J:BMC Pulm Med

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT243043 Binding of Mmp9 and Timp1 1 2 0.05 0.25 1.86
2 INT168529 APP Regulation of FSIP1 2 3 0.65 2.26 1.07
3 INT168528 QRFP Regulation of FSIP1 2 2 0.07 1.32 0.93
4 INT243044 Mmp8 Regulation of Mmp9 1 1 0.05 1.45 0.91
5 INT194644 Tlr4 Positive_regulation of TNF 6 2 0.58 2.42 0.76
6 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 2 0.02 0.7 0.54
7 INT310769 Pam Regulation of Tlr4 1 1 0.01 0.69 0.46
8 INT231225 Binding of C1S and SFTPC 1 2 0.39 1.51 0.43
9 INT168533 Binding of FSIP1 and Aia1 2 2 0.01 1.97 0.4
10 INT239398 Atp7b Regulation of OAP 1 1 0.03 1.1 0.35
11 INT310765 Binding of Pam and Tlr2 1 1 0.01 0.57 0.35
12 INT319220 FSIP1 Regulation of APP 1 1 0.29 1.46 0.29
13 INT319221 FSIP1 Regulation of ADAM33 1 1 0.31 1.47 0.29
14 INT310771 Pam Positive_regulation of TNF 1 2 0.02 0.29 0.27
15 INT310768 Pam Positive_regulation of Cxcl2 1 2 0.01 0.29 0.26
16 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 1 0.07 1.69 0.26
17 INT310766 Tlr4 Positive_regulation of Cxcl2 1 2 0.29 0.28 0.26
18 INT319229 Binding of SNRNP70 and Aia1 2 1 0.00 2.92 0.25
19 INT350006 Tlr4 Regulation of Positive_regulation of Tlr3 1 1 0.41 0.17 0.21
20 INT350005 Tlr3 Positive_regulation of Il17rb 1 1 0.09 0.32 0.21
21 INT239393 Atp7b Positive_regulation of Gene_expression of Amigo2 1 1 0.03 1.37 0.16
22 INT239395 Atp7b Positive_regulation of Amigo2 1 1 0.03 1.36 0.16
23 INT239394 Atp7b Positive_regulation of Positive_regulation of Amigo2 1 1 0.03 1.36 0.16
24 INT239397 OAP Positive_regulation of Amigo2 1 2 0.00 0.56 0.1
25 INT319223 RS1 Regulation of Positive_regulation of FSIP1 1 1 0.05 0.42 0.05
26 INT175393 Binding of Ugcg and Ssr1 1 1 0.04 0.6 0.03
27 INT249046 Binding of LEP and ARID1B 1 1 0.01 1.3 0.03
28 INT249045 CENPJ Regulation of Regulation of LEP 1 1 0.14 0.81 0
29 INT249047 CENPJ Negative_regulation of LEP 1 1 0.22 0.8 0
30 INT307774 Binding of ARMC9 and RCT 1 1 0.01 1.27 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 2 3152 0.78 2515.62 929.82
2 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
3 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
4 INT9659 Gene_expression of Il6 4 991 0.78 715.11 265.57
5 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
6 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
7 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
8 INT15515 Positive_regulation of Crp 2 700 0.70 604.24 150.15
9 INT7533 Gene_expression of Tlr4 2 720 0.78 343.22 121.57
10 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
11 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
12 INT12082 Localization of IL6 1 365 0.81 241.78 105.78
13 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
14 INT82448 Gene_expression of S100a8 2 246 0.77 236.72 84.02
15 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
16 INT56298 Gene_expression of IL4 2 306 0.78 182.18 72.92
17 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
18 INT8357 Gene_expression of KNG1 5 153 0.75 77.26 68.66
19 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
20 INT102546 Gene_expression of Ccl2 6 197 0.78 192.8 67.41
21 INT5374 Gene_expression of Esr1 1 412 0.77 263.89 67.34
22 INT9657 Positive_regulation of Gene_expression of Il6 4 237 0.70 180.45 63.6
23 INT1951 Positive_regulation of Tlr4 4 345 0.70 176.99 62.42
24 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
25 INT169926 Positive_regulation of Gopc 1 416 0.46 157.8 58.67
26 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
27 INT96937 Gene_expression of Mmp9 4 191 0.75 150.3 56.01
28 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
29 INT72182 Gene_expression of Mcpt1 3 167 0.75 123.7 52.15
30 INT17881 Gene_expression of LEP 4 278 0.78 221.61 48.31
31 INT3361 Positive_regulation of Esr1 2 273 0.69 208.53 44.81
32 INT83953 Gene_expression of Cxcl2 1 140 0.75 113.07 43.65
33 INT115384 Positive_regulation of Mmp9 14 121 0.68 94.74 43.02
34 INT30 Gene_expression of Gast 1 158 0.78 99 41.45
35 INT48933 Gene_expression of Mapk3 1 93 0.75 44.39 37.92
36 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
37 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
38 INT30169 Negative_regulation of Pde4a 20 107 0.58 81 36.23
39 INT60710 Gene_expression of Col7a1 7 217 0.78 113.2 35.2
40 INT1624 Gene_expression of Cea 1 212 0.76 180.44 34.21
41 INT48924 Positive_regulation of Mapk3 1 107 0.67 50.53 34.05
42 INT81289 Positive_regulation of Gene_expression of Tlr4 1 192 0.69 104.5 33.89
43 INT608 Negative_regulation of KNG1 31 98 0.43 72.36 31.23
44 INT56809 Binding of Tlr4 3 184 0.48 106.02 31.18
45 INT56290 Negative_regulation of Gene_expression of Il6 1 79 0.59 47.98 31.07
46 INT129207 Gene_expression of Cxcl1 7 114 0.75 68.54 30.82
47 INT169180 Binding of SNRNP70 2 204 0.47 119.1 29.3
48 INT48202 Gene_expression of Tgfb1 2 146 0.78 89.93 27.76
49 INT10799 Localization of ENG 1 63 0.78 18.67 27.28
50 INT59449 Negative_regulation of Timp1 4 76 0.42 54.86 26.99
51 INT3167 Binding of KNG1 1 48 0.48 23.26 26.77
52 INT49141 Gene_expression of Selp 1 157 0.78 85.22 24.78
53 INT86295 Gene_expression of Mmp2 1 114 0.76 73.68 24.25
54 INT72370 Gene_expression of Timp1 2 82 0.65 57.52 24.16
55 INT147792 Gene_expression of COPD 7 230 0.70 287.13 24.1
56 INT44954 Gene_expression of APP 1 191 0.78 105.86 23.9
57 INT58288 Positive_regulation of Gene_expression of Crp 2 83 0.61 82.23 23.7
58 INT142594 Gene_expression of Tlr2 1 165 0.78 139.73 22.26
59 INT5328 Positive_regulation of CD4 1 191 0.69 133.43 21.31
60 INT125312 Positive_regulation of COPD 1 134 0.59 162.55 20.27
61 INT82434 Positive_regulation of LEP 10 117 0.70 95.45 20.22
62 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
63 INT65260 Positive_regulation of Col7a1 2 95 0.69 61.73 18.42
64 INT132997 Localization of Mmp9 3 59 0.80 45.9 17.61
65 INT95767 Negative_regulation of Mmp9 1 72 0.57 49.14 17.1
66 INT95790 Regulation of Mapk1 1 55 0.61 21.17 16.31
67 INT62681 Negative_regulation of LEP 9 93 0.59 66.97 15.77
68 INT43906 Regulation of Tlr4 2 71 0.53 35.18 15.49
69 INT75908 Regulation of LEP 10 77 0.60 60.16 15.19
70 INT113606 Positive_regulation of Gene_expression of Mmp9 1 46 0.64 44 15.07
71 INT75540 Positive_regulation of TH1L 1 62 0.67 43.45 15.02
72 INT1284 Negative_regulation of Mmp13 2 20 0.57 36.21 14.91
73 INT87823 Positive_regulation of Cxcl2 2 51 0.66 35.47 14.79
74 INT36262 Positive_regulation of Tbce 2 35 0.49 28.79 14.33
75 INT142593 Positive_regulation of Tlr2 2 85 0.70 75.9 13.62
76 INT20632 Gene_expression of TNC 3 72 0.78 30.43 13.16
77 INT122812 Gene_expression of SNRNP70 1 130 0.75 67 12.5
78 INT69158 Localization of IL4 1 48 0.71 31.3 11.98
79 INT70905 Positive_regulation of EDNRA 1 49 0.67 24.33 11.79
80 INT14204 Protein_catabolism of KNG1 1 41 0.96 20.94 11.47
81 INT126743 Positive_regulation of Gene_expression of LEP 2 61 0.66 50.02 11.17
82 INT6431 Positive_regulation of Ass1 1 36 0.24 8.08 10.43
83 INT56450 Negative_regulation of Gene_expression of Icam1 1 33 0.52 27.21 10.15
84 INT93309 Positive_regulation of CAP1 1 17 0.43 11.4 9.13
85 INT60436 Negative_regulation of COPD 1 76 0.37 84.22 9.08
86 INT80420 Gene_expression of IFI27 1 145 0.78 63.61 8.83
87 INT150867 Regulation of COPD 1 54 0.48 71.38 8.8
88 INT111397 Localization of Timp1 1 17 0.70 11.67 8.76
89 INT57057 Gene_expression of APC 1 131 0.78 122.24 8.7
90 INT939 Gene_expression of PAEP 1 86 0.77 31.02 8.59
91 INT112967 Regulation of Mcpt1 1 15 0.54 13.03 8.58
92 INT93310 Gene_expression of CAP1 1 14 0.58 3.07 8.55
93 INT105777 Gene_expression of Pde4a 3 30 0.76 12.67 8.52
94 INT75907 Binding of LEP 1 53 0.46 46.65 8.44
95 INT96068 Positive_regulation of Timp1 3 30 0.58 23.94 8.17
96 INT42707 Gene_expression of Tbce 2 24 0.65 12.92 7.93
97 INT49437 Gene_expression of OAP 5 25 0.54 20.12 7.34
98 INT89309 Negative_regulation of Pde4b 1 21 0.53 12.81 7.32
99 INT147793 Localization of COPD 4 70 0.64 89.01 7.3
100 INT168600 Binding of Mmp9 2 14 0.44 12.79 6.92
101 INT53704 Negative_regulation of Col7a1 3 42 0.35 22.4 6.88
102 INT132822 Localization of IL13 1 26 0.67 22.85 6.66
103 INT25022 Binding of PAEP 5 66 0.42 22.83 6.59
104 INT9311 Regulation of Ssr1 1 13 0.60 6.41 6.58
105 INT73499 Positive_regulation of IL13 1 23 0.39 20.03 6.53
106 INT155780 Gene_expression of Mmp8 4 19 0.77 15.85 6.33
107 INT60713 Binding of Col7a1 1 47 0.43 22.52 6.29
108 INT118492 Regulation of Pde4a 4 7 0.61 6.32 6.04
109 INT55309 Positive_regulation of Ssr1 2 20 0.46 5.97 5.74
110 INT63351 Negative_regulation of Gene_expression of PECAM1 1 19 0.52 16.06 5.73
111 INT3306 Localization of Tbce 3 16 0.12 8.24 5.71
112 INT43997 Positive_regulation of Gene_expression of Esr1 2 57 0.51 36.66 5.51
113 INT140223 Regulation of Ccl2 1 15 0.45 13.1 5.41
114 INT69156 Localization of IL5 1 21 0.68 14.95 5.37
115 INT197491 Gene_expression of Myd88 3 32 0.74 14.59 5.29
116 INT174688 Binding of Tlr2 1 45 0.42 36.65 5.25
117 INT134966 Localization of Col7a1 1 23 0.42 16.4 5.24
118 INT115816 Protein_catabolism of APP 3 35 0.99 20.14 5.06
119 INT161220 Binding of Ccl2 1 17 0.46 17.63 4.94
120 INT10138 Negative_regulation of Gene_expression of KNG1 1 13 0.57 9.57 4.9
121 INT9310 Negative_regulation of Ssr1 1 20 0.49 6.55 4.73
122 INT14831 Negative_regulation of TNC 3 18 0.50 8.71 4.61
123 INT220861 Positive_regulation of Mmp8 3 14 0.50 12.21 4.6
124 INT8773 Gene_expression of HBG1 4 58 0.76 37.6 4.59
125 INT2836 Positive_regulation of PAEP 2 51 0.67 26.69 4.57
126 INT18639 Positive_regulation of OAP 1 16 0.69 10.49 4.57
127 INT138216 Negative_regulation of PER1 1 13 0.37 9.66 4.55
128 INT183681 Positive_regulation of Tlr3 8 20 0.62 16.25 4.54
129 INT142752 Positive_regulation of Myd88 2 26 0.66 12.07 4.4
130 INT63816 Binding of Aia1 9 20 0.23 22.28 4.13
131 INT158595 Gene_expression of Tlr3 3 25 0.69 12.09 4.07
132 INT57525 Negative_regulation of Ltf 2 9 0.50 4.2 4.03
133 INT64473 Regulation of Gene_expression of IL4 1 17 0.58 6.61 3.96
134 INT124655 Negative_regulation of PECAM1 1 13 0.23 10.32 3.78
135 INT132994 Positive_regulation of Localization of Mmp9 1 12 0.42 9.4 3.75
136 INT180922 Negative_regulation of Mmp8 1 4 0.43 8.35 3.72
137 INT158596 Binding of Tlr3 1 24 0.47 11.66 3.69
138 INT161206 Negative_regulation of Localization of Mmp9 1 10 0.59 9.68 3.59
139 INT94408 Positive_regulation of Gene_expression of IFI27 1 28 0.65 12.89 3.53
140 INT157805 Negative_regulation of Gene_expression of Col7a1 1 22 0.34 12.85 3.51
141 INT220078 Positive_regulation of Negative_regulation of KNG1 2 3 0.13 5.03 3.41
142 INT181355 Regulation of Gene_expression of Ccl2 2 12 0.44 10.37 3.21
143 INT55002 Gene_expression of ASAP1 1 46 0.64 22.8 3.2
144 INT2837 Regulation of PAEP 2 17 0.53 7.84 3.17
145 INT24873 Binding of KLF1 1 12 0.07 6.73 3.1
146 INT146300 Binding of RS1 1 31 0.22 29.55 3.04
147 INT130603 Binding of Timp1 2 9 0.35 8.52 3.04
148 INT28731 Negative_regulation of Elane 2 14 0.14 8.97 3.01
149 INT165915 Regulation of Negative_regulation of Pde4a 5 5 0.29 6.72 2.91
150 INT234717 Regulation of Cxcl1 1 10 0.41 6.14 2.9
151 INT220858 Positive_regulation of Mmp1a 1 15 0.38 9.11 2.77
152 INT48199 Regulation of Tgfb1 2 17 0.54 9.57 2.74
153 INT184257 Positive_regulation of Gene_expression of Mmp8 2 7 0.49 6.32 2.74
154 INT152906 Regulation of Gene_expression of Cxcl1 1 10 0.44 5.83 2.69
155 INT231737 Localization of OAP 1 5 0.50 7.4 2.63
156 INT65258 Regulation of Gene_expression of Col7a1 2 17 0.55 8.26 2.57
157 INT55310 Gene_expression of Ssr1 2 20 0.67 3.47 2.56
158 INT35349 Gene_expression of CENPJ 1 52 0.57 25.36 2.54
159 INT44349 Gene_expression of FSIP1 6 5 0.77 6.56 2.54
160 INT243033 Localization of Mmp8 3 8 0.65 5.59 2.52
161 INT125439 Positive_regulation of NFIB 1 4 0.67 6.71 2.52
162 INT243034 Positive_regulation of Rarb 4 1 0.04 4.07 2.52
163 INT181986 Negative_regulation of Positive_regulation of Col7a1 1 6 0.08 7.4 2.46
164 INT45168 Negative_regulation of ASAP1 4 23 0.58 10.15 2.44
165 INT173511 Localization of Mmp1a 1 4 0.21 2.73 2.39
166 INT186456 Gene_expression of SFTPC 8 2 0.75 11.46 2.38
167 INT9473 Binding of MUC1 1 66 0.48 46.77 2.36
168 INT62511 Negative_regulation of MCS 1 20 0.50 6.77 2.35
169 INT228048 Positive_regulation of Positive_regulation of Tbce 1 3 0.05 2.47 2.35
170 INT191221 Positive_regulation of Amigo2 9 20 0.12 24.24 2.31
171 INT9995 Localization of C6orf25 1 13 0.69 6.48 2.29
172 INT175388 Localization of Ugcg 2 22 0.37 13.84 2.24
173 INT204775 Regulation of Tlr2 1 21 0.41 13.6 2.18
174 INT158459 Negative_regulation of Gene_expression of Timp1 1 8 0.40 4.21 2.16
175 INT178339 Binding of Cxcl1 1 17 0.36 5.14 2.04
176 INT129829 Regulation of Aia1 2 7 0.05 8.47 2.01
177 INT118201 Negative_regulation of Itgam 1 3 0.22 3.41 1.99
178 INT106740 Regulation of Ugcg 5 14 0.22 11.5 1.88
179 INT243030 Binding of Mmp8 2 1 0.10 2.4 1.82
180 INT20394 Binding of Tbce 4 12 0.06 5.47 1.78
181 INT82760 Negative_regulation of Positive_regulation of Mapk3 1 7 0.57 3.18 1.78
182 INT63812 Gene_expression of H1FNT 4 14 0.06 8.41 1.67
183 INT233975 Positive_regulation of Gene_expression of Myd88 2 7 0.66 4.17 1.65
184 INT84310 Regulation of Gene_expression of Tgfb1 1 7 0.29 6.6 1.63
185 INT135930 Regulation of Gene_expression of Pde4a 1 3 0.61 0.52 1.63
186 INT173510 Positive_regulation of Localization of Mmp1a 1 4 0.13 2.55 1.62
187 INT88726 Gene_expression of HPRT1 1 36 0.78 10.12 1.58
188 INT57089 Negative_regulation of Cel 2 10 0.02 4.46 1.58
189 INT234761 Binding of IL13 1 6 0.35 4.18 1.55
190 INT154104 Binding of ARID1B 1 47 0.39 69.82 1.49
191 INT186458 Negative_regulation of SFTPC 6 11 0.57 8.6 1.29
192 INT177527 Negative_regulation of Binding of Pde4a 1 4 0.28 3.5 1.23
193 INT268662 Regulation of Araf 1 4 0.17 2.5 1.13
194 INT7207 Regulation of HBG1 7 27 0.60 22.1 1.12
195 INT219595 Positive_regulation of Gene_expression of Pde4a 1 3 0.39 2.81 1.11
196 INT186461 Gene_expression of SFTPB 7 10 0.73 8.69 1.09
197 INT175389 Positive_regulation of Ugcg 1 9 0.32 8.79 1.09
198 INT191774 Gene_expression of Amigo2 5 2 0.05 6.81 1.03
199 INT228038 Positive_regulation of Gene_expression of Tbce 1 3 0.07 2.02 1.01
200 INT66725 Binding of Rars 3 6 0.48 8.7 1
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