342 0.70 141.96 104.31
39 INT18009 Positive_regulation of CRP 5 518 0.70 553.03 103.74
40 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
41 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
42 INT97701 Phosphorylation of Mapk14 1 191 0.82 115.33 100.46
43 INT1760 Gene_expression of PTGER2 1 524 0.57 226.94 96.4
44 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
45 INT11587 Gene_expression of CSF2 32 645 0.78 544.38 93.89
46 INT9516 Negative_regulation of Gabrg1 2 149 0.53 27.83 91.02
47 INT5610 Positive_regulation of Insr 1 140 0.69 37.26 86.24
48 INT10534 Positive_regulation of Trib3 4 209 0.60 78.75 81.48
49 INT12476 Negative_regulation of TRPV1 8 124 0.59 47.95 77.98
50 INT9382 Regulation of TRPV1 7 149 0.62 53.99 77.46
51 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
52 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
53 INT39565 Gene_expression of Ptger2 1 424 0.75 229.28 72.68
54 INT13276 Regulation of Ltp 2 107 0.53 30.78 69.13
55 INT55224 Gene_expression of DRGX 5 99 0.31 67.55 67.63
56 INT9489 Gene_expression of SFTPA1 13 112 0.66 55.38 66.45
57 INT253 Regulation of PRL 1 184 0.62 47.27 65.79
58 INT4960 Positive_regulation of CSF2 8 285 0.70 256.73 65.73
59 INT65730 Gene_expression of Cnr2 7 129 0.78 60.15 63.1
60 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
61 INT2761 Regulation of Gabrg1 2 119 0.61 18.8 60.52
62 INT50672 Positive_regulation of CPOX 13 205 0.44 125.93 60.06
63 INT4509 Gene_expression of IGG 4 426 0.76 293.69 56.64
64 INT96937 Gene_expression of Mmp9 2 191 0.75 150.3 56.01
65 INT1579 Gene_expression of PRL 2 279 0.78 119.2 55.41
66 INT49436 Binding of TRPV1 4 145 0.48 38.35 55.08
67 INT117713 Phosphorylation of Akt1 7 275 0.82 95.82 54.34
68 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
69 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
70 INT40777 Positive_regulation of Akt1 27 163 0.69 59.41 49.43
71 INT9383 Localization of TRPV1 5 98 0.81 33.23 46.24
72 INT42980 Gene_expression of GAD1 1 139 0.69 94.77 45.11
73 INT18522 Positive_regulation of Gene_expression of IFNA1 2 248 0.67 160.85 44.87
74 INT63383 Binding of Cnr1 1 77 0.48 22.28 44.61
75 INT4216 Gene_expression of CD40LG 6 328 0.78 256.02 44.23
76 INT25383 Gene_expression of Csf2 3 222 0.76 152.93 43.32
77 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
78 INT4004 Gene_expression of IGHG3 7 321 0.71 221.03 42.33
79 INT13556 Gene_expression of CD4 3 367 0.78 230.82 41.74
80 INT5793 Binding of CTS 1 110 0.48 63.91 40.62
81 INT918 Positive_regulation of Localization of PRL 1 90 0.70 23.97 40.3
82 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
83 INT3758 Gene_expression of ALB 2 326 0.78 184.65 38.75
84 INT50673 Positive_regulation of Gene_expression of CPOX 4 156 0.54 97.31 37.03
85 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
86 INT84260 Positive_regulation of Mapk8 2 124 0.69 72.84 35.98
87 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
88 INT66005 Regulation of Cnr1 2 47 0.61 19.21 34.52
89 INT8905 Gene_expression of EDN1 3 215 0.78 157.1 34.19
90 INT53475 Gene_expression of MRI1 6 116 0.59 77.68 33.98
91 INT81289 Positive_regulation of Gene_expression of Tlr4 1 192 0.69 104.5 33.89
92 INT2732 Gene_expression of VIP 1 74 0.78 24.57 33.72
93 INT5489 Localization of CA2 1 172 0.80 39.46 33.56
94 INT95734 Phosphorylation of Mapk8 2 108 0.82 49.92 33.52
95 INT9694 Positive_regulation of Csf2 1 102 0.68 70.09 33.07
96 INT64171 Regulation of CPOX 3 109 0.36 55.36 32.96
97 INT6302 Binding of IFNA1 2 196 0.48 133.85 32.73
98 INT62830 Gene_expression of VCAM1 1 149 0.78 125.23 32.4
99 INT22939 Gene_expression of Csf2 2 164 0.78 85.1 32.22
100 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
101 INT72923 Positive_regulation of MCRS1 8 72 0.50 99.19 30.36
102 INT64113 Positive_regulation of Gene_expression of NOS1 5 110 0.60 71.03 29.72
103 INT11554 Negative_regulation of CSF2 10 129 0.59 108.55 29.44
104 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
105 INT9199 Positive_regulation of CEBPZ 1 111 0.67 30.99 28.45
106 INT14690 Localization of CSF2 4 124 0.80 85.17 27.26
107 INT1765 Positive_regulation of Gene_expression of PTGER2 1 140 0.51 68.68 27
108 INT127499 Positive_regulation of TRPA1 1 72 0.70 21.7 26.86
109 INT32826 Positive_regulation of Gene_expression of Ltp 2 52 0.45 10.34 26.8
110 INT3760 Positive_regulation of ALB 2 142 0.70 87.46 26.7
111 INT100861 Binding of CRP 1 179 0.48 175.2 26.45
112 INT17739 Gene_expression of S100B 26 226 0.78 132.7 26.4
113 INT79395 Gene_expression of Twist1 1 193 0.77 100.06 26.34
114 INT140413 Gene_expression of AQP4 5 113 0.78 139.25 25.53
115 INT57192 Binding of Ltp 1 43 0.41 17.48 24.96
116 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
117 INT58192 Positive_regulation of MRI1 4 86 0.61 53.81 24.68
118 INT40776 Gene_expression of Akt1 3 99 0.77 34.91 24.39
119 INT117718 Positive_regulation of Phosphorylation of Akt1 7 112 0.69 39.26 24.09
120 INT17275 Gene_expression of HIVEP1 1 267 0.75 232.07 24.06
121 INT44954 Gene_expression of APP 6 191 0.78 105.86 23.9
122 INT8836 Positive_regulation of SFTPA1 1 36 0.47 28.37 23.59
123 INT9292 Positive_regulation of SGCG 1 93 0.67 35.13 23.48
124 INT127500 Gene_expression of TRPA1 4 79 0.78 24.58 23.3
125 INT134651 Binding of TLR4 2 89 0.48 66.96 23.19
126 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
127 INT101592 Gene_expression of TRPM8 3 82 0.78 70.61 22.89
128 INT3330 Gene_expression of AGT 2 149 0.76 98.65 22.73
129 INT16996 Gene_expression of PRTN3 1 113 0.75 85.61 22.57
130 INT48081 Localization of Il1b 1 46 0.80 21.59 22.4
131 INT62373 Negative_regulation of NGF 2 34 0.59 25.87 22.38
132 INT10536 Gene_expression of Trib3 1 67 0.66 27.08 21.58
133 INT14700 Regulation of IFNA1 1 111 0.45 66.16 21.52
134 INT5916 Positive_regulation of HTR1A 1 51 0.67 18.27 21.38
135 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
136 INT95167 Positive_regulation of DRGX 1 33 0.22 26.72 21.04
137 INT28151 Positive_regulation of CTs 1 55 0.61 35.09 20.14
138 INT27018 Gene_expression of PTGER1 8 68 0.75 31.76 20.12
139 INT12265 Positive_regulation of IgG 1 168 0.63 104.89 19.76
140 INT184895 Gene_expression of MCRS1 2 46 0.42 56.03 19.44
141 INT756 Gene_expression of C3 2 138 0.75 100.6 19.2
142 INT5398 Positive_regulation of ALPP 2 178 0.70 110.52 19.18
143 INT101578 Regulation of Cnr2 4 26 0.62 16.7 19.12
144 INT10565 Gene_expression of MRXS5 4 94 0.53 37.35 19.08
145 INT69592 Positive_regulation of PSMD1 1 27 0.70 17.83 18.98
146 INT81194 Binding of CPOX 1 40 0.29 23.7 18.95
147 INT120446 Positive_regulation of Cnr2 4 32 0.70 16.3 18.91
148 INT19763 Gene_expression of CTs 1 69 0.78 32.92 18.87
149 INT66004 Binding of Cnr2 1 35 0.48 12.82 18.63
150 INT18010 Positive_regulation of CD40LG 1 122 0.70 100.8 18.46
151 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
152 INT83198 Positive_regulation of Nos3 1 78 0.64 35.69 17.71
153 INT1578 Negative_regulation of Localization of PRL 1 52 0.59 20.62 17.18
154 INT95767 Negative_regulation of Mmp9 4 72 0.57 49.14 17.1
155 INT24225 Gene_expression of Alms1 1 93 0.62 52.75 16.93
156 INT23657 Positive_regulation of APP 1 64 0.70 39.76 16.68
157 INT10214 Gene_expression of VIM 1 153 0.78 115.88 16.29
158 INT11685 Regulation of CSF2 4 99 0.59 58.82 15.9
159 INT1752 Negative_regulation of Ache 1 109 0.59 42.05 15.73
160 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
161 INT22143 Gene_expression of Gad1 7 35 0.76 14.4 15.4
162 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
163 INT2630 Positive_regulation of Shbg 2 134 0.70 65.26 15.19
164 INT109535 Gene_expression of Vegfa 1 116 0.75 84.61 14.89
165 INT10709 Negative_regulation of CD4 2 106 0.59 95.6 14.89
166 INT9191 Localization of EDN1 2 94 0.81 57.01 14.78
167 INT180497 Binding of MRI1 1 45 0.42 28.35 14.77
168 INT127046 Gene_expression of P2RX7 13 65 0.78 34.28 14.76
169 INT11340 Positive_regulation of SLC17A5 1 120 0.67 113.52 14.5
170 INT8904 Positive_regulation of Gene_expression of EDN1 10 66 0.70 65.4 14.42
171 INT34952 Regulation of ABAT 1 28 0.61 6.05 14.39
172 INT69743 Gene_expression of Hmox2 1 36 0.78 20.77 14.26
173 INT54924 Gene_expression of RLS 6 67 0.62 83.2 14.25
174 INT22301 Positive_regulation of Gene_expression of CSF2 2 66 0.63 59.49 14.24
175 INT70265 Regulation of MRI1 1 42 0.39 30.95 14.18
176 INT95738 Positive_regulation of Phosphorylation of Mapk8 1 40 0.70 23.46 13.88
177 INT22272 Negative_regulation of HTR2A 1 28 0.57 7.62 13.87
178 INT103828 Negative_regulation of Gene_expression of TRPV1 1 23 0.59 13.63 13.81
179 INT28314 Negative_regulation of Gene_expression of Gabrg1 1 29 0.44 12.56 13.8
180 INT184890 Regulation of MCRS1 2 35 0.22 44.35 13.78
181 INT5207 Negative_regulation of Alms1 2 70 0.41 41.56 13.68
182 INT24684 Localization of PLAT 14 30 0.78 26.21 13.56
183 INT2005 Positive_regulation of Gene_expression of PRL 1 55 0.70 21.4 13.44
184 INT103547 Gene_expression of TRPV3 13 47 0.78 17.06 13.34
185 INT39046 Positive_regulation of PTGER1 9 28 0.69 18.18 13.21
186 INT2673 Negative_regulation of PROC 1 93 0.57 50.34 12.79
187 INT3521 Regulation of Csf2 1 38 0.54 11.09 12.73
188 INT90909 Negative_regulation of Gene_expression of NOS1 1 44 0.55 23.83 12.47
189 INT97237 Transcription of TRPV1 1 33 0.72 10.56 12.4
190 INT9832 Gene_expression of Shbg 3 96 0.75 56.71 12.19
191 INT182240 Gene_expression of CXCL13 1 25 0.59 22.77 11.96
192 INT8548 Gene_expression of HP 1 86 0.77 47.62 11.94
193 INT73829 Positive_regulation of Gene_expression of VCAM1 1 41 0.61 35.96 11.92
194 INT39587 Gene_expression of CP 3 42 0.65 31.48 11.87
195 INT26534 Regulation of Akt1 1 34 0.61 14.47 11.86
196 INT83894 Positive_regulation of TRPM8 3 37 0.70 18.28 11.7
197 INT3602 Negative_regulation of Shbg 1 148 0.53 69.05 11.65
198 INT24816 Binding of CD40LG 2 68 0.47 45.48 11.56
199 INT142735 Regulation of RLS 4 33 0.53 45.83 11.35
200 INT9945 Negative_regulation of Csf2 1 35 0.51 17.85 11.22
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